Danio rerio

0 known processes

tjp2a

tight junction protein 2a (zona occludens 2)

(Aliases: tjp2.1,wu:fb10a11,zo-2.1)

tjp2a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell motility GO:0048870 244 0.380
localization of cell GO:0051674 244 0.232
morphogenesis of an epithelium GO:0002009 333 0.223
Fly
heart looping GO:0001947 94 0.139
regulation of multicellular organismal process GO:0051239 277 0.136
Fly
cellular component movement GO:0006928 335 0.120
determination of left right symmetry GO:0007368 179 0.094
protein modification process GO:0036211 100 0.087
synaptic growth at neuromuscular junction GO:0051124 2 0.086
anterior posterior pattern specification GO:0009952 152 0.077
cell surface receptor signaling pathway GO:0007166 325 0.076
cellular component biogenesis GO:0044085 178 0.075
Fly
embryonic heart tube development GO:0035050 133 0.073
protein polymerization GO:0051258 4 0.073
mesenchyme development GO:0060485 127 0.069
regulation of synapse assembly GO:0051963 3 0.069
positive regulation of protein complex assembly GO:0031334 2 0.069
regulation of synapse organization GO:0050807 3 0.067
regulation of signaling GO:0023051 235 0.065
actin filament based movement GO:0030048 1 0.064
cardiac chamber development GO:0003205 19 0.063
cellular protein modification process GO:0006464 100 0.062
specification of symmetry GO:0009799 204 0.062
sensory organ development GO:0007423 393 0.059
Fly
cellular response to external stimulus GO:0071496 2 0.059
determination of heart left right asymmetry GO:0061371 117 0.059
cell migration GO:0016477 237 0.058
negative regulation of stem cell differentiation GO:2000737 2 0.058
regulation of establishment of protein localization GO:0070201 4 0.057
regulation of intracellular protein transport GO:0033157 3 0.057
regulation of cell communication GO:0010646 232 0.057
ameboidal type cell migration GO:0001667 143 0.055
cellular component assembly GO:0022607 170 0.054
Fly
sensory perception GO:0007600 39 0.054
regulation of protein import into nucleus GO:0042306 2 0.054
heart morphogenesis GO:0003007 156 0.053
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.053
cell projection organization GO:0030030 284 0.052
Fly
actin polymerization or depolymerization GO:0008154 2 0.052
central nervous system development GO:0007417 387 0.052
desmosome organization GO:0002934 3 0.052
negative regulation of kinase activity GO:0033673 4 0.050
release of sequestered calcium ion into cytosol GO:0051209 3 0.048
single organism nuclear import GO:1902593 3 0.048
regulation of response to oxidative stress GO:1902882 2 0.048
system process GO:0003008 185 0.048
epithelial tube morphogenesis GO:0060562 148 0.048
Fly
developmental growth GO:0048589 166 0.046
cellular response to radiation GO:0071478 4 0.046
regulation of embryonic development GO:0045995 47 0.045
Fly
cellular response to extracellular stimulus GO:0031668 2 0.045
homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 4 0.045
positive regulation of transport GO:0051050 2 0.045
epithelial cell morphogenesis GO:0003382 2 0.044
head development GO:0060322 303 0.043
cell proliferation GO:0008283 80 0.043
epithelial cell differentiation GO:0030855 116 0.043
embryonic heart tube morphogenesis GO:0003143 108 0.042
regulation of multicellular organismal development GO:2000026 223 0.042
Fly
regulation of muscle contraction GO:0006937 3 0.042
regulation of signal transduction GO:0009966 225 0.042
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.041
negative regulation of cellular process GO:0048523 283 0.041
renal system development GO:0072001 94 0.041
digestive tract development GO:0048565 265 0.041
adherens junction organization GO:0034332 4 0.041
Fly
cellular macromolecule metabolic process GO:0044260 391 0.041
regulation of cell motility GO:2000145 46 0.041
wnt signaling pathway GO:0016055 80 0.040
actin filament polymerization GO:0030041 2 0.040
blood vessel development GO:0001568 246 0.040
