Danio rerio

0 known processes

slc6a8

solute carrier family 6 (neurotransmitter transporter, creatine), member 8

(Aliases: chot1)

slc6a8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryonic organ development GO:0048568 381 0.574
heart development GO:0007507 313 0.486
regulation of cell projection organization GO:0031344 44 0.279
regulation of signaling GO:0023051 235 0.259
Zebrafish
visual perception GO:0007601 17 0.213
heart morphogenesis GO:0003007 156 0.211
signal transduction GO:0007165 455 0.199
ribonucleotide biosynthetic process GO:0009260 20 0.171
cell migration involved in heart development GO:0060973 22 0.169
regulation of cgmp metabolic process GO:0030823 6 0.168
negative regulation of response to cytokine stimulus GO:0060761 2 0.149
cell surface receptor signaling pathway GO:0007166 325 0.148
negative regulation of cytokine mediated signaling pathway GO:0001960 2 0.142
outflow tract morphogenesis GO:0003151 1 0.129
maintenance of location GO:0051235 4 0.128
cardioblast migration to the midline involved in heart field formation GO:0060975 7 0.128
single organism metabolic process GO:0044710 217 0.127
glial cell migration GO:0008347 3 0.125
morphogenesis of an epithelium GO:0002009 333 0.114
retina development in camera type eye GO:0060041 146 0.112
cellular modified amino acid metabolic process GO:0006575 3 0.110
regionalization GO:0003002 274 0.110
central nervous system development GO:0007417 387 0.104
ribose phosphate biosynthetic process GO:0046390 20 0.100
embryonic heart tube development GO:0035050 133 0.095
regulation of synapse organization GO:0050807 3 0.095
embryonic organ morphogenesis GO:0048562 274 0.093
ribose phosphate metabolic process GO:0019693 27 0.092
retina layer formation GO:0010842 24 0.092
negative regulation of cellular process GO:0048523 283 0.091
blood vessel morphogenesis GO:0048514 216 0.089
regulation of cyclic nucleotide metabolic process GO:0030799 15 0.085
regulation of cell development GO:0060284 100 0.084
negative regulation of cell differentiation GO:0045596 46 0.083
localization of cell GO:0051674 244 0.083
digestive system development GO:0055123 289 0.082
ameboidal type cell migration GO:0001667 143 0.082
regulation of cell morphogenesis GO:0022604 42 0.082
response to ketone GO:1901654 1 0.080
fertilization GO:0009566 3 0.078
convergent extension involved in organogenesis GO:0060029 10 0.078
sympathetic nervous system development GO:0048485 3 0.077
generation of neurons GO:0048699 385 0.074
gland development GO:0048732 143 0.074
positive regulation of biological process GO:0048518 253 0.073
positive regulation of nervous system development GO:0051962 25 0.073
regulation of cell communication GO:0010646 232 0.073
Zebrafish
biosynthetic process GO:0009058 294 0.068
axon ensheathment in central nervous system GO:0032291 2 0.068
cell migration GO:0016477 237 0.066
mesoderm morphogenesis GO:0048332 51 0.066
response to chemical GO:0042221 320 0.064
epithelial cell migration GO:0010631 25 0.063
negative regulation of cell growth GO:0030308 7 0.063
regulation of biological quality GO:0065008 263 0.062
Zebrafish
single organism biosynthetic process GO:0044711 71 0.061
digestive tract mesoderm development GO:0007502 1 0.061
photoreceptor cell differentiation GO:0046530 55 0.061
small molecule metabolic process GO:0044281 77 0.060
negative regulation of cell communication GO:0010648 96 0.059
response to vitamin GO:0033273 3 0.057
gastrulation GO:0007369 208 0.057
cellular response to radiation GO:0071478 4 0.056
locomotion GO:0040011 313 0.056
cell substrate adhesion GO:0031589 4 0.054
blood vessel development GO:0001568 246 0.054
neural crest cell migration GO:0001755 42 0.054
gene expression GO:0010467 252 0.053
