Danio rerio

9 known processes

tlr3

toll-like receptor 3

(Aliases: MGC123006,zgc:123006)

tlr3 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cellular response to lipopolysaccharide GO:0071222 3 0.937
response to other organism GO:0051707 97 0.689
defense response to bacterium GO:0042742 22 0.670
Worm Fly
response to external stimulus GO:0009605 264 0.639
neuron development GO:0048666 262 0.587
Fly
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.577
Mouse
immune system process GO:0002376 241 0.574
Human Mouse Fly
immune response regulating signaling pathway GO:0002764 5 0.563
Human
positive regulation of cytokine production GO:0001819 2 0.538
Human Mouse
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.524
Human Mouse
positive regulation of stress activated mapk cascade GO:0032874 3 0.519
Mouse
regulation of production of molecular mediator of immune response GO:0002700 1 0.515
Fly
cellular nitrogen compound metabolic process GO:0034641 290 0.471
Mouse Fly
activation of immune response GO:0002253 9 0.464
Human
leukocyte proliferation GO:0070661 1 0.463
cellular response to molecule of bacterial origin GO:0071219 3 0.446
cellular response to biotic stimulus GO:0071216 3 0.446
regulation of cytokine production GO:0001817 3 0.440
Human Mouse
response to biotic stimulus GO:0009607 97 0.437
regulation of biosynthetic process GO:0009889 250 0.428
Human Mouse Fly
positive regulation of cell activation GO:0050867 1 0.423
regulation of protein transport GO:0051223 3 0.402
Human
i kappab kinase nf kappab signaling GO:0007249 4 0.390
Human Mouse
defense response GO:0006952 47 0.368
Mouse Worm Fly
positive regulation of jnk cascade GO:0046330 3 0.364
Mouse
hematopoietic or lymphoid organ development GO:0048534 191 0.361
cellular protein metabolic process GO:0044267 129 0.345
Human Fly
protein secretion GO:0009306 1 0.344
immune response activating signal transduction GO:0002757 5 0.338
Human
regulation of metabolic process GO:0019222 359 0.327
Human Mouse Fly
cellular macromolecule metabolic process GO:0044260 391 0.312
Human Mouse Fly
defense response to other organism GO:0098542 33 0.309
Mouse Worm Fly
response to bacterium GO:0009617 58 0.303
negative regulation of biological process GO:0048519 304 0.301
regulation of nitrogen compound metabolic process GO:0051171 251 0.295
Mouse Fly
single organism metabolic process GO:0044710 217 0.294
Mouse Fly
regulation of establishment of protein localization GO:0070201 4 0.293
Human
cellular macromolecule biosynthetic process GO:0034645 224 0.291
Mouse Fly
regulation of immune response GO:0050776 14 0.289
Human Fly
nitrogen compound metabolic process GO:0006807 319 0.284
Mouse Fly
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.276
immune system development GO:0002520 191 0.262
myeloid cell differentiation GO:0030099 86 0.261
aromatic compound biosynthetic process GO:0019438 217 0.257
Mouse
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.248
Human Mouse
regulation of cellular metabolic process GO:0031323 320 0.247
Human Mouse Fly
phosphate containing compound metabolic process GO:0006796 108 0.245
Human Mouse
organonitrogen compound metabolic process GO:1901564 74 0.239
Fly
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.233
Mouse Fly
hemopoiesis GO:0030097 183 0.233
response to external biotic stimulus GO:0043207 97 0.231
regulation of cell differentiation GO:0045595 142 0.226
Fly
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.225
response to dsrna GO:0043331 7 0.225
Human Mouse
positive regulation of catalytic activity GO:0043085 25 0.222
regulation of nucleic acid templated transcription GO:1903506 213 0.222
Mouse
mononuclear cell proliferation GO:0032943 1 0.221
central nervous system development GO:0007417 387 0.217
regulation of cellular protein metabolic process GO:0032268 52 0.213
Fly
protein metabolic process GO:0019538 183 0.211
Human Mouse Fly
regulation of primary metabolic process GO:0080090 311 0.210
Human Mouse Fly
regulation of cellular biosynthetic process GO:0031326 245 0.207
Human Mouse Fly
