Danio rerio

0 known processes

soul4

heme-binding protein soul4

soul4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cell surface receptor signaling pathway GO:0007166 325 0.196
regulation of biological quality GO:0065008 263 0.187
morphogenesis of an epithelium GO:0002009 333 0.184
regulation of multicellular organismal process GO:0051239 277 0.153
single organism localization GO:1902578 225 0.129
monovalent inorganic cation transport GO:0015672 42 0.127
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.115
negative regulation of cellular process GO:0048523 283 0.103
synaptic growth at neuromuscular junction GO:0051124 2 0.103
regulation of nucleic acid templated transcription GO:1903506 213 0.100
specification of symmetry GO:0009799 204 0.097
cellular macromolecule metabolic process GO:0044260 391 0.095
tube morphogenesis GO:0035239 349 0.095
heart development GO:0007507 313 0.093
negative regulation of biological process GO:0048519 304 0.092
metal ion transport GO:0030001 58 0.090
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.090
regulation of metabolic process GO:0019222 359 0.088
determination of bilateral symmetry GO:0009855 204 0.088
signal transduction GO:0007165 455 0.084
aromatic compound biosynthetic process GO:0019438 217 0.084
larval development GO:0002164 2 0.080
cell projection morphogenesis GO:0048858 244 0.079
establishment of endothelial barrier GO:0061028 3 0.079
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.075
chordate embryonic development GO:0043009 271 0.072
sensory organ development GO:0007423 393 0.070
cilium morphogenesis GO:0060271 85 0.066
regulation of synapse assembly GO:0051963 3 0.064
neuromast primordium migration GO:0048883 12 0.064
regulation of nitrogen compound metabolic process GO:0051171 251 0.063
cell morphogenesis involved in differentiation GO:0000904 195 0.061
embryonic organ development GO:0048568 381 0.060
single organism transport GO:0044765 206 0.060
retina development in camera type eye GO:0060041 146 0.059
nucleobase containing compound metabolic process GO:0006139 274 0.058
response to endogenous stimulus GO:0009719 83 0.057
regulation of multicellular organismal development GO:2000026 223 0.057
regulation of anatomical structure morphogenesis GO:0022603 130 0.057
transport GO:0006810 220 0.057
cellular nitrogen compound metabolic process GO:0034641 290 0.057
localization of cell GO:0051674 244 0.056
cellular component movement GO:0006928 335 0.054
endocrine process GO:0050886 2 0.054
regulation of primary metabolic process GO:0080090 311 0.053
determination of left right symmetry GO:0007368 179 0.051
regulation of transcription dna templated GO:0006355 213 0.051
immune system process GO:0002376 241 0.051
protein polymerization GO:0051258 4 0.050
hemopoiesis GO:0030097 183 0.050
cell morphogenesis GO:0000902 289 0.050
heart morphogenesis GO:0003007 156 0.050
regulation of signal transduction GO:0009966 225 0.049
establishment of localization GO:0051234 244 0.048
cognition GO:0050890 1 0.048
heterocycle metabolic process GO:0046483 290 0.048
regulation of cellular metabolic process GO:0031323 320 0.047
rna biosynthetic process GO:0032774 181 0.047
regulation of developmental process GO:0050793 247 0.046
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.046
response to alkaloid GO:0043279 2 0.045
cell projection organization GO:0030030 284 0.045
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.045
regulation of response to stimulus GO:0048583 269 0.044
phosphorus metabolic process GO:0006793 109 0.043
cellular aromatic compound metabolic process GO:0006725 295 0.042
regulation of protein complex assembly GO:0043254 3 0.042
growth GO:0040007 174 0.041
response to chemical GO:0042221 320 0.041
cellular component morphogenesis GO:0032989 336 0.041
generation of neurons GO:0048699 385 0.040
digestive tract morphogenesis GO:0048546 231 0.039
gastrulation GO:0007369 208 0.039
taxis GO:0042330 109 0.039
nitrogen compound metabolic process GO:0006807 319 0.039
homeostatic process GO:0042592 142 0.039
