Danio rerio

0 known processes

smek1

SMEK homolog 1, suppressor of mek1 (Dictyostelium)

(Aliases: si:dkey-65b13.2,wu:fc60g09,fc60g09)

smek1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
modification dependent protein catabolic process GO:0019941 3 0.300
negative regulation of cellular process GO:0048523 283 0.287
gene expression GO:0010467 252 0.204
signal transduction GO:0007165 455 0.194
larval development GO:0002164 2 0.165
cellular protein catabolic process GO:0044257 4 0.163
protein localization to nucleus GO:0034504 3 0.147
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.134
aging GO:0007568 2 0.133
axon guidance GO:0007411 86 0.118
nucleocytoplasmic transport GO:0006913 4 0.105
sensory organ development GO:0007423 393 0.101
cellular component movement GO:0006928 335 0.092
axon development GO:0061564 166 0.088
modification dependent macromolecule catabolic process GO:0043632 3 0.086
cell projection morphogenesis GO:0048858 244 0.085
ubiquitin dependent protein catabolic process GO:0006511 3 0.079
regulation of biosynthetic process GO:0009889 250 0.075
nuclear transport GO:0051169 4 0.074
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.072
cellular macromolecule metabolic process GO:0044260 391 0.072
positive regulation of transport GO:0051050 2 0.065
organic cyclic compound biosynthetic process GO:1901362 223 0.064
regionalization GO:0003002 274 0.061
generation of neurons GO:0048699 385 0.057
cellular nitrogen compound metabolic process GO:0034641 290 0.056
protein targeting to nucleus GO:0044744 3 0.053
cellular component biogenesis GO:0044085 178 0.052
heterocycle metabolic process GO:0046483 290 0.051
cell projection organization GO:0030030 284 0.050
organic cyclic compound metabolic process GO:1901360 301 0.050
nuclear import GO:0051170 3 0.049
neuron differentiation GO:0030182 353 0.049
proteasomal protein catabolic process GO:0010498 2 0.049
organelle assembly GO:0070925 110 0.045
transcription dna templated GO:0006351 181 0.044
protein import GO:0017038 3 0.043
organic substance biosynthetic process GO:1901576 289 0.043
regulation of protein localization to nucleus GO:1900180 2 0.043
regulation of protein metabolic process GO:0051246 56 0.040
regulation of organelle assembly GO:1902115 4 0.040
locomotor rhythm GO:0045475 3 0.039
regulation of cellular biosynthetic process GO:0031326 245 0.039
cellular nitrogen compound biosynthetic process GO:0044271 218 0.039
regulation of cell differentiation GO:0045595 142 0.039
establishment of protein localization to organelle GO:0072594 4 0.038
single organism nuclear import GO:1902593 3 0.037
regulation of nucleocytoplasmic transport GO:0046822 2 0.037
negative regulation of reproductive process GO:2000242 3 0.036
tube morphogenesis GO:0035239 349 0.036
cell part morphogenesis GO:0032990 246 0.035
heterocycle biosynthetic process GO:0018130 215 0.035
negative regulation of catabolic process GO:0009895 3 0.034
dorsal ventral pattern formation GO:0009953 125 0.034
protein dephosphorylation GO:0006470 3 0.032
chemotaxis GO:0006935 104 0.032
cellular response to radiation GO:0071478 4 0.032
regulation of primary metabolic process GO:0080090 311 0.032
cell morphogenesis GO:0000902 289 0.031
cellular biosynthetic process GO:0044249 286 0.031
nucleic acid metabolic process GO:0090304 244 0.031
protein import into nucleus GO:0006606 3 0.030
regulation of cytoplasmic transport GO:1903649 4 0.030
regulation of rna biosynthetic process GO:2001141 213 0.030
spliceosomal complex assembly GO:0000245 1 0.030
cell morphogenesis involved in differentiation GO:0000904 195 0.029
neuron projection development GO:0031175 180 0.029
regulation of gene expression GO:0010468 265 0.029
regulation of cell communication GO:0010646 232 0.028
cell death GO:0008219 121 0.028
peptidyl serine modification GO:0018209 2 0.028
macromolecule biosynthetic process GO:0009059 227 0.028
regulation of reproductive process GO:2000241 4 0.027
protein metabolic process GO:0019538 183 0.027
regulation of intracellular protein transport GO:0033157 3 0.026
negative regulation of biological process GO:0048519 304 0.026
centrosome cycle GO:0007098 1 0.026
positive regulation of map kinase activity GO:0043406 3 0.026
positive regulation of cellular process GO:0048522 201 0.026
morphogenesis of an epithelium GO:0002009 333 0.026
neuron projection guidance GO:0097485 86 0.025
response to external stimulus GO:0009605 264 0.025
peptide transport GO:0015833 1 0.025
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.025
positive regulation of cellular catabolic process GO:0031331 3 0.025
regulation of circadian rhythm GO:0042752 4 0.025
