Danio rerio

13 known processes

tnfb

tumor necrosis factor b (TNF superfamily, member 2)

(Aliases: Tnf-alpha,tnf,tnfa-like)

tnfb biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of innate immune response GO:0045089 8 0.323
defense response GO:0006952 47 0.283
Zebrafish Mouse Rat Fly
toll like receptor signaling pathway GO:0002224 4 0.250
innate immune response activating signal transduction GO:0002758 5 0.229
response to other organism GO:0051707 97 0.228
Zebrafish Mouse Rat Fly
activation of innate immune response GO:0002218 6 0.210
response to bacterium GO:0009617 58 0.200
Zebrafish Mouse Rat Fly
activation of immune response GO:0002253 9 0.177
defense response to other organism GO:0098542 33 0.165
Zebrafish Mouse Fly
positive regulation of immune response GO:0050778 11 0.157
Mouse
regulation of innate immune response GO:0045088 11 0.157
response to external biotic stimulus GO:0043207 97 0.134
Zebrafish Mouse Rat Fly
signal transduction GO:0007165 455 0.129
Zebrafish Mouse Rat Fly
antimicrobial humoral response GO:0019730 2 0.127
immune response activating signal transduction GO:0002757 5 0.127
response to biotic stimulus GO:0009607 97 0.120
Zebrafish Mouse Rat Fly
i kappab kinase nf kappab signaling GO:0007249 4 0.115
Mouse Rat
immune system process GO:0002376 241 0.110
Zebrafish Mouse Fly
pattern recognition receptor signaling pathway GO:0002221 5 0.109
immune response regulating signaling pathway GO:0002764 5 0.100
response to external stimulus GO:0009605 264 0.099
Zebrafish Mouse Rat Fly
positive regulation of defense response GO:0031349 9 0.096
Mouse Rat
blood vessel development GO:0001568 246 0.086
blood vessel morphogenesis GO:0048514 216 0.084
response to stress GO:0006950 263 0.083
Zebrafish Mouse Rat Fly
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.082
Mouse Rat
regulation of response to stimulus GO:0048583 269 0.078
Zebrafish Mouse Rat
multi organism process GO:0051704 134 0.076
Zebrafish Mouse Rat Fly
larval development GO:0002164 2 0.075
positive regulation of biological process GO:0048518 253 0.074
Zebrafish Mouse Rat
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.073
Mouse Rat
immune response GO:0006955 28 0.067
Zebrafish Mouse Fly
regulation of metabolic process GO:0019222 359 0.064
Mouse
regulation of signal transduction GO:0009966 225 0.064
Zebrafish Mouse Rat
positive regulation of cytokine production GO:0001819 2 0.063
Mouse Rat
innate immune response GO:0045087 13 0.062
Fly
response to nutrient GO:0007584 3 0.056
Rat
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.056
Mouse
regulation of response to stress GO:0080134 36 0.054
Mouse Rat
cellular response to external stimulus GO:0071496 2 0.054
stem cell proliferation GO:0072089 4 0.054
cellular macromolecule metabolic process GO:0044260 391 0.053
Mouse
cell migration GO:0016477 237 0.053
Mouse
positive regulation of cellular process GO:0048522 201 0.051
Zebrafish Mouse Rat
cellular component movement GO:0006928 335 0.050
Mouse
regulation of cytokine production GO:0001817 3 0.050
Mouse Rat
regulation of cell communication GO:0010646 232 0.048
Zebrafish Mouse Rat Fly
aging GO:0007568 2 0.047
cellular response to molecule of bacterial origin GO:0071219 3 0.047
Mouse
regulation of biological quality GO:0065008 263 0.047
Mouse Rat Fly
localization of cell GO:0051674 244 0.046
Mouse
cell motility GO:0048870 244 0.046
Mouse
positive regulation of immune system process GO:0002684 17 0.046
Mouse
regulation of signaling GO:0023051 235 0.045
Zebrafish Mouse Rat Fly
regulation of gene expression GO:0010468 265 0.045