multi organism process GO:0051704 134 0.205
aging GO:0007568 2 0.203
organic cyclic compound metabolic process GO:1901360 301 0.203
Mouse
transport GO:0006810 220 0.198
Human
regulation of macromolecule biosynthetic process GO:0010556 225 0.193
Human Mouse Fly
gene expression GO:0010467 252 0.190
Mouse
nucleocytoplasmic transport GO:0006913 4 0.188
Human
cellular response to lipid GO:0071396 39 0.187
positive regulation of cellular process GO:0048522 201 0.186
Human Mouse Fly
regulation of gene expression GO:0010468 265 0.183
Mouse
organic substance biosynthetic process GO:1901576 289 0.182
Human Mouse Fly
response to wounding GO:0009611 116 0.180
nucleobase containing compound metabolic process GO:0006139 274 0.179
Mouse
biosynthetic process GO:0009058 294 0.177
Human Mouse Fly
cellular component movement GO:0006928 335 0.177
multicellular organismal homeostasis GO:0048871 29 0.175
regulation of binding GO:0051098 3 0.173
neuron projection development GO:0031175 180 0.172
regulation of cellular amine metabolic process GO:0033238 0 0.170
positive regulation of immune effector process GO:0002699 3 0.167
Fly
protein modification process GO:0036211 100 0.166
Human Fly
intracellular signal transduction GO:0035556 85 0.165
Human Mouse
response to chemical GO:0042221 320 0.165
Human Mouse Fly
cell projection organization GO:0030030 284 0.164
regulation of response to stimulus GO:0048583 269 0.164
Human Mouse Fly
reactive nitrogen species metabolic process GO:2001057 0 0.162
neuron differentiation GO:0030182 353 0.160
Fly
regulation of localization GO:0032879 104 0.155
Human
extrinsic apoptotic signaling pathway GO:0097191 3 0.154
Human
positive regulation of molecular function GO:0044093 33 0.152
Mouse
regulation of transcription dna templated GO:0006355 213 0.151
Mouse
nitric oxide biosynthetic process GO:0006809 2 0.150
response to organic substance GO:0010033 153 0.150
Human Mouse
cellular amino acid metabolic process GO:0006520 7 0.148
leukocyte differentiation GO:0002521 25 0.146
response to nutrient GO:0007584 3 0.145
signal transduction GO:0007165 455 0.145
Human Mouse
positive regulation of cellular metabolic process GO:0031325 94 0.145
Human Mouse Fly
regulation of macromolecule metabolic process GO:0060255 317 0.142
Human Mouse Fly
regulation of multicellular organismal development GO:2000026 223 0.141
regulation of biological quality GO:0065008 263 0.141
regulation of protein localization to nucleus GO:1900180 2 0.139
Human
rna biosynthetic process GO:0032774 181 0.138
Mouse
phosphorylation GO:0016310 69 0.135
Human Mouse
response to molecule of bacterial origin GO:0002237 14 0.135
protein import GO:0017038 3 0.134
Human
cellular biosynthetic process GO:0044249 286 0.133
Human Mouse Fly
small molecule metabolic process GO:0044281 77 0.133
generation of neurons GO:0048699 385 0.131
Fly
cellular response to organic substance GO:0071310 105 0.130
response to lipopolysaccharide GO:0032496 13 0.129
regulation of reactive oxygen species metabolic process GO:2000377 2 0.129
regulation of sequence specific dna binding transcription factor activity GO:0051090 9 0.128
Mouse
positive regulation of interferon beta production GO:0032728 1 0.127
Human Mouse
transcription dna templated GO:0006351 181 0.126
Mouse
regulation of protein targeting GO:1903533 2 0.125
Human
nucleobase containing compound biosynthetic process GO:0034654 205 0.122
Mouse
reactive oxygen species metabolic process GO:0072593 6 0.121
amine metabolic process GO:0009308 2 0.121
regulation of protein import into nucleus GO:0042306 2 0.119
Human
phosphorus metabolic process GO:0006793 109 0.119
Human Mouse
regulation of developmental process GO:0050793 247 0.118
Fly
regulation of cell activation GO:0050865 1 0.117
response to abiotic stimulus GO:0009628 122 0.114
Human
negative regulation of gene expression GO:0010629 65 0.112
morphogenesis of an epithelium GO:0002009 333 0.111
oxoacid metabolic process GO:0043436 31 0.110
regulation of phosphorus metabolic process GO:0051174 43 0.110
Mouse
