Danio rerio

33 known processes

spg11

spastic paraplegia 11

spg11 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.260
cytokinesis GO:0000910 3 0.171
regulation of blood pressure GO:0008217 1 0.117
response to alkaloid GO:0043279 2 0.114
phototransduction visible light GO:0007603 2 0.105
membrane lipid biosynthetic process GO:0046467 2 0.081
response to stress GO:0006950 263 0.072
somite development GO:0061053 96 0.062
actomyosin structure organization GO:0031032 53 0.060
sensory perception of chemical stimulus GO:0007606 3 0.060
protein polymerization GO:0051258 4 0.059
cognition GO:0050890 1 0.057
biosynthetic process GO:0009058 294 0.057
embryonic organ development GO:0048568 381 0.056
single organism metabolic process GO:0044710 217 0.056
regulation of multicellular organism growth GO:0040014 4 0.055
regulation of tube size GO:0035150 2 0.054
sequestering of metal ion GO:0051238 3 0.053
taxis GO:0042330 109 0.053
organonitrogen compound metabolic process GO:1901564 74 0.053
maintenance of location GO:0051235 4 0.052
regulation of protein polymerization GO:0032271 2 0.052
organic substance biosynthetic process GO:1901576 289 0.051
regulation of protein complex assembly GO:0043254 3 0.050
multicellular organism growth GO:0035264 4 0.050
response to external stimulus GO:0009605 264 0.050
cytoskeleton organization GO:0007010 96 0.050
cytokinetic process GO:0032506 2 0.050
organelle organization GO:0006996 227 0.046
chordate embryonic development GO:0043009 271 0.046
estrogen metabolic process GO:0008210 2 0.045
cellular response to chemical stimulus GO:0070887 157 0.045
neuron development GO:0048666 262 0.045
calcium ion transport into cytosol GO:0060402 3 0.044
cellular response to light stimulus GO:0071482 4 0.044
regulation of epithelial cell proliferation GO:0050678 3 0.043
embryonic organ morphogenesis GO:0048562 274 0.042
response to chemical GO:0042221 320 0.042
androgen metabolic process GO:0008209 2 0.041
organelle assembly GO:0070925 110 0.041
skeletal system development GO:0001501 181 0.041
sphingolipid biosynthetic process GO:0030148 2 0.041
neurotransmitter secretion GO:0007269 2 0.040
autophagy GO:0006914 4 0.040
regulation of dna templated transcription in response to stress GO:0043620 0 0.040
phototransduction GO:0007602 2 0.039
response to endogenous stimulus GO:0009719 83 0.039
cell part morphogenesis GO:0032990 246 0.038
generation of neurons GO:0048699 385 0.038
fat soluble vitamin metabolic process GO:0006775 4 0.037
response to abiotic stimulus GO:0009628 122 0.037
regulation of biological quality GO:0065008 263 0.037
embryonic skeletal system development GO:0048706 97 0.037
sequestering of calcium ion GO:0051208 3 0.036
regulation of multicellular organismal development GO:2000026 223 0.036
cellular response to endogenous stimulus GO:0071495 68 0.036
positive regulation of myeloid cell differentiation GO:0045639 2 0.036
cellular biosynthetic process GO:0044249 286 0.035
hormone biosynthetic process GO:0042446 3 0.035
neuron differentiation GO:0030182 353 0.034
histone phosphorylation GO:0016572 2 0.034
negative regulation of sequestering of calcium ion GO:0051283 4 0.034
calcium ion import GO:0070509 4 0.034
positive regulation of cellular component biogenesis GO:0044089 3 0.033
positive regulation of catabolic process GO:0009896 4 0.032
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.032
spermatid development GO:0007286 2 0.032
glycolipid biosynthetic process GO:0009247 1 0.032
mitochondrion organization GO:0007005 4 0.032
single organism organelle organization GO:1902589 199 0.031
lipid metabolic process GO:0006629 52 0.031
muscle cell differentiation GO:0042692 139 0.031
aging GO:0007568 2 0.029
system process GO:0003008 185 0.029
