Danio rerio

18 known processes

tcf4

transcription factor 4

tcf4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
central nervous system development GO:0007417 387 0.871
skeletal system development GO:0001501 181 0.430
rna biosynthetic process GO:0032774 181 0.372
locomotion GO:0040011 313 0.371
cell motility GO:0048870 244 0.317
brain development GO:0007420 293 0.269
stem cell development GO:0048864 82 0.238
cell projection organization GO:0030030 284 0.238
nucleic acid templated transcription GO:0097659 181 0.237
head development GO:0060322 303 0.227
cellular macromolecule metabolic process GO:0044260 391 0.225
cellular nitrogen compound metabolic process GO:0034641 290 0.222
regulation of rna biosynthetic process GO:2001141 213 0.203
hematopoietic or lymphoid organ development GO:0048534 191 0.202
cellular component morphogenesis GO:0032989 336 0.182
ameboidal type cell migration GO:0001667 143 0.176
nitrogen compound metabolic process GO:0006807 319 0.172
organic cyclic compound biosynthetic process GO:1901362 223 0.165
regulation of transcription dna templated GO:0006355 213 0.160
embryonic organ development GO:0048568 381 0.154
embryonic skeletal joint development GO:0072498 3 0.154
cellular aromatic compound metabolic process GO:0006725 295 0.150
localization of cell GO:0051674 244 0.148
cell morphogenesis involved in differentiation GO:0000904 195 0.142
regionalization GO:0003002 274 0.140
regulation of macromolecule metabolic process GO:0060255 317 0.136
cell migration GO:0016477 237 0.136
nucleobase containing compound biosynthetic process GO:0034654 205 0.130
regulation of primary metabolic process GO:0080090 311 0.128
regulation of gene expression GO:0010468 265 0.125
heart development GO:0007507 313 0.121
immune system process GO:0002376 241 0.120
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.120
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.116
vasculature development GO:0001944 278 0.115
gene expression GO:0010467 252 0.114
tissue remodeling GO:0048771 4 0.113
muscle organ development GO:0007517 101 0.113
axon development GO:0061564 166 0.113
regulation of nitrogen compound metabolic process GO:0051171 251 0.110
regulation of cellular metabolic process GO:0031323 320 0.106
cellular component movement GO:0006928 335 0.106
heterocycle metabolic process GO:0046483 290 0.105
chordate embryonic development GO:0043009 271 0.104
catechol containing compound biosynthetic process GO:0009713 2 0.101
organic cyclic compound metabolic process GO:1901360 301 0.101
heterocycle biosynthetic process GO:0018130 215 0.100
mesenchymal cell development GO:0014031 78 0.100
neuron differentiation GO:0030182 353 0.098
somitogenesis GO:0001756 87 0.097
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.095
embryonic organ morphogenesis GO:0048562 274 0.088
rna metabolic process GO:0016070 219 0.087
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.085
cellular nitrogen compound biosynthetic process GO:0044271 218 0.085
signal transduction GO:0007165 455 0.084
nucleobase containing compound metabolic process GO:0006139 274 0.084
immune system development GO:0002520 191 0.081
regulation of cell communication GO:0010646 232 0.081
regulation of rna metabolic process GO:0051252 224 0.081
mesenchymal cell differentiation GO:0048762 87 0.080
cell morphogenesis GO:0000902 289 0.079
embryonic skeletal system development GO:0048706 97 0.079
skeletal muscle organ development GO:0060538 78 0.078
regulation of macromolecule biosynthetic process GO:0010556 225 0.078
urogenital system development GO:0001655 97 0.078
regulation of cellular biosynthetic process GO:0031326 245 0.078
skeletal system morphogenesis GO:0048705 102 0.078