regulation of synapse assembly GO:0051963 3 0.052
cellular lipid catabolic process GO:0044242 3 0.052
regulation of response to stimulus GO:0048583 269 0.051
purine nucleotide biosynthetic process GO:0006164 20 0.051
lateral inhibition GO:0046331 1 0.050
multicellular organism growth GO:0035264 4 0.049
organonitrogen compound metabolic process GO:1901564 74 0.048
regulation of signal transduction GO:0009966 225 0.048
negative regulation of synapse assembly GO:0051964 2 0.047
brain development GO:0007420 293 0.047
tube morphogenesis GO:0035239 349 0.047
negative regulation of biological process GO:0048519 304 0.046
response to organic substance GO:0010033 153 0.046
regulation of response to cytokine stimulus GO:0060759 3 0.046
purine containing compound biosynthetic process GO:0072522 20 0.046
positive regulation of synapse assembly GO:0051965 1 0.045
axon midline choice point recognition GO:0016199 4 0.045
positive regulation of cellular metabolic process GO:0031325 94 0.045
negative regulation of chemotaxis GO:0050922 4 0.045
small gtpase mediated signal transduction GO:0007264 8 0.044
digestive tract morphogenesis GO:0048546 231 0.044
cellular biosynthetic process GO:0044249 286 0.044
negative regulation of nervous system development GO:0051961 22 0.044
camera type eye development GO:0043010 222 0.043
carboxylic acid metabolic process GO:0019752 22 0.043
regulation of developmental process GO:0050793 247 0.043
central nervous system neuron axonogenesis GO:0021955 18 0.043
regulation of macromolecule metabolic process GO:0060255 317 0.042
neuron differentiation GO:0030182 353 0.042
negative regulation of developmental process GO:0051093 65 0.041
heart formation GO:0060914 13 0.041
regulation of inflammatory response GO:0050727 2 0.041
cell migration involved in heart formation GO:0060974 10 0.040
regulation of binding GO:0051098 3 0.039
response to nutrient GO:0007584 3 0.039
intracellular signal transduction GO:0035556 85 0.039
negative regulation of innate immune response GO:0045824 2 0.038
neural retina development GO:0003407 49 0.037
response to amino acid GO:0043200 2 0.037
neuron projection morphogenesis GO:0048812 161 0.037
positive regulation of cell adhesion GO:0045785 1 0.037
cranial ganglion development GO:0061550 3 0.037
cell migration to the midline involved in heart development GO:0003318 12 0.036
gliogenesis GO:0042063 45 0.035
retina morphogenesis in camera type eye GO:0060042 79 0.035
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 8 0.035
cellular response to oxygen levels GO:0071453 1 0.035
negative regulation of cell development GO:0010721 26 0.034
digestive tract development GO:0048565 265 0.034
cardiac cell development GO:0055006 21 0.034
neuron development GO:0048666 262 0.034
cytokinesis GO:0000910 3 0.033
response to steroid hormone GO:0048545 35 0.033
pole plasm assembly GO:0007315 4 0.033
response to corticosteroid GO:0031960 1 0.033
cellular macromolecule metabolic process GO:0044260 391 0.033
protein alkylation GO:0008213 13 0.033
positive regulation of cellular process GO:0048522 201 0.033
lipid homeostasis GO:0055088 3 0.032
eye development GO:0001654 277 0.032
alpha amino acid metabolic process GO:1901605 3 0.032
response to external stimulus GO:0009605 264 0.032
nitrogen compound metabolic process GO:0006807 319 0.031
cgmp metabolic process GO:0046068 7 0.031
regulation of protein metabolic process GO:0051246 56 0.031
nucleoside phosphate biosynthetic process GO:1901293 21 0.031
transport GO:0006810 220 0.030
Zebrafish
negative regulation of signal transduction GO:0009968 94 0.030
regulation of primary metabolic process GO:0080090 311 0.030
camera type eye photoreceptor cell differentiation GO:0060219 19 0.030
regulation of interferon gamma mediated signaling pathway GO:0060334 1 0.030