regulation of cell shape GO:0008360 1 0.038
microtubule based movement GO:0007018 33 0.037
cell motility GO:0048870 244 0.037
nucleic acid metabolic process GO:0090304 244 0.037
adult behavior GO:0030534 2 0.037
transcription dna templated GO:0006351 181 0.036
cellular response to chemical stimulus GO:0070887 157 0.036
positive regulation of cellular process GO:0048522 201 0.036
regulation of endocrine process GO:0044060 2 0.036
cation homeostasis GO:0055080 33 0.035
lateral inhibition GO:0046331 1 0.035
regulation of dendrite morphogenesis GO:0048814 3 0.035
nucleobase containing compound biosynthetic process GO:0034654 205 0.035
locomotion GO:0040011 313 0.035
positive regulation of transport GO:0051050 2 0.034
cranial nerve development GO:0021545 42 0.034
regulation of macromolecule biosynthetic process GO:0010556 225 0.033
determination of heart left right asymmetry GO:0061371 117 0.032
rna metabolic process GO:0016070 219 0.031
cellular response to organic substance GO:0071310 105 0.031
chemical homeostasis GO:0048878 49 0.031
guanosine containing compound catabolic process GO:1901069 2 0.030
response to organic substance GO:0010033 153 0.030
embryonic heart tube morphogenesis GO:0003143 108 0.030
neuron projection development GO:0031175 180 0.030
inorganic ion transmembrane transport GO:0098660 57 0.030
neuron development GO:0048666 262 0.030
developmental growth GO:0048589 166 0.029
regionalization GO:0003002 274 0.029
cation transport GO:0006812 81 0.028
cellular component disassembly GO:0022411 1 0.028
enzyme linked receptor protein signaling pathway GO:0007167 106 0.028
positive regulation of cytoskeleton organization GO:0051495 3 0.027
synaptic vesicle transport GO:0048489 1 0.027
regulation of transmembrane transporter activity GO:0022898 2 0.027
rna modification GO:0009451 2 0.027
ion transport GO:0006811 114 0.027
developmental programmed cell death GO:0010623 4 0.026
regulation of jak stat cascade GO:0046425 3 0.026
ion transmembrane transport GO:0034220 91 0.026
regulation of cellular biosynthetic process GO:0031326 245 0.026
regulation of synapse organization GO:0050807 3 0.026
blood vessel development GO:0001568 246 0.026
regulation of circadian rhythm GO:0042752 4 0.025
regulation of rna biosynthetic process GO:2001141 213 0.025
regulation of metal ion transport GO:0010959 4 0.025
chemotaxis GO:0006935 104 0.025
positive regulation of metabolic process GO:0009893 108 0.025
organelle organization GO:0006996 227 0.025
single organism cell adhesion GO:0098602 29 0.025
positive regulation of cellular component biogenesis GO:0044089 3 0.025
regulation of cell migration GO:0030334 40 0.025
regulation of localization GO:0032879 104 0.024
amine metabolic process GO:0009308 2 0.024
single organism organelle organization GO:1902589 199 0.024
regulation of protein complex disassembly GO:0043244 1 0.024
organic cyclic compound metabolic process GO:1901360 301 0.024
cellular component biogenesis GO:0044085 178 0.024
response to stress GO:0006950 263 0.024
cell migration GO:0016477 237 0.023
cell part morphogenesis GO:0032990 246 0.023
cellular component assembly GO:0022607 170 0.023
purine nucleoside monophosphate catabolic process GO:0009128 4 0.023
nucleic acid templated transcription GO:0097659 181 0.023
gene expression GO:0010467 252 0.023
digestive tract development GO:0048565 265 0.023
regulation of molecular function GO:0065009 70 0.022
heterocycle biosynthetic process GO:0018130 215 0.022
microtubule polymerization or depolymerization GO:0031109 3 0.022
regulation of cytokine production GO:0001817 3 0.022
organophosphate metabolic process GO:0019637 37 0.022
cellular localization GO:0051641 97 0.022
negative regulation of cell projection organization GO:0031345 9 0.022
neural crest cell development GO:0014032 62 0.022
carbohydrate homeostasis GO:0033500 1 0.022
positive regulation of catabolic process GO:0009896 4 0.022
peptidyl threonine modification GO:0018210 1 0.022
regulation of apoptotic process GO:0042981 98 0.022
cellular response to endogenous stimulus GO:0071495 68 0.022
