Danio rerio

14 known processes

tgfb1a

transforming growth factor, beta 1a

(Aliases: tgfb1,ai39657,xx:ai39657,wu:fb13a07)

tgfb1a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cellular metabolic process GO:0031323 320 0.808
Human Mouse Rat Worm Fly
regulation of macromolecule metabolic process GO:0060255 317 0.804
Human Mouse Rat Worm
regulation of biosynthetic process GO:0009889 250 0.804
Human Mouse Rat Worm
organic cyclic compound biosynthetic process GO:1901362 223 0.730
Human Mouse Rat Worm
regulation of metabolic process GO:0019222 359 0.725
Human Mouse Rat Worm Fly
cognition GO:0050890 1 0.677
cell proliferation GO:0008283 80 0.649
Human Mouse Rat
cellular nitrogen compound biosynthetic process GO:0044271 218 0.644
Human Mouse Rat Worm
cellular macromolecule metabolic process GO:0044260 391 0.644
Human Mouse Rat Worm
regulation of primary metabolic process GO:0080090 311 0.627
Human Mouse Rat Worm
response to chemical GO:0042221 320 0.627
Human Zebrafish Mouse Rat Fly
nucleic acid metabolic process GO:0090304 244 0.621
Human Mouse Rat Worm
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.597
Human Mouse Rat Worm
regulation of nitrogen compound metabolic process GO:0051171 251 0.570
Human Mouse Rat Worm
regulation of gene expression GO:0010468 265 0.550
Human Mouse Rat Worm
nitrogen compound metabolic process GO:0006807 319 0.526
Human Mouse Rat Worm
regulation of transcription dna templated GO:0006355 213 0.490
Human Mouse Rat Worm
regulation of rna metabolic process GO:0051252 224 0.476
Human Mouse Rat Worm
macromolecule biosynthetic process GO:0009059 227 0.475
Human Mouse Rat Worm
cellular aromatic compound metabolic process GO:0006725 295 0.443
Human Mouse Rat Worm
immune system process GO:0002376 241 0.431
Human Mouse Rat
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.423
Human Mouse Rat Worm
cellular component morphogenesis GO:0032989 336 0.395
Human Mouse Rat Fly
response to drug GO:0042493 3 0.388
Rat
cellular biosynthetic process GO:0044249 286 0.383
Human Mouse Rat Worm
aromatic compound biosynthetic process GO:0019438 217 0.380
Human Mouse Rat Worm
nucleobase containing compound metabolic process GO:0006139 274 0.370
Human Mouse Rat Worm
cellular response to organic substance GO:0071310 105 0.354
Human Zebrafish Mouse Rat Fly
regulation of nucleic acid templated transcription GO:1903506 213 0.332
Human Mouse Rat Worm
cellular macromolecule biosynthetic process GO:0034645 224 0.328
Human Mouse Rat Worm
nucleic acid templated transcription GO:0097659 181 0.321
Human Mouse Rat Worm
heterocycle biosynthetic process GO:0018130 215 0.317
Human Mouse Rat Worm
regulation of cellular biosynthetic process GO:0031326 245 0.312
Human Mouse Rat Worm
cell migration GO:0016477 237 0.303
Human Mouse
organic cyclic compound metabolic process GO:1901360 301 0.297
Human Mouse Rat Worm
single organism metabolic process GO:0044710 217 0.296
Human Mouse
organic substance biosynthetic process GO:1901576 289 0.295
Human Mouse Rat Worm
positive regulation of macromolecule metabolic process GO:0010604 93 0.291
Human Mouse Worm
cellular response to chemical stimulus GO:0070887 157 0.289
Human Zebrafish Mouse Rat Fly
protein modification process GO:0036211 100 0.287
Human Mouse
cell part morphogenesis GO:0032990 246 0.287
Fly
positive regulation of cellular metabolic process GO:0031325 94 0.267
Human Mouse Worm
heterocycle metabolic process GO:0046483 290 0.263
Human Mouse Rat Worm
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.261
Fly
negative regulation of biological process GO:0048519 304 0.260
Human Zebrafish Mouse Rat Fly
growth GO:0040007 174 0.259
Human Zebrafish Mouse
chemotaxis GO:0006935 104 0.255
Human Fly
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.255
