Danio rerio

0 known processes

slc4a4b

solute carrier family 4, sodium bicarbonate cotransporter, member 4b

(Aliases: nbc1)

slc4a4b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
anion homeostasis GO:0055081 9 0.950
bicarbonate transport GO:0015701 4 0.772
Zebrafish Mouse
chloride transport GO:0006821 8 0.580
Worm
anion transport GO:0006820 38 0.479
Zebrafish Mouse Worm
ammonia homeostasis GO:0097272 3 0.378
nitrogen compound metabolic process GO:0006807 319 0.317
metal ion transport GO:0030001 58 0.310
Zebrafish Mouse
chloride transmembrane transport GO:1902476 4 0.285
Worm
hematopoietic or lymphoid organ development GO:0048534 191 0.217
Zebrafish
humoral immune response mediated by circulating immunoglobulin GO:0002455 3 0.204
inorganic anion transport GO:0015698 25 0.202
Zebrafish Worm
regulation of ph GO:0006885 3 0.168
cellular response to molecule of bacterial origin GO:0071219 3 0.155
transmembrane transport GO:0055085 120 0.151
Zebrafish Worm
immune system process GO:0002376 241 0.150
Zebrafish
activation of immune response GO:0002253 9 0.148
ear development GO:0043583 127 0.140
ion transport GO:0006811 114 0.126
Zebrafish Mouse Worm
cellular macromolecule biosynthetic process GO:0034645 224 0.122
embryonic cranial skeleton morphogenesis GO:0048701 90 0.121
biosynthetic process GO:0009058 294 0.109
toxin transport GO:1901998 2 0.106
Zebrafish
erythrocyte differentiation GO:0030218 54 0.103
Zebrafish
regulation of nucleic acid templated transcription GO:1903506 213 0.102
sodium ion transport GO:0006814 24 0.098
Zebrafish Mouse
one carbon compound transport GO:0019755 14 0.092
ammonium transport GO:0015696 6 0.092
establishment of localization GO:0051234 244 0.090
Zebrafish Mouse Worm
cellular response to lipopolysaccharide GO:0071222 3 0.086
cation transport GO:0006812 81 0.085
Zebrafish Mouse
monovalent inorganic cation homeostasis GO:0055067 9 0.084
monovalent inorganic cation transport GO:0015672 42 0.080
Zebrafish Mouse
positive regulation of map kinase activity GO:0043406 3 0.080
cellular component assembly involved in morphogenesis GO:0010927 107 0.076
negative regulation of cysteine type endopeptidase activity GO:2000117 8 0.073
protein activation cascade GO:0072376 6 0.071
inorganic anion transmembrane transport GO:0098661 10 0.070
Worm
immunoglobulin mediated immune response GO:0016064 3 0.069
cellular ketone metabolic process GO:0042180 11 0.066
erythrocyte homeostasis GO:0034101 55 0.064
Zebrafish
homeostatic process GO:0042592 142 0.064
Zebrafish
regulation of membrane potential GO:0042391 23 0.063
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.063
cation homeostasis GO:0055080 33 0.062
response to chemical GO:0042221 320 0.061
Zebrafish Worm
nucleic acid metabolic process GO:0090304 244 0.060
complement activation classical pathway GO:0006958 3 0.060
sodium ion import GO:0097369 3 0.059
response to carbohydrate GO:0009743 3 0.059
embryonic viscerocranium morphogenesis GO:0048703 52 0.059
response to stress GO:0006950 263 0.058
mononuclear cell proliferation GO:0032943 1 0.057
response to drug GO:0042493 3 0.057
Zebrafish
hemopoiesis GO:0030097 183 0.057
Zebrafish
ion transmembrane transport GO:0034220 91 0.055
Zebrafish Worm
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.055
embryo development ending in birth or egg hatching GO:0009792 271 0.054
sensory organ development GO:0007423 393 0.051
regulation of cellular ph GO:0030641 1 0.051
regulation of biological quality GO:0065008 263 0.049
Zebrafish
head development GO:0060322 303 0.049
regulation of cellular biosynthetic process GO:0031326 245 0.048
regulation of inflammatory response GO:0050727 2 0.048