cellular response to nutrient levels GO:0031669 2 0.029
response to hormone GO:0009725 48 0.029
heart looping GO:0001947 94 0.029
cardioblast migration GO:0003260 7 0.029
regulation of cytokine mediated signaling pathway GO:0001959 3 0.029
anterior posterior pattern specification GO:0009952 152 0.029
light adaption GO:0036367 1 0.028
cellular component disassembly GO:0022411 1 0.028
response to glucocorticoid GO:0051384 1 0.027
sensory organ development GO:0007423 393 0.027
regulation of neuron differentiation GO:0045664 56 0.027
myelin assembly GO:0032288 1 0.027
hydrogen peroxide metabolic process GO:0042743 2 0.027
cellular component movement GO:0006928 335 0.027
regulation of cellular component organization GO:0051128 86 0.027
cellular component morphogenesis GO:0032989 336 0.026
guanosine containing compound catabolic process GO:1901069 2 0.026
negative regulation of signaling GO:0023057 96 0.026
aging GO:0007568 2 0.026
cell projection morphogenesis GO:0048858 244 0.026
cellular amino acid metabolic process GO:0006520 7 0.026
positive regulation of cgmp biosynthetic process GO:0030828 6 0.026
golgi vesicle transport GO:0048193 3 0.026
forebrain cell migration GO:0021885 1 0.026
dopamine metabolic process GO:0042417 2 0.026
cellular response to extracellular stimulus GO:0031668 2 0.026
response to drug GO:0042493 3 0.026
positive regulation of metabolic process GO:0009893 108 0.025
hormone transport GO:0009914 2 0.025
chordate embryonic development GO:0043009 271 0.025
digestive system process GO:0022600 9 0.025
maternal determination of anterior posterior axis embryo GO:0008358 4 0.025
atrioventricular valve development GO:0003171 11 0.025
developmental growth involved in morphogenesis GO:0060560 86 0.025
organic acid metabolic process GO:0006082 31 0.025
retinal cone cell differentiation GO:0042670 12 0.024
mesodermal cell migration GO:0008078 12 0.024
single organism localization GO:1902578 225 0.024
Zebrafish
protein localization GO:0008104 40 0.024
stem cell maintenance GO:0019827 4 0.024
establishment of synaptic vesicle localization GO:0097480 1 0.024
immune response GO:0006955 28 0.024
lipoprotein biosynthetic process GO:0042158 3 0.023
olfactory lobe development GO:0021988 4 0.023
glucose homeostasis GO:0042593 1 0.023
cellular amino acid biosynthetic process GO:0008652 2 0.023
embryonic cranial skeleton morphogenesis GO:0048701 90 0.023
cell projection organization GO:0030030 284 0.023
regulation of localization GO:0032879 104 0.023
inflammatory response GO:0006954 8 0.023
lipid catabolic process GO:0016042 4 0.022
response to estrogen GO:0043627 27 0.022
regulation of cell differentiation GO:0045595 142 0.022
response to lipid GO:0033993 60 0.022
embryo development ending in birth or egg hatching GO:0009792 271 0.021
histone h3 k4 methylation GO:0051568 2 0.021
single organismal cell cell adhesion GO:0016337 29 0.021
regulation of neurogenesis GO:0050767 87 0.021
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.021
cellular nitrogen compound metabolic process GO:0034641 290 0.021
developmental cell growth GO:0048588 52 0.021
central nervous system neuron differentiation GO:0021953 74 0.021
negative regulation of protein kinase activity GO:0006469 4 0.021
cellular response to steroid hormone stimulus GO:0071383 31 0.021
phosphate containing compound metabolic process GO:0006796 108 0.020
organic substance transport GO:0071702 58 0.020
Zebrafish
regulation of molecular function GO:0065009 70 0.020
oxoacid metabolic process GO:0043436 31 0.020
endosomal transport GO:0016197 2 0.020
regulation of biosynthetic process GO:0009889 250 0.020
positive regulation of cellular component biogenesis GO:0044089 3 0.020
positive regulation of cell cycle GO:0045787 3 0.020
