Danio rerio

0 known processes

thoc1

THO complex 1

(Aliases: p84)

thoc1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.784
regulation of mrna splicing via spliceosome GO:0048024 3 0.595
nucleic acid metabolic process GO:0090304 244 0.271
organic cyclic compound metabolic process GO:1901360 301 0.256
nitrogen compound metabolic process GO:0006807 319 0.246
rna metabolic process GO:0016070 219 0.230
cellular nitrogen compound metabolic process GO:0034641 290 0.227
heterocycle metabolic process GO:0046483 290 0.226
embryo development ending in birth or egg hatching GO:0009792 271 0.225
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.214
regulation of mrna processing GO:0050684 3 0.206
alternative mrna splicing via spliceosome GO:0000380 1 0.190
nucleobase containing compound metabolic process GO:0006139 274 0.188
cellular aromatic compound metabolic process GO:0006725 295 0.187
gene expression GO:0010467 252 0.177
locomotion GO:0040011 313 0.148
cellular macromolecule metabolic process GO:0044260 391 0.147
signal transduction GO:0007165 455 0.128
mrna processing GO:0006397 14 0.120
regulation of epithelial cell proliferation GO:0050678 3 0.100
response to stress GO:0006950 263 0.098
heterocycle biosynthetic process GO:0018130 215 0.093
organelle organization GO:0006996 227 0.089
cell cycle GO:0007049 93 0.088
dna templated transcription initiation GO:0006352 1 0.088
phagocytosis GO:0006909 3 0.087
protein localization to nucleus GO:0034504 3 0.086
rna splicing GO:0008380 16 0.086
rna processing GO:0006396 25 0.085
regulation of primary metabolic process GO:0080090 311 0.083
cell motility GO:0048870 244 0.079
regulation of gene expression GO:0010468 265 0.072
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.069
regulation of macromolecule metabolic process GO:0060255 317 0.068
stem cell proliferation GO:0072089 4 0.068
mrna splicing via spliceosome GO:0000398 10 0.064
nuclear transport GO:0051169 4 0.060
cytokinesis GO:0000910 3 0.058
negative regulation of biological process GO:0048519 304 0.058
macromolecule biosynthetic process GO:0009059 227 0.055
multicellular organism growth GO:0035264 4 0.054
mrna metabolic process GO:0016071 20 0.054
biosynthetic process GO:0009058 294 0.053
cellular component movement GO:0006928 335 0.053
nucleic acid templated transcription GO:0097659 181 0.052
cellular component biogenesis GO:0044085 178 0.052
nucleocytoplasmic transport GO:0006913 4 0.052
organic substance biosynthetic process GO:1901576 289 0.051
mitotic cell cycle GO:0000278 64 0.048
single organism metabolic process GO:0044710 217 0.048
regulation of multicellular organism growth GO:0040014 4 0.048
regulation of synapse organization GO:0050807 3 0.047
cellular component morphogenesis GO:0032989 336 0.047
organic cyclic compound biosynthetic process GO:1901362 223 0.046
organelle assembly GO:0070925 110 0.046
cell cycle process GO:0022402 53 0.046
rna biosynthetic process GO:0032774 181 0.045
aging GO:0007568 2 0.045
regulation of transcription dna templated GO:0006355 213 0.044
retina development in camera type eye GO:0060041 146 0.044
transcription dna templated GO:0006351 181 0.042
proteasomal protein catabolic process GO:0010498 2 0.042
localization of cell GO:0051674 244 0.042
regulation of multicellular organismal development GO:2000026 223 0.041
regulation of macromolecule biosynthetic process GO:0010556 225 0.041
dna templated transcription elongation GO:0006354 3 0.041
single organism organelle organization GO:1902589 199 0.041
negative regulation of neural precursor cell proliferation GO:2000178 1 0.040
cellular macromolecule biosynthetic process GO:0034645 224 0.040
mitotic cell cycle process GO:1903047 48 0.039
establishment of localization GO:0051234 244 0.039
transcription from rna polymerase ii promoter GO:0006366 80 0.039
regulation of nitrogen compound metabolic process GO:0051171 251 0.039
regulation of stem cell proliferation GO:0072091 2 0.038
rna localization GO:0006403 4 0.037
ribonucleoside monophosphate catabolic process GO:0009158 4 0.037