Mouse
protein import into nucleus GO:0006606 3 0.045
Mouse
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.044
Mouse
morphogenesis of an epithelium GO:0002009 333 0.043
Mouse
programmed cell death GO:0012501 119 0.043
Zebrafish Mouse Rat Fly
positive regulation of cellular component biogenesis GO:0044089 3 0.043
organonitrogen compound metabolic process GO:1901564 74 0.043
nucleocytoplasmic transport GO:0006913 4 0.043
Mouse
response to organic substance GO:0010033 153 0.041
Zebrafish Mouse Rat
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.041
Mouse
regulation of immune response GO:0050776 14 0.041
Mouse
cellular response to biotic stimulus GO:0071216 3 0.037
Mouse
positive regulation of transport GO:0051050 2 0.037
Mouse Rat
regulation of macromolecule metabolic process GO:0060255 317 0.036
Mouse
intracellular signal transduction GO:0035556 85 0.036
Mouse Rat Fly
cellular response to lipopolysaccharide GO:0071222 3 0.036
Mouse
gtp metabolic process GO:0046039 4 0.034
regulation of protein transport GO:0051223 3 0.034
Mouse Rat
synaptic growth at neuromuscular junction GO:0051124 2 0.034
multicellular organismal metabolic process GO:0044236 2 0.034
autophagy GO:0006914 4 0.034
protein localization to nucleus GO:0034504 3 0.034
Mouse
nuclear transport GO:0051169 4 0.034
Mouse
response to chemical GO:0042221 320 0.034
Zebrafish Mouse Rat
cognition GO:0050890 1 0.034
interspecies interaction between organisms GO:0044419 4 0.033
Mouse
response to virus GO:0009615 21 0.033
Zebrafish
negative regulation of biological process GO:0048519 304 0.033
Mouse Rat Fly
regulation of protein targeting GO:1903533 2 0.033
Mouse
regulation of defense response GO:0031347 14 0.032
Mouse Rat
maintenance of location GO:0051235 4 0.032
cellular response to extracellular stimulus GO:0031668 2 0.032
positive regulation of response to stimulus GO:0048584 80 0.032
Zebrafish Mouse Rat
single organism nuclear import GO:1902593 3 0.031
Mouse
nuclear import GO:0051170 3 0.031
Mouse
multicellular organism growth GO:0035264 4 0.031
regulation of nucleocytoplasmic transport GO:0046822 2 0.031
Mouse
regulation of cellular amino acid metabolic process GO:0006521 0 0.031
cellular macromolecule biosynthetic process GO:0034645 224 0.031
Mouse
regulation of reproductive process GO:2000241 4 0.031
regulation of tube size GO:0035150 2 0.031
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.031
defense response to bacterium GO:0042742 22 0.030
Zebrafish Mouse Fly
positive regulation of cellular metabolic process GO:0031325 94 0.030
Mouse
regulation of cellular amine metabolic process GO:0033238 0 0.030
positive regulation of cellular catabolic process GO:0031331 3 0.029
guanosine containing compound catabolic process GO:1901069 2 0.029
response to vitamin GO:0033273 3 0.028
regulation of metal ion transport GO:0010959 4 0.028
cellular amine metabolic process GO:0044106 2 0.028
regulation of cytoplasmic transport GO:1903649 4 0.028
Mouse
positive regulation of catabolic process GO:0009896 4 0.028
angiogenesis GO:0001525 158 0.028
cytokinesis GO:0000910 3 0.028
vasculature development GO:0001944 278 0.027
negative regulation of catabolic process GO:0009895 3 0.027
aromatic compound biosynthetic process GO:0019438 217 0.027
Mouse
adult behavior GO:0030534 2 0.027
stem cell division GO:0017145 1 0.027
regulation of cell shape GO:0008360 1 0.027
regulation of binding GO:0051098 3 0.027
regulation of wound healing GO:0061041 2 0.027
regulation of multicellular organism growth GO:0040014 4 0.027
extrinsic apoptotic signaling pathway GO:0097191 3 0.027