central nervous system neuron differentiation GO:0021953 74 0.077
adult behavior GO:0030534 2 0.076
response to chemical GO:0042221 320 0.075
neural crest cell differentiation GO:0014033 72 0.075
central nervous system neuron axonogenesis GO:0021955 18 0.075
regulation of metabolic process GO:0019222 359 0.074
negative regulation of axon guidance GO:1902668 1 0.072
mesenchyme development GO:0060485 127 0.071
transcription dna templated GO:0006351 181 0.071
amine metabolic process GO:0009308 2 0.071
organelle organization GO:0006996 227 0.070
muscle structure development GO:0061061 196 0.067
nucleic acid metabolic process GO:0090304 244 0.067
stem cell differentiation GO:0048863 117 0.067
larval development GO:0002164 2 0.066
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.065
negative regulation of biological process GO:0048519 304 0.065
organic substance biosynthetic process GO:1901576 289 0.062
phagocytosis GO:0006909 3 0.062
response to drug GO:0042493 3 0.061
morphogenesis of an epithelium GO:0002009 333 0.059
cellular biosynthetic process GO:0044249 286 0.059
cell death GO:0008219 121 0.058
nuclear transport GO:0051169 4 0.058
catechol containing compound metabolic process GO:0009712 2 0.058
regulation of biosynthetic process GO:0009889 250 0.058
positive regulation of cellular process GO:0048522 201 0.057
axonogenesis GO:0007409 152 0.057
regulation of multicellular organismal process GO:0051239 277 0.057
aging GO:0007568 2 0.057
connective tissue development GO:0061448 99 0.056
sensory organ development GO:0007423 393 0.056
stem cell proliferation GO:0072089 4 0.056
larval heart development GO:0007508 2 0.055
negative regulation of axon extension involved in axon guidance GO:0048843 1 0.054
neural crest cell development GO:0014032 62 0.054
transcription from rna polymerase ii promoter GO:0006366 80 0.053
generation of neurons GO:0048699 385 0.053
embryo development ending in birth or egg hatching GO:0009792 271 0.052
regulation of reproductive process GO:2000241 4 0.051
forebrain development GO:0030900 96 0.051
sprouting angiogenesis GO:0002040 53 0.051
aromatic compound biosynthetic process GO:0019438 217 0.051
single organism metabolic process GO:0044710 217 0.049
peptidyl serine phosphorylation GO:0018105 1 0.048
small molecule metabolic process GO:0044281 77 0.047
hemopoiesis GO:0030097 183 0.047
macromolecule biosynthetic process GO:0009059 227 0.045
neural crest cell migration GO:0001755 42 0.045
maintenance of location GO:0051235 4 0.045
organonitrogen compound metabolic process GO:1901564 74 0.044
cell projection morphogenesis GO:0048858 244 0.044
cartilage development GO:0051216 96 0.044
central nervous system neuron development GO:0021954 29 0.043
neuron projection development GO:0031175 180 0.043
bmp signaling pathway GO:0030509 52 0.042
axonal defasciculation GO:0007414 2 0.042
striated muscle tissue development GO:0014706 110 0.040
cognition GO:0050890 1 0.040
embryonic skeletal joint morphogenesis GO:0060272 3 0.039
cellular amine metabolic process GO:0044106 2 0.039
regulation of intracellular protein transport GO:0033157 3 0.039
developmental growth GO:0048589 166 0.038
establishment of protein localization to organelle GO:0072594 4 0.038
regulation of cellular amine metabolic process GO:0033238 0 0.038
regulation of cell death GO:0010941 103 0.038
stem cell maintenance GO:0019827 4 0.038
renal system development GO:0072001 94 0.038
somatic stem cell maintenance GO:0035019 1 0.037
death GO:0016265 121 0.037
nucleocytoplasmic transport GO:0006913 4 0.037
response to stress GO:0006950 263 0.037
gastrulation GO:0007369 208 0.036
neurological system process GO:0050877 62 0.036
regulation of signal transduction GO:0009966 225 0.036