b cell activation GO:0042113 2 0.029
cellular component biogenesis GO:0044085 178 0.029
small molecule metabolic process GO:0044281 77 0.029
axon development GO:0061564 166 0.028
regulation of mrna processing GO:0050684 3 0.027
homeostatic process GO:0042592 142 0.027
cellular component disassembly GO:0022411 1 0.027
cellular response to radiation GO:0071478 4 0.027
hormone metabolic process GO:0042445 19 0.027
muscle structure development GO:0061061 196 0.027
organelle fusion GO:0048284 3 0.026
nitrogen compound metabolic process GO:0006807 319 0.026
cellular response to starvation GO:0009267 1 0.026
protein metabolic process GO:0019538 183 0.026
carbohydrate homeostasis GO:0033500 1 0.026
regulation of blood vessel size GO:0050880 2 0.026
carbohydrate derivative biosynthetic process GO:1901137 43 0.026
phagocytosis GO:0006909 3 0.026
cellular amide metabolic process GO:0043603 4 0.025
female gonad development GO:0008585 4 0.025
response to organic substance GO:0010033 153 0.025
regulation of transcription from rna polymerase ii promoter in response to oxidative stress GO:0043619 0 0.025
amine metabolic process GO:0009308 2 0.025
endocrine process GO:0050886 2 0.025
morphogenesis of an epithelium GO:0002009 333 0.025
cellular response to extracellular stimulus GO:0031668 2 0.025
regulation of cell activation GO:0050865 1 0.025
cytosolic calcium ion transport GO:0060401 3 0.024
positive regulation of immune effector process GO:0002699 3 0.024
regulation of cell differentiation GO:0045595 142 0.024
cell substrate adhesion GO:0031589 4 0.024
macromolecule modification GO:0043412 111 0.024
transport GO:0006810 220 0.024
protein modification process GO:0036211 100 0.024
cellular component morphogenesis GO:0032989 336 0.023
regulation of response to stimulus GO:0048583 269 0.023
regulation of cytokine production GO:0001817 3 0.023
positive regulation of protein complex assembly GO:0031334 2 0.023
cellular response to estrogen stimulus GO:0071391 24 0.023
regulation of response to nutrient levels GO:0032107 1 0.023
response to glucocorticoid GO:0051384 1 0.023
development of primary female sexual characteristics GO:0046545 4 0.023
muscle cell development GO:0055001 115 0.022
extrinsic apoptotic signaling pathway GO:0097191 3 0.022
actin cytoskeleton organization GO:0030036 63 0.022
rhodopsin mediated signaling pathway GO:0016056 1 0.022
embryonic cranial skeleton morphogenesis GO:0048701 90 0.022
photoperiodism GO:0009648 11 0.022
cortical cytoskeleton organization GO:0030865 1 0.022
microtubule polymerization or depolymerization GO:0031109 3 0.022
positive regulation of protein polymerization GO:0032273 2 0.022
sodium ion transmembrane transport GO:0035725 21 0.022
cell morphogenesis involved in differentiation GO:0000904 195 0.021
neurotransmitter transport GO:0006836 2 0.021
response to oxidative stress GO:0006979 11 0.021
central nervous system development GO:0007417 387 0.021
embryo development ending in birth or egg hatching GO:0009792 271 0.021
exocytosis GO:0006887 1 0.021
signal transduction GO:0007165 455 0.021
positive regulation of cellular catabolic process GO:0031331 3 0.021
renal system process involved in regulation of systemic arterial blood pressure GO:0003071 1 0.021
regulation of synaptic plasticity GO:0048167 1 0.021
programmed cell death GO:0012501 119 0.021
regulation of systemic arterial blood pressure GO:0003073 1 0.021
b cell differentiation GO:0030183 1 0.021
actin filament based process GO:0030029 64 0.021
cellular nitrogen compound metabolic process GO:0034641 290 0.021
myofibril assembly GO:0030239 48 0.021
cellular response to nutrient levels GO:0031669 2 0.020
cellular ketone metabolic process GO:0042180 11 0.020
tube morphogenesis GO:0035239 349 0.020