Human Mouse Worm
regulation of reactive oxygen species metabolic process GO:2000377 2 0.250
Human
positive regulation of metabolic process GO:0009893 108 0.250
Human Mouse Worm
neuron differentiation GO:0030182 353 0.249
Fly
gene expression GO:0010467 252 0.249
Human Mouse Rat Worm
cell surface receptor signaling pathway GO:0007166 325 0.247
Human Zebrafish Mouse Rat Fly
regulation of cell proliferation GO:0042127 37 0.238
Human Mouse Rat
regulation of rna biosynthetic process GO:2001141 213 0.236
Human Mouse Rat Worm
regulation of signal transduction GO:0009966 225 0.230
Human Fly
cellular component movement GO:0006928 335 0.222
Human Mouse Fly
rna metabolic process GO:0016070 219 0.219
Human Mouse Rat Worm
biosynthetic process GO:0009058 294 0.219
Human Mouse Rat Worm
positive regulation of biological process GO:0048518 253 0.217
Human Mouse Rat Worm Fly
regulation of developmental process GO:0050793 247 0.215
Human Zebrafish Mouse Rat
taxis GO:0042330 109 0.215
Human Fly
cellular nitrogen compound metabolic process GO:0034641 290 0.214
Human Mouse Rat Worm
reactive oxygen species metabolic process GO:0072593 6 0.214
Human
macromolecular complex subunit organization GO:0043933 74 0.212
Human Mouse
maintenance of location GO:0051235 4 0.211
response to external stimulus GO:0009605 264 0.205
Human Rat Worm Fly
regulation of cellular component movement GO:0051270 55 0.203
Human
defense response GO:0006952 47 0.203
Human Mouse Rat Worm
regulation of biological quality GO:0065008 263 0.201
Human Mouse Rat Fly
regulation of multicellular organismal development GO:2000026 223 0.197
Human Zebrafish Mouse Rat
regulation of immune system process GO:0002682 34 0.197
Human Mouse Rat
stem cell maintenance GO:0019827 4 0.195
protein metabolic process GO:0019538 183 0.194
Human Mouse
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.193
regulation of chondrocyte differentiation GO:0032330 1 0.189
neurological system process GO:0050877 62 0.189
Rat
multi organism process GO:0051704 134 0.187
Human Mouse Rat Worm
response to oxygen containing compound GO:1901700 55 0.187
Human Rat
cell projection organization GO:0030030 284 0.183
Fly
response to wounding GO:0009611 116 0.183
Human Rat
muscle structure development GO:0061061 196 0.178
Human Zebrafish Mouse Rat
gland development GO:0048732 143 0.173
Human Mouse
response to external biotic stimulus GO:0043207 97 0.171
Human Rat Worm
regulation of multicellular organismal process GO:0051239 277 0.170
Human Zebrafish Mouse Rat
regulation of cellular protein metabolic process GO:0032268 52 0.170
Human Mouse
stem cell proliferation GO:0072089 4 0.166
Rat
regulation of macromolecule biosynthetic process GO:0010556 225 0.163
Human Mouse Rat Worm
multicellular organism growth GO:0035264 4 0.162
digestive tract morphogenesis GO:0048546 231 0.162
aging GO:0007568 2 0.161
Rat Fly
regulation of stem cell proliferation GO:0072091 2 0.158
Rat
defense response to other organism GO:0098542 33 0.157
Rat Worm
system process GO:0003008 185 0.156
Rat
tissue regeneration GO:0042246 74 0.154
rna biosynthetic process GO:0032774 181 0.153
Human Mouse Rat Worm
positive regulation of cellular process GO:0048522 201 0.151
Human Mouse Rat Worm Fly
negative regulation of developmental process GO:0051093 65 0.150
Human Zebrafish Rat
extrinsic apoptotic signaling pathway GO:0097191 3 0.150
Human
cell growth GO:0016049 57 0.148
Human Mouse
signal transduction GO:0007165 455 0.147
Human Zebrafish Mouse Rat Fly
gastrulation GO:0007369 208 0.147
cell projection morphogenesis GO:0048858 244 0.146
Fly
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.146
Human Mouse Worm
transcription from rna polymerase ii promoter GO:0006366 80 0.142
Human Mouse Worm
camera type eye morphogenesis GO:0048593 108 0.142
