Danio rerio

75 known processes

ticam1

toll-like receptor adaptor molecule 1

(Aliases: trif)

ticam1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of multicellular organismal process GO:0051239 277 0.149
signal transduction GO:0007165 455 0.132
response to stress GO:0006950 263 0.112
Mouse
positive regulation of transport GO:0051050 2 0.105
type i interferon production GO:0032606 2 0.098
activation of immune response GO:0002253 9 0.096
Mouse
larval development GO:0002164 2 0.095
cellular response to biotic stimulus GO:0071216 3 0.093
Mouse
positive regulation of cytokine production GO:0001819 2 0.089
biosynthetic process GO:0009058 294 0.083
cellular response to molecule of bacterial origin GO:0071219 3 0.080
Mouse
protein secretion GO:0009306 1 0.075
positive regulation of immune effector process GO:0002699 3 0.065
regulation of cytokine production GO:0001817 3 0.061
response to chemical GO:0042221 320 0.061
Mouse
aging GO:0007568 2 0.060
response to other organism GO:0051707 97 0.060
Mouse
positive regulation of biological process GO:0048518 253 0.056
reactive nitrogen species metabolic process GO:2001057 0 0.056
regulation of biosynthetic process GO:0009889 250 0.056
positive regulation of secretion GO:0051047 1 0.055
regulation of nucleic acid templated transcription GO:1903506 213 0.054
Mouse
cellular response to external stimulus GO:0071496 2 0.054
organic cyclic compound metabolic process GO:1901360 301 0.053
Mouse
cellular biosynthetic process GO:0044249 286 0.053
multicellular organism growth GO:0035264 4 0.052
response to external biotic stimulus GO:0043207 97 0.051
Mouse
regulation of protein transport GO:0051223 3 0.051
nucleic acid metabolic process GO:0090304 244 0.051
Mouse
organic substance biosynthetic process GO:1901576 289 0.051
nitric oxide biosynthetic process GO:0006809 2 0.051
Mouse
reactive oxygen species metabolic process GO:0072593 6 0.050
regulation of establishment of protein localization GO:0070201 4 0.050
regulation of reactive oxygen species metabolic process GO:2000377 2 0.048
regulation of production of molecular mediator of immune response GO:0002700 1 0.048
response to external stimulus GO:0009605 264 0.046
Mouse
production of molecular mediator of immune response GO:0002440 2 0.045
embryonic organ development GO:0048568 381 0.044
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.043
vasculature development GO:0001944 278 0.042
immune system process GO:0002376 241 0.042
Mouse
single organism transport GO:0044765 206 0.041
defense response GO:0006952 47 0.040
Mouse
interspecies interaction between organisms GO:0044419 4 0.040
regulation of primary metabolic process GO:0080090 311 0.040
positive regulation of secretion by cell GO:1903532 1 0.040
nucleobase containing compound metabolic process GO:0006139 274 0.039
Mouse
regulation of rna biosynthetic process GO:2001141 213 0.039
Mouse
response to carbohydrate GO:0009743 3 0.039
regulation of gene expression GO:0010468 265 0.038
Mouse
tube morphogenesis GO:0035239 349 0.038
cellular nitrogen compound biosynthetic process GO:0044271 218 0.038
Mouse
blood vessel morphogenesis GO:0048514 216 0.037
cellular component movement GO:0006928 335 0.037
immunoglobulin mediated immune response GO:0016064 3 0.037
nucleocytoplasmic transport GO:0006913 4 0.037
nucleobase containing compound biosynthetic process GO:0034654 205 0.036
Mouse
cellular aromatic compound metabolic process GO:0006725 295 0.036
Mouse
cellular nitrogen compound metabolic process GO:0034641 290 0.035
Mouse
cellular response to nutrient levels GO:0031669 2 0.035
striated muscle cell differentiation GO:0051146 129 0.035
single organism localization GO:1902578 225 0.034
single organism nuclear import GO:1902593 3 0.034
rna biosynthetic process GO:0032774 181 0.034
Mouse
neuron differentiation GO:0030182 353 0.033
regulation of multicellular organism growth GO:0040014 4 0.033
regulation of cellular biosynthetic process GO:0031326 245 0.032
response to hexose GO:0009746 3 0.032
aromatic compound biosynthetic process GO:0019438 217 0.032
Mouse
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.031
response to organic substance GO:0010033 153 0.031
Mouse
gene expression GO:0010467 252 0.031
Mouse
heterocycle biosynthetic process GO:0018130 215 0.030
Mouse