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.020
regulation of protein ubiquitination GO:0031396 3 0.020
peptide metabolic process GO:0006518 1 0.020
regulation of programmed cell death GO:0043067 101 0.020
positive regulation of transport GO:0051050 2 0.020
locomotion GO:0040011 313 0.020
stem cell maintenance GO:0019827 4 0.019
response to corticosteroid GO:0031960 1 0.019
negative regulation of catabolic process GO:0009895 3 0.019
regulation of circadian rhythm GO:0042752 4 0.019
regulation of cellular amino acid metabolic process GO:0006521 0 0.019
single organism membrane fusion GO:0044801 2 0.019
embryonic heart tube morphogenesis GO:0003143 108 0.019
cell death GO:0008219 121 0.019
positive regulation of neuron death GO:1901216 1 0.019
synaptic growth at neuromuscular junction GO:0051124 2 0.019
multi organism process GO:0051704 134 0.019
regulation of metal ion transport GO:0010959 4 0.019
actin filament polymerization GO:0030041 2 0.019
mesenchyme development GO:0060485 127 0.019
receptor recycling GO:0001881 4 0.019
organonitrogen compound biosynthetic process GO:1901566 47 0.019
production of molecular mediator of immune response GO:0002440 2 0.019
macromolecular complex disassembly GO:0032984 1 0.019
cellular macromolecule metabolic process GO:0044260 391 0.018
negative regulation of kinase activity GO:0033673 4 0.018
positive regulation of cytoskeleton organization GO:0051495 3 0.018
positive regulation of epithelial cell proliferation GO:0050679 1 0.018
membrane lipid metabolic process GO:0006643 10 0.018
gene expression GO:0010467 252 0.018
heart development GO:0007507 313 0.018
regulation of metabolic process GO:0019222 359 0.018
mechanosensory lateral line system development GO:0048881 49 0.018
regulation of multicellular organismal process GO:0051239 277 0.018
cellular component assembly involved in morphogenesis GO:0010927 107 0.018
regulation of cell death GO:0010941 103 0.018
cellular response to lipopolysaccharide GO:0071222 3 0.018
membrane invagination GO:0010324 1 0.018
death GO:0016265 121 0.018
positive regulation of biological process GO:0048518 253 0.018
negative regulation of cellular process GO:0048523 283 0.017
positive regulation of cell cycle GO:0045787 3 0.017
peptidyl serine phosphorylation GO:0018105 1 0.017
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.017
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.017
cell projection morphogenesis GO:0048858 244 0.017
regulation of nucleic acid templated transcription GO:1903506 213 0.017
actin polymerization or depolymerization GO:0008154 2 0.017
regulation of sequestering of calcium ion GO:0051282 4 0.017
regulation of reproductive process GO:2000241 4 0.017
regulation of dna replication GO:0006275 3 0.017
regulation of protein catabolic process GO:0042176 1 0.017
regulation of synapse organization GO:0050807 3 0.017
positive regulation of cell division GO:0051781 2 0.017
cell surface receptor signaling pathway GO:0007166 325 0.017
cellular protein metabolic process GO:0044267 129 0.017
microtubule polymerization GO:0046785 2 0.017
nucleoside monophosphate catabolic process GO:0009125 4 0.017
glucose homeostasis GO:0042593 1 0.016
somitogenesis GO:0001756 87 0.016
meiotic nuclear division GO:0007126 4 0.016
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.016
regulation of signaling GO:0023051 235 0.016
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.016
cellular response to molecule of bacterial origin GO:0071219 3 0.016
cell migration GO:0016477 237 0.016
regulation of response to extracellular stimulus GO:0032104 1 0.016
somatic muscle development GO:0007525 4 0.016
regulation of cytoplasmic transport GO:1903649 4 0.016
response to uv GO:0009411 3 0.016