cell motility GO:0048870 244 0.140
Human Mouse
positive regulation of cellular biosynthetic process GO:0031328 68 0.140
Human Mouse Worm
neuron development GO:0048666 262 0.138
Fly
positive regulation of response to stimulus GO:0048584 80 0.138
Human Fly
digestive system development GO:0055123 289 0.138
Rat
regulation of signaling GO:0023051 235 0.135
Human Fly
tube morphogenesis GO:0035239 349 0.132
Mouse Rat
regulation of cell differentiation GO:0045595 142 0.131
Human Mouse Rat
regulation of tube size GO:0035150 2 0.130
striated muscle cell development GO:0055002 108 0.130
Human
neuron projection morphogenesis GO:0048812 161 0.129
Fly
response to abiotic stimulus GO:0009628 122 0.126
Rat
axon development GO:0061564 166 0.125
Fly
positive regulation of endothelial cell proliferation GO:0001938 1 0.125
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.124
epithelium migration GO:0090132 25 0.123
Human
homeostatic process GO:0042592 142 0.122
Mouse Rat
organelle organization GO:0006996 227 0.120
Mouse Rat
cell morphogenesis GO:0000902 289 0.114
Human Mouse Rat Fly
transcription dna templated GO:0006351 181 0.113
Human Mouse Rat Worm
regulation of cellular component organization GO:0051128 86 0.112
Human Mouse Rat
regulation of cell shape GO:0008360 1 0.111
reproduction GO:0000003 40 0.111
Mouse
response to other organism GO:0051707 97 0.109
Human Rat Worm
epithelial cell migration GO:0010631 25 0.109
Human
positive regulation of transcription dna templated GO:0045893 57 0.106
Human Mouse Worm
response to biotic stimulus GO:0009607 97 0.105
Human Rat Worm
cell cycle g1 s phase transition GO:0044843 1 0.105
generation of neurons GO:0048699 385 0.104
Rat Fly
sensory organ morphogenesis GO:0090596 200 0.104
regulation of epithelial cell proliferation GO:0050678 3 0.103
Human Rat
single fertilization GO:0007338 3 0.101
skeletal muscle tissue development GO:0007519 67 0.100
Human Zebrafish
cellular protein metabolic process GO:0044267 129 0.099
Human Mouse
muscle cell migration GO:0014812 4 0.098
regulation of synapse organization GO:0050807 3 0.096
negative regulation of multicellular organismal process GO:0051241 69 0.096
Human Zebrafish Mouse Rat
positive regulation of cell cycle GO:0045787 3 0.096
Mouse Rat
macromolecule modification GO:0043412 111 0.094
Human Mouse
negative regulation of cellular process GO:0048523 283 0.094
Human Mouse Rat Fly
regionalization GO:0003002 274 0.094
Zebrafish
divalent inorganic cation homeostasis GO:0072507 22 0.093
Mouse Rat
regulation of wound healing GO:0061041 2 0.093
cellular amino acid metabolic process GO:0006520 7 0.092
positive regulation of protein kinase b signaling GO:0051897 1 0.090
Human
specification of symmetry GO:0009799 204 0.090
positive regulation of rna metabolic process GO:0051254 59 0.090
Human Mouse Worm
positive regulation of neuron projection development GO:0010976 9 0.090
reactive oxygen species biosynthetic process GO:1903409 1 0.089
cytoskeleton organization GO:0007010 96 0.089
Mouse
response to endogenous stimulus GO:0009719 83 0.088
Human Zebrafish Mouse Rat Fly
regulation of phosphorus metabolic process GO:0051174 43 0.088
Human
multicellular organismal reproductive process GO:0048609 35 0.087
Mouse
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 1 0.086
g1 s transition of mitotic cell cycle GO:0000082 1 0.084
hematopoietic or lymphoid organ development GO:0048534 191 0.083
Human Mouse
protein localization to nucleus GO:0034504 3 0.082
Human Mouse Rat
neuron projection development GO:0031175 180 0.080
Fly
signal transduction in absence of ligand GO:0038034 1 0.080
positive regulation of gene expression GO:0010628 71 0.079
Human Mouse Worm
cell cycle arrest GO:0007050 1 0.078
Human Mouse
