Danio rerio

0 known processes

slc8a4b

solute carrier family 8 (sodium/calcium exchanger), member 4b

(Aliases: ncx4b,ncx4,slc8a1b)

slc8a4b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organic substance biosynthetic process GO:1901576 289 0.338
maintenance of location GO:0051235 4 0.330
g protein coupled receptor signaling pathway GO:0007186 74 0.248
circadian sleep wake cycle process GO:0022410 2 0.241
ribose phosphate biosynthetic process GO:0046390 20 0.214
regulation of hormone secretion GO:0046883 2 0.165
modification dependent protein catabolic process GO:0019941 3 0.152
organic cyclic compound biosynthetic process GO:1901362 223 0.134
regulation of circadian sleep wake cycle GO:0042749 1 0.129
organic cyclic compound metabolic process GO:1901360 301 0.127
generation of neurons GO:0048699 385 0.122
morphogenesis of an epithelium GO:0002009 333 0.119
Zebrafish
circadian sleep wake cycle sleep GO:0050802 1 0.114
sleep GO:0030431 1 0.112
regulation of biological quality GO:0065008 263 0.111
Zebrafish
regulation of cyclic nucleotide biosynthetic process GO:0030802 15 0.111
regulation of cyclic nucleotide metabolic process GO:0030799 15 0.108
hormone transport GO:0009914 2 0.107
digestive tract morphogenesis GO:0048546 231 0.106
single organism localization GO:1902578 225 0.106
Zebrafish
aging GO:0007568 2 0.105
transport GO:0006810 220 0.104
Zebrafish
cellular protein catabolic process GO:0044257 4 0.101
circadian sleep wake cycle GO:0042745 2 0.099
proteasomal protein catabolic process GO:0010498 2 0.098
organonitrogen compound metabolic process GO:1901564 74 0.097
hormone secretion GO:0046879 2 0.096
single organism metabolic process GO:0044710 217 0.096
single organism biosynthetic process GO:0044711 71 0.095
lipid storage GO:0019915 1 0.094
nucleobase containing compound biosynthetic process GO:0034654 205 0.093
regulation of metal ion transport GO:0010959 4 0.092
single organism transport GO:0044765 206 0.092
Zebrafish
cyclic nucleotide biosynthetic process GO:0009190 18 0.090
regulation of primary metabolic process GO:0080090 311 0.087
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.086
type b pancreatic cell development GO:0003323 4 0.079
cellular aromatic compound metabolic process GO:0006725 295 0.078
biosynthetic process GO:0009058 294 0.078
peptide transport GO:0015833 1 0.078
cellular nitrogen compound biosynthetic process GO:0044271 218 0.076
locomotion GO:0040011 313 0.076
secondary metabolic process GO:0019748 3 0.074
regulation of cellular metabolic process GO:0031323 320 0.073
organonitrogen compound biosynthetic process GO:1901566 47 0.072
oocyte maturation GO:0001556 4 0.071
ubiquitin dependent protein catabolic process GO:0006511 3 0.071
regulation of nitrogen compound metabolic process GO:0051171 251 0.070
small molecule metabolic process GO:0044281 77 0.070
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.069
regulation of nucleic acid templated transcription GO:1903506 213 0.068
regulation of circadian rhythm GO:0042752 4 0.067
regulation of multicellular organism growth GO:0040014 4 0.066
multicellular organism growth GO:0035264 4 0.066
regulation of metabolic process GO:0019222 359 0.066
regulation of multicellular organismal development GO:2000026 223 0.065
negative regulation of cyclase activity GO:0031280 6 0.064
nitrogen compound metabolic process GO:0006807 319 0.064
cell volume homeostasis GO:0006884 1 0.063
regulation of protein complex assembly GO:0043254 3 0.062
cyclic purine nucleotide metabolic process GO:0052652 18 0.059
transcription dna templated GO:0006351 181 0.059
adult behavior GO:0030534 2 0.057
inorganic ion transmembrane transport GO:0098660 57 0.057
Zebrafish