lipid storage GO:0019915 1 0.030
organic cyclic compound biosynthetic process GO:1901362 223 0.030
Mouse
positive regulation of innate immune response GO:0045089 8 0.030
Mouse
response to abiotic stimulus GO:0009628 122 0.029
locomotion GO:0040011 313 0.029
b cell mediated immunity GO:0019724 3 0.029
response to biotic stimulus GO:0009607 97 0.029
Mouse
reactive oxygen species biosynthetic process GO:1903409 1 0.029
regulation of biological quality GO:0065008 263 0.028
establishment of localization GO:0051234 244 0.028
transport GO:0006810 220 0.028
stem cell division GO:0017145 1 0.028
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.027
negative regulation of cytokine production GO:0001818 1 0.027
response to molecule of bacterial origin GO:0002237 14 0.027
Mouse
response to drug GO:0042493 3 0.026
establishment of protein localization to organelle GO:0072594 4 0.026
regulation of inflammatory response GO:0050727 2 0.026
nuclear import GO:0051170 3 0.026
blood vessel development GO:0001568 246 0.026
regulation of localization GO:0032879 104 0.026
protein targeting to nucleus GO:0044744 3 0.026
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.025
Mouse
rna metabolic process GO:0016070 219 0.025
Mouse
establishment of endothelial barrier GO:0061028 3 0.025
cell migration GO:0016477 237 0.025
transcription dna templated GO:0006351 181 0.025
Mouse
positive regulation of cellular process GO:0048522 201 0.025
transmembrane transport GO:0055085 120 0.025
regulation of protein localization to nucleus GO:1900180 2 0.025
regulation of response to stimulus GO:0048583 269 0.024
immune response GO:0006955 28 0.024
Mouse
localization of cell GO:0051674 244 0.024
muscle cell differentiation GO:0042692 139 0.024
regulation of metal ion transport GO:0010959 4 0.023
positive regulation of stress activated mapk cascade GO:0032874 3 0.023
nitrogen compound metabolic process GO:0006807 319 0.023
Mouse
interferon beta production GO:0032608 1 0.023
chordate embryonic development GO:0043009 271 0.022
stem cell proliferation GO:0072089 4 0.022
cellular response to extracellular stimulus GO:0031668 2 0.022
response to glucose GO:0009749 3 0.022
multi organism process GO:0051704 134 0.022
Mouse
heterocycle metabolic process GO:0046483 290 0.022
Mouse
intracellular signal transduction GO:0035556 85 0.022
programmed cell death GO:0012501 119 0.022
Mouse
regulation of type i interferon production GO:0032479 2 0.022
regulation of dendrite development GO:0050773 3 0.022
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.022
response to glucocorticoid GO:0051384 1 0.022
growth GO:0040007 174 0.022
gastrulation GO:0007369 208 0.022
angiogenesis GO:0001525 158 0.021
cellular response to starvation GO:0009267 1 0.021
immune effector process GO:0002252 23 0.021
Mouse
regulation of macromolecule biosynthetic process GO:0010556 225 0.021
interaction with host GO:0051701 4 0.021
response to nutrient GO:0007584 3 0.021
response to vitamin GO:0033273 3 0.021
hematopoietic or lymphoid organ development GO:0048534 191 0.021
response to bacterium GO:0009617 58 0.020
Mouse
digestive tract morphogenesis GO:0048546 231 0.020
response to monosaccharide GO:0034284 3 0.020
cellular macromolecule metabolic process GO:0044260 391 0.020
Mouse
developmental growth GO:0048589 166 0.020
cell surface receptor signaling pathway GO:0007166 325 0.020
Mouse
muscle cell development GO:0055001 115 0.020
response to wounding GO:0009611 116 0.020
nuclear transport GO:0051169 4 0.020
regulation of innate immune response GO:0045088 11 0.019
Mouse
i kappab kinase nf kappab signaling GO:0007249 4 0.019
complement activation GO:0006956 3 0.019
phagocytosis GO:0006909 3 0.019
cellular response to lipopolysaccharide GO:0071222 3 0.019
Mouse
cellular amine metabolic process GO:0044106 2 0.019
protein import GO:0017038 3 0.019
protein import into nucleus GO:0006606 3 0.019
regulation of binding GO:0051098 3 0.019
Mouse
maintenance of location GO:0051235 4 0.019
nucleic acid templated transcription GO:0097659 181 0.019
Mouse
regulation of protein import into nucleus GO:0042306 2 0.019
amine metabolic process GO:0009308 2 0.019
cellular carbohydrate metabolic process GO:0044262 4 0.018
macromolecule biosynthetic process GO:0009059 227 0.018
regulation of cellular component movement GO:0051270 55 0.018