regulation of nucleic acid templated transcription GO:1903506 213 0.036
notochord development GO:0030903 54 0.036
positive regulation of cellular biosynthetic process GO:0031328 68 0.035
biological adhesion GO:0022610 40 0.035
blood vessel development GO:0001568 246 0.035
muscle cell differentiation GO:0042692 139 0.035
developmental growth involved in morphogenesis GO:0060560 86 0.034
central nervous system projection neuron axonogenesis GO:0021952 15 0.033
biosynthetic process GO:0009058 294 0.033
kidney development GO:0001822 92 0.033
eye development GO:0001654 277 0.033
regulation of cell activation GO:0050865 1 0.033
neuron projection extension GO:1990138 45 0.033
negative regulation of cellular process GO:0048523 283 0.032
regulation of cellular amino acid metabolic process GO:0006521 0 0.032
response to external stimulus GO:0009605 264 0.032
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.032
cell part morphogenesis GO:0032990 246 0.031
positive regulation of transport GO:0051050 2 0.031
digestive system development GO:0055123 289 0.031
epithelial tube morphogenesis GO:0060562 148 0.030
positive regulation of transcription dna templated GO:0045893 57 0.030
cellular localization GO:0051641 97 0.029
forebrain generation of neurons GO:0021872 14 0.029
cellular amino acid metabolic process GO:0006520 7 0.029
eye morphogenesis GO:0048592 144 0.028
positive regulation of biological process GO:0048518 253 0.028
response to organic substance GO:0010033 153 0.028
embryonic skeletal system morphogenesis GO:0048704 93 0.028
cell substrate adhesion GO:0031589 4 0.028
lateral inhibition GO:0046331 1 0.028
centrosome cycle GO:0007098 1 0.027
microtubule organizing center organization GO:0031023 1 0.027
system process GO:0003008 185 0.026
regulation of establishment of protein localization GO:0070201 4 0.026
regulation of cell shape GO:0008360 1 0.026
regulation of anatomical structure morphogenesis GO:0022603 130 0.026
regulation of signaling GO:0023051 235 0.026
cellular macromolecule biosynthetic process GO:0034645 224 0.026
specification of symmetry GO:0009799 204 0.026
regulation of skeletal muscle fiber development GO:0048742 2 0.025
smoothened signaling pathway GO:0007224 30 0.025
neuron development GO:0048666 262 0.025
blood vessel morphogenesis GO:0048514 216 0.025
extrinsic apoptotic signaling pathway GO:0097191 3 0.025
hypothalamus cell differentiation GO:0021979 4 0.025
post embryonic organ development GO:0048569 4 0.025
protein secretion GO:0009306 1 0.025
cellular ketone metabolic process GO:0042180 11 0.025
regulation of rho protein signal transduction GO:0035023 2 0.025
programmed cell death GO:0012501 119 0.024
cellular response to extracellular stimulus GO:0031668 2 0.024
single organism nuclear import GO:1902593 3 0.024
cell proliferation in hindbrain GO:0021534 4 0.024
positive regulation of striated muscle cell differentiation GO:0051155 1 0.023
cellular protein catabolic process GO:0044257 4 0.023
regulation of response to biotic stimulus GO:0002831 2 0.023
protein import GO:0017038 3 0.023
anterior posterior pattern specification GO:0009952 152 0.023
mitochondrion organization GO:0007005 4 0.023
proteasomal protein catabolic process GO:0010498 2 0.023
sensory perception of chemical stimulus GO:0007606 3 0.023
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.023
mesoderm development GO:0007498 88 0.023
regulation of nucleotide catabolic process GO:0030811 2 0.023
single organism organelle organization GO:1902589 199 0.022
regulation of collateral sprouting in absence of injury GO:0048696 4 0.022
odontogenesis of dentin containing tooth GO:0042475 1 0.022
segmentation GO:0035282 97 0.022
