Danio rerio

0 known processes

tk2

thymidine kinase 2, mitochondrial

(Aliases: zgc:100948)

tk2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.200
mitochondrion organization GO:0007005 4 0.137
aging GO:0007568 2 0.092
purine nucleoside monophosphate catabolic process GO:0009128 4 0.084
nitrogen compound metabolic process GO:0006807 319 0.068
response to topologically incorrect protein GO:0035966 2 0.066
maintenance of location GO:0051235 4 0.066
regulation of cell death GO:0010941 103 0.061
olfactory bulb development GO:0021772 4 0.058
proteasomal protein catabolic process GO:0010498 2 0.054
cellular modified amino acid metabolic process GO:0006575 3 0.052
response to oxygen radical GO:0000305 2 0.051
circulatory system process GO:0003013 87 0.051
entrainment of circadian clock GO:0009649 2 0.049
regulation of tube size GO:0035150 2 0.048
cell substrate adhesion GO:0031589 4 0.047
ribonucleoside monophosphate catabolic process GO:0009158 4 0.047
biosynthetic process GO:0009058 294 0.047
system process GO:0003008 185 0.047
cellular macromolecule biosynthetic process GO:0034645 224 0.046
positive regulation of cell cycle GO:0045787 3 0.046
lipid storage GO:0019915 1 0.044
alpha amino acid metabolic process GO:1901605 3 0.044
nucleoside monophosphate catabolic process GO:0009125 4 0.044
organic cyclic compound metabolic process GO:1901360 301 0.043
locomotion GO:0040011 313 0.043
carboxylic acid metabolic process GO:0019752 22 0.043
regulation of metabolic process GO:0019222 359 0.043
signal transduction GO:0007165 455 0.042
head development GO:0060322 303 0.041
blood circulation GO:0008015 87 0.041
single organism metabolic process GO:0044710 217 0.040
regulation of autophagy GO:0010506 3 0.040
olfactory lobe development GO:0021988 4 0.040
gastrulation GO:0007369 208 0.039
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.039
organic acid metabolic process GO:0006082 31 0.038
regulation of nitrogen compound metabolic process GO:0051171 251 0.038
lipid homeostasis GO:0055088 3 0.036
establishment of localization GO:0051234 244 0.036
regulation of synaptic plasticity GO:0048167 1 0.036
regulation of nucleic acid templated transcription GO:1903506 213 0.035
regulation of rna biosynthetic process GO:2001141 213 0.035
negative regulation of biological process GO:0048519 304 0.035
female sex differentiation GO:0046660 4 0.034
cellular response to radiation GO:0071478 4 0.034
very long chain fatty acid metabolic process GO:0000038 4 0.034
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.034
fatty acid biosynthetic process GO:0006633 4 0.034
nucleobase containing compound metabolic process GO:0006139 274 0.034
central nervous system development GO:0007417 387 0.033
digestive system development GO:0055123 289 0.033
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.033
modification dependent protein catabolic process GO:0019941 3 0.033
cellular macromolecule metabolic process GO:0044260 391 0.033
nuclear transport GO:0051169 4 0.033
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.033
transport GO:0006810 220 0.032
positive regulation of apoptotic signaling pathway GO:2001235 1 0.031
atp catabolic process GO:0006200 4 0.031
response to nutrient GO:0007584 3 0.031
oxoacid metabolic process GO:0043436 31 0.031
regulation of developmental process GO:0050793 247 0.031
digestive tract morphogenesis GO:0048546 231 0.031
negative regulation of protein import into nucleus GO:0042308 2 0.030
regulation of protein ubiquitination GO:0031396 3 0.030
cellular nitrogen compound metabolic process GO:0034641 290 0.030
regulation of macromolecule metabolic process GO:0060255 317 0.030
peptide metabolic process GO:0006518 1 0.030
reciprocal meiotic recombination GO:0007131 1 0.029
regulation of cell activation GO:0050865 1 0.029
regulation of blood vessel size GO:0050880 2 0.029
cellular response to external stimulus GO:0071496 2 0.028
response to stress GO:0006950 263 0.028
transcription from rna polymerase ii promoter GO:0006366 80 0.028
positive regulation of biological process GO:0048518 253 0.027
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.027
nucleic acid metabolic process GO:0090304 244 0.027
positive regulation of catabolic process GO:0009896 4 0.026
modification dependent macromolecule catabolic process GO:0043632 3 0.026
chordate embryonic development GO:0043009 271 0.026
carbohydrate homeostasis GO:0033500 1 0.026