cellular response to organic substance GO:0071310 105 0.016
nuclear transport GO:0051169 4 0.016
ribonucleoside monophosphate catabolic process GO:0009158 4 0.016
regulation of cellular amine metabolic process GO:0033238 0 0.016
androgen biosynthetic process GO:0006702 1 0.016
single organism biosynthetic process GO:0044711 71 0.016
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.016
smooth muscle contraction GO:0006939 2 0.016
atp catabolic process GO:0006200 4 0.016
organic cyclic compound biosynthetic process GO:1901362 223 0.016
fluid transport GO:0042044 17 0.016
cellular component assembly GO:0022607 170 0.015
positive regulation of secretion GO:0051047 1 0.015
regulation of neural precursor cell proliferation GO:2000177 3 0.015
lipid storage GO:0019915 1 0.015
inorganic cation transmembrane transport GO:0098662 50 0.015
heart process GO:0003015 71 0.015
antimicrobial humoral response GO:0019730 2 0.015
regulation of inflammatory response GO:0050727 2 0.015
germ line stem cell maintenance GO:0030718 2 0.015
modification dependent macromolecule catabolic process GO:0043632 3 0.015
spermatid differentiation GO:0048515 2 0.015
proteasomal protein catabolic process GO:0010498 2 0.015
guanosine containing compound metabolic process GO:1901068 4 0.015
ion transport GO:0006811 114 0.015
neuron projection development GO:0031175 180 0.015
nucleocytoplasmic transport GO:0006913 4 0.015
inositol lipid mediated signaling GO:0048017 2 0.015
sensory organ development GO:0007423 393 0.015
response to steroid hormone GO:0048545 35 0.015
cellular aromatic compound metabolic process GO:0006725 295 0.015
cytoskeleton dependent cytokinesis GO:0061640 3 0.015
negative regulation of apoptotic process GO:0043066 55 0.015
hemopoiesis GO:0030097 183 0.014
response to external biotic stimulus GO:0043207 97 0.014
establishment of protein localization to organelle GO:0072594 4 0.014
membrane hyperpolarization GO:0060081 1 0.014
sensory system development GO:0048880 76 0.014
regionalization GO:0003002 274 0.014
negative regulation of protein kinase activity GO:0006469 4 0.014
protein secretion GO:0009306 1 0.014
cellular amine metabolic process GO:0044106 2 0.014
lateral line system development GO:0048925 76 0.014
cell division GO:0051301 20 0.014
protein complex disassembly GO:0043241 1 0.014
nucleobase containing compound biosynthetic process GO:0034654 205 0.014
regulation of microtubule cytoskeleton organization GO:0070507 3 0.014
regulation of erythrocyte differentiation GO:0045646 2 0.014
oxidation reduction process GO:0055114 41 0.014
negative regulation of myeloid cell differentiation GO:0045638 1 0.014
cellular protein modification process GO:0006464 100 0.014
neuron projection morphogenesis GO:0048812 161 0.014
regulation of binding GO:0051098 3 0.014
skeletal muscle tissue development GO:0007519 67 0.013
cellular response to oxygen levels GO:0071453 1 0.013
negative regulation of protein phosphorylation GO:0001933 4 0.013
lateral line development GO:0048882 66 0.013
regulation of cellular ketone metabolic process GO:0010565 7 0.013
cortical actin cytoskeleton organization GO:0030866 1 0.013
regulation of protein transport GO:0051223 3 0.013
microtubule based movement GO:0007018 33 0.013
cellular response to external stimulus GO:0071496 2 0.013
single organism transport GO:0044765 206 0.013
mechanosensory behavior GO:0007638 2 0.013
specification of organ identity GO:0010092 2 0.013
specification of symmetry GO:0009799 204 0.013
fertilization GO:0009566 3 0.013
positive regulation of dna metabolic process GO:0051054 1 0.013
negative regulation of biological process GO:0048519 304 0.013
golgi vesicle transport GO:0048193 3 0.013
regulation of system process GO:0044057 40 0.013