Zebrafish Mouse Fly
nitric oxide biosynthetic process GO:0006809 2 0.027
positive regulation of stress activated mapk cascade GO:0032874 3 0.026
Mouse
gtp catabolic process GO:0006184 2 0.026
cell substrate adhesion GO:0031589 4 0.026
positive regulation of cell activation GO:0050867 1 0.026
nitrogen compound metabolic process GO:0006807 319 0.026
Mouse
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.026
Mouse
positive regulation of immune effector process GO:0002699 3 0.026
Mouse
cellular response to nutrient levels GO:0031669 2 0.026
regulation of intracellular protein transport GO:0033157 3 0.026
Mouse
central nervous system development GO:0007417 387 0.026
circulatory system process GO:0003013 87 0.026
regulation of establishment of protein localization GO:0070201 4 0.026
Mouse Rat
nitric oxide metabolic process GO:0046209 2 0.026
immunoglobulin mediated immune response GO:0016064 3 0.025
Mouse
regulation of cellular metabolic process GO:0031323 320 0.025
Mouse
response to drug GO:0042493 3 0.025
Rat
b cell mediated immunity GO:0019724 3 0.025
Mouse
regulation of endopeptidase activity GO:0052548 23 0.025
Mouse
protein targeting to nucleus GO:0044744 3 0.025
Mouse
protein import GO:0017038 3 0.024
Mouse
positive regulation of cell cycle GO:0045787 3 0.024
Rat
adherens junction organization GO:0034332 4 0.024
muscle structure development GO:0061061 196 0.024
Mouse
somatic muscle development GO:0007525 4 0.024
regulation of cell activation GO:0050865 1 0.024
antibacterial humoral response GO:0019731 2 0.024
regulation of protein catabolic process GO:0042176 1 0.024
phagocytosis GO:0006909 3 0.024
Fly
neuroblast proliferation GO:0007405 2 0.024
liver development GO:0001889 96 0.024
production of molecular mediator of immune response GO:0002440 2 0.024
Mouse
positive regulation of cellular amine metabolic process GO:0033240 0 0.024
establishment of localization GO:0051234 244 0.024
Mouse Rat Fly
mitochondrion organization GO:0007005 4 0.024
regulation of stem cell differentiation GO:2000736 4 0.024
regulation of protein localization to nucleus GO:1900180 2 0.023
Mouse
protein metabolic process GO:0019538 183 0.023
Mouse
leukocyte proliferation GO:0070661 1 0.023
collagen metabolic process GO:0032963 2 0.023
regulation of blood vessel size GO:0050880 2 0.023
response to abiotic stimulus GO:0009628 122 0.023
Rat
reactive nitrogen species metabolic process GO:2001057 0 0.023
positive regulation of jnk cascade GO:0046330 3 0.023
Mouse
response to glucocorticoid GO:0051384 1 0.023
regulation of immune system process GO:0002682 34 0.023
Mouse
regulation of autophagy GO:0010506 3 0.023
tissue remodeling GO:0048771 4 0.022
system process GO:0003008 185 0.022
Rat
cellular amino acid metabolic process GO:0006520 7 0.022
intracellular mrna localization GO:0008298 1 0.022
purine nucleoside monophosphate catabolic process GO:0009128 4 0.022
response to corticosteroid GO:0031960 1 0.022
heterocycle biosynthetic process GO:0018130 215 0.022
Mouse
tyrosine phosphorylation of stat protein GO:0007260 1 0.022
locomotion GO:0040011 313 0.022
Mouse
heart contraction GO:0060047 71 0.022
regulation of nucleoside metabolic process GO:0009118 2 0.022
nucleic acid templated transcription GO:0097659 181 0.021
Mouse
establishment of protein localization to organelle GO:0072594 4 0.021
Mouse
regulation of apoptotic process GO:0042981 98 0.021
Zebrafish Mouse Rat
response to dsrna GO:0043331 7 0.021
Zebrafish
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.021
regulation of multicellular organismal process GO:0051239 277 0.021