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.037
cell migration GO:0016477 237 0.037
transport GO:0006810 220 0.037
cellular biosynthetic process GO:0044249 286 0.036
negative regulation of synapse assembly GO:0051964 2 0.035
regulation of biological quality GO:0065008 263 0.035
ubiquitin dependent protein catabolic process GO:0006511 3 0.035
negative regulation of cellular process GO:0048523 283 0.035
regulation of metabolic process GO:0019222 359 0.035
lateral inhibition GO:0046331 1 0.034
growth GO:0040007 174 0.034
cellular protein catabolic process GO:0044257 4 0.034
spliceosomal complex assembly GO:0000245 1 0.034
regulation of erk1 and erk2 cascade GO:0070372 4 0.033
maintenance of location GO:0051235 4 0.033
meiotic nuclear division GO:0007126 4 0.033
generation of neurons GO:0048699 385 0.033
synaptic growth at neuromuscular junction GO:0051124 2 0.032
protein complex disassembly GO:0043241 1 0.032
developmental process involved in reproduction GO:0003006 27 0.031
response to external stimulus GO:0009605 264 0.031
mechanosensory behavior GO:0007638 2 0.031
microtubule based process GO:0007017 60 0.031
stem cell division GO:0017145 1 0.031
cellular component disassembly GO:0022411 1 0.030
cellular nitrogen compound biosynthetic process GO:0044271 218 0.030
rna 3 end processing GO:0031123 2 0.030
modification dependent macromolecule catabolic process GO:0043632 3 0.030
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.030
reproduction GO:0000003 40 0.030
microtubule cytoskeleton organization GO:0000226 33 0.029
multicellular organism reproduction GO:0032504 35 0.029
negative regulation of protein phosphorylation GO:0001933 4 0.029
single fertilization GO:0007338 3 0.029
muscle organ development GO:0007517 101 0.028
chemotaxis GO:0006935 104 0.028
oocyte anterior posterior axis specification GO:0007314 4 0.028
dendrite guidance GO:0070983 0 0.028
macromolecular complex subunit organization GO:0043933 74 0.028
modification dependent protein catabolic process GO:0019941 3 0.028
rna splicing via transesterification reactions GO:0000375 10 0.027
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.027
macromolecular complex disassembly GO:0032984 1 0.027
fertilization GO:0009566 3 0.027
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.027
developmental growth GO:0048589 166 0.026
pathway restricted smad protein phosphorylation GO:0060389 1 0.026
response to chemical GO:0042221 320 0.026
nucleobase containing compound biosynthetic process GO:0034654 205 0.026
regulation of biosynthetic process GO:0009889 250 0.026
sensory organ development GO:0007423 393 0.026
rna transport GO:0050658 2 0.026
aromatic compound biosynthetic process GO:0019438 217 0.026
lipid storage GO:0019915 1 0.026
response to abiotic stimulus GO:0009628 122 0.025
nucleobase containing compound transport GO:0015931 2 0.025
nucleic acid transport GO:0050657 2 0.025
positive regulation of translation GO:0045727 1 0.025
regulation of protein catabolic process GO:0042176 1 0.025
regulation of nucleic acid templated transcription GO:1903506 213 0.025
cellular component assembly GO:0022607 170 0.025
regulation of cellular biosynthetic process GO:0031326 245 0.024
regulation of synapse assembly GO:0051963 3 0.024
positive regulation of rna splicing GO:0033120 1 0.024
regulation of cellular metabolic process GO:0031323 320 0.024
ncrna catabolic process GO:0034661 1 0.024
organelle fission GO:0048285 23 0.023
regulation of protein transport GO:0051223 3 0.023
response to nutrient GO:0007584 3 0.023
nuclear import GO:0051170 3 0.023
positive regulation of ras protein signal transduction GO:0046579 1 0.023
cell morphogenesis GO:0000902 289 0.023
cellular response to chemical stimulus GO:0070887 157 0.023
mrna transport GO:0051028 2 0.023
cellular response to external stimulus GO:0071496 2 0.022
positive regulation of epithelial cell proliferation GO:0050679 1 0.022
regulation of meiotic cell cycle GO:0051445 1 0.022
positive regulation of metabolic process GO:0009893 108 0.022
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.022