adult behavior GO:0030534 2 0.040
kidney development GO:0001822 92 0.040
regulation of anatomical structure morphogenesis GO:0022603 130 0.040
Fly
negative regulation of sequestering of calcium ion GO:0051283 4 0.039
regulation of blood pressure GO:0008217 1 0.039
response to abiotic stimulus GO:0009628 122 0.039
female sex differentiation GO:0046660 4 0.039
multicellular organism growth GO:0035264 4 0.038
protein targeting to nucleus GO:0044744 3 0.038
negative regulation of biological process GO:0048519 304 0.038
regulation of wnt signaling pathway GO:0030111 53 0.038
nuclear migration GO:0007097 3 0.038
carboxylic acid metabolic process GO:0019752 22 0.037
glucose import GO:0046323 2 0.037
regulation of cytoplasmic transport GO:1903649 4 0.037
regulation of vasculature development GO:1901342 33 0.037
odontogenesis of dentin containing tooth GO:0042475 1 0.036
stem cell proliferation GO:0072089 4 0.035
regulation of mrna processing GO:0050684 3 0.035
positive regulation of cellular component biogenesis GO:0044089 3 0.035
negative regulation of protein phosphorylation GO:0001933 4 0.034
regionalization GO:0003002 274 0.034
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016339 2 0.034
locomotor rhythm GO:0045475 3 0.034
response to stress GO:0006950 263 0.034
macromolecule modification GO:0043412 111 0.033
regulation of glucose transport GO:0010827 1 0.033
locomotion GO:0040011 313 0.033
eye development GO:0001654 277 0.032
Fly
regulation of circadian rhythm GO:0042752 4 0.032
regulation of protein transport GO:0051223 3 0.032
calcium ion transport into cytosol GO:0060402 3 0.031
oxoacid metabolic process GO:0043436 31 0.031
ras protein signal transduction GO:0007265 7 0.031
macromolecular complex assembly GO:0065003 35 0.031
determination of bilateral symmetry GO:0009855 204 0.031
cellular ketone metabolic process GO:0042180 11 0.031
regulation of cell migration GO:0030334 40 0.030
nuclear transport GO:0051169 4 0.030
regulation of response to stimulus GO:0048583 269 0.030
organic acid metabolic process GO:0006082 31 0.030
macroautophagy GO:0016236 1 0.030
regulation of tube size GO:0035150 2 0.029
single organism organelle organization GO:1902589 199 0.029
cellular response to starvation GO:0009267 1 0.029
segmentation GO:0035282 97 0.029
cellular carbohydrate metabolic process GO:0044262 4 0.029
regulation of sequestering of calcium ion GO:0051282 4 0.029
regulation of macromolecule metabolic process GO:0060255 317 0.029
response to decreased oxygen levels GO:0036293 25 0.028
digestive system development GO:0055123 289 0.028
negative regulation of multicellular organismal process GO:0051241 69 0.028
stem cell differentiation GO:0048863 117 0.028
detection of external stimulus GO:0009581 24 0.028
heterocycle biosynthetic process GO:0018130 215 0.027
angiogenesis GO:0001525 158 0.027
sequestering of calcium ion GO:0051208 3 0.027
regulation of protein localization to nucleus GO:1900180 2 0.027
nucleocytoplasmic transport GO:0006913 4 0.027
regulation of endocrine process GO:0044060 2 0.027
regulation of wound healing GO:0061041 2 0.027
vasculature development GO:0001944 278 0.026
cellular localization GO:0051641 97 0.026
regulation of reproductive process GO:2000241 4 0.026
regulation of cellular metabolic process GO:0031323 320 0.026
response to endogenous stimulus GO:0009719 83 0.026
cellular response to light stimulus GO:0071482 4 0.026
leukocyte chemotaxis GO:0030595 12 0.026
urogenital system development GO:0001655 97 0.026
regulation of nucleocytoplasmic transport GO:0046822 2 0.025
protein import into nucleus GO:0006606 3 0.025
regulation of stem cell proliferation GO:0072091 2 0.025
positive regulation of cytokine production GO:0001819 2 0.025
response to chemical GO:0042221 320 0.025
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.025
maintenance of location GO:0051235 4 0.025
cellular protein metabolic process GO:0044267 129 0.025
nuclear import GO:0051170 3 0.024