embryo development ending in birth or egg hatching GO:0009792 271 0.026
organic cyclic compound biosynthetic process GO:1901362 223 0.026
positive regulation of cellular catabolic process GO:0031331 3 0.026
guanosine containing compound catabolic process GO:1901069 2 0.025
heart development GO:0007507 313 0.025
extrinsic apoptotic signaling pathway GO:0097191 3 0.025
locomotory behavior GO:0007626 34 0.024
regulation of signal transduction GO:0009966 225 0.024
regulation of primary metabolic process GO:0080090 311 0.024
small molecule metabolic process GO:0044281 77 0.024
regulation of rna metabolic process GO:0051252 224 0.024
negative regulation of protein kinase activity GO:0006469 4 0.024
macromolecule biosynthetic process GO:0009059 227 0.024
regulation of nucleotide catabolic process GO:0030811 2 0.024
transmembrane transport GO:0055085 120 0.024
cell migration GO:0016477 237 0.024
regulation of inflammatory response GO:0050727 2 0.024
regulation of biological quality GO:0065008 263 0.023
single organism biosynthetic process GO:0044711 71 0.023
guanosine containing compound metabolic process GO:1901068 4 0.023
organonitrogen compound metabolic process GO:1901564 74 0.023
g1 s transition of mitotic cell cycle GO:0000082 1 0.023
response to oxidative stress GO:0006979 11 0.023
neurological system process GO:0050877 62 0.023
reactive oxygen species biosynthetic process GO:1903409 1 0.023
regulation of multicellular organism growth GO:0040014 4 0.023
carboxylic acid biosynthetic process GO:0046394 12 0.023
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.023
release of sequestered calcium ion into cytosol GO:0051209 3 0.022
negative regulation of protein phosphorylation GO:0001933 4 0.022
positive regulation of map kinase activity GO:0043406 3 0.022
autophagy GO:0006914 4 0.022
cellular amide metabolic process GO:0043603 4 0.022
intracellular signal transduction GO:0035556 85 0.022
oxidation reduction process GO:0055114 41 0.022
regulation of blood pressure GO:0008217 1 0.022
skin development GO:0043588 54 0.022
heterocycle metabolic process GO:0046483 290 0.022
digestive tract development GO:0048565 265 0.022
positive regulation of cell adhesion GO:0045785 1 0.021
cellular amino acid biosynthetic process GO:0008652 2 0.021
positive regulation of translation GO:0045727 1 0.021
adult behavior GO:0030534 2 0.021
lateral inhibition GO:0046331 1 0.021
hindbrain development GO:0030902 91 0.021
regulation of cellular metabolic process GO:0031323 320 0.021
regulation of cytokine production GO:0001817 3 0.021
rna metabolic process GO:0016070 219 0.021
nucleobase containing compound biosynthetic process GO:0034654 205 0.021
photoreceptor cell development GO:0042461 40 0.020
regulation of response to stimulus GO:0048583 269 0.020
cellular biosynthetic process GO:0044249 286 0.020
multicellular organismal response to stress GO:0033555 2 0.020
regulation of signaling GO:0023051 235 0.020
response to biotic stimulus GO:0009607 97 0.020
regulation of dna templated transcription in response to stress GO:0043620 0 0.020
regionalization GO:0003002 274 0.020
positive regulation of stress activated mapk cascade GO:0032874 3 0.020
regulation of macromolecule biosynthetic process GO:0010556 225 0.020
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.020
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.020
b cell differentiation GO:0030183 1 0.020
cellular aromatic compound metabolic process GO:0006725 295 0.020
mitochondrial transport GO:0006839 2 0.020
positive regulation of cytokine production GO:0001819 2 0.019
locomotor rhythm GO:0045475 3 0.019
regulation of production of molecular mediator of immune response GO:0002700 1 0.019
endocardium morphogenesis GO:0003160 4 0.019
sensory organ development GO:0007423 393 0.019
regulation of reproductive process GO:2000241 4 0.019
cellular response to extracellular stimulus GO:0031668 2 0.019
regulation of binding GO:0051098 3 0.019
lipid metabolic process GO:0006629 52 0.019
negative regulation of epithelial cell proliferation GO:0050680 1 0.019
positive regulation of jnk cascade GO:0046330 3 0.019
protein localization to nucleus GO:0034504 3 0.019
positive regulation of gene expression GO:0010628 71 0.019
regulation of protein transport GO:0051223 3 0.019
brain development GO:0007420 293 0.019
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.019
negative regulation of kinase activity GO:0033673 4 0.019