cellular response to extracellular stimulus GO:0031668 2 0.022
response to drug GO:0042493 3 0.022
response to organic substance GO:0010033 153 0.022
positive regulation of transport GO:0051050 2 0.022
development of primary female sexual characteristics GO:0046545 4 0.021
regulation of receptor activity GO:0010469 2 0.021
cell cell recognition GO:0009988 1 0.021
single organism nuclear import GO:1902593 3 0.021
multi organism process GO:0051704 134 0.021
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.020
regulation of neural precursor cell proliferation GO:2000177 3 0.020
establishment of protein localization to organelle GO:0072594 4 0.020
single organism localization GO:1902578 225 0.020
single organism reproductive process GO:0044702 40 0.020
protein dephosphorylation GO:0006470 3 0.020
female gonad development GO:0008585 4 0.020
cellular response to starvation GO:0009267 1 0.020
mesenchyme development GO:0060485 127 0.019
regulation of cell shape GO:0008360 1 0.019
macroautophagy GO:0016236 1 0.019
cytoskeleton organization GO:0007010 96 0.019
eye development GO:0001654 277 0.019
protein complex subunit organization GO:0071822 46 0.019
neuron development GO:0048666 262 0.019
neuromuscular synaptic transmission GO:0007274 2 0.019
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.019
protein stabilization GO:0050821 2 0.019
central nervous system development GO:0007417 387 0.019
regulation of reproductive process GO:2000241 4 0.019
regulation of wound healing GO:0061041 2 0.018
regulation of rna biosynthetic process GO:2001141 213 0.018
autophagy GO:0006914 4 0.018
cellular carbohydrate metabolic process GO:0044262 4 0.018
muscle structure development GO:0061061 196 0.018
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.018
internal peptidyl lysine acetylation GO:0018393 2 0.018
regulation of organ growth GO:0046620 3 0.018
mitochondrion organization GO:0007005 4 0.018
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.018
cell part morphogenesis GO:0032990 246 0.018
regulation of cellular protein catabolic process GO:1903362 1 0.018
organonitrogen compound metabolic process GO:1901564 74 0.018
negative regulation of rna splicing GO:0033119 1 0.018
atp catabolic process GO:0006200 4 0.018
cellular response to stress GO:0033554 62 0.018
erk1 and erk2 cascade GO:0070371 4 0.018
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.018
cell surface receptor signaling pathway GO:0007166 325 0.017
small molecule metabolic process GO:0044281 77 0.017
carboxylic acid metabolic process GO:0019752 22 0.017
vasculature development GO:0001944 278 0.017
double strand break repair GO:0006302 3 0.017
regulation of molecular function GO:0065009 70 0.017
cellular response to nutrient levels GO:0031669 2 0.017
cellular response to dna damage stimulus GO:0006974 24 0.017
neuron projection guidance GO:0097485 86 0.017
neuron differentiation GO:0030182 353 0.017
regulation of rna splicing GO:0043484 8 0.017
meiotic cell cycle process GO:1903046 3 0.017
gamete generation GO:0007276 33 0.017
positive regulation of mrna splicing via spliceosome GO:0048026 1 0.017
reproductive process GO:0022414 40 0.017
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 10 0.017
negative regulation of epithelial cell proliferation GO:0050680 1 0.017
oxoacid metabolic process GO:0043436 31 0.017
regulation of response to stimulus GO:0048583 269 0.017
cellular amine metabolic process GO:0044106 2 0.017
regulation of cell activation GO:0050865 1 0.017
regulation of multicellular organismal process GO:0051239 277 0.017
regulation of cytoplasmic transport GO:1903649 4 0.016
regulation of cellular ketone metabolic process GO:0010565 7 0.016
regulation of establishment of protein localization GO:0070201 4 0.016
amine metabolic process GO:0009308 2 0.016
regulation of autophagy GO:0010506 3 0.016
nucleoside monophosphate catabolic process GO:0009125 4 0.016
organic substance transport GO:0071702 58 0.016
neuron projection development GO:0031175 180 0.016
nuclear export GO:0051168 1 0.016