regulation of developmental process GO:0050793 247 0.024
Fly
ribosomal small subunit biogenesis GO:0042274 2 0.024
biological adhesion GO:0022610 40 0.024
Fly
regulation of membrane potential GO:0042391 23 0.024
detection of abiotic stimulus GO:0009582 24 0.024
neuroblast proliferation GO:0007405 2 0.023
regulation of reactive oxygen species metabolic process GO:2000377 2 0.023
regulation of striated muscle contraction GO:0006942 2 0.023
single organism transport GO:0044765 206 0.023
regulation of cellular protein metabolic process GO:0032268 52 0.023
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.023
multicellular organismal metabolic process GO:0044236 2 0.023
regulation of cytokine production GO:0001817 3 0.023
determination of dorsal ventral asymmetry GO:0048262 34 0.022
circulatory system process GO:0003013 87 0.022
aging GO:0007568 2 0.022
embryonic organ morphogenesis GO:0048562 274 0.022
regulation of synapse structure and activity GO:0050803 5 0.022
nucleobase containing compound metabolic process GO:0006139 274 0.022
taxis GO:0042330 109 0.022
establishment of protein localization to organelle GO:0072594 4 0.022
neural crest cell migration GO:0001755 42 0.022
negative regulation of cell death GO:0060548 60 0.022
protein import GO:0017038 3 0.021
autophagy GO:0006914 4 0.021
regulation of stem cell differentiation GO:2000736 4 0.021
regulation of mrna catabolic process GO:0061013 3 0.021
growth GO:0040007 174 0.021
cell morphogenesis involved in differentiation GO:0000904 195 0.021
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.021
dorsal motor nucleus of vagus nerve development GO:0021744 4 0.021
negative regulation of protein kinase activity GO:0006469 4 0.021
cell projection morphogenesis GO:0048858 244 0.021
Fly
larval development GO:0002164 2 0.021
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.020
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.020
regulation of carbohydrate metabolic process GO:0006109 4 0.020
establishment of endothelial barrier GO:0061028 3 0.020
regulation of receptor mediated endocytosis GO:0048259 4 0.020
action potential GO:0001508 19 0.020
cell cell junction organization GO:0045216 10 0.020
Fly
positive regulation of protein polymerization GO:0032273 2 0.020
developmental programmed cell death GO:0010623 4 0.020
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.020
cellular modified amino acid metabolic process GO:0006575 3 0.020
cognition GO:0050890 1 0.020
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.020
protein metabolic process GO:0019538 183 0.019
regulation of glucose import GO:0046324 1 0.019
regulation of multicellular organism growth GO:0040014 4 0.019
embryonic organ development GO:0048568 381 0.019
response to xenobiotic stimulus GO:0009410 45 0.018
protein complex disassembly GO:0043241 1 0.018
cellular response to nutrient levels GO:0031669 2 0.018
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.018
positive regulation of epithelial cell migration GO:0010634 2 0.018
cytosolic calcium ion transport GO:0060401 3 0.018
cellular response to hypoxia GO:0071456 1 0.018
regulation of gene expression GO:0010468 265 0.017
cellular component disassembly GO:0022411 1 0.017
organelle organization GO:0006996 227 0.017
cellular transition metal ion homeostasis GO:0046916 3 0.017
aorta development GO:0035904 4 0.017
ventricular cardiac muscle tissue development GO:0003229 3 0.017
response to drug GO:0042493 3 0.017
neural crest cell development GO:0014032 62 0.017
response to external stimulus GO:0009605 264 0.017
regulation of cellular component movement GO:0051270 55 0.017
regulation of blood vessel size GO:0050880 2 0.016
cellular amine metabolic process GO:0044106 2 0.016
establishment of nucleus localization GO:0040023 7 0.016
blood vessel endothelial cell migration GO:0043534 18 0.016
positive regulation of cytoskeleton organization GO:0051495 3 0.016
multi organism process GO:0051704 134 0.016
