Danio rerio

92 known processes

sox2

SRY-box containing gene 2

(Aliases: zgc:65860,wu:fb83g04,zgc:77389,cb236,wu:fc14d07)

sox2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
central nervous system development GO:0007417 387 1.000
Human Zebrafish Mouse Fly
sensory organ morphogenesis GO:0090596 200 0.997
ameboidal type cell migration GO:0001667 143 0.996
Zebrafish
sensory organ development GO:0007423 393 0.995
neuron differentiation GO:0030182 353 0.995
axon guidance GO:0007411 86 0.992
Fly
forebrain development GO:0030900 96 0.992
Human Mouse
pigmentation GO:0043473 85 0.992
Zebrafish
ear morphogenesis GO:0042471 64 0.988
Zebrafish Mouse
ectodermal placode development GO:0071696 37 0.980
Zebrafish Mouse
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.976
Fly
neuron projection morphogenesis GO:0048812 161 0.970
Fly
inner ear development GO:0048839 126 0.967
photoreceptor cell differentiation GO:0046530 55 0.967
negative regulation of biological process GO:0048519 304 0.966
Human Mouse
pituitary gland development GO:0021983 16 0.964
Human Mouse
embryonic camera type eye development GO:0031076 29 0.964
neural tube development GO:0021915 62 0.963
regulation of biological quality GO:0065008 263 0.959
camera type eye morphogenesis GO:0048593 108 0.959
Mouse
cell proliferation in forebrain GO:0021846 3 0.953
generation of neurons GO:0048699 385 0.951
stem cell development GO:0048864 82 0.949
Human Mouse
ectodermal placode formation GO:0060788 26 0.948
Zebrafish Mouse
neuron projection guidance GO:0097485 86 0.944
Fly
neuron projection development GO:0031175 180 0.936
Fly
ectodermal placode morphogenesis GO:0071697 32 0.934
Zebrafish Mouse
regulation of signal transduction GO:0009966 225 0.932
Human Mouse Fly
embryonic organ development GO:0048568 381 0.930
Zebrafish Mouse
diencephalon development GO:0021536 58 0.927
Human Mouse
axonogenesis GO:0007409 152 0.922
Fly
biosynthetic process GO:0009058 294 0.921
developmental pigmentation GO:0048066 48 0.921
Zebrafish
eye development GO:0001654 277 0.912
regulation of gene expression GO:0010468 265 0.909
neuromast development GO:0048884 46 0.907
brain development GO:0007420 293 0.899
Human Mouse
blood vessel morphogenesis GO:0048514 216 0.899
Zebrafish
anterior posterior pattern specification GO:0009952 152 0.897
tube morphogenesis GO:0035239 349 0.895
Human Zebrafish Mouse
regulation of cellular metabolic process GO:0031323 320 0.894
response to external stimulus GO:0009605 264 0.892
Mouse Fly
ear development GO:0043583 127 0.884
negative regulation of cellular process GO:0048523 283 0.884
Human Mouse
eye morphogenesis GO:0048592 144 0.878
hindbrain development GO:0030902 91 0.877
cell morphogenesis involved in differentiation GO:0000904 195 0.876
Fly
melanocyte differentiation GO:0030318 26 0.874
Zebrafish
regulation of inner ear receptor cell differentiation GO:2000980 1 0.871
chemotaxis GO:0006935 104 0.861
Fly
otic vesicle morphogenesis GO:0071600 34 0.850
Zebrafish
lens morphogenesis in camera type eye GO:0002089 7 0.850
Mouse
regionalization GO:0003002 274 0.842
Zebrafish
inner ear morphogenesis GO:0042472 63 0.839
Zebrafish Mouse
vasculature development GO:0001944 278 0.836
Zebrafish
otic vesicle formation GO:0030916 27 0.818
Zebrafish
taxis GO:0042330 109 0.805
Fly
central nervous system myelination GO:0022010 2 0.803
signal transduction GO:0007165 455 0.787
Human Mouse Fly
locomotion GO:0040011 313 0.784
Zebrafish Worm Fly
embryonic organ morphogenesis GO:0048562 274 0.775
Zebrafish Mouse
embryonic pectoral fin morphogenesis GO:0035118 24 0.775
Zebrafish
blood vessel development GO:0001568 246 0.767
Zebrafish