cation transmembrane transport GO:0098655 65 0.048
Zebrafish
inner ear development GO:0048839 126 0.047
system process GO:0003008 185 0.047
leukocyte proliferation GO:0070661 1 0.047
ensheathment of neurons GO:0007272 18 0.046
sensory system development GO:0048880 76 0.046
embryonic organ development GO:0048568 381 0.046
Zebrafish
multicellular organismal signaling GO:0035637 22 0.045
positive regulation of catabolic process GO:0009896 4 0.045
divalent inorganic anion homeostasis GO:0072505 5 0.044
cranial nerve development GO:0021545 42 0.043
fatty acid catabolic process GO:0009062 1 0.043
camera type eye morphogenesis GO:0048593 108 0.043
myeloid cell differentiation GO:0030099 86 0.043
Zebrafish
cell migration GO:0016477 237 0.043
regulation of transcription dna templated GO:0006355 213 0.042
response to salt stress GO:0009651 10 0.042
positive regulation of transport GO:0051050 2 0.042
immune system development GO:0002520 191 0.042
Zebrafish
organic substance biosynthetic process GO:1901576 289 0.041
blood vessel development GO:0001568 246 0.041
myeloid cell homeostasis GO:0002262 56 0.040
Zebrafish
response to monosaccharide GO:0034284 3 0.040
inorganic ion transmembrane transport GO:0098660 57 0.040
Zebrafish Worm
antibacterial humoral response GO:0019731 2 0.039
homeostasis of number of cells GO:0048872 62 0.039
Zebrafish
vasculature development GO:0001944 278 0.039
regulation of nitrogen compound metabolic process GO:0051171 251 0.038
regulation of cellular ketone metabolic process GO:0010565 7 0.038
larval development GO:0002164 2 0.037
action potential GO:0001508 19 0.037
complement activation GO:0006956 3 0.037
lymphocyte mediated immunity GO:0002449 5 0.037
ear morphogenesis GO:0042471 64 0.037
carbon dioxide transport GO:0015670 3 0.037
cell death in response to oxidative stress GO:0036473 2 0.037
response to biotic stimulus GO:0009607 97 0.037
negative regulation of programmed cell death GO:0043069 58 0.036
regulation of immune response GO:0050776 14 0.036
organic anion transport GO:0015711 15 0.036
Zebrafish Mouse
blood vessel morphogenesis GO:0048514 216 0.036
myelin assembly GO:0032288 1 0.035
i kappab kinase nf kappab signaling GO:0007249 4 0.035
membrane repolarization GO:0086009 2 0.035
rna metabolic process GO:0016070 219 0.034
maintenance of location GO:0051235 4 0.034
rna biosynthetic process GO:0032774 181 0.034
cytosolic calcium ion transport GO:0060401 3 0.033
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.033
epidermal cell fate specification GO:0009957 4 0.032
response to hexose GO:0009746 3 0.032
regulation of biosynthetic process GO:0009889 250 0.032
regulation of response to biotic stimulus GO:0002831 2 0.032
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.032
hydrogen peroxide metabolic process GO:0042743 2 0.032
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.032
cellular response to hormone stimulus GO:0032870 39 0.032
sodium ion transmembrane transport GO:0035725 21 0.031
Zebrafish
autophagy GO:0006914 4 0.031
cellular nitrogen compound metabolic process GO:0034641 290 0.031
embryonic organ morphogenesis GO:0048562 274 0.031
single organism localization GO:1902578 225 0.031
Zebrafish Mouse Worm
axon ensheathment in central nervous system GO:0032291 2 0.031
response to lipid GO:0033993 60 0.031
response to organic substance GO:0010033 153 0.031
sulfate transmembrane transport GO:1902358 2 0.031
sympathetic nervous system development GO:0048485 3 0.030
aging GO:0007568 2 0.030
protein secretion GO:0009306 1 0.030
b cell mediated immunity GO:0019724 3 0.030
heterocycle biosynthetic process GO:0018130 215 0.029