negative regulation of chromosome organization GO:2001251 1 0.024
system process GO:0003008 185 0.024
axonogenesis GO:0007409 152 0.024
negative regulation of ras protein signal transduction GO:0046580 1 0.024
blood vessel morphogenesis GO:0048514 216 0.023
response to radiation GO:0009314 51 0.023
peptidyl serine phosphorylation GO:0018105 1 0.023
regulation of protein targeting GO:1903533 2 0.023
muscle structure development GO:0061061 196 0.023
regulation of macromolecule metabolic process GO:0060255 317 0.022
apoptotic process GO:0006915 116 0.022
regulation of protein transport GO:0051223 3 0.022
neuron projection morphogenesis GO:0048812 161 0.022
neuroblast proliferation GO:0007405 2 0.022
regulation of multicellular organismal process GO:0051239 277 0.021
negative regulation of small gtpase mediated signal transduction GO:0051058 1 0.021
regulation of cellular protein metabolic process GO:0032268 52 0.021
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.021
cellular aromatic compound metabolic process GO:0006725 295 0.021
regulation of metabolic process GO:0019222 359 0.021
muscle cell differentiation GO:0042692 139 0.021
immune system process GO:0002376 241 0.021
negative regulation of cell differentiation GO:0045596 46 0.021
rna biosynthetic process GO:0032774 181 0.021
regulation of dendrite development GO:0050773 3 0.020
nitrogen compound metabolic process GO:0006807 319 0.020
cellular component morphogenesis GO:0032989 336 0.020
positive regulation of catabolic process GO:0009896 4 0.020
developmental maturation GO:0021700 34 0.020
cellular macromolecule biosynthetic process GO:0034645 224 0.019
striated muscle cell differentiation GO:0051146 129 0.019
nucleobase containing compound metabolic process GO:0006139 274 0.019
phosphorus metabolic process GO:0006793 109 0.019
negative regulation of translation GO:0017148 1 0.019
taxis GO:0042330 109 0.019
connective tissue development GO:0061448 99 0.019
cellular response to external stimulus GO:0071496 2 0.019
regulation of receptor mediated endocytosis GO:0048259 4 0.018
phagocytosis GO:0006909 3 0.018
programmed cell death GO:0012501 119 0.018
regulation of neurological system process GO:0031644 2 0.018
eye development GO:0001654 277 0.018
response to external biotic stimulus GO:0043207 97 0.018
camera type eye development GO:0043010 222 0.017
rna metabolic process GO:0016070 219 0.017
regulation of nitrogen compound metabolic process GO:0051171 251 0.017
developmental growth involved in morphogenesis GO:0060560 86 0.017
regulation of cellular metabolic process GO:0031323 320 0.017
regulation of apoptotic process GO:0042981 98 0.017
chordate embryonic development GO:0043009 271 0.017
regulation of nucleoside metabolic process GO:0009118 2 0.017
regulation of gtpase activity GO:0043087 2 0.017
response to chemical GO:0042221 320 0.017
regulation of protein import into nucleus GO:0042306 2 0.016
neuron projection extension GO:1990138 45 0.016
regulation of cytokine production GO:0001817 3 0.016
anterior posterior pattern specification GO:0009952 152 0.016
negative regulation of macromolecule metabolic process GO:0010605 76 0.016
regulation of response to stimulus GO:0048583 269 0.016
wnt signaling pathway GO:0016055 80 0.016
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.016
positive regulation of biological process GO:0048518 253 0.016
centrosome duplication GO:0051298 1 0.016
regulation of purine nucleotide catabolic process GO:0033121 2 0.016
negative regulation of i kappab kinase nf kappab signaling GO:0043124 1 0.016
cellular localization GO:0051641 97 0.016
cellular macromolecular complex assembly GO:0034622 24 0.016
regulation of anatomical structure morphogenesis GO:0022603 130 0.015
regulation of localization GO:0032879 104 0.015
skeletal system development GO:0001501 181 0.015
muscle cell development GO:0055001 115 0.015
regulation of protein processing GO:0070613 10 0.015
regulation of dendrite morphogenesis GO:0048814 3 0.015
nucleobase containing compound biosynthetic process GO:0034654 205 0.015
negative regulation of intracellular transport GO:0032387 3 0.015
stem cell proliferation GO:0072089 4 0.015
convergent extension GO:0060026 118 0.015
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.015
heart process GO:0003015 71 0.014
regulation of cell death GO:0010941 103 0.014
organic substance transport GO:0071702 58 0.014
mrna transport GO:0051028 2 0.014
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.014
cellular component assembly GO:0022607 170 0.014
regulation of gtp catabolic process GO:0033124 2 0.014
protein modification process GO:0036211 100 0.014
regulation of cell morphogenesis GO:0022604 42 0.014