positive regulation of neurogenesis GO:0050769 24 0.020
response to light intensity GO:0009642 1 0.020
negative regulation of kinase activity GO:0033673 4 0.020
long chain fatty acid transport GO:0015909 1 0.019
programmed cell death GO:0012501 119 0.019
organonitrogen compound biosynthetic process GO:1901566 47 0.019
regulation of lyase activity GO:0051339 12 0.019
neuron neuron synaptic transmission GO:0007270 1 0.019
Zebrafish
regulation of cellular metabolic process GO:0031323 320 0.019
negative regulation of defense response GO:0031348 2 0.019
purine ribonucleotide biosynthetic process GO:0009152 20 0.019
system process GO:0003008 185 0.019
regulation of multicellular organismal development GO:2000026 223 0.019
response to carbohydrate GO:0009743 3 0.019
regulation of guanylate cyclase activity GO:0031282 6 0.019
ventricular cardiac muscle tissue development GO:0003229 3 0.019
dna biosynthetic process GO:0071897 3 0.019
regulation of neuron migration GO:2001222 2 0.019
ectodermal placode formation GO:0060788 26 0.018
response to stress GO:0006950 263 0.018
proximal distal pattern formation GO:0009954 1 0.018
positive regulation of purine nucleotide biosynthetic process GO:1900373 8 0.018
acylglycerol homeostasis GO:0055090 2 0.018
regulation of stem cell differentiation GO:2000736 4 0.018
photoreceptor cell fate commitment GO:0046552 1 0.018
post golgi vesicle mediated transport GO:0006892 1 0.018
alcohol biosynthetic process GO:0046165 2 0.018
phototransduction GO:0007602 2 0.018
stem cell proliferation GO:0072089 4 0.018
single organism transport GO:0044765 206 0.018
Zebrafish
cytoplasm organization GO:0007028 4 0.017
regulation of response to interferon gamma GO:0060330 1 0.017
regulation of glial cell differentiation GO:0045685 4 0.017
cellular response to external stimulus GO:0071496 2 0.017
sleep GO:0030431 1 0.017
cell projection assembly GO:0030031 64 0.017
phosphorus metabolic process GO:0006793 109 0.017
photoreceptor cell development GO:0042461 40 0.017
enzyme linked receptor protein signaling pathway GO:0007167 106 0.017
phototransduction visible light GO:0007603 2 0.016
protein metabolic process GO:0019538 183 0.016
nucleobase containing compound metabolic process GO:0006139 274 0.016
neurotransmitter transport GO:0006836 2 0.016
multicellular organismal signaling GO:0035637 22 0.016
regulation of stem cell proliferation GO:0072091 2 0.016
cell morphogenesis GO:0000902 289 0.016
central nervous system myelin formation GO:0032289 1 0.016
positive regulation of cellular catabolic process GO:0031331 3 0.016
negative regulation of neuron projection development GO:0010977 9 0.016
cellular component biogenesis GO:0044085 178 0.016
defense response GO:0006952 47 0.016
nucleobase containing compound biosynthetic process GO:0034654 205 0.016
development of primary female sexual characteristics GO:0046545 4 0.016
hindbrain development GO:0030902 91 0.016
regulation of phosphate metabolic process GO:0019220 43 0.016
regulation of fatty acid metabolic process GO:0019217 1 0.016
synaptic vesicle localization GO:0097479 1 0.016
organ formation GO:0048645 17 0.016
axon development GO:0061564 166 0.016
regulation of reproductive process GO:2000241 4 0.015
protein complex disassembly GO:0043241 1 0.015
hormone secretion GO:0046879 2 0.015
chloride transmembrane transport GO:1902476 4 0.015
cell motility GO:0048870 244 0.015
regulation of carbohydrate metabolic process GO:0006109 4 0.015
glial cell differentiation GO:0010001 42 0.015
intracellular mrna localization GO:0008298 1 0.015
single organism cell adhesion GO:0098602 29 0.015
organophosphate biosynthetic process GO:0090407 23 0.015
eye morphogenesis GO:0048592 144 0.015
formation of primary germ layer GO:0001704 62 0.015