Mouse Rat
regulation of production of molecular mediator of immune response GO:0002700 1 0.021
Mouse
positive regulation of leukocyte mediated immunity GO:0002705 1 0.021
Mouse
amine metabolic process GO:0009308 2 0.021
cell death GO:0008219 121 0.021
Zebrafish Mouse Rat Fly
negative regulation of protein phosphorylation GO:0001933 4 0.021
positive regulation of secretion GO:0051047 1 0.021
rna localization GO:0006403 4 0.021
regulation of jak stat cascade GO:0046425 3 0.021
regulation of synaptic plasticity GO:0048167 1 0.020
apoptotic process GO:0006915 116 0.020
Zebrafish Mouse Rat Fly
regulation of blood pressure GO:0008217 1 0.020
b cell activation GO:0042113 2 0.020
positive regulation of dna metabolic process GO:0051054 1 0.020
single organism metabolic process GO:0044710 217 0.020
Mouse Fly
lipid storage GO:0019915 1 0.020
gene expression GO:0010467 252 0.020
Mouse
small molecule metabolic process GO:0044281 77 0.020
developmental growth GO:0048589 166 0.020
single organism localization GO:1902578 225 0.020
Mouse Rat Fly
regulation of protein import into nucleus GO:0042306 2 0.020
Mouse
response to carbohydrate GO:0009743 3 0.020
atp catabolic process GO:0006200 4 0.020
regulation of cellular ketone metabolic process GO:0010565 7 0.020
biosynthetic process GO:0009058 294 0.020
Mouse
stem cell maintenance GO:0019827 4 0.019
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.019
regulation of muscle contraction GO:0006937 3 0.019
regulation of purine nucleotide catabolic process GO:0033121 2 0.019
blood circulation GO:0008015 87 0.019
ameboidal type cell migration GO:0001667 143 0.019
endosomal transport GO:0016197 2 0.019
rna biosynthetic process GO:0032774 181 0.019
Mouse
embryonic organ development GO:0048568 381 0.019
neuron neuron synaptic transmission GO:0007270 1 0.019
reactive oxygen species biosynthetic process GO:1903409 1 0.019
organic substance biosynthetic process GO:1901576 289 0.019
Mouse
cellular ketone metabolic process GO:0042180 11 0.019
positive regulation of metabolic process GO:0009893 108 0.019
Mouse
death GO:0016265 121 0.019
Zebrafish Mouse Rat Fly
regulation of response to nutrient levels GO:0032107 1 0.019
multicellular organismal macromolecule metabolic process GO:0044259 2 0.019
ribonucleoside monophosphate catabolic process GO:0009158 4 0.019
cellular aromatic compound metabolic process GO:0006725 295 0.019
Mouse Fly
regulation of response to biotic stimulus GO:0002831 2 0.019
regionalization GO:0003002 274 0.019
embryonic organ morphogenesis GO:0048562 274 0.019
wound healing GO:0042060 90 0.019
cellular response to starvation GO:0009267 1 0.019
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.018
cellular response to chemical stimulus GO:0070887 157 0.018
Mouse
negative regulation of reproductive process GO:2000242 3 0.018
carboxylic acid metabolic process GO:0019752 22 0.018
tube morphogenesis GO:0035239 349 0.018
regulation of nucleotide catabolic process GO:0030811 2 0.018
connective tissue development GO:0061448 99 0.018
cellular amide metabolic process GO:0043603 4 0.018
cellular biosynthetic process GO:0044249 286 0.018
Mouse
sensory perception of chemical stimulus GO:0007606 3 0.018
astrocyte differentiation GO:0048708 1 0.018
regulation of synapse assembly GO:0051963 3 0.018
organic cyclic compound biosynthetic process GO:1901362 223 0.018
Mouse
phosphate containing compound metabolic process GO:0006796 108 0.018
Mouse Fly
positive regulation of cell death GO:0010942 29 0.018
Zebrafish Mouse Rat
fatty acid transport GO:0015908 1 0.018