peptidyl serine phosphorylation GO:0018105 1 0.077
Human
regulation of anatomical structure morphogenesis GO:0022603 130 0.077
Human Mouse Rat
regulation of locomotion GO:0040012 55 0.077
Human
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.076
Human Mouse Worm
positive regulation of nucleic acid templated transcription GO:1903508 57 0.076
Human Mouse Worm
germ line stem cell maintenance GO:0030718 2 0.075
female sex differentiation GO:0046660 4 0.072
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.072
regulation of epithelial to mesenchymal transition GO:0010717 3 0.071
Human Mouse
cellular component assembly GO:0022607 170 0.071
Human Mouse
nucleocytoplasmic transport GO:0006913 4 0.071
Human Mouse Rat
regulation of bmp signaling pathway GO:0030510 39 0.069
hepaticobiliary system development GO:0061008 98 0.069
regulation of synapse assembly GO:0051963 3 0.069
cellular response to endogenous stimulus GO:0071495 68 0.068
Human Zebrafish Mouse Rat Fly
protein stabilization GO:0050821 2 0.068
multi organism reproductive process GO:0044703 36 0.067
Mouse Rat
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.065
response to stress GO:0006950 263 0.065
Human Mouse Rat Worm
sensory organ development GO:0007423 393 0.065
mononuclear cell proliferation GO:0032943 1 0.064
Mouse
negative regulation of gene expression GO:0010629 65 0.064
Human Mouse
fin regeneration GO:0031101 51 0.064
axonal defasciculation GO:0007414 2 0.064
determination of bilateral symmetry GO:0009855 204 0.064
negative regulation of cell differentiation GO:0045596 46 0.063
Human Rat
cell migration involved in gastrulation GO:0042074 79 0.062
regulation of response to stimulus GO:0048583 269 0.062
Human Rat Worm Fly
locomotion GO:0040011 313 0.062
Human Mouse Fly
tissue migration GO:0090130 37 0.062
Human
nucleobase containing compound biosynthetic process GO:0034654 205 0.061
Human Mouse Rat Worm
digestive tract development GO:0048565 265 0.061
Rat
embryonic heart tube morphogenesis GO:0003143 108 0.060
phagocytosis GO:0006909 3 0.060
Rat
regulation of multicellular organism growth GO:0040014 4 0.060
i kappab kinase nf kappab signaling GO:0007249 4 0.060
negative regulation of signaling GO:0023057 96 0.059
negative regulation of signal transduction GO:0009968 94 0.059
glial cell migration GO:0008347 3 0.059
carboxylic acid metabolic process GO:0019752 22 0.058
eye development GO:0001654 277 0.058
Mouse
negative regulation of catabolic process GO:0009895 3 0.058
Fly
embryonic organ morphogenesis GO:0048562 274 0.058
negative regulation of bmp signaling pathway GO:0030514 13 0.058
regulation of protein localization to nucleus GO:1900180 2 0.057
Human Mouse
regulation of molecular function GO:0065009 70 0.057
Human Mouse Rat
response to vitamin GO:0033273 3 0.057
Rat
cellular protein modification process GO:0006464 100 0.057
Human Mouse
determination of heart left right asymmetry GO:0061371 117 0.057
larval development GO:0002164 2 0.056
Worm
regulation of reproductive process GO:2000241 4 0.055
lens fiber cell morphogenesis GO:0070309 3 0.055
axon guidance GO:0007411 86 0.055
Fly
regulation of establishment of protein localization GO:0070201 4 0.054
Human Mouse
single organism localization GO:1902578 225 0.054
Human Mouse Rat Fly
digestive tract mesoderm development GO:0007502 1 0.053
cell fate commitment GO:0045165 99 0.053
cellular amine metabolic process GO:0044106 2 0.053
regulation of skeletal muscle fiber development GO:0048742 2 0.053
Human
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.053
convergent extension involved in gastrulation GO:0060027 71 0.053
regulation of cellular amine metabolic process GO:0033238 0 0.052
immune response GO:0006955 28 0.052
Human Mouse Rat
mitotic cell cycle process GO:1903047 48 0.051