eye field cell fate commitment involved in camera type eye formation GO:0060898 3 0.765
apoptotic process GO:0006915 116 0.763
Human
nucleobase containing compound metabolic process GO:0006139 274 0.761
regulation of signaling GO:0023051 235 0.756
Human Mouse Fly
forebrain anterior posterior pattern specification GO:0021797 3 0.754
convergent extension GO:0060026 118 0.754
Zebrafish
neuron development GO:0048666 262 0.752
mesenchymal cell development GO:0014031 78 0.751
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.751
mesenchymal cell differentiation GO:0048762 87 0.743
cellular macromolecule metabolic process GO:0044260 391 0.734
otic placode formation GO:0043049 23 0.732
Zebrafish
cell part morphogenesis GO:0032990 246 0.730
Fly
axis specification GO:0009798 43 0.729
Zebrafish
stem cell maintenance GO:0019827 4 0.727
Human Mouse
dopaminergic neuron differentiation GO:0071542 14 0.723
regulation of wnt signaling pathway involved in digestive tract morphogenesis GO:2000056 2 0.722
cellular biosynthetic process GO:0044249 286 0.716
patterning of blood vessels GO:0001569 15 0.715
chordate embryonic development GO:0043009 271 0.703
positive regulation of notch signaling pathway GO:0045747 3 0.703
Mouse
heterocycle metabolic process GO:0046483 290 0.703
cell morphogenesis GO:0000902 289 0.695
Fly
head development GO:0060322 303 0.693
Human Mouse
forebrain neuron fate commitment GO:0021877 1 0.690
stem cell proliferation GO:0072089 4 0.685
Mouse
regulation of oligodendrocyte differentiation GO:0048713 1 0.683
mesenchyme development GO:0060485 127 0.675
retina development in camera type eye GO:0060041 146 0.645
Zebrafish Mouse
pectoral fin morphogenesis GO:0035138 29 0.643
Zebrafish
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.639
Zebrafish
connective tissue development GO:0061448 99 0.637
Zebrafish
neuroblast fate commitment GO:0014017 1 0.625
camera type eye development GO:0043010 222 0.622
Zebrafish Mouse
embryonic retina morphogenesis in camera type eye GO:0060059 22 0.620
forebrain generation of neurons GO:0021872 14 0.615
Mouse
pancreas development GO:0031016 84 0.613
Zebrafish
sensory system development GO:0048880 76 0.608
digestive tract morphogenesis GO:0048546 231 0.597
Human Zebrafish
embryonic viscerocranium morphogenesis GO:0048703 52 0.585
positive regulation of gene expression GO:0010628 71 0.581
Human Zebrafish Mouse Fly
immune system process GO:0002376 241 0.580
cell fate commitment GO:0045165 99 0.579
Human Zebrafish Mouse
larval development GO:0002164 2 0.577
Worm
gland development GO:0048732 143 0.571
Human Zebrafish Mouse
homeostatic process GO:0042592 142 0.561
embryonic camera type eye morphogenesis GO:0048596 19 0.561
radial glial cell differentiation GO:0060019 2 0.554
heart looping GO:0001947 94 0.553
cellular component morphogenesis GO:0032989 336 0.552
Fly
cellular aromatic compound metabolic process GO:0006725 295 0.550
regulation of metabolic process GO:0019222 359 0.547
hemopoiesis GO:0030097 183 0.540
oligodendrocyte development GO:0014003 7 0.537
axon development GO:0061564 166 0.529
Fly
optic placode formation involved in camera type eye formation GO:0046619 3 0.526
glial cell differentiation GO:0010001 42 0.521
Zebrafish
forebrain regionalization GO:0021871 4 0.519
negative regulation of cell cycle GO:0045786 14 0.516
Human
regulation of response to stimulus GO:0048583 269 0.512
Human Mouse Fly
neural crest cell differentiation GO:0014033 72 0.511
neural crest cell development GO:0014032 62 0.509
angiogenesis GO:0001525 158 0.508
neuronal stem cell maintenance GO:0097150 2 0.507
Mouse
embryonic skeletal system development GO:0048706 97 0.500