gland development GO:0048732 143 0.018
response to monosaccharide GO:0034284 3 0.018
establishment of protein localization to plasma membrane GO:0090002 1 0.018
sensory organ morphogenesis GO:0090596 200 0.017
skeletal muscle organ development GO:0060538 78 0.017
Mouse
sprouting angiogenesis GO:0002040 53 0.017
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.017
multi organism cellular process GO:0044764 2 0.017
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.017
peptide metabolic process GO:0006518 1 0.017
secondary metabolic process GO:0019748 3 0.017
Fly
regulation of protein complex assembly GO:0043254 3 0.017
digestive tract morphogenesis GO:0048546 231 0.017
positive regulation of wound healing GO:0090303 1 0.017
positive regulation of secretion by cell GO:1903532 1 0.017
gastrulation GO:0007369 208 0.017
negative regulation of cellular catabolic process GO:0031330 3 0.017
regulation of inflammatory response GO:0050727 2 0.017
Mouse Rat
g1 s transition of mitotic cell cycle GO:0000082 1 0.017
regulation of nucleic acid templated transcription GO:1903506 213 0.017
Mouse
response to uv GO:0009411 3 0.017
cellular response to hypoxia GO:0071456 1 0.017
myeloid cell differentiation GO:0030099 86 0.017
Mouse
regulation of organelle assembly GO:1902115 4 0.017
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.016
sensory organ development GO:0007423 393 0.016
protein secretion GO:0009306 1 0.016
Mouse
heart process GO:0003015 71 0.016
positive regulation of gliogenesis GO:0014015 2 0.016
Rat
carboxylic acid catabolic process GO:0046395 3 0.016
regulation of hormone secretion GO:0046883 2 0.016
skeletal system development GO:0001501 181 0.016
growth GO:0040007 174 0.016
Mouse
positive regulation of myeloid cell differentiation GO:0045639 2 0.016
regulation of reactive oxygen species metabolic process GO:2000377 2 0.016
Mouse
inositol lipid mediated signaling GO:0048017 2 0.016
cell cycle g1 s phase transition GO:0044843 1 0.016
protein localization to plasma membrane GO:0072659 1 0.016
regulation of intracellular signal transduction GO:1902531 57 0.016
Mouse Rat
negative regulation of cytokine production GO:0001818 1 0.016
nucleoside monophosphate catabolic process GO:0009125 4 0.016
regulation of programmed cell death GO:0043067 101 0.016
Zebrafish Mouse Rat
guanosine containing compound metabolic process GO:1901068 4 0.016
positive regulation of blood circulation GO:1903524 2 0.016
heterocycle metabolic process GO:0046483 290 0.015
Mouse
specification of symmetry GO:0009799 204 0.015
determination of heart left right asymmetry GO:0061371 117 0.015
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 1 0.015
transcription dna templated GO:0006351 181 0.015
Mouse
cell morphogenesis GO:0000902 289 0.015
glial cell migration GO:0008347 3 0.015
modification dependent macromolecule catabolic process GO:0043632 3 0.015
regulation of transcription dna templated GO:0006355 213 0.015
Mouse
germ line stem cell maintenance GO:0030718 2 0.015
positive regulation of gtp catabolic process GO:0033126 1 0.015
mononuclear cell proliferation GO:0032943 1 0.015
lymphocyte proliferation GO:0046651 1 0.015
oxoacid metabolic process GO:0043436 31 0.015
response to hydrogen peroxide GO:0042542 3 0.015
segmentation GO:0035282 97 0.015
regulation of response to extracellular stimulus GO:0032104 1 0.015
interaction with host GO:0051701 4 0.015
response to organic cyclic compound GO:0014070 51 0.015
Zebrafish
negative regulation of protein localization to nucleus GO:1900181 2 0.015