Human Rat
regulation of apoptotic process GO:0042981 98 0.051
Rat
sensory perception of smell GO:0007608 2 0.051
amine metabolic process GO:0009308 2 0.050
positive regulation of epithelial cell proliferation GO:0050679 1 0.050
Rat
positive regulation of wound healing GO:0090303 1 0.050
axonogenesis GO:0007409 152 0.050
Fly
exocrine system development GO:0035272 28 0.050
Human
formation of primary germ layer GO:0001704 62 0.050
heart contraction GO:0060047 71 0.050
regulation of dendrite development GO:0050773 3 0.049
regulation of cell migration GO:0030334 40 0.048
Human
response to growth factor GO:0070848 39 0.048
Human Zebrafish Mouse Fly
leukocyte proliferation GO:0070661 1 0.048
Mouse
negative regulation of metabolic process GO:0009892 86 0.048
Human Mouse Fly
lens fiber cell development GO:0070307 3 0.048
positive regulation of biosynthetic process GO:0009891 68 0.048
Human Mouse Worm
negative regulation of protein phosphorylation GO:0001933 4 0.047
Human
cell morphogenesis involved in differentiation GO:0000904 195 0.047
Human Mouse Rat Fly
protein localization to plasma membrane GO:0072659 1 0.047
cellular response to growth factor stimulus GO:0071363 39 0.047
Human Zebrafish Mouse Fly
regulation of system process GO:0044057 40 0.046
regulation of cell motility GO:2000145 46 0.045
Human
protein phosphorylation GO:0006468 47 0.045
Human Mouse
striated muscle cell differentiation GO:0051146 129 0.045
Human
regulation of blood circulation GO:1903522 32 0.044
intracellular signal transduction GO:0035556 85 0.044
Human
bmp signaling pathway GO:0030509 52 0.044
single organism biosynthetic process GO:0044711 71 0.043
Human Mouse
lipid storage GO:0019915 1 0.043
nuclear import GO:0051170 3 0.043
Human Mouse Rat
negative regulation of signal transduction in absence of ligand GO:1901099 1 0.043
actin polymerization or depolymerization GO:0008154 2 0.043
regulation of neuron differentiation GO:0045664 56 0.043
ameboidal type cell migration GO:0001667 143 0.042
Human
lateral inhibition GO:0046331 1 0.042
negative regulation of cell proliferation GO:0008285 8 0.042
Human Mouse Rat
regeneration GO:0031099 91 0.042
Rat
regulation of nervous system development GO:0051960 90 0.042
Rat
negative regulation of synapse assembly GO:0051964 2 0.042
regulation of cell communication GO:0010646 232 0.042
Human Fly
eye morphogenesis GO:0048592 144 0.041
heart development GO:0007507 313 0.041
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.041
Human Zebrafish Mouse Rat Fly
peptide transport GO:0015833 1 0.041
Fly
synaptic growth at neuromuscular junction GO:0051124 2 0.041
convergent extension GO:0060026 118 0.041
calcium mediated signaling GO:0019722 2 0.041
regulation of catalytic activity GO:0050790 55 0.041
Human
embryo development ending in birth or egg hatching GO:0009792 271 0.040
liver development GO:0001889 96 0.040
positive regulation of cell communication GO:0010647 56 0.040
Human Fly
positive regulation of neurogenesis GO:0050769 24 0.040
regulation of heart contraction GO:0008016 32 0.040
phosphate containing compound metabolic process GO:0006796 108 0.040
Human Mouse
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.039
Human Mouse Worm
peptidyl serine modification GO:0018209 2 0.039
Human
endothelial cell migration GO:0043542 19 0.039
Human
insulin like growth factor receptor signaling pathway GO:0048009 4 0.039
heart process GO:0003015 71 0.039
organic acid metabolic process GO:0006082 31 0.039
central nervous system development GO:0007417 387 0.038
muscle cell differentiation GO:0042692 139 0.038
Human Rat
neuron projection extension GO:1990138 45 0.038
oxoacid metabolic process GO:0043436 31 0.038
olfactory lobe development GO:0021988 4 0.038
