Danio rerio

0 known processes

tbx6

T-box gene 6

(Aliases: cb123,ZF-TBX6,sb:cb123,z.TBX6)

tbx6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of biological process GO:0048519 304 0.990
Zebrafish
organic cyclic compound biosynthetic process GO:1901362 223 0.970
Zebrafish
regulation of rna metabolic process GO:0051252 224 0.967
Zebrafish
regulation of response to stimulus GO:0048583 269 0.966
Zebrafish
transcription dna templated GO:0006351 181 0.877
Zebrafish
regulation of macromolecule biosynthetic process GO:0010556 225 0.861
Zebrafish
regulation of multicellular organismal development GO:2000026 223 0.858
Zebrafish
central nervous system development GO:0007417 387 0.856
Zebrafish
regulation of primary metabolic process GO:0080090 311 0.830
Zebrafish
chordate embryonic development GO:0043009 271 0.826
Zebrafish
cell surface receptor signaling pathway involved in heart development GO:0061311 20 0.825
Zebrafish
signal transduction GO:0007165 455 0.824
Zebrafish
regionalization GO:0003002 274 0.823
Zebrafish
negative regulation of cellular process GO:0048523 283 0.821
Zebrafish
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.815
Zebrafish
regulation of metabolic process GO:0019222 359 0.807
Zebrafish
organic cyclic compound metabolic process GO:1901360 301 0.799
Zebrafish
tube morphogenesis GO:0035239 349 0.799
Zebrafish
cellular nitrogen compound metabolic process GO:0034641 290 0.790
Zebrafish
rna biosynthetic process GO:0032774 181 0.789
Zebrafish
anterior posterior pattern specification GO:0009952 152 0.775
Zebrafish
embryo development ending in birth or egg hatching GO:0009792 271 0.754
Zebrafish
bmp signaling pathway GO:0030509 52 0.753
Zebrafish
regulation of biosynthetic process GO:0009889 250 0.749
Zebrafish
cell surface receptor signaling pathway GO:0007166 325 0.746
Zebrafish
regulation of developmental process GO:0050793 247 0.733
Zebrafish
brain development GO:0007420 293 0.718
Zebrafish
digestive system development GO:0055123 289 0.694
Zebrafish
eye development GO:0001654 277 0.678
Zebrafish
regulation of nitrogen compound metabolic process GO:0051171 251 0.677
Zebrafish
cellular aromatic compound metabolic process GO:0006725 295 0.672
Zebrafish
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.669
Zebrafish
heart development GO:0007507 313 0.669
Zebrafish
regulation of mesoderm development GO:2000380 11 0.666
regulation of cellular metabolic process GO:0031323 320 0.661
Zebrafish
regulation of macromolecule metabolic process GO:0060255 317 0.656
Zebrafish
sensory organ development GO:0007423 393 0.653
Zebrafish
head development GO:0060322 303 0.652
Zebrafish
formation of primary germ layer GO:0001704 62 0.645
Zebrafish
gene expression GO:0010467 252 0.638
Zebrafish
heterocycle biosynthetic process GO:0018130 215 0.615
Zebrafish
hemopoiesis GO:0030097 183 0.609
Zebrafish
mesoderm formation GO:0001707 43 0.600
Zebrafish
embryonic organ morphogenesis GO:0048562 274 0.582
Zebrafish
regulation of nucleic acid templated transcription GO:1903506 213 0.574
Zebrafish
regulation of gene expression GO:0010468 265 0.569
Zebrafish
ameboidal type cell migration GO:0001667 143 0.566
Zebrafish
negative regulation of gene expression GO:0010629 65 0.561
Zebrafish
negative regulation of cellular metabolic process GO:0031324 77 0.559
Zebrafish
digestive tract development GO:0048565 265 0.547
Zebrafish
nucleobase containing compound metabolic process GO:0006139 274 0.545
Zebrafish
positive regulation of stem cell proliferation GO:2000648 1 0.544
gastrulation GO:0007369 208 0.541
Zebrafish
embryonic organ development GO:0048568 381 0.524
Zebrafish
cell fate specification GO:0001708 68 0.519
Zebrafish