negative regulation of autophagy GO:0010507 1 0.015
cellular response to unfolded protein GO:0034620 2 0.015
regulation of cell substrate adhesion GO:0010810 1 0.015
regulation of dna recombination GO:0000018 2 0.015
peptidyl serine modification GO:0018209 2 0.015
inner ear development GO:0048839 126 0.015
embryo development ending in birth or egg hatching GO:0009792 271 0.015
regulation of epithelial cell proliferation GO:0050678 3 0.015
post embryonic organ development GO:0048569 4 0.015
regulation of circadian rhythm GO:0042752 4 0.015
positive regulation of nucleotide catabolic process GO:0030813 1 0.015
regulation of biosynthetic process GO:0009889 250 0.015
Mouse
organic cyclic compound metabolic process GO:1901360 301 0.015
Mouse Fly
cellular response to oxygen levels GO:0071453 1 0.015
homeostatic process GO:0042592 142 0.015
Mouse Fly
negative regulation of cytoplasmic transport GO:1903650 2 0.015
cellular response to decreased oxygen levels GO:0036294 1 0.014
regulation of synapse organization GO:0050807 3 0.014
determination of bilateral symmetry GO:0009855 204 0.014
membrane fusion GO:0061025 2 0.014
protein polyubiquitination GO:0000209 4 0.014
regulation of gtpase activity GO:0043087 2 0.014
fertilization GO:0009566 3 0.014
regulation of gtp catabolic process GO:0033124 2 0.014
energy reserve metabolic process GO:0006112 2 0.014
protein complex disassembly GO:0043241 1 0.014
macroautophagy GO:0016236 1 0.014
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.014
negative regulation of kinase activity GO:0033673 4 0.014
phosphatidylinositol mediated signaling GO:0048015 2 0.014
muscle organ development GO:0007517 101 0.014
Mouse
organic acid metabolic process GO:0006082 31 0.014
regulation of nitrogen compound metabolic process GO:0051171 251 0.014
Mouse
long chain fatty acid metabolic process GO:0001676 1 0.014
modification dependent protein catabolic process GO:0019941 3 0.014
regulation of developmental process GO:0050793 247 0.014
Mouse Rat
cellular nitrogen compound metabolic process GO:0034641 290 0.014
Mouse
eye development GO:0001654 277 0.014
tyrosine phosphorylation of stat3 protein GO:0042503 1 0.014
positive regulation of epithelial cell proliferation GO:0050679 1 0.014
nucleobase containing compound biosynthetic process GO:0034654 205 0.014
Mouse
positive regulation of map kinase activity GO:0043406 3 0.014
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.014
Mouse
regulation of tyrosine phosphorylation of stat protein GO:0042509 1 0.014
cellular protein metabolic process GO:0044267 129 0.014
Mouse
response to cadmium ion GO:0046686 14 0.014
cellular carbohydrate metabolic process GO:0044262 4 0.014
positive regulation of programmed cell death GO:0043068 29 0.014
Zebrafish Mouse Rat
single organism transport GO:0044765 206 0.014
Mouse Rat Fly
regulation of stem cell proliferation GO:0072091 2 0.014
exocytosis GO:0006887 1 0.014
regulation of striated muscle contraction GO:0006942 2 0.014
cellular response to topologically incorrect protein GO:0035967 2 0.014
cellular response to stress GO:0033554 62 0.014
Mouse Fly
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.014
single fertilization GO:0007338 3 0.014
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.014
negative regulation of intracellular transport GO:0032387 3 0.013
embryonic skeletal system morphogenesis GO:0048704 93 0.013
regulation of heart contraction GO:0008016 32 0.013
superoxide metabolic process GO:0006801 2 0.013
response to topologically incorrect protein GO:0035966 2 0.013
generation of neurons GO:0048699 385 0.013