single organismal cell cell adhesion GO:0016337 29 0.037
Human
response to decreased oxygen levels GO:0036293 25 0.037
Rat
intracellular receptor signaling pathway GO:0030522 30 0.037
oocyte maturation GO:0001556 4 0.037
programmed cell death GO:0012501 119 0.037
Human Rat
muscle cell development GO:0055001 115 0.037
Human
phosphorylation GO:0016310 69 0.036
Human Mouse
regulation of neurogenesis GO:0050767 87 0.036
Rat
lymphocyte proliferation GO:0046651 1 0.036
Mouse
caudal fin development GO:0033336 9 0.036
heart looping GO:0001947 94 0.036
signal transduction by phosphorylation GO:0023014 18 0.036
Human
skeletal system development GO:0001501 181 0.035
Human Mouse Rat
regulation of cytoplasmic transport GO:1903649 4 0.035
Human Mouse Rat
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.035
Human Fly
cell division GO:0051301 20 0.035
Rat
embryonic limb morphogenesis GO:0030326 2 0.035
positive regulation of reproductive process GO:2000243 2 0.035
positive regulation of signaling GO:0023056 56 0.035
Human Fly
endothelial cell proliferation GO:0001935 11 0.035
multicellular organismal metabolic process GO:0044236 2 0.034
Human Mouse
blood vessel endothelial cell migration GO:0043534 18 0.034
Human
response to hormone GO:0009725 48 0.034
Human Rat
stem cell division GO:0017145 1 0.034
developmental growth involved in morphogenesis GO:0060560 86 0.034
Mouse
response to organic substance GO:0010033 153 0.034
Human Zebrafish Mouse Rat Fly
multicellular organism reproduction GO:0032504 35 0.034
Mouse
positive regulation of stem cell proliferation GO:2000648 1 0.034
compound eye development GO:0048749 2 0.034
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.034
dorsal ventral pattern formation GO:0009953 125 0.034
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.034
response to nutrient GO:0007584 3 0.033
Rat
regulation of carbohydrate metabolic process GO:0006109 4 0.033
Human
regulation of cell morphogenesis GO:0022604 42 0.033
Human Mouse
catabolic process GO:0009056 32 0.033
Human Fly
fertilization GO:0009566 3 0.033
regulation of localization GO:0032879 104 0.032
Human Mouse Rat Fly
positive regulation of cell differentiation GO:0045597 30 0.032
Human Mouse Rat
astrocyte differentiation GO:0048708 1 0.032
regulation of protein metabolic process GO:0051246 56 0.032
Human Mouse
regulation of striated muscle contraction GO:0006942 2 0.032
positive regulation of cellular protein metabolic process GO:0032270 22 0.032
Human Mouse
biological adhesion GO:0022610 40 0.032
Human
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.032
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.031
Human Mouse
pancreas development GO:0031016 84 0.031
positive regulation of molecular function GO:0044093 33 0.031
Human Rat
reproductive process GO:0022414 40 0.031
Mouse Rat
small molecule metabolic process GO:0044281 77 0.030
Human
positive regulation of signal transduction GO:0009967 56 0.030
Human Fly
cell cycle process GO:0022402 53 0.030
Human Mouse Rat
regulation of dna replication GO:0006275 3 0.030
Human
defense response to fungus GO:0050832 2 0.030
Rat
localization of cell GO:0051674 244 0.030
Human Mouse
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 22 0.030
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.030
rna localization GO:0006403 4 0.030
peptidyl amino acid modification GO:0018193 16 0.029
Human Mouse
blood vessel morphogenesis GO:0048514 216 0.029
positive regulation of cellular component biogenesis GO:0044089 3 0.029
Human
behavior GO:0007610 74 0.029
Human Worm
cellular response to lipid GO:0071396 39 0.029
Human Rat
cellular response to extracellular stimulus GO:0031668 2 0.029
skeletal muscle organ development GO:0060538 78 0.029
Human Zebrafish
nitric oxide metabolic process GO:0046209 2 0.029