positive regulation of ras protein signal transduction GO:0046579 1 0.016
protein dephosphorylation GO:0006470 3 0.016
tube morphogenesis GO:0035239 349 0.016
Fly
water homeostasis GO:0030104 4 0.016
protein complex biogenesis GO:0070271 30 0.016
protein localization to nucleus GO:0034504 3 0.016
regulation of blood coagulation GO:0030193 1 0.016
regulation of localization GO:0032879 104 0.016
negative regulation of cell differentiation GO:0045596 46 0.016
desmosome assembly GO:0002159 2 0.016
signal transduction GO:0007165 455 0.016
amine metabolic process GO:0009308 2 0.016
regulation of anterior head development GO:2000742 2 0.015
regulation of cell cell adhesion GO:0022407 13 0.015
aromatic compound biosynthetic process GO:0019438 217 0.015
sequestering of metal ion GO:0051238 3 0.015
cell cell junction maintenance GO:0045217 1 0.015
myotube differentiation GO:0014902 45 0.015
regulation of blood circulation GO:1903522 32 0.015
regulation of establishment or maintenance of cell polarity GO:0032878 2 0.015
macromolecular complex disassembly GO:0032984 1 0.015
response to organic cyclic compound GO:0014070 51 0.015
regulation of cell differentiation GO:0045595 142 0.015
monoamine transport GO:0015844 1 0.015
glomerular filtration GO:0003094 6 0.014
response to carbohydrate GO:0009743 3 0.014
pigmentation GO:0043473 85 0.014
tissue migration GO:0090130 37 0.014
renal filtration GO:0097205 10 0.014
muscle attachment GO:0016203 9 0.014
innervation GO:0060384 3 0.014
adherens junction assembly GO:0034333 1 0.014
Fly
intracellular transport GO:0046907 32 0.014
phosphorus metabolic process GO:0006793 109 0.014
endocrine process GO:0050886 2 0.014
cell morphogenesis GO:0000902 289 0.014
Fly
specification of organ identity GO:0010092 2 0.014
lymph vessel development GO:0001945 27 0.014
regulation of organ morphogenesis GO:2000027 35 0.014
regulation of cellular response to oxidative stress GO:1900407 2 0.014
wnt signaling pathway involved in digestive tract morphogenesis GO:0044333 4 0.014
notochord development GO:0030903 54 0.014
regulation of cell projection assembly GO:0060491 4 0.014
regulation of cellular amino acid metabolic process GO:0006521 0 0.014
detection of stimulus GO:0051606 29 0.014
stem cell maintenance GO:0019827 4 0.014
heart jogging GO:0003146 40 0.013
adherens junction maintenance GO:0034334 2 0.013
establishment of organelle localization GO:0051656 45 0.013
muscle organ development GO:0007517 101 0.013
macromolecular complex subunit organization GO:0043933 74 0.013
chemosensory behavior GO:0007635 1 0.013
response to oxygen levels GO:0070482 25 0.013
lipid storage GO:0019915 1 0.013
cardiac cell fate commitment GO:0060911 1 0.013
phosphate containing compound metabolic process GO:0006796 108 0.013
protein phosphorylation GO:0006468 47 0.013
leukocyte proliferation GO:0070661 1 0.013
stem cell development GO:0048864 82 0.013
muscle structure development GO:0061061 196 0.013
fin development GO:0033333 77 0.013
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.013
renal system process involved in regulation of systemic arterial blood pressure GO:0003071 1 0.013
regulation of angiogenesis GO:0045765 26 0.013
rna metabolic process GO:0016070 219 0.013
regulation of epithelial cell proliferation GO:0050678 3 0.013
immune system development GO:0002520 191 0.013
rna 3 end processing GO:0031123 2 0.013
organic substance transport GO:0071702 58 0.013
endocrine hormone secretion GO:0060986 2 0.013
regulation of protein complex assembly GO:0043254 3 0.012
smooth muscle contraction GO:0006939 2 0.012
regulation of hemostasis GO:1900046 1 0.012
single organism cell adhesion GO:0098602 29 0.012
Fly
regulation of metal ion transport GO:0010959 4 0.012
blood circulation GO:0008015 87 0.012
protein k48 linked ubiquitination GO:0070936 1 0.012
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.012
actin filament based process GO:0030029 64 0.012