regulation of cell communication GO:0010646 232 0.021
negative regulation of multicellular organismal process GO:0051241 69 0.021
cell cell signaling GO:0007267 52 0.021
synaptic vesicle localization GO:0097479 1 0.021
positive regulation of protein complex assembly GO:0031334 2 0.021
microtubule based process GO:0007017 60 0.021
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.021
biological adhesion GO:0022610 40 0.021
embryonic heart tube development GO:0035050 133 0.021
response to abiotic stimulus GO:0009628 122 0.021
ameboidal type cell migration GO:0001667 143 0.021
mesenchymal cell development GO:0014031 78 0.020
exocytosis GO:0006887 1 0.020
macromolecular complex disassembly GO:0032984 1 0.020
regulation of cell activation GO:0050865 1 0.020
cellular protein metabolic process GO:0044267 129 0.020
regulation of biosynthetic process GO:0009889 250 0.020
reflex GO:0060004 2 0.020
regulation of macromolecule metabolic process GO:0060255 317 0.020
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.020
tyrosine phosphorylation of stat protein GO:0007260 1 0.020
neuron projection morphogenesis GO:0048812 161 0.020
regulation of synaptic plasticity GO:0048167 1 0.020
gtp metabolic process GO:0046039 4 0.019
cell death GO:0008219 121 0.019
regulation of reproductive process GO:2000241 4 0.019
response to other organism GO:0051707 97 0.019
atp catabolic process GO:0006200 4 0.019
protein dephosphorylation GO:0006470 3 0.019
transmembrane transport GO:0055085 120 0.019
aging GO:0007568 2 0.019
guanosine containing compound metabolic process GO:1901068 4 0.019
protein complex disassembly GO:0043241 1 0.019
camera type eye development GO:0043010 222 0.019
immune system development GO:0002520 191 0.019
neurotransmitter transport GO:0006836 2 0.019
regulation of purine nucleotide catabolic process GO:0033121 2 0.019
regulation of filopodium assembly GO:0051489 2 0.019
positive regulation of cellular catabolic process GO:0031331 3 0.018
g protein coupled receptor signaling pathway GO:0007186 74 0.018
cortical cytoskeleton organization GO:0030865 1 0.018
establishment of protein localization to plasma membrane GO:0090002 1 0.018
central nervous system development GO:0007417 387 0.018
divalent inorganic cation homeostasis GO:0072507 22 0.018
small molecule metabolic process GO:0044281 77 0.018
pronephros development GO:0048793 69 0.018
negative regulation of cell death GO:0060548 60 0.018
response to light stimulus GO:0009416 46 0.018
regulation of system process GO:0044057 40 0.018
regulation of establishment of protein localization GO:0070201 4 0.018
response to hormone GO:0009725 48 0.018
protein metabolic process GO:0019538 183 0.018
stem cell differentiation GO:0048863 117 0.017
negative regulation of kinase activity GO:0033673 4 0.017
hematopoietic or lymphoid organ development GO:0048534 191 0.017
regulation of cellular response to growth factor stimulus GO:0090287 35 0.017
positive regulation of cellular metabolic process GO:0031325 94 0.017
establishment of synaptic vesicle localization GO:0097480 1 0.017
phosphate containing compound metabolic process GO:0006796 108 0.017
cytoskeleton organization GO:0007010 96 0.017
cortical actin cytoskeleton organization GO:0030866 1 0.017
post golgi vesicle mediated transport GO:0006892 1 0.017
macromolecule modification GO:0043412 111 0.017
regulation of photoreceptor cell differentiation GO:0046532 2 0.017
macromolecule biosynthetic process GO:0009059 227 0.017
positive regulation of biological process GO:0048518 253 0.016
regulation of protein transport GO:0051223 3 0.016
regulation of gene expression GO:0010468 265 0.016
response to oxygen containing compound GO:1901700 55 0.016
lateral line system development GO:0048925 76 0.016
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.016
axonogenesis GO:0007409 152 0.016
epithelial cell development GO:0002064 42 0.016
head development GO:0060322 303 0.016
erythrocyte homeostasis GO:0034101 55 0.016
negative regulation of signal transduction GO:0009968 94 0.016