somatic stem cell maintenance GO:0035019 1 0.029
positive regulation of cell adhesion GO:0045785 1 0.028
osteoclast differentiation GO:0030316 1 0.028
cellular carbohydrate metabolic process GO:0044262 4 0.028
determination of left right symmetry GO:0007368 179 0.028
actin filament organization GO:0007015 15 0.028
regulation of endothelial cell proliferation GO:0001936 1 0.028
negative regulation of response to stimulus GO:0048585 104 0.028
Human Rat
regulation of cell cycle GO:0051726 52 0.028
Human Mouse Rat
dorsal convergence GO:0060030 14 0.028
cell cycle GO:0007049 93 0.028
Human Mouse Rat
inner ear development GO:0048839 126 0.027
regulation of blood vessel size GO:0050880 2 0.027
determination of ventral identity GO:0048264 21 0.027
cellular component maintenance GO:0043954 3 0.027
sensory perception GO:0007600 39 0.027
cell migration involved in sprouting angiogenesis GO:0002042 8 0.027
regulation of protein transport GO:0051223 3 0.027
Human Mouse
blood vessel development GO:0001568 246 0.027
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.026
regulation of protein modification process GO:0031399 29 0.026
Human Mouse
establishment of protein localization to organelle GO:0072594 4 0.026
Human Mouse Rat
cellular response to molecule of bacterial origin GO:0071219 3 0.026
Human
cellular response to lipopolysaccharide GO:0071222 3 0.026
Human
regulation of hormone secretion GO:0046883 2 0.026
Fly
pericardium development GO:0060039 1 0.026
single organism reproductive process GO:0044702 40 0.026
Mouse
regulation of stem cell differentiation GO:2000736 4 0.026
Human Mouse
regulation of phosphate metabolic process GO:0019220 43 0.026
Human
muscle tissue development GO:0060537 110 0.026
Human Zebrafish Mouse
regulation of phosphorylation GO:0042325 26 0.026
Human
positive regulation of multicellular organismal process GO:0051240 52 0.026
Human Mouse Rat
macromolecule localization GO:0033036 54 0.026
Human Mouse Rat
regulation of oocyte development GO:0060281 3 0.026
negative regulation of autophagy GO:0010507 1 0.026
Fly
axis specification GO:0009798 43 0.026
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.026
hormone transport GO:0009914 2 0.025
Fly
regulation of cellular amino acid metabolic process GO:0006521 0 0.025
cellular calcium ion homeostasis GO:0006874 13 0.025
Mouse Rat
antimicrobial humoral response GO:0019730 2 0.025
positive regulation of nervous system development GO:0051962 25 0.025
regulation of anatomical structure size GO:0090066 33 0.025
response to mechanical stimulus GO:0009612 24 0.025
protein polymerization GO:0051258 4 0.025
anterior posterior pattern specification GO:0009952 152 0.025
Zebrafish
death GO:0016265 121 0.025
Human Rat
medial fin development GO:0033338 16 0.025
regulation of developmental growth GO:0048638 38 0.025
calcium ion dependent exocytosis GO:0017156 1 0.024
skeletal system morphogenesis GO:0048705 102 0.024
Rat
single organism organelle organization GO:1902589 199 0.024
Mouse Rat
actin filament bundle organization GO:0061572 6 0.024
cellular component biogenesis GO:0044085 178 0.024
Human Mouse
regulation of erk1 and erk2 cascade GO:0070372 4 0.024
single organism nuclear import GO:1902593 3 0.024
Human Mouse Rat
regulation of cellular ketone metabolic process GO:0010565 7 0.023
regulation of inflammatory response GO:0050727 2 0.023
morphogenesis of an epithelium GO:0002009 333 0.023
Mouse Rat
blood circulation GO:0008015 87 0.023
regulation of protein targeting GO:1903533 2 0.023
Human Mouse
regulation of response to oxidative stress GO:1902882 2 0.023
sarcomere organization GO:0045214 26 0.023
sprouting angiogenesis GO:0002040 53 0.023
regulation of growth GO:0040008 42 0.023
Human Zebrafish Mouse