regulation of epithelial to mesenchymal transition GO:0010717 3 0.012
multi organism reproductive process GO:0044703 36 0.012
regulation of wnt signaling pathway involved in heart development GO:0003307 2 0.012
regulation of epithelial cell migration GO:0010632 5 0.012
organonitrogen compound metabolic process GO:1901564 74 0.012
defense response to fungus GO:0050832 2 0.012
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 2 0.012
mitochondrion organization GO:0007005 4 0.012
gastrulation GO:0007369 208 0.012
cell cell signaling involved in cell fate commitment GO:0045168 12 0.012
Fly
chordate embryonic development GO:0043009 271 0.012
positive regulation of blood circulation GO:1903524 2 0.012
organelle localization GO:0051640 49 0.012
small molecule metabolic process GO:0044281 77 0.012
regulation of phospholipase c activity GO:1900274 1 0.012
gene expression GO:0010467 252 0.012
negative regulation of tor signaling GO:0032007 2 0.012
intracellular signal transduction GO:0035556 85 0.012
regulation of cell death GO:0010941 103 0.012
regulation of cell projection organization GO:0031344 44 0.011
regulation of cellular amine metabolic process GO:0033238 0 0.011
chondrocyte development GO:0002063 4 0.011
regulation of rho protein signal transduction GO:0035023 2 0.011
cell death GO:0008219 121 0.011
locomotory behavior GO:0007626 34 0.011
cellular response to endogenous stimulus GO:0071495 68 0.011
transcription from rna polymerase ii promoter GO:0006366 80 0.011
meiotic spindle organization GO:0000212 1 0.011
cellular aromatic compound metabolic process GO:0006725 295 0.011
cellular component maintenance GO:0043954 3 0.011
behavior GO:0007610 74 0.011
transport GO:0006810 220 0.011
somite development GO:0061053 96 0.011
granulocyte chemotaxis GO:0071621 11 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.011
negative regulation of epithelial cell proliferation GO:0050680 1 0.011
regulation of systemic arterial blood pressure GO:0003073 1 0.011
regulation of fibroblast growth factor receptor signaling pathway GO:0040036 20 0.011
establishment of localization GO:0051234 244 0.011
entrainment of circadian clock GO:0009649 2 0.011
leukocyte migration GO:0050900 15 0.011
specification of axis polarity GO:0065001 4 0.011
regulation of heart growth GO:0060420 2 0.011
positive regulation of secretion by cell GO:1903532 1 0.011
positive regulation of myeloid cell differentiation GO:0045639 2 0.011
response to nutrient GO:0007584 3 0.011
regulation of myotube differentiation GO:0010830 2 0.011
regulation of coagulation GO:0050818 2 0.010
morphogenesis of an epithelial sheet GO:0002011 49 0.010
positive regulation of jnk cascade GO:0046330 3 0.010
regulation of cell shape GO:0008360 1 0.010
Fly
zymogen activation GO:0031638 3 0.010
regulation of organ growth GO:0046620 3 0.010
single organism localization GO:1902578 225 0.010
establishment or maintenance of polarity of embryonic epithelium GO:0016332 2 0.010
response to organic substance GO:0010033 153 0.010
cytoskeleton organization GO:0007010 96 0.010
positive regulation of multicellular organismal process GO:0051240 52 0.010
negative regulation of biosynthetic process GO:0009890 55 0.010
fertilization GO:0009566 3 0.010
lymphangiogenesis GO:0001946 25 0.010
cardiac atrium development GO:0003230 4 0.010
regulation of primary metabolic process GO:0080090 311 0.010
neural crest cell differentiation GO:0014033 72 0.010

tjp2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cardiovascular system disease DOID:1287 0 0.312
disease of anatomical entity DOID:7 0 0.312
Human
muscle tissue disease DOID:66 0 0.104
musculoskeletal system disease DOID:17 0 0.104
myopathy DOID:423 0 0.104
muscular disease DOID:0080000 0 0.104
intrinsic cardiomyopathy DOID:0060036 0 0.104
cardiomyopathy DOID:0050700 0 0.104
heart disease DOID:114 0 0.104
disease of cellular proliferation DOID:14566 0 0.012
organ system cancer DOID:0050686 0 0.012
cancer DOID:162 0 0.012