heterocycle metabolic process GO:0046483 290 0.013
oxoacid metabolic process GO:0043436 31 0.013
cellular component movement GO:0006928 335 0.013
regulation of apoptotic process GO:0042981 98 0.013
neuron neuron synaptic transmission GO:0007270 1 0.013
regulation of response to biotic stimulus GO:0002831 2 0.013
phagocytosis engulfment GO:0006911 1 0.013
positive regulation of epithelial cell differentiation GO:0030858 2 0.013
catechol containing compound metabolic process GO:0009712 2 0.013
neural crest cell differentiation GO:0014033 72 0.013
regulation of autophagy GO:0010506 3 0.013
response to hydrogen peroxide GO:0042542 3 0.013
double strand break repair GO:0006302 3 0.013
negative regulation of dna replication GO:0008156 2 0.013
regulation of developmental process GO:0050793 247 0.013
regulation of biosynthetic process GO:0009889 250 0.012
peptidyl serine modification GO:0018209 2 0.012
digestive system development GO:0055123 289 0.012
immune system process GO:0002376 241 0.012
locomotor rhythm GO:0045475 3 0.012
positive regulation of cell activation GO:0050867 1 0.012
positive regulation of blood circulation GO:1903524 2 0.012
cellular respiration GO:0045333 3 0.012
blood circulation GO:0008015 87 0.012
negative regulation of dna metabolic process GO:0051053 4 0.012
cellular protein catabolic process GO:0044257 4 0.012
purine nucleoside monophosphate catabolic process GO:0009128 4 0.012
striated muscle tissue development GO:0014706 110 0.012
regulation of cell projection assembly GO:0060491 4 0.012
macroautophagy GO:0016236 1 0.012
ubiquitin dependent protein catabolic process GO:0006511 3 0.012
phosphate containing compound metabolic process GO:0006796 108 0.012
protein targeting to nucleus GO:0044744 3 0.012
liver development GO:0001889 96 0.012
gtp catabolic process GO:0006184 2 0.012
transcription dna templated GO:0006351 181 0.012
endocardial cushion formation GO:0003272 2 0.012
cellular response to organic cyclic compound GO:0071407 38 0.012
positive regulation of nucleoside metabolic process GO:0045979 1 0.012
oxidative phosphorylation GO:0006119 1 0.012
regulation of localization GO:0032879 104 0.012
regulation of nucleocytoplasmic transport GO:0046822 2 0.012
embryonic heart tube development GO:0035050 133 0.012
regulation of dendrite morphogenesis GO:0048814 3 0.012
gastrulation GO:0007369 208 0.012
stem cell proliferation GO:0072089 4 0.012
organic cyclic compound metabolic process GO:1901360 301 0.012
sensory perception of touch GO:0050975 2 0.012
immune system development GO:0002520 191 0.012
regulation of protein binding GO:0043393 3 0.012
cellular macromolecule biosynthetic process GO:0034645 224 0.012
protein localization to nucleus GO:0034504 3 0.012
liposaccharide metabolic process GO:1903509 8 0.012
carboxylic acid metabolic process GO:0019752 22 0.012
rna localization GO:0006403 4 0.012
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.012
positive regulation of stress activated mapk cascade GO:0032874 3 0.012
neural crest formation GO:0014029 14 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.012
actin filament based movement GO:0030048 1 0.012
carbohydrate derivative metabolic process GO:1901135 61 0.012
cellular response to stress GO:0033554 62 0.012
positive regulation of neutrophil migration GO:1902624 0 0.012
cellular carbohydrate metabolic process GO:0044262 4 0.012
striated muscle cell development GO:0055002 108 0.012
response to biotic stimulus GO:0009607 97 0.012
purine containing compound metabolic process GO:0072521 29 0.012
eye development GO:0001654 277 0.012
apoptotic process GO:0006915 116 0.012
regulation of establishment of protein localization GO:0070201 4 0.011
behavior GO:0007610 74 0.011
positive regulation of neuron apoptotic process GO:0043525 1 0.011