somite specification GO:0001757 12 0.518
morphogenesis of an epithelium GO:0002009 333 0.518
Zebrafish
nucleic acid templated transcription GO:0097659 181 0.514
Zebrafish
digestive tract morphogenesis GO:0048546 231 0.514
Zebrafish
regulation of multicellular organismal process GO:0051239 277 0.508
Zebrafish
immune system development GO:0002520 191 0.493
Zebrafish
camera type eye development GO:0043010 222 0.485
Zebrafish
regulation of signaling GO:0023051 235 0.481
Zebrafish
epithelial tube morphogenesis GO:0060562 148 0.475
Zebrafish
negative regulation of wnt signaling pathway involved in heart development GO:0003308 2 0.469
biosynthetic process GO:0009058 294 0.469
Zebrafish
cell fate commitment GO:0045165 99 0.466
Zebrafish
positive regulation of biological process GO:0048518 253 0.463
Zebrafish
regulation of transcription dna templated GO:0006355 213 0.462
Zebrafish
nucleic acid metabolic process GO:0090304 244 0.449
Zebrafish
regulation of endodermal cell fate specification GO:0042663 15 0.448
somitogenesis GO:0001756 87 0.447
Zebrafish
negative regulation of response to stimulus GO:0048585 104 0.447
heart valve formation GO:0003188 4 0.444
Zebrafish
forebrain development GO:0030900 96 0.439
Zebrafish
regulation of organ morphogenesis GO:2000027 35 0.434
Zebrafish
negative regulation of mesodermal cell fate specification GO:0042662 3 0.431
regulation of gastrulation GO:0010470 24 0.422
cellular nitrogen compound biosynthetic process GO:0044271 218 0.413
Zebrafish
determination of bilateral symmetry GO:0009855 204 0.408
Zebrafish
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.403
Zebrafish
regulation of rna biosynthetic process GO:2001141 213 0.394
Zebrafish
cellular biosynthetic process GO:0044249 286 0.391
Zebrafish
aromatic compound biosynthetic process GO:0019438 217 0.391
Zebrafish
mesodermal cell differentiation GO:0048333 21 0.389
heterocycle metabolic process GO:0046483 290 0.380
Zebrafish
blood vessel development GO:0001568 246 0.371
Zebrafish
erythrocyte differentiation GO:0030218 54 0.366
Zebrafish
cellular macromolecule metabolic process GO:0044260 391 0.365
Zebrafish
regulation of bmp signaling pathway GO:0030510 39 0.362
Zebrafish
hematopoietic or lymphoid organ development GO:0048534 191 0.361
Zebrafish
appendage development GO:0048736 80 0.359
Zebrafish
determination of left right symmetry GO:0007368 179 0.345
Zebrafish
regulation of response to stress GO:0080134 36 0.331
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.331
Zebrafish
negative regulation of signaling GO:0023057 96 0.329
regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901213 15 0.329
Zebrafish
somite development GO:0061053 96 0.328
Zebrafish
negative regulation of multicellular organismal process GO:0051241 69 0.325
cellular macromolecule biosynthetic process GO:0034645 224 0.325
Zebrafish
regulation of mesodermal cell fate specification GO:0042661 9 0.313
endothelial cell fate commitment GO:0060839 3 0.311
cell projection morphogenesis GO:0048858 244 0.304
mesodermal cell fate specification GO:0007501 12 0.302
regulation of cell differentiation GO:0045595 142 0.297
developmental growth involved in morphogenesis GO:0060560 86 0.285
Zebrafish
organic substance biosynthetic process GO:1901576 289 0.281
Zebrafish
arterial endothelial cell differentiation GO:0060842 2 0.280
transcription from rna polymerase ii promoter GO:0006366 80 0.279
Zebrafish
regulation of inner ear receptor cell differentiation GO:2000980 1 0.278
central nervous system neuron differentiation GO:0021953 74 0.276
Zebrafish
endoderm development GO:0007492 49 0.274
Zebrafish
vasculature development GO:0001944 278 0.272
Zebrafish
locomotion GO:0040011 313 0.270
Zebrafish