negative regulation of stem cell differentiation GO:2000737 2 0.016
fibroblast growth factor receptor signaling pathway GO:0008543 22 0.015
morphogenesis of an epithelial sheet GO:0002011 49 0.015
apoptotic process GO:0006915 116 0.015
organonitrogen compound metabolic process GO:1901564 74 0.015
single organism metabolic process GO:0044710 217 0.015
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.015
phagocytosis GO:0006909 3 0.015
actin polymerization or depolymerization GO:0008154 2 0.015
organic substance biosynthetic process GO:1901576 289 0.015
peptidyl threonine phosphorylation GO:0018107 1 0.015
calcium ion dependent exocytosis GO:0017156 1 0.015
positive regulation of protein polymerization GO:0032273 2 0.015
detection of mechanical stimulus involved in sensory perception of sound GO:0050910 3 0.015
establishment of localization in cell GO:0051649 77 0.015
epithelial cell differentiation GO:0030855 116 0.015
glucose import GO:0046323 2 0.015
regulation of rna metabolic process GO:0051252 224 0.015
cellular nitrogen compound biosynthetic process GO:0044271 218 0.015
system process GO:0003008 185 0.014
positive regulation of jak stat cascade GO:0046427 2 0.014
sensory perception of pain GO:0019233 1 0.014
protein depolymerization GO:0051261 1 0.014
mechanosensory lateral line system development GO:0048881 49 0.014
membrane hyperpolarization GO:0060081 1 0.014
response to carbohydrate GO:0009743 3 0.014
sensory perception GO:0007600 39 0.014
organic cyclic compound biosynthetic process GO:1901362 223 0.014
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.014
regulation of dendrite development GO:0050773 3 0.014
gland development GO:0048732 143 0.014
cellular monovalent inorganic cation homeostasis GO:0030004 2 0.014
positive regulation of multi organism process GO:0043902 3 0.014
mitochondrion organization GO:0007005 4 0.014
regulation of signaling GO:0023051 235 0.014
anatomical structure arrangement GO:0048532 2 0.014
glucose homeostasis GO:0042593 1 0.014
tissue remodeling GO:0048771 4 0.014
regulation of cellular protein catabolic process GO:1903362 1 0.013
cellular macromolecule biosynthetic process GO:0034645 224 0.013
cell proliferation GO:0008283 80 0.013
embryonic organ morphogenesis GO:0048562 274 0.013
regulation of nervous system development GO:0051960 90 0.013
mesenchyme development GO:0060485 127 0.013
regulation of nucleotide catabolic process GO:0030811 2 0.013
regulation of protein polymerization GO:0032271 2 0.013
neural tube patterning GO:0021532 33 0.013
neural crest cell migration GO:0001755 42 0.013
myeloid cell homeostasis GO:0002262 56 0.013
response to growth factor GO:0070848 39 0.013
cellular component assembly involved in morphogenesis GO:0010927 107 0.013
regulation of blood pressure GO:0008217 1 0.013
axon development GO:0061564 166 0.013
response to uv GO:0009411 3 0.013
cell adhesion GO:0007155 40 0.013
nucleoside monophosphate catabolic process GO:0009125 4 0.013
vasculature development GO:0001944 278 0.013
regulation of protein depolymerization GO:1901879 1 0.013
protein targeting to membrane GO:0006612 1 0.013
auditory receptor cell morphogenesis GO:0002093 4 0.013
eye development GO:0001654 277 0.013
hormone secretion GO:0046879 2 0.013
golgi vesicle transport GO:0048193 3 0.013
erythrocyte differentiation GO:0030218 54 0.013
neuron differentiation GO:0030182 353 0.013
regulation of protein catabolic process GO:0042176 1 0.013
cellular protein complex assembly GO:0043623 19 0.013
regulation of cellular component organization GO:0051128 86 0.013
cellular response to biotic stimulus GO:0071216 3 0.013
nuclear export GO:0051168 1 0.013
mesenchymal cell differentiation GO:0048762 87 0.013
muscle structure development GO:0061061 196 0.013
production of molecular mediator of immune response GO:0002440 2 0.013
primitive hemopoiesis GO:0060215 27 0.012
alcohol biosynthetic process GO:0046165 2 0.012
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.012
autophagy GO:0006914 4 0.012
response to monosaccharide GO:0034284 3 0.012
renal system development GO:0072001 94 0.012