localization of cell GO:0051674 244 0.029
calcium ion transport into cytosol GO:0060402 3 0.029
iron ion homeostasis GO:0055072 4 0.029
cellular nitrogen compound biosynthetic process GO:0044271 218 0.028
central nervous system neuron axonogenesis GO:0021955 18 0.028
response to hormone GO:0009725 48 0.028
angiogenesis GO:0001525 158 0.028
lymphocyte proliferation GO:0046651 1 0.028
negative regulation of defense response GO:0031348 2 0.028
regulation of sequestering of calcium ion GO:0051282 4 0.027
central nervous system myelination GO:0022010 2 0.027
cell motility GO:0048870 244 0.027
innate immune response activating signal transduction GO:0002758 5 0.027
regulation of production of molecular mediator of immune response GO:0002700 1 0.027
fatty acid transport GO:0015908 1 0.026
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.026
regulation of macromolecule biosynthetic process GO:0010556 225 0.026
regulation of rna metabolic process GO:0051252 224 0.026
regulation of cellular component movement GO:0051270 55 0.026
response to endogenous stimulus GO:0009719 83 0.026
cellular macromolecule metabolic process GO:0044260 391 0.026
response to other organism GO:0051707 97 0.026
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.026
macromolecule biosynthetic process GO:0009059 227 0.026
inorganic cation transmembrane transport GO:0098662 50 0.026
Zebrafish
response to glucocorticoid GO:0051384 1 0.026
ameboidal type cell migration GO:0001667 143 0.026
adult behavior GO:0030534 2 0.025
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.025
regulation of cellular amine metabolic process GO:0033238 0 0.025
membrane fusion GO:0061025 2 0.025
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.025
transmission of nerve impulse GO:0019226 19 0.025
stem cell maintenance GO:0019827 4 0.025
purine nucleoside monophosphate catabolic process GO:0009128 4 0.024
negative regulation of protein phosphorylation GO:0001933 4 0.024
single organism biosynthetic process GO:0044711 71 0.024
myeloid cell development GO:0061515 32 0.024
aromatic compound biosynthetic process GO:0019438 217 0.024
organelle fusion GO:0048284 3 0.024
cellular response to chemical stimulus GO:0070887 157 0.024
regulation of rna biosynthetic process GO:2001141 213 0.024
positive regulation of jun kinase activity GO:0043507 2 0.024
carboxylic acid metabolic process GO:0019752 22 0.024
signal transduction GO:0007165 455 0.024
cellular amine metabolic process GO:0044106 2 0.023
lateral line system development GO:0048925 76 0.023
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.023
morphogenesis of an epithelium GO:0002009 333 0.023
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.023
nucleoside monophosphate catabolic process GO:0009125 4 0.023
response to wounding GO:0009611 116 0.023
hypotonic salinity response GO:0042539 5 0.023
response to exogenous dsrna GO:0043330 6 0.023
cellular component movement GO:0006928 335 0.022
heterocycle metabolic process GO:0046483 290 0.022
single organism transport GO:0044765 206 0.022
Zebrafish Mouse Worm
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.022
single organism metabolic process GO:0044710 217 0.022
central nervous system neuron development GO:0021954 29 0.022
response to external biotic stimulus GO:0043207 97 0.022
eye development GO:0001654 277 0.021
nucleic acid templated transcription GO:0097659 181 0.021
nucleobase containing compound metabolic process GO:0006139 274 0.021
mitochondrion organization GO:0007005 4 0.021
regulation of cell death GO:0010941 103 0.021
cellular carbohydrate metabolic process GO:0044262 4 0.021