positive regulation of cellular amine metabolic process GO:0033240 0 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.022
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.022
regulation of localization GO:0032879 104 0.021
regulation of myotube differentiation GO:0010830 2 0.021
regulation of neurotransmitter transport GO:0051588 1 0.021
camera type eye morphogenesis GO:0048593 108 0.021
regulation of protein transport GO:0051223 3 0.021
lipid storage GO:0019915 1 0.021
regulation of developmental process GO:0050793 247 0.021
cell migration involved in vasculogenesis GO:0035441 1 0.021
embryonic cranial skeleton morphogenesis GO:0048701 90 0.021
regulation of cytoplasmic transport GO:1903649 4 0.021
response to corticosteroid GO:0031960 1 0.021
regulation of nucleoside metabolic process GO:0009118 2 0.021
determination of bilateral symmetry GO:0009855 204 0.020
cell matrix adhesion GO:0007160 4 0.020
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.020
regulation of production of molecular mediator of immune response GO:0002700 1 0.020
positive regulation of rna metabolic process GO:0051254 59 0.020
cellular component biogenesis GO:0044085 178 0.020
dopaminergic neuron differentiation GO:0071542 14 0.020
stem cell division GO:0017145 1 0.020
cellular response to external stimulus GO:0071496 2 0.020
dorsal ventral pattern formation GO:0009953 125 0.019
positive regulation of dna templated transcription elongation GO:0032786 1 0.019
regulation of protein binding GO:0043393 3 0.019
nuclear import GO:0051170 3 0.019
dopamine biosynthetic process GO:0042416 2 0.019
reproductive process GO:0022414 40 0.019
protein import into nucleus GO:0006606 3 0.019
regulation of cellular component movement GO:0051270 55 0.019
regulation of gtp catabolic process GO:0033124 2 0.019
single organism localization GO:1902578 225 0.019
regulation of epithelial cell proliferation GO:0050678 3 0.019
regulation of protein targeting GO:1903533 2 0.019
renal tubule morphogenesis GO:0061333 1 0.019
convergent extension GO:0060026 118 0.018
muscle tissue development GO:0060537 110 0.018
guanosine containing compound metabolic process GO:1901068 4 0.018
regulation of bmp signaling pathway GO:0030510 39 0.018
cellular response to nutrient levels GO:0031669 2 0.018
growth GO:0040007 174 0.018
regulation of neuron migration GO:2001222 2 0.018
lipid homeostasis GO:0055088 3 0.018
negative regulation of cell communication GO:0010648 96 0.018
somite development GO:0061053 96 0.018
regulation of gtpase activity GO:0043087 2 0.018
regulation of cytokine production GO:0001817 3 0.017
positive regulation of rna biosynthetic process GO:1902680 57 0.017
regulation of heart growth GO:0060420 2 0.017
b cell activation GO:0042113 2 0.017
epithalamus development GO:0021538 10 0.017
chemotaxis GO:0006935 104 0.017
tube morphogenesis GO:0035239 349 0.017
cellular protein modification process GO:0006464 100 0.017
positive regulation of multicellular organismal process GO:0051240 52 0.017
production of molecular mediator of immune response GO:0002440 2 0.017
digestive tract morphogenesis GO:0048546 231 0.017
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.017
sensory organ morphogenesis GO:0090596 200 0.017
cell migration involved in gastrulation GO:0042074 79 0.017
regulation of cell differentiation GO:0045595 142 0.016
regulation of organ growth GO:0046620 3 0.016
cellular component assembly GO:0022607 170 0.016
regulation of glial cell differentiation GO:0045685 4 0.016
cell recognition GO:0008037 19 0.016
developmental cell growth GO:0048588 52 0.016
protein localization to nucleus GO:0034504 3 0.016
axon extension GO:0048675 45 0.016