cellular amine metabolic process GO:0044106 2 0.110
larval development GO:0002164 2 0.110
Worm
cellular response to chemical stimulus GO:0070887 157 0.109
response to glucocorticoid GO:0051384 1 0.108
regulation of signaling GO:0023051 235 0.107
Human Mouse
cellular localization GO:0051641 97 0.107
Human
carboxylic acid metabolic process GO:0019752 22 0.106
nucleic acid metabolic process GO:0090304 244 0.106
Mouse
response to drug GO:0042493 3 0.105
cell part morphogenesis GO:0032990 246 0.105
reactive oxygen species biosynthetic process GO:1903409 1 0.105
regulation of signal transduction GO:0009966 225 0.105
Human Mouse
regulation of protein metabolic process GO:0051246 56 0.104
Human Mouse Fly
positive regulation of metabolic process GO:0009893 108 0.104
Human Mouse Fly
positive regulation of leukocyte mediated immunity GO:0002705 1 0.103
regulation of leukocyte mediated immunity GO:0002703 1 0.102
neuron projection morphogenesis GO:0048812 161 0.102
organic cyclic compound biosynthetic process GO:1901362 223 0.102
Mouse
innate immune response GO:0045087 13 0.102
Fly
positive regulation of response to external stimulus GO:0032103 9 0.101
Fly
response to organic cyclic compound GO:0014070 51 0.101
Human Mouse
multicellular organismal metabolic process GO:0044236 2 0.100
cell projection morphogenesis GO:0048858 244 0.100
cell morphogenesis involved in differentiation GO:0000904 195 0.100
lymphocyte proliferation GO:0046651 1 0.099
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.097
Mouse
regulation of immune system process GO:0002682 34 0.097
Human Fly
peptide transport GO:0015833 1 0.097
Human
positive regulation of map kinase activity GO:0043406 3 0.095
negative regulation of cellular process GO:0048523 283 0.094
axon development GO:0061564 166 0.094
positive regulation of biological process GO:0048518 253 0.093
Human Mouse Fly
cytokine mediated signaling pathway GO:0019221 7 0.092
homeostatic process GO:0042592 142 0.092
cell proliferation GO:0008283 80 0.091
Fly
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.090
Mouse Fly
tissue homeostasis GO:0001894 25 0.090
cellular response to nutrient levels GO:0031669 2 0.090
protein targeting to nucleus GO:0044744 3 0.090
Human
regulation of cellular amino acid metabolic process GO:0006521 0 0.090
macromolecule modification GO:0043412 111 0.089
Human Fly
cell surface receptor signaling pathway GO:0007166 325 0.088
Human
regulation of cell communication GO:0010646 232 0.088
Human Mouse
cellular ketone metabolic process GO:0042180 11 0.088
ossification GO:0001503 23 0.087
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.086
Mouse
response to transition metal nanoparticle GO:1990267 28 0.086
protein localization to nucleus GO:0034504 3 0.086
Human
embryonic organ development GO:0048568 381 0.085
cellular component biogenesis GO:0044085 178 0.085
Fly
negative regulation of metabolic process GO:0009892 86 0.085
positive regulation of tyrosine phosphorylation of stat3 protein GO:0042517 1 0.084
cellular protein modification process GO:0006464 100 0.084
Human Fly
positive regulation of cellular catabolic process GO:0031331 3 0.084
negative regulation of protein phosphorylation GO:0001933 4 0.083
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.083
protein phosphorylation GO:0006468 47 0.083
Human
cellular nitrogen compound biosynthetic process GO:0044271 218 0.083
Mouse Fly
nuclear transport GO:0051169 4 0.082
Human
establishment of localization GO:0051234 244 0.082
Human
liver development GO:0001889 96 0.081
single organism nuclear import GO:1902593 3 0.081
Human
nik nf kappab signaling GO:0038061 1 0.081
anatomical structure homeostasis GO:0060249 36 0.081
regulation of molecular function GO:0065009 70 0.079
Mouse
retina development in camera type eye GO:0060041 146 0.079
macromolecule biosynthetic process GO:0009059 227 0.079
Human Mouse Fly
erythrocyte homeostasis GO:0034101 55 0.077
axonogenesis GO:0007409 152 0.076
osteoclast differentiation GO:0030316 1 0.076
negative regulation of protein transport GO:0051224 3 0.076