positive regulation of rna biosynthetic process GO:1902680 57 0.023
Human Mouse Worm
chemosensory behavior GO:0007635 1 0.023
cellular response to external stimulus GO:0071496 2 0.023
phosphatidylinositol mediated signaling GO:0048015 2 0.023
response to antibiotic GO:0046677 1 0.023
myofibril assembly GO:0030239 48 0.022
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.022
peptidyl tyrosine modification GO:0018212 5 0.022
developmental growth GO:0048589 166 0.022
Mouse
segmentation GO:0035282 97 0.022
wound healing GO:0042060 90 0.022
Rat
cellular localization GO:0051641 97 0.022
Human Mouse Rat Fly
establishment of localization in cell GO:0051649 77 0.022
Human Mouse Rat Fly
actomyosin structure organization GO:0031032 53 0.022
response to hypoxia GO:0001666 25 0.022
Rat
cellular response to nutrient levels GO:0031669 2 0.021
inositol lipid mediated signaling GO:0048017 2 0.021
post embryonic organ development GO:0048569 4 0.021
cell fate specification GO:0001708 68 0.021
chromosome organization GO:0051276 31 0.021
Mouse
regulation of filopodium assembly GO:0051489 2 0.021
muscle organ development GO:0007517 101 0.021
Human Zebrafish Mouse
regulation of metal ion transport GO:0010959 4 0.021
Mouse Rat
positive regulation of locomotion GO:0040017 14 0.021
Human
lipid metabolic process GO:0006629 52 0.021
Human
response to transforming growth factor beta GO:0071559 7 0.021
Human Zebrafish Mouse Fly
appendage development GO:0048736 80 0.021
positive regulation of carbohydrate metabolic process GO:0045913 1 0.021
response to fluid shear stress GO:0034405 2 0.021
Rat
negative regulation of protein metabolic process GO:0051248 16 0.020
Human
immune system development GO:0002520 191 0.020
Human Mouse
positive regulation of secretion GO:0051047 1 0.020
Human
cell adhesion mediated by integrin GO:0033627 1 0.020
positive regulation of synapse assembly GO:0051965 1 0.020
negative regulation of cell motility GO:2000146 17 0.020
Human
cellular response to oxygen levels GO:0071453 1 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.020
response to nitrogen compound GO:1901698 19 0.020
regulation of dendrite morphogenesis GO:0048814 3 0.020
striated muscle tissue development GO:0014706 110 0.020
Human Zebrafish Mouse
regulation of intracellular signal transduction GO:1902531 57 0.020
Human
regulation of establishment of protein localization to plasma membrane GO:0090003 1 0.020
positive regulation of immune system process GO:0002684 17 0.020
Human
establishment of protein localization to plasma membrane GO:0090002 1 0.020
cellular response to oxygen containing compound GO:1901701 20 0.020
Human Rat
hemopoiesis GO:0030097 183 0.020
Human Mouse
protein import GO:0017038 3 0.020
Human Mouse Rat
ossification GO:0001503 23 0.020
Human Mouse
cellular response to hypoxia GO:0071456 1 0.019
negative regulation of cell migration GO:0030336 17 0.019
Human
regulation of nucleocytoplasmic transport GO:0046822 2 0.019
Human Mouse
response to lipid GO:0033993 60 0.019
Human Rat
head development GO:0060322 303 0.019
Mouse
reactive nitrogen species metabolic process GO:2001057 0 0.019
cilium morphogenesis GO:0060271 85 0.019
protein import into nucleus GO:0006606 3 0.019
Human Mouse Rat

tgfb1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.089
Human
bone disease DOID:0080001 0 0.055
Human
musculoskeletal system disease DOID:17 0 0.055
Human
connective tissue disease DOID:65 0 0.055
Human
myopathy DOID:423 0 0.037
muscular disease DOID:0080000 0 0.037
heart disease DOID:114 0 0.037
cardiomyopathy DOID:0050700 0 0.037
cardiovascular system disease DOID:1287 0 0.037
muscle tissue disease DOID:66 0 0.037
cancer DOID:162 0 0.027
disease of cellular proliferation DOID:14566 0 0.027
organ system cancer DOID:0050686 0 0.027