cell cycle GO:0007049 93 0.011
nucleic acid metabolic process GO:0090304 244 0.011
catecholamine metabolic process GO:0006584 2 0.011
skeletal muscle organ development GO:0060538 78 0.011
cellular response to biotic stimulus GO:0071216 3 0.011
cellular amino acid metabolic process GO:0006520 7 0.011
cell migration involved in gastrulation GO:0042074 79 0.011
ear development GO:0043583 127 0.011
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.011
positive regulation of defense response to virus by host GO:0002230 0 0.011
regulation of signal transduction GO:0009966 225 0.011
rna biosynthetic process GO:0032774 181 0.011
protein import into nucleus GO:0006606 3 0.011
glutamate receptor signaling pathway GO:0007215 1 0.011
camera type eye development GO:0043010 222 0.011
metal ion homeostasis GO:0055065 26 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.011
response to carbohydrate GO:0009743 3 0.011
muscle fiber development GO:0048747 52 0.011
negative regulation of leukocyte differentiation GO:1902106 1 0.011
receptor internalization GO:0031623 2 0.011
protein import GO:0017038 3 0.011
er to golgi vesicle mediated transport GO:0006888 1 0.011
peptide transport GO:0015833 1 0.011
determination of bilateral symmetry GO:0009855 204 0.011
blood vessel morphogenesis GO:0048514 216 0.011
regulation of production of molecular mediator of immune response GO:0002700 1 0.011
establishment of localization GO:0051234 244 0.011
gtp metabolic process GO:0046039 4 0.011
cell projection organization GO:0030030 284 0.011
positive regulation of secretion by cell GO:1903532 1 0.011
detection of external stimulus GO:0009581 24 0.011
heart looping GO:0001947 94 0.011
regulation of organelle assembly GO:1902115 4 0.011
regulation of erk1 and erk2 cascade GO:0070372 4 0.011
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.011
embryonic skeletal system morphogenesis GO:0048704 93 0.011
regulation of reactive oxygen species metabolic process GO:2000377 2 0.011
intracellular mrna localization GO:0008298 1 0.011
oocyte anterior posterior axis specification GO:0007314 4 0.011
negative regulation of defense response GO:0031348 2 0.011
negative regulation of secretion GO:0051048 2 0.011
adult behavior GO:0030534 2 0.011
meiotic cell cycle process GO:1903046 3 0.011
regulation of heart contraction GO:0008016 32 0.010
regulation of oocyte development GO:0060281 3 0.010
somatic cell dna recombination GO:0016444 1 0.010
stem cell division GO:0017145 1 0.010
negative regulation of cell death GO:0060548 60 0.010
glycolipid metabolic process GO:0006664 8 0.010
regulation of cellular metabolic process GO:0031323 320 0.010
skeletal system morphogenesis GO:0048705 102 0.010
protein modification by small protein removal GO:0070646 1 0.010
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.010
regulation of wound healing GO:0061041 2 0.010
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.010
neural crest cell development GO:0014032 62 0.010
detection of abiotic stimulus GO:0009582 24 0.010
response to xenobiotic stimulus GO:0009410 45 0.010
female sex differentiation GO:0046660 4 0.010
regulation of cell substrate adhesion GO:0010810 1 0.010
regulation of cellular protein catabolic process GO:1903362 1 0.010

spg11 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 0 0.040
disease of anatomical entity DOID:7 0 0.040
eye and adnexa disease DOID:1492 0 0.040
nervous system disease DOID:863 0 0.040
eye disease DOID:5614 0 0.040
cancer DOID:162 0 0.025
disease of cellular proliferation DOID:14566 0 0.025
disease of metabolism DOID:0014667 0 0.023
inherited metabolic disorder DOID:655 0 0.023
retinal disease DOID:5679 0 0.017
organ system cancer DOID:0050686 0 0.015