heart development GO:0007507 313 0.057
Zebrafish
regulation of protein catabolic process GO:0042176 1 0.056
regulation of biosynthetic process GO:0009889 250 0.056
regulation of reproductive process GO:2000241 4 0.055
positive regulation of protein complex assembly GO:0031334 2 0.054
negative regulation of hormone secretion GO:0046888 2 0.054
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.053
embryonic organ development GO:0048568 381 0.053
Zebrafish
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.052
long chain fatty acid transport GO:0015909 1 0.051
cellular response to extracellular stimulus GO:0031668 2 0.049
embryo development ending in birth or egg hatching GO:0009792 271 0.049
Worm
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.047
nucleoside phosphate biosynthetic process GO:1901293 21 0.046
cellular biosynthetic process GO:0044249 286 0.046
regulation of gene expression GO:0010468 265 0.046
regulation of purine nucleotide biosynthetic process GO:1900371 15 0.046
cell morphogenesis GO:0000902 289 0.046
regulation of transcription dna templated GO:0006355 213 0.045
phagocytosis GO:0006909 3 0.045
response to external stimulus GO:0009605 264 0.045
muscle cell differentiation GO:0042692 139 0.044
Zebrafish
cyclic nucleotide metabolic process GO:0009187 18 0.042
carbohydrate derivative biosynthetic process GO:1901137 43 0.042
positive regulation of cell cycle GO:0045787 3 0.041
regulation of cellular biosynthetic process GO:0031326 245 0.041
purine ribonucleotide biosynthetic process GO:0009152 20 0.040
heterocycle biosynthetic process GO:0018130 215 0.040
rna metabolic process GO:0016070 219 0.040
organophosphate biosynthetic process GO:0090407 23 0.039
negative regulation of cellular process GO:0048523 283 0.038
regulation of oligodendrocyte differentiation GO:0048713 1 0.037
cognition GO:0050890 1 0.037
regulation of nucleotide biosynthetic process GO:0030808 15 0.037
carboxylic acid metabolic process GO:0019752 22 0.036
negative regulation of cellular metabolic process GO:0031324 77 0.036
ribonucleotide biosynthetic process GO:0009260 20 0.036
regulation of tube size GO:0035150 2 0.035
nucleobase containing small molecule metabolic process GO:0055086 32 0.035
negative regulation of biological process GO:0048519 304 0.034
heterocycle metabolic process GO:0046483 290 0.034
glucose homeostasis GO:0042593 1 0.034
developmental growth GO:0048589 166 0.034
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.034
carbohydrate homeostasis GO:0033500 1 0.033
macromolecule biosynthetic process GO:0009059 227 0.033
purine nucleotide biosynthetic process GO:0006164 20 0.032
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.032
negative regulation of cellular catabolic process GO:0031330 3 0.032
regulation of blood vessel size GO:0050880 2 0.031
blood circulation GO:0008015 87 0.031
Zebrafish
regulation of autophagy GO:0010506 3 0.030
establishment of localization GO:0051234 244 0.030
Zebrafish
cell surface receptor signaling pathway GO:0007166 325 0.030
positive regulation of cellular component biogenesis GO:0044089 3 0.030
ion transport GO:0006811 114 0.030
Zebrafish
cellular macromolecule biosynthetic process GO:0034645 224 0.030
regulation of dna replication GO:0006275 3 0.030
regulation of signal transduction GO:0009966 225 0.030
transcription from rna polymerase ii promoter GO:0006366 80 0.030
smooth muscle contraction GO:0006939 2 0.030
modification dependent macromolecule catabolic process GO:0043632 3 0.029
embryonic organ morphogenesis GO:0048562 274 0.028
Zebrafish
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.028
cellular response to reactive oxygen species GO:0034614 2 0.028
positive regulation of map kinase activity GO:0043406 3 0.028