negative regulation of cellular process GO:0048523 283 0.019
meiosis i GO:0007127 1 0.019
peripheral nervous system development GO:0007422 55 0.019
cellular response to nutrient levels GO:0031669 2 0.019
anterior posterior pattern specification GO:0009952 152 0.019
hormone biosynthetic process GO:0042446 3 0.018
negative regulation of macromolecule metabolic process GO:0010605 76 0.018
gtp metabolic process GO:0046039 4 0.018
regulation of purine nucleotide catabolic process GO:0033121 2 0.018
organic substance biosynthetic process GO:1901576 289 0.018
regulation of multicellular organismal development GO:2000026 223 0.018
ion transmembrane transport GO:0034220 91 0.018
cellular amine metabolic process GO:0044106 2 0.018
regulation of circadian rhythm GO:0042752 4 0.018
response to organic substance GO:0010033 153 0.018
very long chain fatty acid biosynthetic process GO:0042761 4 0.018
single organism transport GO:0044765 206 0.018
immune system process GO:0002376 241 0.018
regulation of response to oxidative stress GO:1902882 2 0.018
regulation of establishment of protein localization GO:0070201 4 0.018
cation transport GO:0006812 81 0.018
single organism localization GO:1902578 225 0.018
regulation of membrane potential GO:0042391 23 0.018
small molecule biosynthetic process GO:0044283 16 0.018
gtp catabolic process GO:0006184 2 0.018
synaptic growth at neuromuscular junction GO:0051124 2 0.017
cellular response to oxygen radical GO:0071450 2 0.017
developmental programmed cell death GO:0010623 4 0.017
cellular response to light stimulus GO:0071482 4 0.017
cellular nitrogen compound biosynthetic process GO:0044271 218 0.017
response to monosaccharide GO:0034284 3 0.017
antimicrobial humoral response GO:0019730 2 0.017
regulation of organelle assembly GO:1902115 4 0.017
dicarboxylic acid metabolic process GO:0043648 1 0.017
cellular response to decreased oxygen levels GO:0036294 1 0.017
inorganic cation transmembrane transport GO:0098662 50 0.017
eye development GO:0001654 277 0.017
multicellular organism growth GO:0035264 4 0.017
positive regulation of immune effector process GO:0002699 3 0.017
programmed cell death GO:0012501 119 0.017
cellular response to starvation GO:0009267 1 0.017
protein dephosphorylation GO:0006470 3 0.017
regulation of cell substrate adhesion GO:0010810 1 0.017
regulation of biosynthetic process GO:0009889 250 0.017
cellular response to stress GO:0033554 62 0.017
cellular amino acid metabolic process GO:0006520 7 0.017
establishment of protein localization to organelle GO:0072594 4 0.017
hepaticobiliary system development GO:0061008 98 0.017
negative regulation of intracellular protein transport GO:0090317 3 0.017
glucose homeostasis GO:0042593 1 0.017
regulation of epithelial cell proliferation GO:0050678 3 0.016
cognition GO:0050890 1 0.016
determination of intestine left right asymmetry GO:0071908 2 0.016
meiotic cell cycle process GO:1903046 3 0.016
regulation of dendrite morphogenesis GO:0048814 3 0.016
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.016
regulation of cell communication GO:0010646 232 0.016
response to wounding GO:0009611 116 0.016
positive regulation of neuron death GO:1901216 1 0.016
regulation of synapse organization GO:0050807 3 0.016
rna localization GO:0006403 4 0.016
morphogenesis of an epithelium GO:0002009 333 0.016
negative regulation of sequestering of calcium ion GO:0051283 4 0.016
regulation of nucleoside metabolic process GO:0009118 2 0.016
regulation of reactive oxygen species metabolic process GO:2000377 2 0.016
microtubule organizing center organization GO:0031023 1 0.016
behavior GO:0007610 74 0.016
response to carbohydrate GO:0009743 3 0.016
regulation of response to nutrient levels GO:0032107 1 0.016
homeostatic process GO:0042592 142 0.016
immune system development GO:0002520 191 0.016
regulation of cell shape GO:0008360 1 0.016
regulation of dendrite development GO:0050773 3 0.016
protein stabilization GO:0050821 2 0.016
response to glucose GO:0009749 3 0.016
regulation of cellular response to oxidative stress GO:1900407 2 0.015
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.015
cell surface receptor signaling pathway GO:0007166 325 0.015
heterocycle biosynthetic process GO:0018130 215 0.015
response to uv GO:0009411 3 0.015
negative regulation of response to stimulus GO:0048585 104 0.015
cellular carbohydrate metabolic process GO:0044262 4 0.015