nucleobase containing compound biosynthetic process GO:0034654 205 0.267
Zebrafish
regulation of cellular biosynthetic process GO:0031326 245 0.265
Zebrafish
stem cell proliferation GO:0072089 4 0.264
cardiac cell fate commitment GO:0060911 1 0.263
macromolecule biosynthetic process GO:0009059 227 0.261
Zebrafish
mesenchyme development GO:0060485 127 0.261
Zebrafish
convergent extension GO:0060026 118 0.256
Zebrafish
mesodermal to mesenchymal transition involved in gastrulation GO:0060809 1 0.256
Zebrafish
negative regulation of nucleic acid templated transcription GO:1903507 45 0.252
Zebrafish
negative regulation of metabolic process GO:0009892 86 0.250
Zebrafish
positive regulation of signaling GO:0023056 56 0.247
segmentation GO:0035282 97 0.243
Zebrafish
morphogenesis of an epithelial sheet GO:0002011 49 0.241
Zebrafish
diencephalon development GO:0021536 58 0.240
Zebrafish
generation of neurons GO:0048699 385 0.239
Zebrafish
negative regulation of cellular biosynthetic process GO:0031327 55 0.239
Zebrafish
eye morphogenesis GO:0048592 144 0.238
Zebrafish
mesoderm morphogenesis GO:0048332 51 0.236
Zebrafish
ear morphogenesis GO:0042471 64 0.235
Zebrafish
negative regulation of macromolecule metabolic process GO:0010605 76 0.226
Zebrafish
negative regulation of collateral sprouting of intact axon in response to injury GO:0048685 2 0.214
connective tissue development GO:0061448 99 0.210
Zebrafish
nitrogen compound metabolic process GO:0006807 319 0.209
Zebrafish
skeletal system development GO:0001501 181 0.209
Zebrafish
negative regulation of cell differentiation GO:0045596 46 0.203
atrioventricular valve formation GO:0003190 3 0.194
Zebrafish
photoreceptor cell fate commitment GO:0046552 1 0.194
Zebrafish
heart field specification GO:0003128 1 0.194
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.191
Zebrafish
regulation of anatomical structure morphogenesis GO:0022603 130 0.190
Zebrafish
positive regulation of neural precursor cell proliferation GO:2000179 1 0.190
positive regulation of notch signaling pathway GO:0045747 3 0.188
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.188
Zebrafish
cellular response to stress GO:0033554 62 0.187
epidermal cell fate specification GO:0009957 4 0.185
negative regulation of embryonic development GO:0045992 11 0.181
mesoderm development GO:0007498 88 0.176
Zebrafish
muscle organ development GO:0007517 101 0.176
Zebrafish
negative regulation of cell communication GO:0010648 96 0.174
response to chemical GO:0042221 320 0.169
gastrulation with mouth forming second GO:0001702 44 0.168
Zebrafish
notch signaling pathway GO:0007219 35 0.166
ear development GO:0043583 127 0.164
Zebrafish
positive regulation of cell cycle GO:0045787 3 0.163
cardiac chamber formation GO:0003207 4 0.160
positive regulation of gene expression GO:0010628 71 0.160
Zebrafish
foregut morphogenesis GO:0007440 4 0.158
regulation of neural precursor cell proliferation GO:2000177 3 0.155
negative regulation of rna biosynthetic process GO:1902679 45 0.154
Zebrafish
endoderm formation GO:0001706 29 0.153
Zebrafish
protein metabolic process GO:0019538 183 0.151
homeostatic process GO:0042592 142 0.147
Zebrafish
muscle structure development GO:0061061 196 0.147
Zebrafish
thalamus development GO:0021794 6 0.147
cellular protein modification process GO:0006464 100 0.146
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.146
Zebrafish
cell migration to the midline involved in heart development GO:0003318 12 0.145
regulation of stem cell proliferation GO:0072091 2 0.145
ectodermal placode formation GO:0060788 26 0.140
embryonic foregut morphogenesis GO:0048617 1 0.140
tissue remodeling GO:0048771 4 0.140
Zebrafish