protein import GO:0017038 3 0.028
muscle structure development GO:0061061 196 0.028
Zebrafish
neurological system process GO:0050877 62 0.028
spemann organizer formation at the embryonic shield GO:0060063 2 0.028
tissue remodeling GO:0048771 4 0.027
energy reserve metabolic process GO:0006112 2 0.027
head development GO:0060322 303 0.027
fatty acid transport GO:0015908 1 0.027
nucleobase containing compound metabolic process GO:0006139 274 0.027
negative regulation of cell fate specification GO:0009996 11 0.027
regulation of system process GO:0044057 40 0.027
Zebrafish
eye development GO:0001654 277 0.026
regulation of macromolecule metabolic process GO:0060255 317 0.026
negative regulation of catabolic process GO:0009895 3 0.026
cellular response to nutrient levels GO:0031669 2 0.026
metal ion transport GO:0030001 58 0.026
Zebrafish
regulation of multicellular organismal process GO:0051239 277 0.026
Zebrafish
sensory perception GO:0007600 39 0.025
nitric oxide metabolic process GO:0046209 2 0.025
regulation of protein transport GO:0051223 3 0.025
growth GO:0040007 174 0.025
striated muscle cell development GO:0055002 108 0.025
Zebrafish
digestive tract development GO:0048565 265 0.024
regulation of neural precursor cell proliferation GO:2000177 3 0.024
stem cell proliferation GO:0072089 4 0.024
regulation of stem cell differentiation GO:2000736 4 0.024
response to drug GO:0042493 3 0.023
cellular macromolecule metabolic process GO:0044260 391 0.023
organic acid metabolic process GO:0006082 31 0.023
homeostatic process GO:0042592 142 0.023
Zebrafish
positive regulation of neural precursor cell proliferation GO:2000179 1 0.023
protein localization to nucleus GO:0034504 3 0.023
toxin metabolic process GO:0009404 1 0.023
response to topologically incorrect protein GO:0035966 2 0.023
aromatic compound biosynthetic process GO:0019438 217 0.023
nuclear transport GO:0051169 4 0.023
single organism organelle organization GO:1902589 199 0.022
Zebrafish
regulation of cytoplasmic transport GO:1903649 4 0.022
larval development GO:0002164 2 0.022
negative regulation of metabolic process GO:0009892 86 0.022
cellular nitrogen compound metabolic process GO:0034641 290 0.022
nucleotide biosynthetic process GO:0009165 21 0.022
dorsal ventral pattern formation GO:0009953 125 0.022
epiboly GO:0090504 41 0.022
response to carbohydrate GO:0009743 3 0.022
negative regulation of nucleotide metabolic process GO:0045980 7 0.022
positive regulation of transport GO:0051050 2 0.022
phosphate containing compound metabolic process GO:0006796 108 0.022
system process GO:0003008 185 0.021
Zebrafish
regulation of camp biosynthetic process GO:0030817 9 0.021
cellular amide metabolic process GO:0043603 4 0.021
positive regulation of catabolic process GO:0009896 4 0.021
signal transduction GO:0007165 455 0.021
sensory perception of chemical stimulus GO:0007606 3 0.021
cytoskeleton organization GO:0007010 96 0.021
Zebrafish
gene expression GO:0010467 252 0.021
positive regulation of cellular process GO:0048522 201 0.021
cellular component morphogenesis GO:0032989 336 0.021
Zebrafish
negative regulation of cyclic nucleotide metabolic process GO:0030800 7 0.021
gastrulation GO:0007369 208 0.020
regulation of establishment of protein localization GO:0070201 4 0.020
positive regulation of cellular catabolic process GO:0031331 3 0.020
response to corticosteroid GO:0031960 1 0.020
lipid metabolic process GO:0006629 52 0.020
long chain fatty acid metabolic process GO:0001676 1 0.020
autophagy GO:0006914 4 0.019
positive regulation of camp biosynthetic process GO:0030819 2 0.019
nuclear import GO:0051170 3 0.019
cellular ketone metabolic process GO:0042180 11 0.019