cell projection organization GO:0030030 284 0.499
Fly
immune system development GO:0002520 191 0.487
determination of left right symmetry GO:0007368 179 0.476
Zebrafish
wnt signaling pathway GO:0016055 80 0.472
Human Mouse Fly
digestive system development GO:0055123 289 0.471
Human Zebrafish
forebrain dorsal ventral pattern formation GO:0021798 1 0.469
embryonic heart tube development GO:0035050 133 0.463
Zebrafish
positive regulation of secretion by cell GO:1903532 1 0.460
cellular nitrogen compound metabolic process GO:0034641 290 0.451
neuroblast differentiation GO:0014016 1 0.451
photoreceptor cell development GO:0042461 40 0.448
growth GO:0040007 174 0.440
neuroepithelial cell differentiation GO:0060563 26 0.435
Zebrafish
transcription from rna polymerase ii promoter GO:0006366 80 0.434
Human Mouse Fly
endodermal digestive tract morphogenesis GO:0061031 2 0.434
stem cell differentiation GO:0048863 117 0.431
Human Mouse
organic cyclic compound metabolic process GO:1901360 301 0.428
cell motility GO:0048870 244 0.421
Zebrafish
positive regulation of stem cell proliferation GO:2000648 1 0.421
Mouse
positive regulation of biosynthetic process GO:0009891 68 0.417
Human Zebrafish Mouse Fly
developmental growth GO:0048589 166 0.415
cellular response to external stimulus GO:0071496 2 0.412
embryonic eye morphogenesis GO:0048048 30 0.407
eye photoreceptor cell development GO:0042462 30 0.407
regulation of epithelial cell proliferation GO:0050678 3 0.402
Human
sexual reproduction GO:0019953 36 0.402
cardioblast migration to the midline involved in heart field formation GO:0060975 7 0.402
Zebrafish
negative regulation of cellular biosynthetic process GO:0031327 55 0.401
Mouse
regulation of neuron differentiation GO:0045664 56 0.397
Mouse
negative regulation of anterior neural cell fate commitment of the neural plate by wnt signaling pathway GO:0022002 1 0.397
positive regulation of biological process GO:0048518 253 0.396
regulation of macromolecule biosynthetic process GO:0010556 225 0.395
nucleic acid templated transcription GO:0097659 181 0.392
nephron development GO:0072006 31 0.388
gene expression GO:0010467 252 0.387
response to drug GO:0042493 3 0.386
morphogenesis of an epithelium GO:0002009 333 0.385
Zebrafish Mouse
multicellular organism reproduction GO:0032504 35 0.380
Worm
peripheral nervous system development GO:0007422 55 0.378
Zebrafish
nose development GO:0043584 3 0.369
Mouse
response to wounding GO:0009611 116 0.368
establishment of localization GO:0051234 244 0.365
retina morphogenesis in camera type eye GO:0060042 79 0.364
Mouse
positive regulation of nucleic acid templated transcription GO:1903508 57 0.360
Human Zebrafish Mouse Fly
wnt signaling pathway involved in digestive tract morphogenesis GO:0044333 4 0.359
cellular macromolecule biosynthetic process GO:0034645 224 0.354
central nervous system myelin formation GO:0032289 1 0.352
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.349
Mouse
positive regulation of oligodendrocyte differentiation GO:0048714 1 0.347
appendage development GO:0048736 80 0.347
Zebrafish
retinal cell programmed cell death GO:0046666 2 0.344
cartilage development GO:0051216 96 0.344
Zebrafish
peripheral nervous system neuron differentiation GO:0048934 28 0.342
regulation of nucleic acid templated transcription GO:1903506 213 0.341
oligodendrocyte differentiation GO:0048709 23 0.331
Zebrafish
adult behavior GO:0030534 2 0.323
determination of heart left right asymmetry GO:0061371 117 0.322
Zebrafish
lateral line system development GO:0048925 76 0.321
sympathetic nervous system development GO:0048485 3 0.315
reproductive process GO:0022414 40 0.314