cell migration GO:0016477 237 0.139
Zebrafish
gliogenesis GO:0042063 45 0.139
positive regulation of jnk cascade GO:0046330 3 0.137
paraxial mesoderm development GO:0048339 8 0.137
positive regulation of cell fate commitment GO:0010455 1 0.136
cardiac conduction system development GO:0003161 1 0.134
rna metabolic process GO:0016070 219 0.133
Zebrafish
somite rostral caudal axis specification GO:0032525 5 0.131
regulation of biological quality GO:0065008 263 0.131
Zebrafish
cellular protein metabolic process GO:0044267 129 0.130
embryonic hemopoiesis GO:0035162 53 0.129
Zebrafish
hepaticobiliary system development GO:0061008 98 0.129
heart jogging GO:0003146 40 0.128
Zebrafish
compound eye development GO:0048749 2 0.127
immune system process GO:0002376 241 0.127
Zebrafish
response to stress GO:0006950 263 0.127
positive regulation of cellular process GO:0048522 201 0.126
Zebrafish
regulation of wnt signaling pathway involved in heart development GO:0003307 2 0.126
neuroblast proliferation GO:0007405 2 0.126
anterior posterior axis specification GO:0009948 20 0.123
neuron differentiation GO:0030182 353 0.117
Zebrafish
liver development GO:0001889 96 0.117
determination of heart left right asymmetry GO:0061371 117 0.116
Zebrafish
embryonic pattern specification GO:0009880 44 0.116
cellular component movement GO:0006928 335 0.113
Zebrafish
myeloid cell differentiation GO:0030099 86 0.113
Zebrafish
negative regulation of signal transduction GO:0009968 94 0.112
retina morphogenesis in camera type eye GO:0060042 79 0.111
Zebrafish
embryonic skeletal system morphogenesis GO:0048704 93 0.110
homeostasis of number of cells GO:0048872 62 0.109
Zebrafish
axis specification GO:0009798 43 0.108
striated muscle cell differentiation GO:0051146 129 0.108
Zebrafish
sensory organ morphogenesis GO:0090596 200 0.107
Zebrafish
cell morphogenesis involved in differentiation GO:0000904 195 0.107
Zebrafish
positive regulation of response to stimulus GO:0048584 80 0.107
embryonic heart tube development GO:0035050 133 0.106
Zebrafish
negative regulation of rna metabolic process GO:0051253 48 0.105
Zebrafish
negative regulation of mesoderm development GO:2000381 5 0.103
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.102
Zebrafish
cell proliferation GO:0008283 80 0.101
Zebrafish
eye photoreceptor cell differentiation GO:0001754 45 0.099
Zebrafish
negative regulation of developmental process GO:0051093 65 0.099
negative regulation of transcription dna templated GO:0045892 45 0.098
Zebrafish
regulation of nervous system development GO:0051960 90 0.098
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.097
convergent extension involved in gastrulation GO:0060027 71 0.097
regulation of cell fate specification GO:0042659 20 0.096
developmental maturation GO:0021700 34 0.093
specification of organ position GO:0010159 3 0.091
Zebrafish
cardioblast migration GO:0003260 7 0.090
phosphorus metabolic process GO:0006793 109 0.090
oocyte maturation GO:0001556 4 0.090
embryonic skeletal system development GO:0048706 97 0.090
single organism organelle organization GO:1902589 199 0.089
negative regulation of biosynthetic process GO:0009890 55 0.089
Zebrafish
negative regulation of cell development GO:0010721 26 0.089
cell migration involved in gastrulation GO:0042074 79 0.088
Zebrafish
peripheral nervous system development GO:0007422 55 0.087
embryonic camera type eye development GO:0031076 29 0.086
erythrocyte homeostasis GO:0034101 55 0.085
Zebrafish
endodermal cell fate specification GO:0001714 17 0.085
Zebrafish
cell morphogenesis GO:0000902 289 0.085
Zebrafish
macromolecule modification GO:0043412 111 0.084
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.083