protein polymerization GO:0051258 4 0.019
pathway restricted smad protein phosphorylation GO:0060389 1 0.019
regulation of response to extracellular stimulus GO:0032104 1 0.019
negative regulation of biosynthetic process GO:0009890 55 0.019
amine metabolic process GO:0009308 2 0.019
regulation of stem cell proliferation GO:0072091 2 0.019
protein import into nucleus GO:0006606 3 0.018
skeletal system development GO:0001501 181 0.018
circulatory system process GO:0003013 87 0.018
Zebrafish
peptidyl lysine acetylation GO:0018394 2 0.018
cation transport GO:0006812 81 0.018
Zebrafish
wound healing GO:0042060 90 0.018
regulation of lyase activity GO:0051339 12 0.018
skeletal muscle tissue development GO:0007519 67 0.018
Zebrafish
positive regulation of signaling GO:0023056 56 0.018
protein modification process GO:0036211 100 0.018
macromolecular complex subunit organization GO:0043933 74 0.018
multi organism process GO:0051704 134 0.018
cation transmembrane transport GO:0098655 65 0.018
Zebrafish
heart contraction GO:0060047 71 0.018
Zebrafish
negative regulation of secretion by cell GO:1903531 2 0.018
nucleic acid templated transcription GO:0097659 181 0.018
negative regulation of oocyte development GO:0060283 2 0.017
carbohydrate derivative metabolic process GO:1901135 61 0.017
negative regulation of cellular biosynthetic process GO:0031327 55 0.017
positive regulation of stem cell proliferation GO:2000648 1 0.017
cgmp metabolic process GO:0046068 7 0.017
regulation of intracellular protein transport GO:0033157 3 0.017
positive regulation of signal transduction GO:0009967 56 0.017
estrogen metabolic process GO:0008210 2 0.017
cellular component movement GO:0006928 335 0.017
collagen fibril organization GO:0030199 1 0.017
multicellular organismal homeostasis GO:0048871 29 0.017
negative regulation of gene expression GO:0010629 65 0.017
cellular response to unfolded protein GO:0034620 2 0.016
single organism nuclear import GO:1902593 3 0.016
intracellular signal transduction GO:0035556 85 0.016
regulation of hormone levels GO:0010817 21 0.016
morphogenesis of an epithelial sheet GO:0002011 49 0.016
semicircular canal morphogenesis GO:0048752 18 0.016
protein targeting to nucleus GO:0044744 3 0.016
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.016
nucleotide metabolic process GO:0009117 28 0.016
membrane invagination GO:0010324 1 0.016
regulation of transporter activity GO:0032409 2 0.016
positive regulation of cellular metabolic process GO:0031325 94 0.016
nucleic acid metabolic process GO:0090304 244 0.016
cellular response to starvation GO:0009267 1 0.016
response to nicotine GO:0035094 2 0.016
aflatoxin metabolic process GO:0046222 1 0.016
cellular response to antibiotic GO:0071236 1 0.016
cell part morphogenesis GO:0032990 246 0.016
response to external biotic stimulus GO:0043207 97 0.016
regulation of mesoderm development GO:2000380 11 0.016
negative regulation of feeding behavior GO:2000252 2 0.016
negative regulation of protein transport GO:0051224 3 0.016
inorganic cation transmembrane transport GO:0098662 50 0.016
Zebrafish
regulation of receptor activity GO:0010469 2 0.015
blood vessel development GO:0001568 246 0.015
opioid receptor signaling pathway GO:0038003 3 0.015
regulation of cyclase activity GO:0031279 12 0.015
axon development GO:0061564 166 0.015
positive regulation of camp metabolic process GO:0030816 2 0.015
female gonad development GO:0008585 4 0.015
neurotransmitter secretion GO:0007269 2 0.015
retina development in camera type eye GO:0060041 146 0.015
regulation of sequestering of calcium ion GO:0051282 4 0.015
sensory organ morphogenesis GO:0090596 200 0.015
internal protein amino acid acetylation GO:0006475 2 0.015