Mouse Worm
skeletal system morphogenesis GO:0048705 102 0.313
transcription dna templated GO:0006351 181 0.307
regulation of nervous system development GO:0051960 90 0.304
Mouse
negative regulation of neuron differentiation GO:0045665 10 0.304
Mouse
embryonic skeletal system morphogenesis GO:0048704 93 0.301
regulation of mechanoreceptor differentiation GO:0045631 1 0.300
epithelial cell differentiation GO:0030855 116 0.294
Zebrafish Mouse
negative regulation of response to stimulus GO:0048585 104 0.289
Human Mouse
positive regulation of cell cycle GO:0045787 3 0.288
protein metabolic process GO:0019538 183 0.287
Human
neuroblast proliferation GO:0007405 2 0.283
Mouse
multi organism process GO:0051704 134 0.281
Worm
gliogenesis GO:0042063 45 0.281
Zebrafish
otic vesicle development GO:0071599 42 0.280
Zebrafish
cellular component movement GO:0006928 335 0.280
Zebrafish Fly
development of primary female sexual characteristics GO:0046545 4 0.279
liver development GO:0001889 96 0.279
Zebrafish
developmental process involved in reproduction GO:0003006 27 0.277
Mouse Worm
regulation of phosphorus metabolic process GO:0051174 43 0.276
Human
regulation of macromolecule metabolic process GO:0060255 317 0.275
cell migration involved in gastrulation GO:0042074 79 0.274
Zebrafish
neuron fate commitment GO:0048663 26 0.273
Mouse
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.273
Human Zebrafish
rna metabolic process GO:0016070 219 0.272
nucleobase containing compound biosynthetic process GO:0034654 205 0.272
aromatic compound biosynthetic process GO:0019438 217 0.272
cell projection morphogenesis GO:0048858 244 0.271
Fly
cellular component assembly involved in morphogenesis GO:0010927 107 0.270
negative regulation of cell differentiation GO:0045596 46 0.267
Human Mouse
neural crest formation GO:0014029 14 0.267
negative regulation of cell development GO:0010721 26 0.267
Mouse
nitrogen compound metabolic process GO:0006807 319 0.266
response to acid chemical GO:0001101 17 0.266
Mouse
negative regulation of cellular metabolic process GO:0031324 77 0.266
Mouse
programmed cell death GO:0012501 119 0.265
Human
neural plate regionalization GO:0060897 10 0.263
embryonic cranial skeleton morphogenesis GO:0048701 90 0.260
fin development GO:0033333 77 0.258
Zebrafish
regulation of rna metabolic process GO:0051252 224 0.258
limbic system development GO:0021761 16 0.256
cell migration GO:0016477 237 0.255
Zebrafish
regulation of cell communication GO:0010646 232 0.255
Human Mouse Fly
midbrain hindbrain boundary development GO:0030917 23 0.254
cell differentiation in spinal cord GO:0021515 40 0.251
inner ear receptor cell fate commitment GO:0060120 4 0.251
multi organism reproductive process GO:0044703 36 0.250
Worm
response to chemical GO:0042221 320 0.246
Human Mouse Fly
skin development GO:0043588 54 0.245
regulation of intracellular signal transduction GO:1902531 57 0.243
Human
dorsal ventral pattern formation GO:0009953 125 0.243
Zebrafish
neural plate pattern specification GO:0060896 12 0.238
cell proliferation in hindbrain GO:0021534 4 0.238
midbrain development GO:0030901 28 0.237
regulation of multicellular organismal development GO:2000026 223 0.236
Zebrafish Mouse
positive regulation of cellular biosynthetic process GO:0031328 68 0.236
Human Zebrafish Mouse Fly
hair cell differentiation GO:0035315 32 0.233
rhombomere development GO:0021546 19 0.233
positive regulation of nervous system development GO:0051962 25 0.231
Mouse
neural crest cell migration GO:0001755 42 0.231
regulation of rna biosynthetic process GO:2001141 213 0.229
negative regulation of anterior neural cell fate commitment of the neural plate GO:0022001 1 0.228