toll like receptor signaling pathway GO:0002224 4 0.018
Mouse
regulation of metabolic process GO:0019222 359 0.018
multicellular organismal metabolic process GO:0044236 2 0.018
regulation of nitrogen compound metabolic process GO:0051171 251 0.018
Mouse
activation of innate immune response GO:0002218 6 0.018
Mouse
establishment of protein localization to plasma membrane GO:0090002 1 0.018
regulation of locomotion GO:0040012 55 0.018
positive regulation of dna metabolic process GO:0051054 1 0.018
negative regulation of protein phosphorylation GO:0001933 4 0.018
cell morphogenesis GO:0000902 289 0.018
apoptotic process GO:0006915 116 0.018
Mouse
regulation of nucleocytoplasmic transport GO:0046822 2 0.017
regulation of apoptotic process GO:0042981 98 0.017
autophagy GO:0006914 4 0.017
innate immune response GO:0045087 13 0.017
Mouse
cellular response to chemical stimulus GO:0070887 157 0.017
Mouse
specification of symmetry GO:0009799 204 0.017
positive regulation of cell cycle GO:0045787 3 0.017
muscle structure development GO:0061061 196 0.017
guanosine containing compound catabolic process GO:1901069 2 0.017
protein localization to nucleus GO:0034504 3 0.017
regulation of immune system process GO:0002682 34 0.017
Mouse
regulation of cellular amine metabolic process GO:0033238 0 0.017
regulation of blood vessel size GO:0050880 2 0.017
defense response to bacterium GO:0042742 22 0.017
central nervous system development GO:0007417 387 0.017
immune system development GO:0002520 191 0.017
regulation of multicellular organismal development GO:2000026 223 0.017
b cell activation GO:0042113 2 0.017
Mouse
regulation of cellular amino acid metabolic process GO:0006521 0 0.017
neuron neuron synaptic transmission GO:0007270 1 0.017
regulation of organ growth GO:0046620 3 0.017
regulation of cytokine biosynthetic process GO:0042035 1 0.016
positive regulation of catabolic process GO:0009896 4 0.016
negative regulation of catabolic process GO:0009895 3 0.016
regulation of muscle contraction GO:0006937 3 0.016
gtp catabolic process GO:0006184 2 0.016
regulation of rna metabolic process GO:0051252 224 0.016
Mouse
gtp metabolic process GO:0046039 4 0.016
negative regulation of multicellular organismal process GO:0051241 69 0.016
regulation of response to nutrient levels GO:0032107 1 0.016
positive regulation of cell adhesion GO:0045785 1 0.016
regulation of cell migration GO:0030334 40 0.016
regulation of transcription dna templated GO:0006355 213 0.016
Mouse
stem cell maintenance GO:0019827 4 0.016
regulation of intracellular protein transport GO:0033157 3 0.016
response to corticosteroid GO:0031960 1 0.015
guanosine containing compound metabolic process GO:1901068 4 0.015
brain development GO:0007420 293 0.015
germ line stem cell division GO:0042078 1 0.015
regulation of synaptic plasticity GO:0048167 1 0.015
regionalization GO:0003002 274 0.015
regulation of cellular ketone metabolic process GO:0010565 7 0.015
regulation of autophagy GO:0010506 3 0.015
ion transmembrane transport GO:0034220 91 0.015
anion transport GO:0006820 38 0.015
generation of neurons GO:0048699 385 0.015
response to ketone GO:1901654 1 0.015
protein acetylation GO:0006473 2 0.015
small molecule metabolic process GO:0044281 77 0.015
regulation of immune effector process GO:0002697 5 0.015
regulation of tube size GO:0035150 2 0.015
somatic muscle development GO:0007525 4 0.015
regulation of signaling GO:0023051 235 0.015
protein localization to plasma membrane GO:0072659 1 0.015
regulation of cytoplasmic transport GO:1903649 4 0.015
hemopoiesis GO:0030097 183 0.015
pericardium development GO:0060039 1 0.015
regulation of macromolecule metabolic process GO:0060255 317 0.015
positive regulation of leukocyte mediated immunity GO:0002705 1 0.015
regulation of protein ubiquitination GO:0031396 3 0.015
Mouse
leukocyte migration GO:0050900 15 0.015
g1 s transition of mitotic cell cycle GO:0000082 1 0.015
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.015
Mouse
positive regulation of blood circulation GO:1903524 2 0.014
regulation of signal transduction GO:0009966 225 0.014
adult behavior GO:0030534 2 0.014
antimicrobial humoral response GO:0019730 2 0.014
carboxylic acid metabolic process GO:0019752 22 0.014
