Danio rerio

14 known processes

spint1b

serine peptidase inhibitor, Kunitz type 1 b

spint1b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of multicellular organismal development GO:2000026 223 0.090
larval development GO:0002164 2 0.069
rna metabolic process GO:0016070 219 0.050
response to metal ion GO:0010038 34 0.044
stem cell maintenance GO:0019827 4 0.042
single organism organelle organization GO:1902589 199 0.042
brain development GO:0007420 293 0.040
cellular amino acid metabolic process GO:0006520 7 0.040
carboxylic acid metabolic process GO:0019752 22 0.039
meiotic nuclear division GO:0007126 4 0.037
response to uv GO:0009411 3 0.036
myotube differentiation GO:0014902 45 0.035
urogenital system development GO:0001655 97 0.034
regulation of multicellular organismal process GO:0051239 277 0.034
aromatic compound biosynthetic process GO:0019438 217 0.034
cellular component biogenesis GO:0044085 178 0.034
cell projection morphogenesis GO:0048858 244 0.033
cellular component assembly GO:0022607 170 0.033
cell part morphogenesis GO:0032990 246 0.033
regulation of blood pressure GO:0008217 1 0.033
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.031
nitrogen compound metabolic process GO:0006807 319 0.031
protein polyubiquitination GO:0000209 4 0.031
mononuclear cell proliferation GO:0032943 1 0.030
melanin metabolic process GO:0006582 2 0.029
regulation of biological quality GO:0065008 263 0.029
cell projection organization GO:0030030 284 0.028
regulation of synapse organization GO:0050807 3 0.027
kidney development GO:0001822 92 0.027
regulation of synapse assembly GO:0051963 3 0.027
detection of mechanical stimulus involved in sensory perception GO:0050974 11 0.026
regulation of carbohydrate metabolic process GO:0006109 4 0.026
retina development in camera type eye GO:0060041 146 0.026
cell surface receptor signaling pathway GO:0007166 325 0.025
immune system development GO:0002520 191 0.025
aging GO:0007568 2 0.025
hemopoiesis GO:0030097 183 0.025
positive regulation of cellular amine metabolic process GO:0033240 0 0.024
heterocycle metabolic process GO:0046483 290 0.024
positive regulation of cellular biosynthetic process GO:0031328 68 0.023
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.023
immune system process GO:0002376 241 0.023
Zebrafish
response to other organism GO:0051707 97 0.023
regulation of cytokine production GO:0001817 3 0.022
multi organism cellular process GO:0044764 2 0.022
interspecies interaction between organisms GO:0044419 4 0.022
developmental programmed cell death GO:0010623 4 0.022
response to carbohydrate GO:0009743 3 0.022
response to external stimulus GO:0009605 264 0.022
Zebrafish
carbohydrate biosynthetic process GO:0016051 1 0.022
organic acid metabolic process GO:0006082 31 0.021
generation of neurons GO:0048699 385 0.021
membrane fusion GO:0061025 2 0.021
cilium organization GO:0044782 71 0.021
leukocyte differentiation GO:0002521 25 0.021
regulation of establishment of protein localization GO:0070201 4 0.020
pigmentation GO:0043473 85 0.020
negative regulation of cellular process GO:0048523 283 0.020
macromolecular complex disassembly GO:0032984 1 0.020
cellular response to oxygen levels GO:0071453 1 0.020
synaptic growth at neuromuscular junction GO:0051124 2 0.020
amine metabolic process GO:0009308 2 0.020
response to biotic stimulus GO:0009607 97 0.020
guanosine containing compound catabolic process GO:1901069 2 0.020
response to abiotic stimulus GO:0009628 122 0.020
inner ear development GO:0048839 126 0.020
cellular nitrogen compound metabolic process GO:0034641 290 0.020
regulation of macromolecule biosynthetic process GO:0010556 225 0.020
cytokinesis GO:0000910 3 0.019
regulation of signaling GO:0023051 235 0.019
positive regulation of cytoskeleton organization GO:0051495 3 0.019
signal transduction in absence of ligand GO:0038034 1 0.019
zymogen activation GO:0031638 3 0.019
biosynthetic process GO:0009058 294 0.019
regulation of nitrogen compound metabolic process GO:0051171 251 0.019
regulation of cellular amine metabolic process GO:0033238 0 0.018
single organism transport GO:0044765 206 0.018
organelle assembly GO:0070925 110 0.018
mitochondrion organization GO:0007005 4 0.018
cellular component movement GO:0006928 335 0.018
Zebrafish
protein complex disassembly GO:0043241 1 0.018
protein localization to plasma membrane GO:0072659 1 0.018
small molecule metabolic process GO:0044281 77 0.017
adherens junction organization GO:0034332 4 0.017