epithelial cell proliferation involved in liver morphogenesis GO:0072575 2 0.226
hepatocyte proliferation GO:0072574 2 0.226
cellular response to extracellular stimulus GO:0031668 2 0.220
negative regulation of wnt signaling pathway GO:0030178 30 0.219
Human Mouse
cell death GO:0008219 121 0.217
Human
single organism reproductive process GO:0044702 40 0.216
Mouse Worm
positive regulation of transport GO:0051050 2 0.216
photoreceptor cell fate commitment GO:0046552 1 0.215
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.214
astrocyte differentiation GO:0048708 1 0.212
Zebrafish
hormone transport GO:0009914 2 0.211
regulation of molecular function GO:0065009 70 0.209
metencephalon development GO:0022037 27 0.207
regulation of stem cell proliferation GO:0072091 2 0.206
Mouse
epithelial cell proliferation GO:0050673 17 0.205
Human
heart morphogenesis GO:0003007 156 0.205
Zebrafish
gastrulation with mouth forming second GO:0001702 44 0.204
Zebrafish
positive regulation of transcription dna templated GO:0045893 57 0.203
Human Zebrafish Mouse Fly
organic substance biosynthetic process GO:1901576 289 0.202
transport GO:0006810 220 0.202
epidermal cell differentiation GO:0009913 36 0.202
heterocycle biosynthetic process GO:0018130 215 0.202
negative regulation of rna biosynthetic process GO:1902679 45 0.200
Mouse
mesoderm development GO:0007498 88 0.199
Zebrafish
appendage morphogenesis GO:0035107 56 0.194
Zebrafish
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.193
Human Zebrafish Mouse Fly
digestive tract development GO:0048565 265 0.192
Human Zebrafish
forebrain morphogenesis GO:0048853 6 0.190
Mouse
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.189
Human Mouse Fly
cellular nitrogen compound biosynthetic process GO:0044271 218 0.188
lateral line ganglion development GO:0048890 2 0.187
determination of pancreatic left right asymmetry GO:0035469 11 0.185
Zebrafish
embryo development ending in birth or egg hatching GO:0009792 271 0.184
Worm
positive regulation of metabolic process GO:0009893 108 0.184
Human Zebrafish Mouse Fly
positive regulation of rna metabolic process GO:0051254 59 0.181
Human Zebrafish Mouse Fly
gamete generation GO:0007276 33 0.181
epidermal cell fate specification GO:0009957 4 0.181
specification of symmetry GO:0009799 204 0.179
Zebrafish
negative regulation of cell migration GO:0030336 17 0.179
positive regulation of gastrulation GO:2000543 2 0.178
negative regulation of canonical wnt signaling pathway GO:0090090 21 0.178
Human Mouse
glial cell development GO:0021782 20 0.177
localization of cell GO:0051674 244 0.175
Zebrafish
epiboly GO:0090504 41 0.175
Zebrafish
mesodermal cell differentiation GO:0048333 21 0.174
regulation of neuron projection development GO:0010975 40 0.174
rostrocaudal neural tube patterning GO:0021903 29 0.174
cellular response to chemical stimulus GO:0070887 157 0.172
retinal pigment epithelium development GO:0003406 8 0.171
regulation of sequence specific dna binding transcription factor activity GO:0051090 9 0.169
renal tubule morphogenesis GO:0061333 1 0.168
inner ear receptor cell development GO:0060119 20 0.168
hatching gland development GO:0048785 3 0.167
regulation of biosynthetic process GO:0009889 250 0.166
somatic stem cell maintenance GO:0035019 1 0.165
Human
response to nutrient GO:0007584 3 0.163
neural tube patterning GO:0021532 33 0.161
hindbrain morphogenesis GO:0021575 22 0.160
hematopoietic or lymphoid organ development GO:0048534 191 0.159
positive regulation of macromolecule metabolic process GO:0010604 93 0.158
Human Zebrafish Mouse Fly