cell part morphogenesis GO:0032990 246 0.014
neuroblast proliferation GO:0007405 2 0.014
regulation of response to extracellular stimulus GO:0032104 1 0.014
cell motility GO:0048870 244 0.014
cellular component disassembly GO:0022411 1 0.014
regulation of cell activation GO:0050865 1 0.014
Mouse
protein metabolic process GO:0019538 183 0.014
system process GO:0003008 185 0.014
neuron development GO:0048666 262 0.014
circulatory system process GO:0003013 87 0.014
regulation of carbohydrate metabolic process GO:0006109 4 0.014
mononuclear cell proliferation GO:0032943 1 0.014
Mouse
modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051817 4 0.014
death GO:0016265 121 0.014
Mouse
cellular ketone metabolic process GO:0042180 11 0.013
regulation of ph GO:0006885 3 0.013
collagen metabolic process GO:0032963 2 0.013
organic acid metabolic process GO:0006082 31 0.013
multicellular organismal response to stress GO:0033555 2 0.013
regulation of protein catabolic process GO:0042176 1 0.013
negative regulation of cellular catabolic process GO:0031330 3 0.013
response to oxygen containing compound GO:1901700 55 0.013
Mouse
regulation of cell motility GO:2000145 46 0.013
striated muscle cell development GO:0055002 108 0.013
phosphatidylinositol mediated signaling GO:0048015 2 0.013
regulation of protein complex assembly GO:0043254 3 0.013
regulation of synapse assembly GO:0051963 3 0.013
determination of left right symmetry GO:0007368 179 0.013
cellular response to organic substance GO:0071310 105 0.013
Mouse
regulation of developmental process GO:0050793 247 0.013
head development GO:0060322 303 0.013
embryonic organ morphogenesis GO:0048562 274 0.013
single organism metabolic process GO:0044710 217 0.013
regulation of protein targeting GO:1903533 2 0.013
leukocyte proliferation GO:0070661 1 0.013
Mouse
organelle fusion GO:0048284 3 0.013
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.013
ameboidal type cell migration GO:0001667 143 0.013
negative regulation of cellular process GO:0048523 283 0.013
modification of morphology or physiology of other organism GO:0035821 4 0.013
internal peptidyl lysine acetylation GO:0018393 2 0.013
immune response regulating signaling pathway GO:0002764 5 0.013
Mouse
negative regulation of small gtpase mediated signal transduction GO:0051058 1 0.013
negative regulation of biological process GO:0048519 304 0.013
defense response to other organism GO:0098542 33 0.013
Mouse
regulation of cellular metabolic process GO:0031323 320 0.012
response to lipid GO:0033993 60 0.012
Mouse
organic substance transport GO:0071702 58 0.012
peptide transport GO:0015833 1 0.012
actin mediated cell contraction GO:0070252 1 0.012
energy reserve metabolic process GO:0006112 2 0.012
inner ear development GO:0048839 126 0.012
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.012
embryonic heart tube development GO:0035050 133 0.012
positive regulation of response to stimulus GO:0048584 80 0.012
positive regulation of cellular component biogenesis GO:0044089 3 0.012
oxoacid metabolic process GO:0043436 31 0.012
positive regulation of cell activation GO:0050867 1 0.012
Mouse
positive regulation of cytokine biosynthetic process GO:0042108 1 0.012
positive regulation of inflammatory response GO:0050729 1 0.012
morphogenesis of an epithelium GO:0002009 333 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
negative regulation of epithelial cell proliferation GO:0050680 1 0.012
long chain fatty acid metabolic process GO:0001676 1 0.012
tissue remodeling GO:0048771 4 0.012
determination of bilateral symmetry GO:0009855 204 0.012
cellular amino acid metabolic process GO:0006520 7 0.012
positive regulation of cellular catabolic process GO:0031331 3 0.012
regulation of programmed cell death GO:0043067 101 0.012
multicellular organismal macromolecule metabolic process GO:0044259 2 0.012
heart looping GO:0001947 94 0.012
negative regulation of multi organism process GO:0043901 3 0.012
regulation of anatomical structure morphogenesis GO:0022603 130 0.012
regulation of reproductive process GO:2000241 4 0.012
internal protein amino acid acetylation GO:0006475 2 0.012
negative regulation of ras protein signal transduction GO:0046580 1 0.012
modification dependent protein catabolic process GO:0019941 3 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.012