transport GO:0006810 220 0.021
Zebrafish Mouse Worm
regulation of cellular amino acid metabolic process GO:0006521 0 0.021
oxoacid metabolic process GO:0043436 31 0.021
hatching gland development GO:0048785 3 0.021
regulation of protein complex assembly GO:0043254 3 0.021
cellular component biogenesis GO:0044085 178 0.020
stem cell proliferation GO:0072089 4 0.020
regulation of glucose import GO:0046324 1 0.020
multi organism process GO:0051704 134 0.020
protein metabolic process GO:0019538 183 0.020
locomotion GO:0040011 313 0.020
calcium ion homeostasis GO:0055074 19 0.020
cellular response to organic substance GO:0071310 105 0.020
nuclear transport GO:0051169 4 0.020
gene expression GO:0010467 252 0.020
response to glucose GO:0009749 3 0.020
fatty acid biosynthetic process GO:0006633 4 0.019
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.019
negative regulation of cell migration GO:0030336 17 0.019
establishment of protein localization to organelle GO:0072594 4 0.019
multicellular organism growth GO:0035264 4 0.019
Worm
cellular response to drug GO:0035690 1 0.019
brain development GO:0007420 293 0.019
chemical homeostasis GO:0048878 49 0.019
central nervous system myelin formation GO:0032289 1 0.019
gas transport GO:0015669 3 0.019
cell surface receptor signaling pathway GO:0007166 325 0.019
monovalent inorganic anion homeostasis GO:0055083 6 0.019
endosomal transport GO:0016197 2 0.018
regulation of intracellular signal transduction GO:1902531 57 0.018
renal absorption GO:0070293 1 0.018
hypotonic response GO:0006971 5 0.018
skeletal system development GO:0001501 181 0.018
ammonium transmembrane transport GO:0072488 2 0.018
antimicrobial humoral response GO:0019730 2 0.018
connective tissue development GO:0061448 99 0.018
positive regulation of cell adhesion GO:0045785 1 0.018
single organism membrane fusion GO:0044801 2 0.018
cranial ganglion development GO:0061550 3 0.018
cellular protein catabolic process GO:0044257 4 0.018
cellular component disassembly GO:0022411 1 0.018
transcription dna templated GO:0006351 181 0.018
regulation of cell communication GO:0010646 232 0.018
Worm
negative regulation of protein kinase activity GO:0006469 4 0.018
retina morphogenesis in camera type eye GO:0060042 79 0.017
positive regulation of jnk cascade GO:0046330 3 0.017
developmental pigmentation GO:0048066 48 0.017
urea transport GO:0015840 11 0.017
response to corticosteroid GO:0031960 1 0.017
negative regulation of macromolecule metabolic process GO:0010605 76 0.017
negative regulation of cell death GO:0060548 60 0.017
regulation of binding GO:0051098 3 0.017
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.017
response to nitrogen compound GO:1901698 19 0.017
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.017
positive regulation of cellular catabolic process GO:0031331 3 0.017
erythrocyte development GO:0048821 24 0.017
positive regulation of lipid metabolic process GO:0045834 1 0.017
nerve development GO:0021675 45 0.017
reactive nitrogen species metabolic process GO:2001057 0 0.016
negative regulation of apoptotic process GO:0043066 55 0.016
regulation of tube size GO:0035150 2 0.016
negative regulation of kinase activity GO:0033673 4 0.016
cellular biosynthetic process GO:0044249 286 0.016
response to oxygen containing compound GO:1901700 55 0.016
ribonucleoside monophosphate catabolic process GO:0009158 4 0.016
cellular response to decreased oxygen levels GO:0036294 1 0.016
regulation of metal ion transport GO:0010959 4 0.016
cellular response to external stimulus GO:0071496 2 0.016
lipid catabolic process GO:0016042 4 0.016
g protein coupled receptor signaling pathway GO:0007186 74 0.016