intermediate mesoderm development GO:0048389 2 0.083
Zebrafish
limb bud formation GO:0060174 2 0.082
Zebrafish
regulation of reproductive process GO:2000241 4 0.082
inner ear development GO:0048839 126 0.081
Zebrafish
protein modification process GO:0036211 100 0.080
endocardial cushion formation GO:0003272 2 0.079
positive regulation of cell communication GO:0010647 56 0.079
epithelial cell differentiation GO:0030855 116 0.078
pancreas development GO:0031016 84 0.077
convergent extension involved in organogenesis GO:0060029 10 0.075
cardiac atrium morphogenesis GO:0003209 2 0.075
non canonical wnt signaling pathway involved in heart development GO:0061341 2 0.075
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.074
Zebrafish
hepatocyte differentiation GO:0070365 1 0.073
positive regulation of multicellular organismal process GO:0051240 52 0.073
neuron development GO:0048666 262 0.072
Zebrafish
mesodermal cell fate commitment GO:0001710 14 0.071
negative regulation of gastrulation GO:2000542 11 0.070
morphogenesis of an epithelial fold GO:0060571 1 0.069
Zebrafish
regulation of cell proliferation involved in heart morphogenesis GO:2000136 2 0.069
Zebrafish
cell part morphogenesis GO:0032990 246 0.068
renal system development GO:0072001 94 0.068
Zebrafish
neuron projection morphogenesis GO:0048812 161 0.068
regulation of cell death GO:0010941 103 0.067
biological adhesion GO:0022610 40 0.066
Zebrafish
cell projection organization GO:0030030 284 0.065
rhombomere development GO:0021546 19 0.065
pharyngeal system development GO:0060037 18 0.065
Zebrafish
oligodendrocyte differentiation GO:0048709 23 0.064
positive regulation of cell differentiation GO:0045597 30 0.063
regulation of stem cell differentiation GO:2000736 4 0.063
nerve development GO:0021675 45 0.063
Zebrafish
heart morphogenesis GO:0003007 156 0.062
Zebrafish
rhombomere formation GO:0021594 12 0.062
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.061
Zebrafish
nephron tubule morphogenesis GO:0072078 1 0.061
bmp signaling pathway involved in heart jogging GO:0003303 14 0.061
Zebrafish
regulation of programmed cell death GO:0043067 101 0.061
regulation of cell communication GO:0010646 232 0.060
Zebrafish
pharyngeal muscle development GO:0043282 4 0.060
Zebrafish
camera type eye photoreceptor cell differentiation GO:0060219 19 0.059
Zebrafish
positive regulation of jun kinase activity GO:0043507 2 0.059
dorsal aorta morphogenesis GO:0035912 3 0.059
determination of left right asymmetry in lateral mesoderm GO:0003140 20 0.058
Zebrafish
positive regulation of rna biosynthetic process GO:1902680 57 0.058
Zebrafish
positive regulation of cellular metabolic process GO:0031325 94 0.058
Zebrafish
aorta morphogenesis GO:0035909 3 0.057
camera type eye morphogenesis GO:0048593 108 0.057
Zebrafish
organelle organization GO:0006996 227 0.057
proepicardium development GO:0003342 4 0.056
Zebrafish
epithelial to mesenchymal transition GO:0001837 21 0.056
Zebrafish
regulation of bmp signaling pathway involved in heart jogging GO:2000223 12 0.056
Zebrafish
gland development GO:0048732 143 0.056
endodermal cell fate commitment GO:0001711 18 0.055
Zebrafish
blood vessel morphogenesis GO:0048514 216 0.055
Zebrafish
skeletal muscle organ development GO:0060538 78 0.054
negative regulation of cell fate specification GO:0009996 11 0.054
muscle tissue development GO:0060537 110 0.054
Zebrafish
septum transversum development GO:0003343 4 0.054
Zebrafish
determination of dorsal ventral asymmetry GO:0048262 34 0.053
Zebrafish
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.053
Zebrafish
aorta development GO:0035904 4 0.053
negative regulation of cell fate commitment GO:0010454 13 0.053