positive regulation of biosynthetic process GO:0009891 68 0.016
extracellular structure organization GO:0043062 27 0.016
negative chemotaxis GO:0050919 1 0.016
g1 s transition of mitotic cell cycle GO:0000082 1 0.016
positive regulation of epithelial cell proliferation GO:0050679 1 0.016
cell adhesion GO:0007155 40 0.016
branching morphogenesis of a nerve GO:0048755 4 0.015
negative regulation of signal transduction GO:0009968 94 0.015
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.015
ear development GO:0043583 127 0.015
regulation of neurogenesis GO:0050767 87 0.015
endoderm development GO:0007492 49 0.015
protein polymerization GO:0051258 4 0.015
positive regulation of nucleic acid templated transcription GO:1903508 57 0.015
response to endogenous stimulus GO:0009719 83 0.015
centrosome organization GO:0051297 1 0.015
meiotic nuclear division GO:0007126 4 0.014
gland development GO:0048732 143 0.014
ear morphogenesis GO:0042471 64 0.014
astrocyte differentiation GO:0048708 1 0.014
forebrain neuron development GO:0021884 7 0.014
sympathetic ganglion development GO:0061549 2 0.014
regulation of mechanoreceptor differentiation GO:0045631 1 0.014
regulation of stem cell differentiation GO:2000736 4 0.014
heart morphogenesis GO:0003007 156 0.014
cell proliferation GO:0008283 80 0.014
regulation of response to stimulus GO:0048583 269 0.014
morphogenesis of embryonic epithelium GO:0016331 30 0.014
camera type eye development GO:0043010 222 0.014
phosphate containing compound metabolic process GO:0006796 108 0.014
regulation of cellular protein catabolic process GO:1903362 1 0.013
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.013
telencephalon development GO:0021537 14 0.013
regulation of tube size GO:0035150 2 0.013
protein targeting to nucleus GO:0044744 3 0.013
cellular response to starvation GO:0009267 1 0.013
regulation of dendrite development GO:0050773 3 0.013
phenol containing compound biosynthetic process GO:0046189 4 0.013
antimicrobial humoral response GO:0019730 2 0.013
embryonic heart tube development GO:0035050 133 0.013
positive regulation of translation GO:0045727 1 0.013
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.013
heart looping GO:0001947 94 0.013
mesenchymal cell proliferation GO:0010463 1 0.013
regulation of biomineral tissue development GO:0070167 2 0.013
negative regulation of cellular biosynthetic process GO:0031327 55 0.013
regulation of molecular function GO:0065009 70 0.013
negative regulation of leukocyte differentiation GO:1902106 1 0.013
muscle fiber development GO:0048747 52 0.013
cellular component assembly involved in morphogenesis GO:0010927 107 0.012
neuron projection guidance GO:0097485 86 0.012
positive regulation of macromolecule metabolic process GO:0010604 93 0.012
positive regulation of muscle organ development GO:0048636 1 0.012
cell growth GO:0016049 57 0.012
response to organic cyclic compound GO:0014070 51 0.012
catecholamine biosynthetic process GO:0042423 2 0.012
positive regulation of cellular component biogenesis GO:0044089 3 0.012
negative regulation of cell death GO:0060548 60 0.012
response to abiotic stimulus GO:0009628 122 0.012
carboxylic acid metabolic process GO:0019752 22 0.012
regulation of cardiac muscle tissue development GO:0055024 1 0.012
leukocyte proliferation GO:0070661 1 0.012
regulation of bone mineralization GO:0030500 2 0.012
regulation of hematopoietic progenitor cell differentiation GO:1901532 1 0.012
negative regulation of rna metabolic process GO:0051253 48 0.012
response to carbohydrate GO:0009743 3 0.012
regulation of transmembrane transporter activity GO:0022898 2 0.012
transport GO:0006810 220 0.012
guanosine containing compound catabolic process GO:1901069 2 0.012