regulation of anatomical structure morphogenesis GO:0022603 130 0.015
growth GO:0040007 174 0.015
olfactory bulb development GO:0021772 4 0.015
regulation of neurotransmitter secretion GO:0046928 1 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 9 0.015
polarized epithelial cell differentiation GO:0030859 4 0.015
organic cyclic compound biosynthetic process GO:1901362 223 0.015
response to food GO:0032094 1 0.015
action potential GO:0001508 19 0.015
establishment of epithelial cell polarity GO:0090162 2 0.015
blood circulation GO:0008015 87 0.015
regulation of metabolic process GO:0019222 359 0.015
neural tube patterning GO:0021532 33 0.014
synaptic vesicle transport GO:0048489 1 0.014
mesoderm formation GO:0001707 43 0.014
neurotransmitter secretion GO:0007269 2 0.014
single organism organelle organization GO:1902589 199 0.014
negative regulation of protein phosphorylation GO:0001933 4 0.014
negative regulation of multicellular organismal process GO:0051241 69 0.014
regulation of phosphorus metabolic process GO:0051174 43 0.014
neural crest cell development GO:0014032 62 0.014
camera type eye morphogenesis GO:0048593 108 0.014
carbohydrate homeostasis GO:0033500 1 0.014
anterior posterior axis specification GO:0009948 20 0.014
immune system process GO:0002376 241 0.014
axonal defasciculation GO:0007414 2 0.014
negative regulation of axon guidance GO:1902668 1 0.014
apoptotic process GO:0006915 116 0.014
determination of bilateral symmetry GO:0009855 204 0.014
regulation of nervous system development GO:0051960 90 0.014
guanosine containing compound metabolic process GO:1901068 4 0.013
establishment of localization GO:0051234 244 0.013
Zebrafish
eye photoreceptor cell differentiation GO:0001754 45 0.013
protein modification by small protein removal GO:0070646 1 0.013
dna alkylation GO:0006305 8 0.013
central nervous system myelination GO:0022010 2 0.013
negative regulation of immune response GO:0050777 2 0.013
intracellular receptor signaling pathway GO:0030522 30 0.013
embryonic heart tube morphogenesis GO:0003143 108 0.013
cell death GO:0008219 121 0.013
negative regulation of cell projection organization GO:0031345 9 0.013
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 4 0.013
cyclic purine nucleotide metabolic process GO:0052652 18 0.013
intrahepatic bile duct development GO:0035622 11 0.013
circadian sleep wake cycle sleep GO:0050802 1 0.013
hatching gland development GO:0048785 3 0.013
cgmp biosynthetic process GO:0006182 7 0.013
cellular component assembly GO:0022607 170 0.013
response to biotic stimulus GO:0009607 97 0.013
response to light stimulus GO:0009416 46 0.013
calcium mediated signaling GO:0019722 2 0.013
positive regulation of cell morphogenesis involved in differentiation GO:0010770 6 0.013
forebrain development GO:0030900 96 0.013
regulation of apoptotic process GO:0042981 98 0.013
axonogenesis GO:0007409 152 0.013
transmission of nerve impulse GO:0019226 19 0.013
female sex differentiation GO:0046660 4 0.013
head development GO:0060322 303 0.013
regulation of membrane potential GO:0042391 23 0.012
Zebrafish
response to inorganic substance GO:0010035 38 0.012
histone methylation GO:0016571 13 0.012
segmentation GO:0035282 97 0.012
convergent extension GO:0060026 118 0.012
multi organism process GO:0051704 134 0.012
determination of heart left right asymmetry GO:0061371 117 0.012
positive regulation of translation GO:0045727 1 0.012
retinal cone cell development GO:0046549 8 0.012
negative regulation of programmed cell death GO:0043069 58 0.012
fatty acid transport GO:0015908 1 0.012
regulation of neuron projection development GO:0010975 40 0.012
negative regulation of response to stimulus GO:0048585 104 0.012