organelle organization GO:0006996 227 0.016
atp catabolic process GO:0006200 4 0.016
antibiotic transport GO:0042891 2 0.015
Zebrafish
organic acid metabolic process GO:0006082 31 0.015
carbohydrate biosynthetic process GO:0016051 1 0.015
metal ion homeostasis GO:0055065 26 0.015
blood circulation GO:0008015 87 0.015
renal system development GO:0072001 94 0.015
negative regulation of metabolic process GO:0009892 86 0.015
cellular response to biotic stimulus GO:0071216 3 0.015
regulation of blood vessel size GO:0050880 2 0.015
regulation of protein catabolic process GO:0042176 1 0.015
regulation of glucose transport GO:0010827 1 0.015
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 7 0.015
chordate embryonic development GO:0043009 271 0.014
response to molecule of bacterial origin GO:0002237 14 0.014
otic vesicle development GO:0071599 42 0.014
pigment cell differentiation GO:0050931 38 0.014
neurological system process GO:0050877 62 0.014
toll like receptor signaling pathway GO:0002224 4 0.014
myelination GO:0042552 18 0.014
cellular component assembly GO:0022607 170 0.014
protein localization to nucleus GO:0034504 3 0.014
brain morphogenesis GO:0048854 18 0.014
phosphatidylinositol mediated signaling GO:0048015 2 0.014
protein acetylation GO:0006473 2 0.014
cartilage development GO:0051216 96 0.014
positive regulation of protein kinase b signaling GO:0051897 1 0.014
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.014
positive regulation of immune system process GO:0002684 17 0.014
nuclear import GO:0051170 3 0.014
embryonic hemopoiesis GO:0035162 53 0.014
Zebrafish
calcium ion import GO:0070509 4 0.014
protein stabilization GO:0050821 2 0.014
somatic muscle development GO:0007525 4 0.013
cellular protein modification process GO:0006464 100 0.013
regulation of signal transduction GO:0009966 225 0.013
central nervous system neuron differentiation GO:0021953 74 0.013
positive regulation of immune response GO:0050778 11 0.013
protein heterooligomerization GO:0051291 1 0.013
small molecule catabolic process GO:0044282 3 0.013
kidney development GO:0001822 92 0.013
nucleobase containing compound biosynthetic process GO:0034654 205 0.013
negative regulation of biological process GO:0048519 304 0.013
regulation of gene expression GO:0010468 265 0.013
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.013
regulation of endothelial cell proliferation GO:0001936 1 0.013
regulation of protein transport GO:0051223 3 0.013
multicellular organismal homeostasis GO:0048871 29 0.013
lateral line ganglion development GO:0048890 2 0.013
protein targeting to nucleus GO:0044744 3 0.013
ph reduction GO:0045851 1 0.013
inner ear morphogenesis GO:0042472 63 0.013
production of molecular mediator of immune response GO:0002440 2 0.013
neuronal action potential GO:0019228 18 0.013
regulation of protein ubiquitination GO:0031396 3 0.013
positive regulation of epithelial cell differentiation GO:0030858 2 0.013
central nervous system development GO:0007417 387 0.013
organic cyclic compound metabolic process GO:1901360 301 0.013
sensory organ morphogenesis GO:0090596 200 0.013
lymphocyte homeostasis GO:0002260 1 0.013
regulation of intracellular ph GO:0051453 1 0.013
enteric nervous system development GO:0048484 12 0.012
entrainment of circadian clock GO:0009649 2 0.012
intracellular signal transduction GO:0035556 85 0.012
positive regulation of response to stimulus GO:0048584 80 0.012
response to bacterium GO:0009617 58 0.012
cellular response to xenobiotic stimulus GO:0071466 35 0.012
regulation of carbohydrate metabolic process GO:0006109 4 0.012