monovalent inorganic cation transport GO:0015672 42 0.015
Zebrafish
carbohydrate biosynthetic process GO:0016051 1 0.015
macromolecule modification GO:0043412 111 0.015
oxoacid metabolic process GO:0043436 31 0.015
regulation of endodermal cell differentiation GO:1903224 15 0.015
gastrulation with mouth forming second GO:0001702 44 0.014
regulation of cell differentiation GO:0045595 142 0.014
pancreas development GO:0031016 84 0.014
somatic stem cell maintenance GO:0035019 1 0.014
establishment of protein localization to organelle GO:0072594 4 0.014
meiotic nuclear division GO:0007126 4 0.014
response to chemical GO:0042221 320 0.014
meiosis i GO:0007127 1 0.014
chemosensory behavior GO:0007635 1 0.014
regulation of macromolecule biosynthetic process GO:0010556 225 0.014
endocrine system development GO:0035270 65 0.014
organic substance transport GO:0071702 58 0.014
macromolecular complex assembly GO:0065003 35 0.014
regulation of protein targeting GO:1903533 2 0.014
regulation of molecular function GO:0065009 70 0.014
cellular response to organic cyclic compound GO:0071407 38 0.014
negative regulation of gastrulation GO:2000542 11 0.014
regulation of cytokine production GO:0001817 3 0.014
regulation of camp metabolic process GO:0030814 9 0.013
optokinetic behavior GO:0007634 9 0.013
i kappab kinase nf kappab signaling GO:0007249 4 0.013
positive regulation of cell communication GO:0010647 56 0.013
ear development GO:0043583 127 0.013
cell aging GO:0007569 2 0.013
regulation of response to stimulus GO:0048583 269 0.013
response to alkaloid GO:0043279 2 0.013
vasculature development GO:0001944 278 0.013
protein acetylation GO:0006473 2 0.013
female sex differentiation GO:0046660 4 0.013
regulation of ion transmembrane transporter activity GO:0032412 2 0.013
protein complex subunit organization GO:0071822 46 0.013
taxis GO:0042330 109 0.013
regulation of phosphorus metabolic process GO:0051174 43 0.013
negative regulation of intracellular transport GO:0032387 3 0.013
nitric oxide biosynthetic process GO:0006809 2 0.013
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.013
cellular response to topologically incorrect protein GO:0035967 2 0.013
chordate embryonic development GO:0043009 271 0.013
nucleocytoplasmic transport GO:0006913 4 0.013
response to glucocorticoid GO:0051384 1 0.013
mechanosensory behavior GO:0007638 2 0.013
negative regulation of secretion GO:0051048 2 0.013
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.013
response to organic substance GO:0010033 153 0.013
inner ear development GO:0048839 126 0.013
regulation of dna metabolic process GO:0051052 11 0.013
negative regulation of macromolecule metabolic process GO:0010605 76 0.013
amide transport GO:0042886 12 0.013
regulation of blood pressure GO:0008217 1 0.013
internal peptidyl lysine acetylation GO:0018393 2 0.013
rna biosynthetic process GO:0032774 181 0.013
regulation of intracellular signal transduction GO:1902531 57 0.013
regulation of systemic arterial blood pressure GO:0003073 1 0.013
positive regulation of cell division GO:0051781 2 0.013
regulation of rna metabolic process GO:0051252 224 0.013
regulation of calcium ion transport GO:0051924 2 0.013
protein metabolic process GO:0019538 183 0.012
positive regulation of muscle organ development GO:0048636 1 0.012
hormone metabolic process GO:0042445 19 0.012
cellular response to external stimulus GO:0071496 2 0.012
response to light stimulus GO:0009416 46 0.012
regulation of cell activation GO:0050865 1 0.012
positive regulation of cytoskeleton organization GO:0051495 3 0.012
neuron development GO:0048666 262 0.012
endodermal cell fate commitment GO:0001711 18 0.012
cell migration GO:0016477 237 0.012