meiotic chromosome segregation GO:0045132 3 0.016
protein metabolic process GO:0019538 183 0.016
cytoplasm organization GO:0007028 4 0.016
protein import into nucleus GO:0006606 3 0.016
multicellular organismal reproductive process GO:0048609 35 0.016
response to hexose GO:0009746 3 0.016
response to wounding GO:0009611 116 0.015
response to monosaccharide GO:0034284 3 0.015
negative regulation of signaling GO:0023057 96 0.015
regulation of cellular amine metabolic process GO:0033238 0 0.015
protein polymerization GO:0051258 4 0.015
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.015
ribonucleoprotein complex biogenesis GO:0022613 13 0.015
macromolecular complex assembly GO:0065003 35 0.015
rrna catabolic process GO:0016075 1 0.015
regulation of protein complex assembly GO:0043254 3 0.015
regulation of developmental process GO:0050793 247 0.015
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.015
cognition GO:0050890 1 0.015
rna polyadenylation GO:0043631 2 0.015
positive regulation of cell cycle GO:0045787 3 0.015
internal protein amino acid acetylation GO:0006475 2 0.015
regulation of rna metabolic process GO:0051252 224 0.015
protein acetylation GO:0006473 2 0.015
regulation of protein ubiquitination GO:0031396 3 0.015
negative regulation of developmental process GO:0051093 65 0.015
regulation of signaling GO:0023051 235 0.015
response to endogenous stimulus GO:0009719 83 0.014
positive regulation of protein complex assembly GO:0031334 2 0.014
peptidyl lysine acetylation GO:0018394 2 0.014
muscle cell differentiation GO:0042692 139 0.014
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.014
ameboidal type cell migration GO:0001667 143 0.014
blood vessel morphogenesis GO:0048514 216 0.014
centrosome organization GO:0051297 1 0.014
cellular response to organic substance GO:0071310 105 0.014
mrna 3 end processing GO:0031124 2 0.014
protein targeting to nucleus GO:0044744 3 0.014
chordate embryonic development GO:0043009 271 0.014
female sex differentiation GO:0046660 4 0.014
positive regulation of macromolecule metabolic process GO:0010604 93 0.014
regulation of gene expression epigenetic GO:0040029 11 0.014
striated muscle cell development GO:0055002 108 0.014
modification of morphology or physiology of other organism GO:0035821 4 0.014
cellular protein metabolic process GO:0044267 129 0.014
negative regulation of stem cell differentiation GO:2000737 2 0.014
protein import GO:0017038 3 0.014
striated muscle cell differentiation GO:0051146 129 0.014
neuron projection morphogenesis GO:0048812 161 0.014
protein polyubiquitination GO:0000209 4 0.014
regulation of cellular amino acid metabolic process GO:0006521 0 0.014
regulation of inflammatory response GO:0050727 2 0.014
cellular macromolecular complex assembly GO:0034622 24 0.014
chromatin organization GO:0006325 22 0.014
establishment of rna localization GO:0051236 3 0.013
negative regulation of mitosis GO:0045839 3 0.013
negative regulation of chromosome organization GO:2001251 1 0.013
regulation of cytokine production GO:0001817 3 0.013
mrna export from nucleus GO:0006406 1 0.013
cytoskeleton dependent cytokinesis GO:0061640 3 0.013
positive regulation of mrna metabolic process GO:1903313 2 0.013
negative regulation of defense response GO:0031348 2 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.013
neuroblast proliferation GO:0007405 2 0.013
wound healing GO:0042060 90 0.013
sexual reproduction GO:0019953 36 0.013
cellular response to endogenous stimulus GO:0071495 68 0.013
mesenchymal cell development GO:0014031 78 0.013
organic acid metabolic process GO:0006082 31 0.013
adult behavior GO:0030534 2 0.013
positive regulation of gene expression GO:0010628 71 0.013
positive regulation of biological process GO:0048518 253 0.013
regulation of anatomical structure morphogenesis GO:0022603 130 0.013
dna metabolic process GO:0006259 27 0.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.013
g2 dna damage checkpoint GO:0031572 3 0.013
negative regulation of metabolic process GO:0009892 86 0.013
positive regulation of immune effector process GO:0002699 3 0.013