stem cell proliferation GO:0072089 4 0.017
maintenance of location GO:0051235 4 0.017
negative regulation of signal transduction in absence of ligand GO:1901099 1 0.017
phagocytosis GO:0006909 3 0.017
negative regulation of cytokine production GO:0001818 1 0.017
viral process GO:0016032 1 0.017
eye development GO:0001654 277 0.017
regulation of mrna processing GO:0050684 3 0.017
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.017
organic cyclic compound metabolic process GO:1901360 301 0.016
cellular response to extracellular stimulus GO:0031668 2 0.016
leukocyte chemotaxis GO:0030595 12 0.016
Zebrafish
head development GO:0060322 303 0.016
defense response to other organism GO:0098542 33 0.016
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.016
nucleic acid templated transcription GO:0097659 181 0.016
epithelial tube morphogenesis GO:0060562 148 0.016
response to stress GO:0006950 263 0.016
regulation of cytoplasmic transport GO:1903649 4 0.016
response to drug GO:0042493 3 0.016
positive regulation of cellular component biogenesis GO:0044089 3 0.016
growth GO:0040007 174 0.016
lipid homeostasis GO:0055088 3 0.015
macroautophagy GO:0016236 1 0.015
cellular response to decreased oxygen levels GO:0036294 1 0.015
stem cell division GO:0017145 1 0.015
regulation of developmental process GO:0050793 247 0.015
nucleobase containing compound metabolic process GO:0006139 274 0.015
epidermis development GO:0008544 48 0.015
positive regulation of cellular carbohydrate metabolic process GO:0010676 1 0.015
protein homooligomerization GO:0051260 3 0.015
single organism membrane fusion GO:0044801 2 0.015
cellular component disassembly GO:0022411 1 0.015
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.015
syncytium formation by plasma membrane fusion GO:0000768 12 0.015
cellular amine metabolic process GO:0044106 2 0.014
b cell activation GO:0042113 2 0.014
axon ensheathment in central nervous system GO:0032291 2 0.014
organonitrogen compound metabolic process GO:1901564 74 0.014
cell morphogenesis GO:0000902 289 0.014
regulation of glial cell differentiation GO:0045685 4 0.014
regulation of protein localization to nucleus GO:1900180 2 0.014
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.014
action potential GO:0001508 19 0.014
blood vessel development GO:0001568 246 0.014
Mouse
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.014
regulation of transporter activity GO:0032409 2 0.014
hematopoietic or lymphoid organ development GO:0048534 191 0.014
nucleocytoplasmic transport GO:0006913 4 0.014
regulation of signal transduction GO:0009966 225 0.014
renal system development GO:0072001 94 0.014
protein modification process GO:0036211 100 0.014
synaptic vesicle endocytosis GO:0048488 1 0.014
cilium morphogenesis GO:0060271 85 0.014
organelle organization GO:0006996 227 0.014
cellular protein metabolic process GO:0044267 129 0.014
cellular response to external stimulus GO:0071496 2 0.014
hematopoietic stem cell differentiation GO:0060218 20 0.014
odontogenesis of dentin containing tooth GO:0042475 1 0.014
embryonic organ morphogenesis GO:0048562 274 0.013
embryonic cranial skeleton morphogenesis GO:0048701 90 0.013
pigment cell differentiation GO:0050931 38 0.013
leukocyte proliferation GO:0070661 1 0.013
regulation of multicellular organism growth GO:0040014 4 0.013
regulation of cellular amino acid metabolic process GO:0006521 0 0.013
positive regulation of transport GO:0051050 2 0.013
s adenosylmethionine metabolic process GO:0046500 1 0.013
regulation of positive chemotaxis GO:0050926 4 0.013
positive regulation of secretion by cell GO:1903532 1 0.013
cellular ketone metabolic process GO:0042180 11 0.013
lipid storage GO:0019915 1 0.013
regulation of intracellular protein transport GO:0033157 3 0.013
regulation of gene expression GO:0010468 265 0.013
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.013
oxoacid metabolic process GO:0043436 31 0.013
heart contraction GO:0060047 71 0.013
gtp catabolic process GO:0006184 2 0.013
cell junction organization GO:0034330 11 0.013
negative chemotaxis GO:0050919 1 0.013
cellular carbohydrate metabolic process GO:0044262 4 0.013
organic substance biosynthetic process GO:1901576 289 0.013
protein dephosphorylation GO:0006470 3 0.013
single organism metabolic process GO:0044710 217 0.013
cellular response to hypoxia GO:0071456 1 0.012
cation transmembrane transport GO:0098655 65 0.012
cellular aromatic compound metabolic process GO:0006725 295 0.012