phagocytosis engulfment GO:0006911 1 0.011
regulation of synapse organization GO:0050807 3 0.011
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.011
heart development GO:0007507 313 0.011
regulation of skeletal muscle tissue development GO:0048641 4 0.011
positive regulation of multicellular organismal process GO:0051240 52 0.011
androgen metabolic process GO:0008209 2 0.011
transcription from rna polymerase ii promoter GO:0006366 80 0.011
regulation of leukocyte mediated immunity GO:0002703 1 0.011
response to decreased oxygen levels GO:0036293 25 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
carbohydrate homeostasis GO:0033500 1 0.011
regulation of cell development GO:0060284 100 0.011
cellular amide metabolic process GO:0043603 4 0.011
organonitrogen compound metabolic process GO:1901564 74 0.011
cellular response to stress GO:0033554 62 0.011
cell death GO:0008219 121 0.011
Mouse
response to alkaloid GO:0043279 2 0.011
rna localization GO:0006403 4 0.011
modification by symbiont of host morphology or physiology GO:0044003 4 0.011
positive regulation of jnk cascade GO:0046330 3 0.011
regulation of stem cell proliferation GO:0072091 2 0.011
negative regulation of defense response GO:0031348 2 0.011
endosomal transport GO:0016197 2 0.011
regulation of wound healing GO:0061041 2 0.011
modification dependent macromolecule catabolic process GO:0043632 3 0.011
peptidyl lysine acetylation GO:0018394 2 0.011
sensory perception of chemical stimulus GO:0007606 3 0.011
female sex differentiation GO:0046660 4 0.011
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.011
regulation of blood pressure GO:0008217 1 0.011
sensory perception of pain GO:0019233 1 0.011
regulation of nucleotide catabolic process GO:0030811 2 0.011
germ line stem cell maintenance GO:0030718 2 0.011
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.011
membrane fusion GO:0061025 2 0.011
regulation of purine nucleotide catabolic process GO:0033121 2 0.011
cell projection organization GO:0030030 284 0.011
humoral immune response mediated by circulating immunoglobulin GO:0002455 3 0.011
regulation of nervous system development GO:0051960 90 0.011
embryo development ending in birth or egg hatching GO:0009792 271 0.011
regulation of dna replication GO:0006275 3 0.011
synaptic transmission cholinergic GO:0007271 4 0.011
lymphocyte proliferation GO:0046651 1 0.011
Mouse
negative regulation of protein kinase activity GO:0006469 4 0.011
epithelial tube morphogenesis GO:0060562 148 0.011
peptide metabolic process GO:0006518 1 0.011
hormone biosynthetic process GO:0042446 3 0.011
somite development GO:0061053 96 0.011
innate immune response activating signal transduction GO:0002758 5 0.011
Mouse
membrane invagination GO:0010324 1 0.011
cell cycle g1 s phase transition GO:0044843 1 0.011
regulation of nucleoside metabolic process GO:0009118 2 0.010
macroautophagy GO:0016236 1 0.010
negative regulation of intracellular transport GO:0032387 3 0.010
synaptic growth at neuromuscular junction GO:0051124 2 0.010
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.010
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.010
Mouse
neurotransmitter secretion GO:0007269 2 0.010
cell matrix adhesion GO:0007160 4 0.010
atp catabolic process GO:0006200 4 0.010
embryonic hemopoiesis GO:0035162 53 0.010
leukocyte mediated cytotoxicity GO:0001909 1 0.010
small gtpase mediated signal transduction GO:0007264 8 0.010
cellular response to lipid GO:0071396 39 0.010
Mouse
cell substrate adhesion GO:0031589 4 0.010
cytokine metabolic process GO:0042107 1 0.010
fatty acid transport GO:0015908 1 0.010
synaptic vesicle localization GO:0097479 1 0.010
protein homooligomerization GO:0051260 3 0.010
protein activation cascade GO:0072376 6 0.010
striated muscle tissue development GO:0014706 110 0.010

ticam1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.026
nervous system disease DOID:863 0 0.024
sensory system disease DOID:0050155 0 0.014
eye and adnexa disease DOID:1492 0 0.014
musculoskeletal system disease DOID:17 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
cancer DOID:162 0 0.013
disease of metabolism DOID:0014667 0 0.012
inherited metabolic disorder DOID:655 0 0.012
organ system cancer DOID:0050686 0 0.011