positive regulation of rna biosynthetic process GO:1902680 57 0.157
Human Zebrafish Mouse Fly
oligodendrocyte cell fate specification GO:0021778 4 0.156
neuroblast fate determination GO:0007400 1 0.154
negative regulation of nuclear division GO:0051784 3 0.153
mesodermal cell fate specification GO:0007501 12 0.152
regulation of nitrogen compound metabolic process GO:0051171 251 0.151
phosphate containing compound metabolic process GO:0006796 108 0.151
Human
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.150
Mouse
renal system development GO:0072001 94 0.149
positive regulation of cell fate specification GO:0042660 1 0.149
single organism organelle organization GO:1902589 199 0.147
response to growth factor GO:0070848 39 0.145
Human
posttranscriptional regulation of gene expression GO:0010608 14 0.141
epidermis development GO:0008544 48 0.140
negative regulation of myeloid cell differentiation GO:0045638 1 0.140
positive regulation of cellular metabolic process GO:0031325 94 0.140
Human Zebrafish Mouse Fly
cell cell signaling involved in cell fate commitment GO:0045168 12 0.140
Mouse
regeneration GO:0031099 91 0.139
mesodermal cell fate commitment GO:0001710 14 0.137
lens development in camera type eye GO:0002088 22 0.136
Mouse
keratinocyte differentiation GO:0030216 0 0.136
abducens nucleus development GO:0021742 2 0.135
reproduction GO:0000003 40 0.135
Worm
regulation of multicellular organismal process GO:0051239 277 0.135
Zebrafish Mouse
negative regulation of neurogenesis GO:0050768 20 0.133
Mouse
negative regulation of axon guidance GO:1902668 1 0.133
epithelial tube formation GO:0072175 19 0.133
smoothened signaling pathway GO:0007224 30 0.132
canonical wnt signaling pathway GO:0060070 48 0.131
Human Mouse
stem cell fate determination GO:0048867 1 0.131
brain morphogenesis GO:0048854 18 0.131
Mouse
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.130
axial mesoderm morphogenesis GO:0048319 8 0.130
glial cell fate commitment GO:0021781 6 0.129
heart development GO:0007507 313 0.127
Zebrafish
morphogenesis of a branching epithelium GO:0061138 16 0.127
Mouse
anterior commissure morphogenesis GO:0021960 3 0.127
inner ear receptor cell differentiation GO:0060113 29 0.127
morphogenesis of embryonic epithelium GO:0016331 30 0.126
startle response GO:0001964 4 0.126
fin morphogenesis GO:0033334 53 0.125
Zebrafish
embryonic camera type eye formation GO:0060900 10 0.124
segmentation GO:0035282 97 0.123
cell fate specification GO:0001708 68 0.123
Human Zebrafish Mouse
negative regulation of catalytic activity GO:0043086 21 0.121
positive regulation of cellular process GO:0048522 201 0.120
Human Zebrafish Mouse Fly
nucleic acid metabolic process GO:0090304 244 0.120
wnt signaling pathway involved in somitogenesis GO:0090244 2 0.120
regulation of developmental process GO:0050793 247 0.119
Human Zebrafish Mouse
mechanoreceptor differentiation GO:0042490 37 0.118
negative regulation of neuron projection regeneration GO:0070571 4 0.118
regulation of glial cell differentiation GO:0045685 4 0.118
positive regulation of neuron migration GO:2001224 2 0.117
regulation of canonical wnt signaling pathway GO:0060828 34 0.117
Human Mouse
negative regulation of gliogenesis GO:0014014 1 0.117
regulation of cell differentiation GO:0045595 142 0.116
Human Zebrafish Mouse
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.115
positive regulation of cellular catabolic process GO:0031331 3 0.115
regulation of cell division GO:0051302 12 0.115
wound healing GO:0042060 90 0.114
determination of bilateral symmetry GO:0009855 204 0.113
Zebrafish
regulation of mitotic cell cycle GO:0007346 25 0.113