response to retinoic acid GO:0032526 6 0.053
retina development in camera type eye GO:0060041 146 0.053
Zebrafish
specification of symmetry GO:0009799 204 0.052
Zebrafish
positive regulation of muscle cell differentiation GO:0051149 1 0.052
astrocyte differentiation GO:0048708 1 0.051
amine metabolic process GO:0009308 2 0.051
cell cell recognition GO:0009988 1 0.051
positive regulation of embryonic development GO:0040019 3 0.050
skeletal system morphogenesis GO:0048705 102 0.050
phosphorylation GO:0016310 69 0.050
response to organic substance GO:0010033 153 0.049
protein phosphorylation GO:0006468 47 0.049
cell proliferation involved in heart morphogenesis GO:0061323 2 0.049
Zebrafish
mesenchyme morphogenesis GO:0072132 5 0.048
mesenchymal cell development GO:0014031 78 0.048
Zebrafish
negative regulation of endodermal cell fate specification GO:0042664 8 0.048
positive regulation of macromolecule metabolic process GO:0010604 93 0.048
Zebrafish
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.047
Zebrafish
nephron tubule epithelial cell differentiation GO:0072160 1 0.047
somatic muscle development GO:0007525 4 0.047
Zebrafish
intracellular signal transduction GO:0035556 85 0.046
neural precursor cell proliferation GO:0061351 20 0.046
regulation of signal transduction GO:0009966 225 0.046
Zebrafish
maintenance of location GO:0051235 4 0.045
positive regulation of metabolic process GO:0009893 108 0.044
Zebrafish
kupffer s vesicle development GO:0070121 50 0.044
Zebrafish
regulation of multicellular organism growth GO:0040014 4 0.044
negative regulation of collateral sprouting GO:0048671 2 0.044
regulation of endodermal cell differentiation GO:1903224 15 0.044
negative regulation of nervous system development GO:0051961 22 0.043
regulation of cell proliferation GO:0042127 37 0.043
Zebrafish
striated muscle tissue development GO:0014706 110 0.043
Zebrafish
cartilage morphogenesis GO:0060536 13 0.043
Zebrafish
heart looping GO:0001947 94 0.043
Zebrafish
cardiogenic plate morphogenesis GO:0003142 1 0.043
dorsal ventral pattern formation GO:0009953 125 0.043
Zebrafish
regulation of collateral sprouting GO:0048670 7 0.042
positive regulation of cyclin dependent protein serine threonine kinase activity GO:0045737 1 0.042
radial glial cell differentiation GO:0060019 2 0.042
dorsal aorta development GO:0035907 4 0.041
growth GO:0040007 174 0.041
Zebrafish
peripheral nervous system neuron development GO:0048935 22 0.041
positive regulation of rna metabolic process GO:0051254 59 0.041
Zebrafish
nephron epithelium morphogenesis GO:0072088 1 0.041
phosphate containing compound metabolic process GO:0006796 108 0.040
negative regulation of endodermal cell differentiation GO:1903225 8 0.040
regulation of neurogenesis GO:0050767 87 0.040
epidermal cell differentiation GO:0009913 36 0.040
eye field cell fate commitment involved in camera type eye formation GO:0060898 3 0.039
positive regulation of signal transduction GO:0009967 56 0.038
endodermal cell differentiation GO:0035987 19 0.038
Zebrafish
kidney epithelium development GO:0072073 23 0.038
Zebrafish
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 17 0.038
Zebrafish
primary neural tube formation GO:0014020 1 0.038
metencephalon development GO:0022037 27 0.038
glial cell differentiation GO:0010001 42 0.038
regulation of binding GO:0051098 3 0.038
rhombomere 4 development GO:0021570 5 0.037
dendrite development GO:0016358 9 0.037
pectoral fin development GO:0033339 50 0.037
Zebrafish
cell adhesion mediated by integrin GO:0033627 1 0.037
endocardial cell differentiation GO:0060956 5 0.037
wound healing GO:0042060 90 0.037
single organism metabolic process GO:0044710 217 0.037