response to glucose GO:0009749 3 0.013
cellular ketone metabolic process GO:0042180 11 0.013
centrosome duplication GO:0051298 1 0.013
interspecies interaction between organisms GO:0044419 4 0.013
response to carbohydrate GO:0009743 3 0.013
g1 s transition of mitotic cell cycle GO:0000082 1 0.013
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.013
positive regulation of cellular biosynthetic process GO:0031328 68 0.012
purine nucleoside monophosphate catabolic process GO:0009128 4 0.012
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 4 0.012
regulation of nucleocytoplasmic transport GO:0046822 2 0.012
response to ketone GO:1901654 1 0.012
positive regulation of cellular component biogenesis GO:0044089 3 0.012
rna export from nucleus GO:0006405 1 0.012
negative regulation of kinase activity GO:0033673 4 0.012
macromolecule modification GO:0043412 111 0.012
single organism transport GO:0044765 206 0.012
skeletal system development GO:0001501 181 0.012
camera type eye development GO:0043010 222 0.012
enzyme linked receptor protein signaling pathway GO:0007167 106 0.012
cellular component assembly involved in morphogenesis GO:0010927 107 0.012
cell proliferation GO:0008283 80 0.012
regulation of cell cycle GO:0051726 52 0.012
meiotic spindle organization GO:0000212 1 0.012
astrocyte differentiation GO:0048708 1 0.012
negative regulation of catabolic process GO:0009895 3 0.012
meiosis i GO:0007127 1 0.012
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.012
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.012
positive regulation of catabolic process GO:0009896 4 0.012
golgi vesicle transport GO:0048193 3 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.011
positive regulation of cellular process GO:0048522 201 0.011
embryonic cranial skeleton morphogenesis GO:0048701 90 0.011
brain development GO:0007420 293 0.011
negative regulation of nuclear division GO:0051784 3 0.011
keratinocyte differentiation GO:0030216 0 0.011
intracellular mrna localization GO:0008298 1 0.011
regulation of cellular component organization GO:0051128 86 0.011
mitotic g2 dna damage checkpoint GO:0007095 3 0.011
cell projection morphogenesis GO:0048858 244 0.011
centrosome cycle GO:0007098 1 0.011
cell substrate junction assembly GO:0007044 2 0.011
somatic muscle development GO:0007525 4 0.011
pole plasm assembly GO:0007315 4 0.011
epithelial cell differentiation GO:0030855 116 0.011
organelle localization GO:0051640 49 0.011
regulation of protein localization to nucleus GO:1900180 2 0.011
mitotic dna integrity checkpoint GO:0044774 4 0.011
negative regulation of protein kinase activity GO:0006469 4 0.011
muscle cell development GO:0055001 115 0.011
ribosomal small subunit biogenesis GO:0042274 2 0.011
nuclear envelope organization GO:0006998 2 0.011
mononuclear cell proliferation GO:0032943 1 0.011
compound eye development GO:0048749 2 0.011
negative regulation of signal transduction GO:0009968 94 0.011
negative regulation of mrna splicing via spliceosome GO:0048025 1 0.011
negative regulation of multicellular organismal process GO:0051241 69 0.011
multi organism reproductive process GO:0044703 36 0.010
spindle assembly GO:0051225 2 0.010
regulation of nucleoside metabolic process GO:0009118 2 0.010
phosphorus metabolic process GO:0006793 109 0.010
positive regulation of nucleic acid templated transcription GO:1903508 57 0.010
establishment of organelle localization GO:0051656 45 0.010
system process GO:0003008 185 0.010
nuclear division GO:0000280 23 0.010
blood vessel development GO:0001568 246 0.010
negative regulation of mrna processing GO:0050686 1 0.010
negative regulation of cell communication GO:0010648 96 0.010
pharyngeal system development GO:0060037 18 0.010
cellular localization GO:0051641 97 0.010

thoc1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.026
nervous system disease DOID:863 0 0.014
musculoskeletal system disease DOID:17 0 0.013
disease of cellular proliferation DOID:14566 0 0.012
cancer DOID:162 0 0.010
organ system cancer DOID:0050686 0 0.010