regulation of macromolecule biosynthetic process GO:0010556 225 0.014
heart contraction GO:0060047 71 0.014
negative regulation of cytoplasmic transport GO:1903650 2 0.014
regulation of cellular protein catabolic process GO:1903362 1 0.014
positive regulation of metabolic process GO:0009893 108 0.013
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.013
positive regulation of response to stimulus GO:0048584 80 0.013
cellular respiration GO:0045333 3 0.013
regulation of microtubule cytoskeleton organization GO:0070507 3 0.013
positive regulation of biosynthetic process GO:0009891 68 0.013
cell surface receptor signaling pathway GO:0007166 325 0.013
regulation of rna metabolic process GO:0051252 224 0.013
aromatic compound biosynthetic process GO:0019438 217 0.013
oocyte axis specification GO:0007309 5 0.013
cellular response to extracellular stimulus GO:0031668 2 0.013
membrane invagination GO:0010324 1 0.013
intracellular signal transduction GO:0035556 85 0.013
negative regulation of multi organism process GO:0043901 3 0.013
autophagy GO:0006914 4 0.013
regulation of cell activation GO:0050865 1 0.013
multi organism cellular process GO:0044764 2 0.013
cellular protein metabolic process GO:0044267 129 0.013
negative regulation of defense response GO:0031348 2 0.013
retina development in camera type eye GO:0060041 146 0.013
cytokinesis GO:0000910 3 0.013
negative regulation of cellular metabolic process GO:0031324 77 0.013
nucleic acid templated transcription GO:0097659 181 0.013
gtp catabolic process GO:0006184 2 0.013
cell growth GO:0016049 57 0.013
negative regulation of gliogenesis GO:0014014 1 0.013
regulation of proteolysis GO:0030162 24 0.013
regulation of stem cell differentiation GO:2000736 4 0.012
cellular response to nutrient levels GO:0031669 2 0.012
enzyme linked receptor protein signaling pathway GO:0007167 106 0.012
cellular response to starvation GO:0009267 1 0.012
negative regulation of neurogenesis GO:0050768 20 0.012
dorsal ventral axis specification GO:0009950 14 0.012
cellular protein modification process GO:0006464 100 0.012
sex determination GO:0007530 1 0.012
guanosine containing compound catabolic process GO:1901069 2 0.012
regulation of establishment of protein localization GO:0070201 4 0.012
developmental programmed cell death GO:0010623 4 0.012
blood vessel development GO:0001568 246 0.012
lateral inhibition GO:0046331 1 0.012
dna templated transcription elongation GO:0006354 3 0.012
death GO:0016265 121 0.012
macromolecule modification GO:0043412 111 0.011
neuron development GO:0048666 262 0.011
embryonic organ development GO:0048568 381 0.011
establishment of rna localization GO:0051236 3 0.011
regulation of chromosome segregation GO:0051983 1 0.011
adult behavior GO:0030534 2 0.011
regulation of wnt signaling pathway GO:0030111 53 0.011
regulation of nucleic acid templated transcription GO:1903506 213 0.011
stem cell maintenance GO:0019827 4 0.011
positive regulation of nucleoside metabolic process GO:0045979 1 0.011
regulation of cytokine mediated signaling pathway GO:0001959 3 0.011
regulation of epithelial to mesenchymal transition GO:0010717 3 0.011
regulation of protein maturation GO:1903317 10 0.011
locomotion GO:0040011 313 0.011
stem cell division GO:0017145 1 0.011
maintenance of location GO:0051235 4 0.011
protein complex localization GO:0031503 1 0.011
g1 s transition of mitotic cell cycle GO:0000082 1 0.011
smoothened signaling pathway GO:0007224 30 0.011
rna localization GO:0006403 4 0.011
regulation of biological quality GO:0065008 263 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.011
embryo development ending in birth or egg hatching GO:0009792 271 0.011
regulation of leukocyte mediated immunity GO:0002703 1 0.011
epithelial tube morphogenesis GO:0060562 148 0.011
meiotic nuclear division GO:0007126 4 0.011
negative regulation of gene expression GO:0010629 65 0.010
translational initiation GO:0006413 3 0.010
regulation of neural precursor cell proliferation GO:2000177 3 0.010
cell cycle g1 s phase transition GO:0044843 1 0.010
convergent extension involved in gastrulation GO:0060027 71 0.010
cellular amine metabolic process GO:0044106 2 0.010
mesenchyme development GO:0060485 127 0.010
gtp metabolic process GO:0046039 4 0.010
centrosome organization GO:0051297 1 0.010
multi organism process GO:0051704 134 0.010
response to abiotic stimulus GO:0009628 122 0.010
regulation of organelle organization GO:0033043 29 0.010
positive regulation of cellular component biogenesis GO:0044089 3 0.010
establishment of localization GO:0051234 244 0.010

smek1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.034
nervous system disease DOID:863 0 0.017