regulation of oocyte development GO:0060281 3 0.036
optic placode formation involved in camera type eye formation GO:0046619 3 0.036
positive regulation of stress activated mapk cascade GO:0032874 3 0.036
enzyme linked receptor protein signaling pathway GO:0007167 106 0.035
Zebrafish
wnt signaling pathway involved in heart development GO:0003306 5 0.035
negative regulation of reproductive process GO:2000242 3 0.035
positive regulation of developmental process GO:0051094 50 0.035
regulation of localization GO:0032879 104 0.035
regulation of embryonic development GO:0045995 47 0.035
Zebrafish
neural retina development GO:0003407 49 0.035
Zebrafish
positive regulation of striated muscle cell differentiation GO:0051155 1 0.035
embryonic cranial skeleton morphogenesis GO:0048701 90 0.034
blood vessel endothelial cell differentiation GO:0060837 2 0.034
regulation of translational initiation GO:0006446 1 0.034
organonitrogen compound metabolic process GO:1901564 74 0.033
cell death GO:0008219 121 0.033
chromatin modification GO:0016568 21 0.033
cell cycle GO:0007049 93 0.033
response to lipid GO:0033993 60 0.033
regulation of cell activation GO:0050865 1 0.032
nephron morphogenesis GO:0072028 2 0.032
cellular amine metabolic process GO:0044106 2 0.032
regulation of cell cycle GO:0051726 52 0.032
regulation of cell development GO:0060284 100 0.032
endocardium morphogenesis GO:0003160 4 0.032
death GO:0016265 121 0.032
cell maturation GO:0048469 23 0.031
pancreatic a cell development GO:0003322 2 0.031
brain morphogenesis GO:0048854 18 0.031
multicellular organism growth GO:0035264 4 0.031
regulation of cytokine production GO:0001817 3 0.031
regulation of canonical wnt signaling pathway GO:0060828 34 0.031
stem cell development GO:0048864 82 0.031
Zebrafish
urogenital system development GO:0001655 97 0.031
Zebrafish
cranial nerve development GO:0021545 42 0.031
Zebrafish
endocardial cushion morphogenesis GO:0003203 3 0.030
cardiac atrium development GO:0003230 4 0.030
anatomical structure homeostasis GO:0060249 36 0.030
cellular response to chemical stimulus GO:0070887 157 0.030
regulation of cell fate commitment GO:0010453 22 0.030
auditory receptor cell fate commitment GO:0009912 4 0.030
angioblast cell migration involved in selective angioblast sprouting GO:0035475 4 0.029
negative regulation of oocyte development GO:0060283 2 0.029
cell motility GO:0048870 244 0.029
Zebrafish
developmental growth GO:0048589 166 0.029
Zebrafish
regulation of heart morphogenesis GO:2000826 17 0.029
Zebrafish
aging GO:0007568 2 0.029
localization of cell GO:0051674 244 0.028
Zebrafish
secondary metabolic process GO:0019748 3 0.028
regulation of cellular amino acid metabolic process GO:0006521 0 0.028
regulation of intracellular signal transduction GO:1902531 57 0.028
embryonic axis specification GO:0000578 12 0.028
embryonic appendage morphogenesis GO:0035113 30 0.027
Zebrafish
positive regulation of cellular biosynthetic process GO:0031328 68 0.027
Zebrafish
pigment metabolic process GO:0042440 12 0.027
tissue regeneration GO:0042246 74 0.027
cardiac muscle tissue development GO:0048738 48 0.027
Zebrafish
outflow tract morphogenesis GO:0003151 1 0.026
negative regulation of response to dna damage stimulus GO:2001021 3 0.026
response to hormone GO:0009725 48 0.026
rhombomere boundary formation GO:0021654 10 0.026
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.026
apoptotic process GO:0006915 116 0.026
dorsal convergence GO:0060030 14 0.026
ectodermal placode development GO:0071696 37 0.026
cellular ketone metabolic process GO:0042180 11 0.026
cellular response to organic substance GO:0071310 105 0.025