rna metabolic process GO:0016070 219 0.075
Mouse
positive regulation of cell communication GO:0010647 56 0.075
Human Mouse
production of molecular mediator of immune response GO:0002440 2 0.074
Fly
positive regulation of immune system process GO:0002684 17 0.074
Human Fly
epithelial tube morphogenesis GO:0060562 148 0.074
alpha amino acid metabolic process GO:1901605 3 0.073
response to stress GO:0006950 263 0.073
Mouse Worm Fly
response to oxygen containing compound GO:1901700 55 0.073
localization of cell GO:0051674 244 0.071
single organism transport GO:0044765 206 0.071
Human
response to virus GO:0009615 21 0.071
chordate embryonic development GO:0043009 271 0.070
tissue remodeling GO:0048771 4 0.070
negative regulation of signal transduction GO:0009968 94 0.070
growth GO:0040007 174 0.070
regulation of rna biosynthetic process GO:2001141 213 0.070
Mouse
regulation of phosphate metabolic process GO:0019220 43 0.070
Mouse
protein localization GO:0008104 40 0.069
Human
cell migration GO:0016477 237 0.069
response to alkaloid GO:0043279 2 0.069
regulation of cell proliferation GO:0042127 37 0.068
regulation of nucleocytoplasmic transport GO:0046822 2 0.068
Human
cellular aromatic compound metabolic process GO:0006725 295 0.068
Mouse
heterocycle biosynthetic process GO:0018130 215 0.068
Mouse
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.067
Human Mouse
nitric oxide metabolic process GO:0046209 2 0.066
anion transport GO:0006820 38 0.066
cell morphogenesis GO:0000902 289 0.065
response to exogenous dsrna GO:0043330 6 0.065
Human Mouse
sensory perception of pain GO:0019233 1 0.065
negative regulation of macromolecule metabolic process GO:0010605 76 0.064
positive regulation of myeloid cell differentiation GO:0045639 2 0.064
cellular response to extracellular stimulus GO:0031668 2 0.064
response to lipid GO:0033993 60 0.064
vasculature development GO:0001944 278 0.063
response to decreased oxygen levels GO:0036293 25 0.063
establishment of protein localization to organelle GO:0072594 4 0.063
Human
response to metal ion GO:0010038 34 0.062
response to ketone GO:1901654 1 0.061
eye development GO:0001654 277 0.061
cellular carbohydrate metabolic process GO:0044262 4 0.061
Fly
small molecule catabolic process GO:0044282 3 0.061
amino acid transport GO:0006865 2 0.060
immunoglobulin mediated immune response GO:0016064 3 0.060
angiogenesis GO:0001525 158 0.060
negative regulation of cytokine production GO:0001818 1 0.060
regulation of phosphorylation GO:0042325 26 0.060
Mouse
positive regulation of transport GO:0051050 2 0.060
Human
erythrocyte differentiation GO:0030218 54 0.060
immunoglobulin production GO:0002377 1 0.059
positive regulation of rna biosynthetic process GO:1902680 57 0.059
Mouse
regulation of response to external stimulus GO:0032101 31 0.059
Fly
phagocytosis GO:0006909 3 0.058
response to endogenous stimulus GO:0009719 83 0.058
immune effector process GO:0002252 23 0.058
Mouse Fly
secondary metabolic process GO:0019748 3 0.058
regulation of cell cycle GO:0051726 52 0.058
negative regulation of cell communication GO:0010648 96 0.057
macromolecule localization GO:0033036 54 0.057
Human
locomotion GO:0040011 313 0.056
Fly
positive regulation of gene expression GO:0010628 71 0.056
Mouse
protein polyubiquitination GO:0000209 4 0.055
gtp metabolic process GO:0046039 4 0.055
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.054
sensory organ development GO:0007423 393 0.054
regulation of intracellular protein transport GO:0033157 3 0.054
Human
nuclear import GO:0051170 3 0.054
Human
ion homeostasis GO:0050801 41 0.053
signal transduction by phosphorylation GO:0023014 18 0.053
Mouse
sensory organ morphogenesis GO:0090596 200 0.053
cell motility GO:0048870 244 0.052
metal ion homeostasis GO:0055065 26 0.052
positive regulation of cellular biosynthetic process GO:0031328 68 0.052
Human Mouse Fly
organic acid catabolic process GO:0016054 3 0.052
guanosine containing compound metabolic process GO:1901068 4 0.052
regulation of rna metabolic process GO:0051252 224 0.051
Mouse