cellular protein modification process GO:0006464 100 0.012
striated muscle tissue development GO:0014706 110 0.012
Zebrafish
regulation of response to nutrient levels GO:0032107 1 0.012
regulation of anatomical structure morphogenesis GO:0022603 130 0.012
circadian regulation of gene expression GO:0032922 8 0.012
regulation of bone remodeling GO:0046850 2 0.012
purine ribonucleotide metabolic process GO:0009150 27 0.012
sensory perception of pain GO:0019233 1 0.012
regulation of neurotransmitter secretion GO:0046928 1 0.012
digestive system development GO:0055123 289 0.012
response to xenobiotic stimulus GO:0009410 45 0.012
response to abiotic stimulus GO:0009628 122 0.012
er nucleus signaling pathway GO:0006984 2 0.011
positive regulation of striated muscle tissue development GO:0045844 1 0.011
phosphorus metabolic process GO:0006793 109 0.011
response to metal ion GO:0010038 34 0.011
negative regulation of purine nucleotide metabolic process GO:1900543 7 0.011
atrial ventricular junction remodeling GO:0003294 2 0.011
determination of ventral identity GO:0048264 21 0.011
regulation of gastrulation GO:0010470 24 0.011
regionalization GO:0003002 274 0.011
negative regulation of reproductive process GO:2000242 3 0.011
synaptic growth at neuromuscular junction GO:0051124 2 0.011
cellular component assembly GO:0022607 170 0.011
Zebrafish
renal system process GO:0003014 14 0.011
regulation of reactive oxygen species metabolic process GO:2000377 2 0.011
negative regulation of adenylate cyclase activity GO:0007194 6 0.011
cellular response to radiation GO:0071478 4 0.011
skeletal system morphogenesis GO:0048705 102 0.011
central nervous system development GO:0007417 387 0.011
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.011
long chain fatty acid biosynthetic process GO:0042759 1 0.011
endoplasmic reticulum unfolded protein response GO:0030968 2 0.011
regulation of neurotransmitter transport GO:0051588 1 0.011
regulation of programmed cell death GO:0043067 101 0.011
retina vasculature development in camera type eye GO:0061298 2 0.011
camp metabolic process GO:0046058 11 0.011
regulation of organ growth GO:0046620 3 0.011
regulation of cellular protein catabolic process GO:1903362 1 0.011
brain development GO:0007420 293 0.011
positive regulation of dna metabolic process GO:0051054 1 0.011
meiotic cell cycle process GO:1903046 3 0.011
cytokinesis GO:0000910 3 0.011
startle response GO:0001964 4 0.011
regulation of oocyte development GO:0060281 3 0.011
endoderm formation GO:0001706 29 0.011
cellular protein metabolic process GO:0044267 129 0.010
negative regulation of cytoplasmic transport GO:1903650 2 0.010
negative regulation of cytokine production GO:0001818 1 0.010
positive regulation of biological process GO:0048518 253 0.010
response to nutrient GO:0007584 3 0.010
lipid catabolic process GO:0016042 4 0.010
neuron differentiation GO:0030182 353 0.010
negative regulation of multicellular organismal process GO:0051241 69 0.010
positive regulation of cyclic nucleotide metabolic process GO:0030801 8 0.010
purine containing compound biosynthetic process GO:0072522 20 0.010
proteolysis GO:0006508 38 0.010
response to other organism GO:0051707 97 0.010
extracellular structure organization GO:0043062 27 0.010
axonogenesis GO:0007409 152 0.010
chromosome organization GO:0051276 31 0.010
negative regulation of multi organism process GO:0043901 3 0.010
sequestering of metal ion GO:0051238 3 0.010
neurotransmitter transport GO:0006836 2 0.010

slc8a4b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.054
disease of metabolism DOID:0014667 0 0.050
nervous system disease DOID:863 0 0.015
sensory system disease DOID:0050155 0 0.012
eye and adnexa disease DOID:1492 0 0.010