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.111
Human Zebrafish Mouse Fly
swim bladder development GO:0048794 19 0.111
negative regulation of nervous system development GO:0051961 22 0.110
Mouse
single organism localization GO:1902578 225 0.109
cell surface receptor signaling pathway GO:0007166 325 0.109
Human Mouse Fly
regulation of anatomical structure morphogenesis GO:0022603 130 0.107
Zebrafish
nephron morphogenesis GO:0072028 2 0.107
hypothalamus development GO:0021854 14 0.106
cellular protein metabolic process GO:0044267 129 0.106
maintenance of location GO:0051235 4 0.106
intracellular signal transduction GO:0035556 85 0.105
Human
epithelial cell morphogenesis GO:0003382 2 0.104
negative regulation of gene expression GO:0010629 65 0.104
Mouse
regulation of transcription dna templated GO:0006355 213 0.104
thalamus development GO:0021794 6 0.104
glial cell fate determination GO:0007403 1 0.104
hepaticobiliary system development GO:0061008 98 0.103
Zebrafish
negative regulation of leukocyte differentiation GO:1902106 1 0.103
regulation of neuron migration GO:2001222 2 0.103
muscle structure development GO:0061061 196 0.102
forebrain midbrain boundary formation GO:0021905 1 0.100
epithelial tube morphogenesis GO:0060562 148 0.100
Mouse
negative regulation of neural precursor cell proliferation GO:2000178 1 0.099
response to carbohydrate GO:0009743 3 0.099
negative regulation of metabolic process GO:0009892 86 0.099
Mouse
stem cell fate commitment GO:0048865 1 0.098
nucleocytoplasmic transport GO:0006913 4 0.098
negative regulation of biosynthetic process GO:0009890 55 0.098
Mouse
negative regulation of multicellular organismal process GO:0051241 69 0.098
Mouse
endocardial progenitor cell migration to the midline involved in heart field formation GO:0003262 4 0.097
Zebrafish
ganglion development GO:0061548 5 0.096
water homeostasis GO:0030104 4 0.096
retina layer formation GO:0010842 24 0.094
fin regeneration GO:0031101 51 0.094
bone development GO:0060348 14 0.094
regulation of transport GO:0051049 45 0.092
regulation of establishment of protein localization GO:0070201 4 0.092
cell migration involved in heart formation GO:0060974 10 0.092
Zebrafish
somite development GO:0061053 96 0.092
blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043 4 0.091
neural crest cell fate commitment GO:0014034 5 0.091
single organism transport GO:0044765 206 0.090
regulation of cell fate commitment GO:0010453 22 0.090
Zebrafish
forebrain neuron differentiation GO:0021879 14 0.090
Mouse
somitogenesis GO:0001756 87 0.089
negative regulation of mitotic cell cycle GO:0045930 11 0.089
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.088
Human Mouse Fly
primary neural tube formation GO:0014020 1 0.087
axon extension GO:0048675 45 0.087
nephron epithelium morphogenesis GO:0072088 1 0.086
kidney development GO:0001822 92 0.083
innervation GO:0060384 3 0.083
axis elongation involved in somitogenesis GO:0090245 2 0.081
branching morphogenesis of an epithelial tube GO:0048754 15 0.081
Mouse
response to stress GO:0006950 263 0.081
regulation of axonogenesis GO:0050770 32 0.081
death GO:0016265 121 0.080
Human
spinal cord anterior posterior patterning GO:0021512 1 0.080
lipid storage GO:0019915 1 0.080
embryonic pattern specification GO:0009880 44 0.079
pectoral fin development GO:0033339 50 0.079
Zebrafish
urogenital system development GO:0001655 97 0.078
regulation of cell projection organization GO:0031344 44 0.077
gastrulation GO:0007369 208 0.077
Human Zebrafish
mesenchymal cell proliferation GO:0010463 1 0.077
negative regulation of apoptotic process GO:0043066 55 0.076
endodermal cell fate determination GO:0007493 2 0.076