cellular response to external stimulus GO:0071496 2 0.051
Human
regulation of mapk cascade GO:0043408 14 0.051
Mouse
blood vessel development GO:0001568 246 0.051
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.049
organic acid metabolic process GO:0006082 31 0.049
positive regulation of cellular amine metabolic process GO:0033240 0 0.049
negative regulation of kinase activity GO:0033673 4 0.048
positive regulation of cell cycle GO:0045787 3 0.048
regulation of transferase activity GO:0051338 16 0.048
brain development GO:0007420 293 0.047
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.047
positive regulation of response to stimulus GO:0048584 80 0.047
Human Mouse Fly
response to acid chemical GO:0001101 17 0.047
regulation of cytoplasmic transport GO:1903649 4 0.047
Human
tyrosine phosphorylation of stat protein GO:0007260 1 0.047
regulation of response to stress GO:0080134 36 0.046
Human Mouse Fly
regulation of protein phosphorylation GO:0001932 18 0.046
positive regulation of neuron apoptotic process GO:0043525 1 0.046
single organism cellular localization GO:1902580 46 0.046
Human
establishment of localization in cell GO:0051649 77 0.046
Human
hindbrain development GO:0030902 91 0.045
iron ion homeostasis GO:0055072 4 0.045
protein complex localization GO:0031503 1 0.045
Human
regulation of nervous system development GO:0051960 90 0.045
developmental growth involved in morphogenesis GO:0060560 86 0.045
positive regulation of jak stat cascade GO:0046427 2 0.045
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.044
adaptive immune response GO:0002250 5 0.044
developmental growth GO:0048589 166 0.044
muscle organ development GO:0007517 101 0.044
chemotaxis GO:0006935 104 0.043
Fly
lymphocyte mediated immunity GO:0002449 5 0.043
regulation of cellular ketone metabolic process GO:0010565 7 0.043
defense response to gram negative bacterium GO:0050829 8 0.043
Worm
response to arsenic containing substance GO:0046685 5 0.043
positive regulation of signal transduction GO:0009967 56 0.042
Human Mouse
tube morphogenesis GO:0035239 349 0.042
hepaticobiliary system development GO:0061008 98 0.042
negative regulation of protein kinase activity GO:0006469 4 0.042
response to monosaccharide GO:0034284 3 0.041
anterior posterior pattern specification GO:0009952 152 0.041
intracellular transport GO:0046907 32 0.041
Human
negative regulation of intracellular signal transduction GO:1902532 22 0.041
regulation of metal ion transport GO:0010959 4 0.041
regulation of multicellular organismal process GO:0051239 277 0.041
Human Mouse Fly
positive regulation of gtp catabolic process GO:0033126 1 0.040
head development GO:0060322 303 0.040
carbohydrate derivative biosynthetic process GO:1901137 43 0.040
Fly
chemical homeostasis GO:0048878 49 0.040
regulation of translation GO:0006417 3 0.040
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.040
cellular response to starvation GO:0009267 1 0.039
system process GO:0003008 185 0.039
multicellular organism growth GO:0035264 4 0.038
embryonic hemopoiesis GO:0035162 53 0.038
leukocyte activation GO:0045321 12 0.038
positive regulation of macromolecule metabolic process GO:0010604 93 0.038
Human Mouse
positive regulation of secretion GO:0051047 1 0.038
positive regulation of gliogenesis GO:0014015 2 0.037
guanosine containing compound catabolic process GO:1901069 2 0.037
regulation of myeloid cell differentiation GO:0045637 8 0.037
positive regulation of cell death GO:0010942 29 0.037
regulation of cellular component organization GO:0051128 86 0.036
nucleic acid templated transcription GO:0097659 181 0.036
Mouse
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.036
positive regulation of catabolic process GO:0009896 4 0.036
somatic muscle development GO:0007525 4 0.035
negative regulation of response to stimulus GO:0048585 104 0.035
carboxylic acid catabolic process GO:0046395 3 0.035
astrocyte differentiation GO:0048708 1 0.035
positive regulation of rna metabolic process GO:0051254 59 0.035
Mouse
regulation of kinase activity GO:0043549 15 0.034