macromolecule modification GO:0043412 111 0.012
vasculature development GO:0001944 278 0.012
Mouse
positive regulation of macromolecule metabolic process GO:0010604 93 0.012
establishment of synaptic vesicle localization GO:0097480 1 0.012
dicarboxylic acid metabolic process GO:0043648 1 0.012
striated muscle cell differentiation GO:0051146 129 0.012
multicellular organism growth GO:0035264 4 0.012
embryo development ending in birth or egg hatching GO:0009792 271 0.012
Mouse
cellular response to radiation GO:0071478 4 0.012
positive regulation of epithelial cell differentiation GO:0030858 2 0.012
synaptic vesicle localization GO:0097479 1 0.012
regulation of synaptic plasticity GO:0048167 1 0.012
neuron development GO:0048666 262 0.012
phosphorus metabolic process GO:0006793 109 0.012
negative regulation of stem cell differentiation GO:2000737 2 0.012
guanosine containing compound metabolic process GO:1901068 4 0.012
establishment of protein localization to plasma membrane GO:0090002 1 0.012
positive regulation of secretion GO:0051047 1 0.012
response to amino acid GO:0043200 2 0.012
negative regulation of protein phosphorylation GO:0001933 4 0.012
protein depolymerization GO:0051261 1 0.012
proteasomal protein catabolic process GO:0010498 2 0.012
peptidyl lysine acetylation GO:0018394 2 0.012
cellular response to starvation GO:0009267 1 0.012
cellular response to nutrient levels GO:0031669 2 0.011
macromolecular complex subunit organization GO:0043933 74 0.011
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.011
secondary metabolic process GO:0019748 3 0.011
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.011
regulation of transmembrane transporter activity GO:0022898 2 0.011
response to external biotic stimulus GO:0043207 97 0.011
blood circulation GO:0008015 87 0.011
dorsal motor nucleus of vagus nerve development GO:0021744 4 0.011
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.011
regulation of protein complex assembly GO:0043254 3 0.011
locomotion GO:0040011 313 0.011
Zebrafish
regulation of protein complex disassembly GO:0043244 1 0.011
protein metabolic process GO:0019538 183 0.011
regulation of dna templated transcription elongation GO:0032784 3 0.011
posterior lateral line system development GO:0048915 46 0.011
peptidyl threonine phosphorylation GO:0018107 1 0.011
cellular protein complex disassembly GO:0043624 1 0.011
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.011
multicellular organismal signaling GO:0035637 22 0.011
cellular component morphogenesis GO:0032989 336 0.011
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.011
cell chemotaxis GO:0060326 17 0.011
Zebrafish
cellular response to chemical stimulus GO:0070887 157 0.011
Zebrafish
regulation of rna biosynthetic process GO:2001141 213 0.011
modification dependent protein catabolic process GO:0019941 3 0.011
regulation of cell death GO:0010941 103 0.011
regulation of cell shape GO:0008360 1 0.011
response to transition metal nanoparticle GO:1990267 28 0.011
chordate embryonic development GO:0043009 271 0.011
Mouse
regulation of protein transport GO:0051223 3 0.011
alpha amino acid metabolic process GO:1901605 3 0.010
organic cyclic compound biosynthetic process GO:1901362 223 0.010
eye morphogenesis GO:0048592 144 0.010
regulation of macromolecule metabolic process GO:0060255 317 0.010
embryonic organ development GO:0048568 381 0.010
Mouse
single organism localization GO:1902578 225 0.010
gene expression GO:0010467 252 0.010
ion transmembrane transport GO:0034220 91 0.010
positive regulation of catabolic process GO:0009896 4 0.010
single fertilization GO:0007338 3 0.010
positive regulation of dna templated transcription elongation GO:0032786 1 0.010
skin development GO:0043588 54 0.010
skeletal system development GO:0001501 181 0.010
regulation of organ growth GO:0046620 3 0.010
camera type eye development GO:0043010 222 0.010
embryonic skeletal system development GO:0048706 97 0.010
blood vessel morphogenesis GO:0048514 216 0.010
system process GO:0003008 185 0.010
morphogenesis of an epithelium GO:0002009 333 0.010
Mouse
cellular response to stress GO:0033554 62 0.010
response to decreased oxygen levels GO:0036293 25 0.010

spint1b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.037
musculoskeletal system disease DOID:17 0 0.015
disease of metabolism DOID:0014667 0 0.014
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
organ system cancer DOID:0050686 0 0.013