Zebrafish
regulation of intracellular protein transport GO:0033157 3 0.076
positive regulation of striated muscle cell differentiation GO:0051155 1 0.076
regulation of protein metabolic process GO:0051246 56 0.075
Human
positive regulation of cell fate commitment GO:0010455 1 0.075
pancreatic a cell development GO:0003322 2 0.075
striated muscle tissue development GO:0014706 110 0.074
regulation of cell migration GO:0030334 40 0.074
cell proliferation in midbrain GO:0033278 4 0.074
aging GO:0007568 2 0.073
spinal cord radial glial cell differentiation GO:0021531 2 0.073
regulation of epithelial to mesenchymal transition GO:0010717 3 0.072
positive regulation of secretion GO:0051047 1 0.072
ectoderm development GO:0007398 9 0.071
iris morphogenesis GO:0061072 1 0.071
regulation of vasculature development GO:1901342 33 0.070
primitive erythrocyte differentiation GO:0060319 5 0.070
regulation of mesodermal cell fate specification GO:0042661 9 0.070
embryonic digestive tract morphogenesis GO:0048557 3 0.069
macromolecule biosynthetic process GO:0009059 227 0.069
regulation of neural precursor cell proliferation GO:2000177 3 0.069
Mouse
negative regulation of locomotion GO:0040013 18 0.069
protein import GO:0017038 3 0.069
anterior posterior axis specification GO:0009948 20 0.068
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.068
auditory receptor cell fate commitment GO:0009912 4 0.068
axon ensheathment in central nervous system GO:0032291 2 0.068
regulation of binding GO:0051098 3 0.067
neural plate anterior posterior regionalization GO:0021999 8 0.067
establishment of protein localization to organelle GO:0072594 4 0.067
anterior head development GO:0097065 2 0.066
forebrain neuron development GO:0021884 7 0.066
androgen biosynthetic process GO:0006702 1 0.066
cardioblast migration GO:0003260 7 0.066
Zebrafish
amine metabolic process GO:0009308 2 0.066
regulation of wnt signaling pathway calcium modulating pathway GO:0008591 3 0.065
negative regulation of epithelial cell proliferation GO:0050680 1 0.065
Human
negative regulation of kinase activity GO:0033673 4 0.065
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.064
Zebrafish
lateral line development GO:0048882 66 0.064
negative regulation of collateral sprouting of intact axon in response to injury GO:0048685 2 0.064
negative regulation of map kinase activity GO:0043407 2 0.063
negative regulation of cell death GO:0060548 60 0.063
venous blood vessel development GO:0060841 9 0.063
multicellular organism growth GO:0035264 4 0.062
cellular response to prostaglandin stimulus GO:0071379 3 0.062
nephron epithelium development GO:0072009 16 0.062
epithelial cell development GO:0002064 42 0.062
Zebrafish
tube closure GO:0060606 1 0.061
cytoskeleton organization GO:0007010 96 0.061
sensory epithelium regeneration GO:0070654 14 0.061
regulation of programmed cell death GO:0043067 101 0.060
Human
regulation of neurogenesis GO:0050767 87 0.059
Mouse
positive regulation of embryonic development GO:0040019 3 0.058
positive regulation of striated muscle tissue development GO:0045844 1 0.058
positive regulation of nucleotide catabolic process GO:0030813 1 0.058
protein import into nucleus GO:0006606 3 0.056
neuron fate determination GO:0048664 2 0.056
negative regulation of programmed cell death GO:0043069 58 0.056
negative regulation of axon extension GO:0030517 7 0.055
ventral spinal cord interneuron fate commitment GO:0060579 3 0.055
cellular response to nutrient levels GO:0031669 2 0.054
axon extension involved in axon guidance GO:0048846 10 0.054

sox2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org