maintenance of location GO:0051235 4 0.034
cellular component morphogenesis GO:0032989 336 0.034
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.034
regulation of jak stat cascade GO:0046425 3 0.034
b cell activation GO:0042113 2 0.034
response to glucose GO:0009749 3 0.034
negative regulation of signaling GO:0023057 96 0.034
positive regulation of inflammatory response GO:0050729 1 0.034
mitochondrion organization GO:0007005 4 0.033
negative regulation of hormone secretion GO:0046888 2 0.033
immune response GO:0006955 28 0.033
Fly
b cell mediated immunity GO:0019724 3 0.033
regulation of catalytic activity GO:0050790 55 0.033
cellular component assembly GO:0022607 170 0.033
Fly
positive regulation of cell proliferation GO:0008284 15 0.032
cell fate commitment GO:0045165 99 0.032
regulation of transport GO:0051049 45 0.032
Human
multicellular organismal macromolecule metabolic process GO:0044259 2 0.032
regulation of neuron differentiation GO:0045664 56 0.032
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 1 0.032
regulation of cell death GO:0010941 103 0.032
negative regulation of phosphate metabolic process GO:0045936 13 0.032
response to corticosteroid GO:0031960 1 0.032
myeloid leukocyte differentiation GO:0002573 15 0.031
translational initiation GO:0006413 3 0.031
dicarboxylic acid transport GO:0006835 1 0.031
gland development GO:0048732 143 0.031
response to amino acid GO:0043200 2 0.031
regulation of anatomical structure morphogenesis GO:0022603 130 0.031
cellular response to stress GO:0033554 62 0.031
Mouse
regulation of calcium ion transport GO:0051924 2 0.031
heterocycle metabolic process GO:0046483 290 0.030
Mouse
phagocytosis engulfment GO:0006911 1 0.030
homeostasis of number of cells GO:0048872 62 0.030
negative regulation of cellular metabolic process GO:0031324 77 0.030
single organism localization GO:1902578 225 0.029
Human
neural retina development GO:0003407 49 0.029
regulation of purine nucleotide catabolic process GO:0033121 2 0.029
regulation of immune effector process GO:0002697 5 0.029
Fly
lipid storage GO:0019915 1 0.029
regulation of cellular component movement GO:0051270 55 0.029
regulation of circadian rhythm GO:0042752 4 0.029
death GO:0016265 121 0.029
Human
response to hypoxia GO:0001666 25 0.029
response to nitrogen compound GO:1901698 19 0.028
Human Mouse
enzyme linked receptor protein signaling pathway GO:0007167 106 0.028
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.028
positive regulation of epithelial cell proliferation GO:0050679 1 0.028
carbohydrate metabolic process GO:0005975 12 0.028
Fly
multi organism cellular process GO:0044764 2 0.028
spinal cord development GO:0021510 46 0.028
regulation of nucleotide catabolic process GO:0030811 2 0.027
protein import into nucleus GO:0006606 3 0.027
Human
regulation of protein ubiquitination GO:0031396 3 0.027
striated muscle cell differentiation GO:0051146 129 0.026
organelle organization GO:0006996 227 0.026
myeloid cell homeostasis GO:0002262 56 0.026
regulation of cell growth GO:0001558 29 0.026
single organism biosynthetic process GO:0044711 71 0.026
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.026
t cell activation GO:0042110 6 0.026
regulation of cell motility GO:2000145 46 0.026
positive regulation of developmental process GO:0051094 50 0.026
carbohydrate derivative metabolic process GO:1901135 61 0.026
Fly
eye morphogenesis GO:0048592 144 0.026
positive regulation of phosphorus metabolic process GO:0010562 21 0.025
Mouse
positive regulation of secretion by cell GO:1903532 1 0.025
regulation of inflammatory response GO:0050727 2 0.025
response to cytokine GO:0034097 7 0.025
cellular response to cytokine stimulus GO:0071345 7 0.025
cellular response to endogenous stimulus GO:0071495 68 0.025
erk1 and erk2 cascade GO:0070371 4 0.025
response to hormone GO:0009725 48 0.025
hormone transport GO:0009914 2 0.025
developmental cell growth GO:0048588 52 0.025
negative regulation of rna metabolic process GO:0051253 48 0.024
energy reserve metabolic process GO:0006112 2 0.024