entrainment of circadian clock by photoperiod GO:0043153 1 0.015
positive regulation of epithelial cell differentiation GO:0030858 2 0.015
negative regulation of protein transport GO:0051224 3 0.015
sensory perception of pain GO:0019233 1 0.015
nucleocytoplasmic transport GO:0006913 4 0.015
response to external stimulus GO:0009605 264 0.015
androgen metabolic process GO:0008209 2 0.015
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 3 0.015
regulation of cellular amine metabolic process GO:0033238 0 0.014
striated muscle tissue development GO:0014706 110 0.014
cellular response to superoxide GO:0071451 2 0.014
heart contraction GO:0060047 71 0.014
energy reserve metabolic process GO:0006112 2 0.014
cytoskeleton dependent cytokinesis GO:0061640 3 0.014
response to xenobiotic stimulus GO:0009410 45 0.014
adherens junction organization GO:0034332 4 0.014
muscle cell differentiation GO:0042692 139 0.014
small molecule catabolic process GO:0044282 3 0.014
response to endogenous stimulus GO:0009719 83 0.014
pancreas development GO:0031016 84 0.014
response to hexose GO:0009746 3 0.014
intrinsic apoptotic signaling pathway GO:0097193 20 0.014
macromolecule modification GO:0043412 111 0.014
reactive oxygen species metabolic process GO:0072593 6 0.014
amine metabolic process GO:0009308 2 0.014
muscle fiber development GO:0048747 52 0.014
inorganic ion transmembrane transport GO:0098660 57 0.014
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.014
spermatid development GO:0007286 2 0.014
lymphocyte proliferation GO:0046651 1 0.014
regulation of jak stat cascade GO:0046425 3 0.013
rna biosynthetic process GO:0032774 181 0.013
mitotic cytokinesis GO:0000281 3 0.013
response to alkaloid GO:0043279 2 0.013
regulation of nucleocytoplasmic transport GO:0046822 2 0.013
adherens junction assembly GO:0034333 1 0.013
estrogen metabolic process GO:0008210 2 0.013
regulation of cell cycle GO:0051726 52 0.013
protein metabolic process GO:0019538 183 0.013
monocarboxylic acid biosynthetic process GO:0072330 12 0.013
cellular respiration GO:0045333 3 0.013
secondary metabolic process GO:0019748 3 0.013
membrane lipid biosynthetic process GO:0046467 2 0.013
regulation of multicellular organismal process GO:0051239 277 0.013
single organism nuclear import GO:1902593 3 0.013
protein homooligomerization GO:0051260 3 0.013
regulation of protein import into nucleus GO:0042306 2 0.013
reciprocal dna recombination GO:0035825 1 0.013
positive regulation of transport GO:0051050 2 0.013
mononuclear cell proliferation GO:0032943 1 0.013
cytokinetic process GO:0032506 2 0.013
negative regulation of protein localization to nucleus GO:1900181 2 0.013
response to glucocorticoid GO:0051384 1 0.013
regulation of response to extracellular stimulus GO:0032104 1 0.013
central nervous system neuron development GO:0021954 29 0.013
cytoplasm organization GO:0007028 4 0.013
startle response GO:0001964 4 0.013
response to methylmercury GO:0051597 11 0.013
positive regulation of cellular amine metabolic process GO:0033240 0 0.013
regulation of gtpase activity GO:0043087 2 0.013
b cell activation GO:0042113 2 0.013
regulation of organ growth GO:0046620 3 0.013
exocytosis GO:0006887 1 0.013
regulation of intracellular protein transport GO:0033157 3 0.013
muscle cell migration GO:0014812 4 0.013
cellular protein catabolic process GO:0044257 4 0.013
cytokinesis GO:0000910 3 0.012
long chain fatty acid metabolic process GO:0001676 1 0.012
removal of superoxide radicals GO:0019430 2 0.012
nucleic acid templated transcription GO:0097659 181 0.012
gland development GO:0048732 143 0.012
regulation of apoptotic process GO:0042981 98 0.012
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.012
auditory receptor cell fate commitment GO:0009912 4 0.012
er nucleus signaling pathway GO:0006984 2 0.012
sensory organ morphogenesis GO:0090596 200 0.012
positive regulation of muscle organ development GO:0048636 1 0.012
regulation of cytoplasmic transport GO:1903649 4 0.012
neuron fate determination GO:0048664 2 0.012
regulation of systemic arterial blood pressure GO:0003073 1 0.012
oocyte maturation GO:0001556 4 0.012
activation of mapk activity GO:0000187 3 0.012
mitotic dna damage checkpoint GO:0044773 4 0.012
death GO:0016265 121 0.012
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.012
myeloid cell development GO:0061515 32 0.012