cellular protein metabolic process GO:0044267 129 0.012
negative regulation of cellular metabolic process GO:0031324 77 0.012
forebrain cell migration GO:0021885 1 0.012
protein metabolic process GO:0019538 183 0.012
mitotic dna integrity checkpoint GO:0044774 4 0.012
bone remodeling GO:0046849 2 0.012
positive regulation of secretion GO:0051047 1 0.012
multi organism process GO:0051704 134 0.012
skeletal muscle tissue development GO:0007519 67 0.011
cell surface receptor signaling pathway GO:0007166 325 0.011
development of primary female sexual characteristics GO:0046545 4 0.011
positive regulation of cell cycle GO:0045787 3 0.011
gabaergic neuron differentiation GO:0097154 2 0.011
regulation of nucleocytoplasmic transport GO:0046822 2 0.011
wound healing GO:0042060 90 0.011
response to glucose GO:0009749 3 0.011
angiogenesis GO:0001525 158 0.011
lymphocyte proliferation GO:0046651 1 0.011
nuclear export GO:0051168 1 0.011
establishment of localization in cell GO:0051649 77 0.011
regulation of protein complex assembly GO:0043254 3 0.011
collateral sprouting in absence of injury GO:0048669 4 0.011
forebrain neuron differentiation GO:0021879 14 0.011
spermatid development GO:0007286 2 0.011
single organism transport GO:0044765 206 0.011
anatomical structure arrangement GO:0048532 2 0.011
female gonad development GO:0008585 4 0.011
regulation of mrna splicing via spliceosome GO:0048024 3 0.011
regulation of n methyl d aspartate selective glutamate receptor activity GO:2000310 1 0.011
sensory neuron axon guidance GO:0097374 3 0.011
negative regulation of biosynthetic process GO:0009890 55 0.011
positive regulation of muscle tissue development GO:1901863 1 0.011
regulation of mesenchymal cell proliferation GO:0010464 1 0.011
compound eye development GO:0048749 2 0.011
response to glucocorticoid GO:0051384 1 0.011
regulation of ras gtpase activity GO:0032318 2 0.011
regulation of purine nucleotide catabolic process GO:0033121 2 0.011
cell type specific apoptotic process GO:0097285 22 0.011
proximal distal pattern formation GO:0009954 1 0.011
intra s dna damage checkpoint GO:0031573 1 0.011
regulation of catalytic activity GO:0050790 55 0.011
taxis GO:0042330 109 0.011
negative regulation of chemotaxis GO:0050922 4 0.011
response to inorganic substance GO:0010035 38 0.011
regulation of neuron differentiation GO:0045664 56 0.010
peptidyl serine modification GO:0018209 2 0.010
negative regulation of programmed cell death GO:0043069 58 0.010
positive regulation of cell activation GO:0050867 1 0.010
pronephros development GO:0048793 69 0.010
circulatory system process GO:0003013 87 0.010
ubiquitin dependent protein catabolic process GO:0006511 3 0.010
protein phosphorylation GO:0006468 47 0.010
protein modification process GO:0036211 100 0.010
synaptic target recognition GO:0008039 1 0.010
positive regulation of stem cell proliferation GO:2000648 1 0.010
striated muscle cell differentiation GO:0051146 129 0.010
cell fate commitment GO:0045165 99 0.010
regulation of blood vessel size GO:0050880 2 0.010
response to other organism GO:0051707 97 0.010
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.010
myoblast fusion GO:0007520 10 0.010
striated muscle cell development GO:0055002 108 0.010
neuron migration GO:0001764 22 0.010
negative regulation of gliogenesis GO:0014014 1 0.010
regulation of protein localization to nucleus GO:1900180 2 0.010
establishment of localization GO:0051234 244 0.010

tcf4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.018
disease of cellular proliferation DOID:14566 0 0.018
organ system cancer DOID:0050686 0 0.018
disease of anatomical entity DOID:7 0 0.012
nervous system disease DOID:863 0 0.010