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.024
negative regulation of cellular biosynthetic process GO:0031327 55 0.024
regulation of neurogenesis GO:0050767 87 0.024
gtp catabolic process GO:0006184 2 0.024
convergent extension GO:0060026 118 0.024
melanin metabolic process GO:0006582 2 0.024
leukocyte mediated immunity GO:0002443 6 0.024
calcium mediated signaling GO:0019722 2 0.024
negative regulation of mapk cascade GO:0043409 4 0.024
regulation of collagen metabolic process GO:0010712 2 0.024
regulation of circadian sleep wake cycle GO:0042749 1 0.024
collagen metabolic process GO:0032963 2 0.024
regulation of cellular response to stress GO:0080135 20 0.024
Mouse
regulation of multicellular organism growth GO:0040014 4 0.024
response to uv GO:0009411 3 0.024
regulation of lymphocyte mediated immunity GO:0002706 1 0.024
retina morphogenesis in camera type eye GO:0060042 79 0.024
negative regulation of biosynthetic process GO:0009890 55 0.023
fatty acid biosynthetic process GO:0006633 4 0.023
regulation of blood vessel size GO:0050880 2 0.023
camera type eye development GO:0043010 222 0.023
regulation of response to cytokine stimulus GO:0060759 3 0.023
negative regulation of cell differentiation GO:0045596 46 0.023
regulation of protein kinase activity GO:0045859 15 0.023
humoral immune response mediated by circulating immunoglobulin GO:0002455 3 0.023
pyruvate metabolic process GO:0006090 1 0.023
determination of left right symmetry GO:0007368 179 0.023
positive regulation of apoptotic signaling pathway GO:2001235 1 0.023
long chain fatty acid metabolic process GO:0001676 1 0.023
regulation of hormone secretion GO:0046883 2 0.023
regulation of programmed cell death GO:0043067 101 0.023
interspecies interaction between organisms GO:0044419 4 0.023
stem cell proliferation GO:0072089 4 0.023
cellular response to oxygen containing compound GO:1901701 20 0.023
transcription from rna polymerase ii promoter GO:0006366 80 0.022
Mouse
cell growth GO:0016049 57 0.022
negative regulation of secretion GO:0051048 2 0.022
regulation of multicellular organismal metabolic process GO:0044246 2 0.022
negative regulation of rna biosynthetic process GO:1902679 45 0.022
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.022
regulation of apoptotic process GO:0042981 98 0.022
negative regulation of secretion by cell GO:1903531 2 0.022
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 1 0.022
cellular response to hypoxia GO:0071456 1 0.022
membrane invagination GO:0010324 1 0.021
lipid metabolic process GO:0006629 52 0.021
neuron death GO:0070997 21 0.021
cellular transition metal ion homeostasis GO:0046916 3 0.021
response to carbohydrate GO:0009743 3 0.021
regulation of tyrosine phosphorylation of stat protein GO:0042509 1 0.021
positive regulation of leukocyte differentiation GO:1902107 1 0.021
regulation of intracellular signal transduction GO:1902531 57 0.021
Human Mouse
regulation of cell development GO:0060284 100 0.021
positive regulation of biosynthetic process GO:0009891 68 0.021
Human Mouse Fly
blood vessel morphogenesis GO:0048514 216 0.021
regulation of glucose transport GO:0010827 1 0.020
glucose homeostasis GO:0042593 1 0.020
regulation of response to nutrient levels GO:0032107 1 0.020
regulation of nucleoside metabolic process GO:0009118 2 0.020
protein kinase b signaling GO:0043491 9 0.020
gliogenesis GO:0042063 45 0.020
positive regulation of protein kinase b signaling GO:0051897 1 0.020
myotube differentiation GO:0014902 45 0.020
response to hexose GO:0009746 3 0.020
positive regulation of multi organism process GO:0043902 3 0.020
Fly
regulation of system process GO:0044057 40 0.020
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.020
negative regulation of multicellular organismal process GO:0051241 69 0.020

tlr3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.036
disease of cellular proliferation DOID:14566 0 0.036
organ system cancer DOID:0050686 0 0.036
disease of metabolism DOID:0014667 0 0.025
disease of anatomical entity DOID:7 0 0.024