single organism nuclear import GO:1902593 3 0.012
multi organism cellular process GO:0044764 2 0.012
positive regulation of cell activation GO:0050867 1 0.012
embryonic skeletal system morphogenesis GO:0048704 93 0.012
oxalate transport GO:0019532 1 0.012
regulation of dendrite development GO:0050773 3 0.012
negative regulation of catabolic process GO:0009895 3 0.012
lateral line nerve development GO:0048892 9 0.012
positive regulation of cytokine production GO:0001819 2 0.012
immunoglobulin production GO:0002377 1 0.012
regulation of carbohydrate biosynthetic process GO:0043255 1 0.012
anion transmembrane transport GO:0098656 12 0.012
Worm
tissue remodeling GO:0048771 4 0.012
regulation of multicellular organismal development GO:2000026 223 0.012
negative regulation of mapk cascade GO:0043409 4 0.012
peripheral nervous system development GO:0007422 55 0.012
negative regulation of signal transduction in absence of ligand GO:1901099 1 0.012
stem cell development GO:0048864 82 0.012
negative regulation of map kinase activity GO:0043407 2 0.012
ion homeostasis GO:0050801 41 0.012
defense response GO:0006952 47 0.012
single organism organelle organization GO:1902589 199 0.012
cellular aromatic compound metabolic process GO:0006725 295 0.012
osteoclast development GO:0036035 1 0.012
axon ensheathment GO:0008366 18 0.011
positive regulation of glucose transport GO:0010828 1 0.011
protein import GO:0017038 3 0.011
autonomic nervous system development GO:0048483 19 0.011
fatty acid elongation unsaturated fatty acid GO:0019368 1 0.011
organic cyclic compound biosynthetic process GO:1901362 223 0.011
glucose import GO:0046323 2 0.011
glial cell differentiation GO:0010001 42 0.011
response to uv GO:0009411 3 0.011
regulation of cellular response to oxidative stress GO:1900407 2 0.011
regulation of response to cytokine stimulus GO:0060759 3 0.011
negative regulation of rna metabolic process GO:0051253 48 0.011
positive regulation of cellular process GO:0048522 201 0.011
multicellular organismal macromolecule metabolic process GO:0044259 2 0.011
smooth muscle contraction GO:0006939 2 0.011
regulation of macromolecule metabolic process GO:0060255 317 0.011
humoral immune response GO:0006959 5 0.011
regulation of cytokine mediated signaling pathway GO:0001959 3 0.011
negative regulation of protein transport GO:0051224 3 0.011
regulation of actin filament based movement GO:1903115 1 0.011
gtp metabolic process GO:0046039 4 0.011
long chain fatty acid transport GO:0015909 1 0.011
amine metabolic process GO:0009308 2 0.011
erk1 and erk2 cascade GO:0070371 4 0.011
positive regulation of multicellular organismal process GO:0051240 52 0.010
Worm
phosphorylation GO:0016310 69 0.010
regulation of response to oxidative stress GO:1902882 2 0.010
negative regulation of multi organism process GO:0043901 3 0.010
positive regulation of cellular amine metabolic process GO:0033240 0 0.010
retina development in camera type eye GO:0060041 146 0.010
carbohydrate homeostasis GO:0033500 1 0.010
regulation of lipid transport GO:0032368 4 0.010
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.010
positive regulation of epithelial cell proliferation GO:0050679 1 0.010
negative regulation of secretion by cell GO:1903531 2 0.010
nucleocytoplasmic transport GO:0006913 4 0.010

slc4a4b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.056
inherited metabolic disorder DOID:655 0 0.056
immune system disease DOID:2914 0 0.013
disease of anatomical entity DOID:7 0 0.013
lysosomal storage disease DOID:3211 0 0.013
sensory system disease DOID:0050155 0 0.011
eye and adnexa disease DOID:1492 0 0.011
nervous system disease DOID:863 0 0.011