sensory perception of chemical stimulus GO:0007606 3 0.025
skin development GO:0043588 54 0.025
cellular response to dna damage stimulus GO:0006974 24 0.025
neural tube development GO:0021915 62 0.025
small molecule metabolic process GO:0044281 77 0.025
embryonic eye morphogenesis GO:0048048 30 0.025
stem cell maintenance GO:0019827 4 0.025
response to wounding GO:0009611 116 0.025
heart formation GO:0060914 13 0.024
Zebrafish
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.024
stem cell fate commitment GO:0048865 1 0.024
cardiac chamber development GO:0003205 19 0.024
Zebrafish
proximal distal pattern formation GO:0009954 1 0.024
gamete generation GO:0007276 33 0.023
regulation of cellular protein metabolic process GO:0032268 52 0.023
positive regulation of epithelial cell proliferation GO:0050679 1 0.023
axial mesodermal cell fate specification GO:0048327 3 0.023
chemotaxis GO:0006935 104 0.023
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.023
Zebrafish
formation of anatomical boundary GO:0048859 14 0.023
positive regulation of endothelial cell differentiation GO:0045603 2 0.023
cellular amino acid metabolic process GO:0006520 7 0.023
cellular component biogenesis GO:0044085 178 0.023
inner ear morphogenesis GO:0042472 63 0.022
Zebrafish
regulation of cellular response to stress GO:0080135 20 0.022
otic vesicle development GO:0071599 42 0.022
eye photoreceptor cell development GO:0042462 30 0.022
Zebrafish
lateral mesoderm development GO:0048368 23 0.022
Zebrafish
swim bladder development GO:0048794 19 0.022
regulation of cellular ketone metabolic process GO:0010565 7 0.022
optic placode formation GO:0001743 4 0.022
heart contraction GO:0060047 71 0.022
Zebrafish
taxis GO:0042330 109 0.022
myeloid cell homeostasis GO:0002262 56 0.022
Zebrafish
atrioventricular valve development GO:0003171 11 0.022
Zebrafish
regulation of cardiac muscle tissue development GO:0055024 1 0.022
positive regulation of cell death GO:0010942 29 0.022
positive regulation of epithelial cell differentiation GO:0030858 2 0.021
cellular component morphogenesis GO:0032989 336 0.021
Zebrafish
cartilage development GO:0051216 96 0.021
Zebrafish
endothelial cell differentiation GO:0045446 20 0.021
regulation of phosphorus metabolic process GO:0051174 43 0.021
cellular response to endogenous stimulus GO:0071495 68 0.021
regulation of cellular component organization GO:0051128 86 0.020
ectodermal placode morphogenesis GO:0071697 32 0.020
regulation of establishment of protein localization GO:0070201 4 0.020
positive regulation of muscle tissue development GO:1901863 1 0.020
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.020
mesenchymal cell differentiation GO:0048762 87 0.020
Zebrafish
response to acid chemical GO:0001101 17 0.020
regulation of blood vessel size GO:0050880 2 0.020
negative regulation of protein complex assembly GO:0031333 1 0.020
regulation of mechanoreceptor differentiation GO:0045631 1 0.020
regulation of molecular function GO:0065009 70 0.020
determination of left right asymmetry in diencephalon GO:0035462 4 0.020
retinal cone cell differentiation GO:0042670 12 0.019
Zebrafish
response to external stimulus GO:0009605 264 0.019
negative regulation of anterior neural cell fate commitment of the neural plate by wnt signaling pathway GO:0022002 1 0.019
regulation of wnt signaling pathway GO:0030111 53 0.019
oxoacid metabolic process GO:0043436 31 0.019

tbx6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
bone development disease DOID:0080006 0 0.114
bone disease DOID:0080001 0 0.114
disease of anatomical entity DOID:7 0 0.114
dysostosis DOID:1934 0 0.114
musculoskeletal system disease DOID:17 0 0.114
connective tissue disease DOID:65 0 0.114