positive regulation of nucleoside metabolic process GO:0045979 1 0.012
multi organism process GO:0051704 134 0.012
ovarian follicle development GO:0001541 2 0.012
tube morphogenesis GO:0035239 349 0.012
response to superoxide GO:0000303 2 0.012
regulation of oxidative stress induced cell death GO:1903201 2 0.012
response to drug GO:0042493 3 0.012
response to transition metal nanoparticle GO:1990267 28 0.012
organic acid biosynthetic process GO:0016053 12 0.012
regulation of cell development GO:0060284 100 0.012
posterior lateral line system development GO:0048915 46 0.012
cellular response to hypoxia GO:0071456 1 0.012
neuron differentiation GO:0030182 353 0.012
gene expression GO:0010467 252 0.012
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.012
photoreceptor cell differentiation GO:0046530 55 0.012
smooth muscle contraction GO:0006939 2 0.012
stem cell maintenance GO:0019827 4 0.012
cellular response to oxygen levels GO:0071453 1 0.012
regulation of gene expression GO:0010468 265 0.012
cell death GO:0008219 121 0.011
compound eye development GO:0048749 2 0.011
response to unfolded protein GO:0006986 2 0.011
cellular component biogenesis GO:0044085 178 0.011
ubiquitin dependent protein catabolic process GO:0006511 3 0.011
spermatid differentiation GO:0048515 2 0.011
androgen biosynthetic process GO:0006702 1 0.011
protein targeting to nucleus GO:0044744 3 0.011
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 2 0.011
sequestering of metal ion GO:0051238 3 0.011
cellular response to reactive oxygen species GO:0034614 2 0.011
leukocyte proliferation GO:0070661 1 0.011
positive regulation of neuron apoptotic process GO:0043525 1 0.011
positive regulation of cell substrate adhesion GO:0010811 1 0.011
response to inorganic substance GO:0010035 38 0.011
carbohydrate biosynthetic process GO:0016051 1 0.011
cellular response to molecule of bacterial origin GO:0071219 3 0.011
chemical homeostasis GO:0048878 49 0.011
exocrine pancreas development GO:0031017 28 0.011
retina layer formation GO:0010842 24 0.011
response to virus GO:0009615 21 0.011
cellular response to drug GO:0035690 1 0.011
vacuolar transport GO:0007034 2 0.011
cation transmembrane transport GO:0098655 65 0.011
ovulation cycle process GO:0022602 2 0.011
production of molecular mediator of immune response GO:0002440 2 0.011
positive regulation of secretion GO:0051047 1 0.011
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.011
cell cycle arrest GO:0007050 1 0.011
neurotransmitter transport GO:0006836 2 0.011
protein localization to plasma membrane GO:0072659 1 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.011
extracellular matrix organization GO:0030198 27 0.011
regulation of gtp catabolic process GO:0033124 2 0.011
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 9 0.011
protein import GO:0017038 3 0.011
regulation of cellular ketone metabolic process GO:0010565 7 0.011
mitotic dna integrity checkpoint GO:0044774 4 0.011
endosomal transport GO:0016197 2 0.011
calcium ion transport into cytosol GO:0060402 3 0.011
regulation of calcium ion transport GO:0051924 2 0.011
water homeostasis GO:0030104 4 0.011
cell projection morphogenesis GO:0048858 244 0.011
regulation of mrna processing GO:0050684 3 0.011
neuron neuron synaptic transmission GO:0007270 1 0.011
regulation of mitochondrion organization GO:0010821 1 0.010
negative regulation of catabolic process GO:0009895 3 0.010
regulation of skeletal muscle tissue development GO:0048641 4 0.010
regulation of transcription dna templated GO:0006355 213 0.010
ion homeostasis GO:0050801 41 0.010
embryonic organ development GO:0048568 381 0.010
regulation of photoreceptor cell differentiation GO:0046532 2 0.010
g protein coupled receptor signaling pathway GO:0007186 74 0.010
nuclear import GO:0051170 3 0.010
regulation of protein binding GO:0043393 3 0.010
epidermis development GO:0008544 48 0.010
negative regulation of autophagy GO:0010507 1 0.010

tk2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
inherited metabolic disorder DOID:655 0 0.040
disease of metabolism DOID:0014667 0 0.040
nervous system disease DOID:863 0 0.022
disease of anatomical entity DOID:7 0 0.022
disease of cellular proliferation DOID:14566 0 0.018
musculoskeletal system disease DOID:17 0 0.013
cancer DOID:162 0 0.013
cardiovascular system disease DOID:1287 0 0.011
muscular disease DOID:0080000 0 0.011
organ system cancer DOID:0050686 0 0.010