peptide metabolic process GO:0006518 1 0.012
regulation of cell death GO:0010941 103 0.012
organic acid metabolic process GO:0006082 31 0.012
organic substance transport GO:0071702 58 0.012
death GO:0016265 121 0.012
regulation of growth rate GO:0040009 1 0.012
regulation of rho protein signal transduction GO:0035023 2 0.012
regulation of nucleoside metabolic process GO:0009118 2 0.012
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
ion homeostasis GO:0050801 41 0.012
protein import GO:0017038 3 0.012
negative regulation of protein kinase activity GO:0006469 4 0.012
multicellular organismal response to stress GO:0033555 2 0.012
negative regulation of apoptotic process GO:0043066 55 0.012
cellular response to oxygen levels GO:0071453 1 0.012
positive regulation of response to stimulus GO:0048584 80 0.012
embryonic hemopoiesis GO:0035162 53 0.012
lymphangiogenesis GO:0001946 25 0.012
programmed cell death GO:0012501 119 0.012
regulation of catalytic activity GO:0050790 55 0.012
protein phosphorylation GO:0006468 47 0.012
regulation of carbohydrate metabolic process GO:0006109 4 0.012
epidermis development GO:0008544 48 0.012
epithelial cell morphogenesis GO:0003382 2 0.012
sodium ion transmembrane transport GO:0035725 21 0.012
endocrine hormone secretion GO:0060986 2 0.012
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.012
ribosomal small subunit biogenesis GO:0042274 2 0.011
potassium ion transmembrane transport GO:0071805 10 0.011
regulation of exocytosis GO:0017157 1 0.011
skin development GO:0043588 54 0.011
single fertilization GO:0007338 3 0.011
cation transmembrane transport GO:0098655 65 0.011
skeletal system morphogenesis GO:0048705 102 0.011
phosphorylation GO:0016310 69 0.011
axonal defasciculation GO:0007414 2 0.011
regulation of programmed cell death GO:0043067 101 0.011
regulation of transporter activity GO:0032409 2 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.011
somatic stem cell maintenance GO:0035019 1 0.011
cellular response to nutrient levels GO:0031669 2 0.011
regulation of organ growth GO:0046620 3 0.011
cellular response to fibroblast growth factor stimulus GO:0044344 22 0.011
response to fibroblast growth factor GO:0071774 22 0.011
sodium ion transport GO:0006814 24 0.011
developmental growth involved in morphogenesis GO:0060560 86 0.011
protein complex assembly GO:0006461 30 0.011
protein secretion GO:0009306 1 0.011
protein complex subunit organization GO:0071822 46 0.011
synaptic vesicle endocytosis GO:0048488 1 0.011
interspecies interaction between organisms GO:0044419 4 0.011
rna localization GO:0006403 4 0.011
response to hydrogen peroxide GO:0042542 3 0.011
midbrain development GO:0030901 28 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.011
protein modification process GO:0036211 100 0.011
cellular amine metabolic process GO:0044106 2 0.010
negative chemotaxis GO:0050919 1 0.010
posterior lateral line neuromast primordium migration GO:0048920 12 0.010
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.010
cellular protein complex disassembly GO:0043624 1 0.010
mitochondrial transport GO:0006839 2 0.010
segmentation GO:0035282 97 0.010
startle response GO:0001964 4 0.010
digestive system development GO:0055123 289 0.010
response to salt stress GO:0009651 10 0.010
regulation of microtubule cytoskeleton organization GO:0070507 3 0.010
cellular response to radiation GO:0071478 4 0.010
cell projection assembly GO:0030031 64 0.010
embryonic pattern specification GO:0009880 44 0.010
protein localization to plasma membrane GO:0072659 1 0.010
rostrocaudal neural tube patterning GO:0021903 29 0.010
embryo development ending in birth or egg hatching GO:0009792 271 0.010

soul4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.047
immune system disease DOID:2914 0 0.028
hematopoietic system disease DOID:74 0 0.028
disease of cellular proliferation DOID:14566 0 0.016
cancer DOID:162 0 0.015
organ system cancer DOID:0050686 0 0.013
nervous system disease DOID:863 0 0.012
disease of metabolism DOID:0014667 0 0.010