cellular response to light stimulus GO:0071482 4 0.012
negative regulation of axon extension involved in axon guidance GO:0048843 1 0.012
neuroblast proliferation GO:0007405 2 0.012
negative regulation of behavior GO:0048521 6 0.012
pancreas development GO:0031016 84 0.012
regulation of metal ion transport GO:0010959 4 0.012
endocardial progenitor cell migration to the midline involved in heart field formation GO:0003262 4 0.012
regulation of multicellular organism growth GO:0040014 4 0.012
regulation of cellular ketone metabolic process GO:0010565 7 0.012
response to amphetamine GO:0001975 1 0.012
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.012
neuron projection extension GO:1990138 45 0.011
epidermal cell fate specification GO:0009957 4 0.011
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.011
regulation of embryonic development GO:0045995 47 0.011
actin cytoskeleton organization GO:0030036 63 0.011
organic cyclic compound metabolic process GO:1901360 301 0.011
negative regulation of growth GO:0045926 10 0.011
energy reserve metabolic process GO:0006112 2 0.011
gtp catabolic process GO:0006184 2 0.011
regulation of protein binding GO:0043393 3 0.011
regulation of myelination GO:0031641 1 0.011
cellular respiration GO:0045333 3 0.011
formation of anatomical boundary GO:0048859 14 0.011
antimicrobial humoral response GO:0019730 2 0.011
circadian sleep wake cycle GO:0042745 2 0.011
protein modification process GO:0036211 100 0.011
regulation of cytoplasmic transport GO:1903649 4 0.011
bmp signaling pathway GO:0030509 52 0.011
retinoic acid receptor signaling pathway GO:0048384 16 0.011
specification of axis polarity GO:0065001 4 0.011
calcium ion dependent exocytosis GO:0017156 1 0.011
regulation of purine nucleotide biosynthetic process GO:1900371 15 0.011
stem cell differentiation GO:0048863 117 0.011
cytoskeleton dependent cytokinesis GO:0061640 3 0.011
larval development GO:0002164 2 0.011
regulation of epithelial cell migration GO:0010632 5 0.011
actin filament based process GO:0030029 64 0.011
muscle system process GO:0003012 20 0.011
cellular response to hypoxia GO:0071456 1 0.011
heterocycle biosynthetic process GO:0018130 215 0.011
aromatic compound biosynthetic process GO:0019438 217 0.010
neuron projection development GO:0031175 180 0.010
left right pattern formation GO:0060972 19 0.010
regulation of cell motility GO:2000145 46 0.010
neural crest cell differentiation GO:0014033 72 0.010
macromolecule methylation GO:0043414 19 0.010
oocyte anterior posterior axis specification GO:0007314 4 0.010
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.010
regulation of transcription involved in cell fate commitment GO:0060850 1 0.010
negative regulation of translation GO:0017148 1 0.010
response to bacterium GO:0009617 58 0.010
homeostasis of number of cells within a tissue GO:0048873 4 0.010
cyclic nucleotide biosynthetic process GO:0009190 18 0.010
retinal rod cell development GO:0046548 4 0.010
organic substance biosynthetic process GO:1901576 289 0.010
response to cortisol GO:0051414 1 0.010

slc6a8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.066
immune system disease DOID:2914 0 0.022
retinal disease DOID:5679 0 0.017
sensory system disease DOID:0050155 0 0.017
eye and adnexa disease DOID:1492 0 0.017
nervous system disease DOID:863 0 0.017
eye disease DOID:5614 0 0.017
retinal degeneration DOID:8466 0 0.016
disease of metabolism DOID:0014667 0 0.015
Human
physical disorder DOID:0080015 0 0.012
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.011
diabetes mellitus DOID:9351 0 0.010
type 2 diabetes mellitus DOID:9352 0 0.010
carbohydrate metabolism disease DOID:0050013 0 0.010
glucose metabolism disease DOID:4194 0 0.010
acquired metabolic disease DOID:0060158 0 0.010