Rat
circadian sleep wake cycle GO:0042745 2 0.013
embryonic heart tube development GO:0035050 133 0.013
muscle cell development GO:0055001 115 0.013
Mouse
cell matrix adhesion GO:0007160 4 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.013
regulation of carbohydrate metabolic process GO:0006109 4 0.013
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.013
Mouse
neuron differentiation GO:0030182 353 0.013
neurological system process GO:0050877 62 0.013
Rat
negative regulation of intracellular protein transport GO:0090317 3 0.013
viral process GO:0016032 1 0.013
transcription from rna polymerase ii promoter GO:0006366 80 0.013
Mouse
hepaticobiliary system development GO:0061008 98 0.013
protein homooligomerization GO:0051260 3 0.013
ubiquitin dependent protein catabolic process GO:0006511 3 0.013
striated muscle tissue development GO:0014706 110 0.013
Mouse
alcohol biosynthetic process GO:0046165 2 0.013
protein acetylation GO:0006473 2 0.013
regulation of protein ubiquitination GO:0031396 3 0.013
negative regulation of protein import into nucleus GO:0042308 2 0.013
regulation of rna biosynthetic process GO:2001141 213 0.013
Mouse
response to ketone GO:1901654 1 0.013
single organism biosynthetic process GO:0044711 71 0.013
regulation of cell death GO:0010941 103 0.013
Zebrafish Mouse Rat
phagocytosis engulfment GO:0006911 1 0.013
Fly
compound eye development GO:0048749 2 0.013
response to hexose GO:0009746 3 0.013
skeletal system morphogenesis GO:0048705 102 0.013
positive regulation of histone modification GO:0031058 1 0.013
embryonic skeletal system development GO:0048706 97 0.013
establishment of endothelial barrier GO:0061028 3 0.013
regulation of cellular protein catabolic process GO:1903362 1 0.013
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.013
female gonad development GO:0008585 4 0.013
cellular component disassembly GO:0022411 1 0.013
positive regulation of multi organism process GO:0043902 3 0.012
chordate embryonic development GO:0043009 271 0.012
regulation of dna replication GO:0006275 3 0.012
determination of left right symmetry GO:0007368 179 0.012
cellular protein catabolic process GO:0044257 4 0.012
pericardium development GO:0060039 1 0.012
ion transport GO:0006811 114 0.012
Rat
immune system development GO:0002520 191 0.012
Mouse
regulation of organ growth GO:0046620 3 0.012
negative regulation of protein kinase activity GO:0006469 4 0.012
response to glucose GO:0009749 3 0.012
cytoplasm organization GO:0007028 4 0.012
positive regulation of nucleoside metabolic process GO:0045979 1 0.012
endoplasmic reticulum unfolded protein response GO:0030968 2 0.012
regulation of response to cytokine stimulus GO:0060759 3 0.012
regulation of transporter activity GO:0032409 2 0.012
negative regulation of multi organism process GO:0043901 3 0.012
Mouse
regulation of dna templated transcription in response to stress GO:0043620 0 0.012
organic acid catabolic process GO:0016054 3 0.012
positive regulation of leukocyte mediated cytotoxicity GO:0001912 1 0.012
single organism membrane fusion GO:0044801 2 0.012
positive regulation of camp biosynthetic process GO:0030819 2 0.012
cellular response to radiation GO:0071478 4 0.012
neurotransmitter secretion GO:0007269 2 0.012
peptidyl lysine acetylation GO:0018394 2 0.012
lipid catabolic process GO:0016042 4 0.012
female sex differentiation GO:0046660 4 0.012
regulation of cardiac muscle contraction GO:0055117 2 0.012
positive regulation of jak stat cascade GO:0046427 2 0.012
regulation of sodium ion transport GO:0002028 2 0.012
peptide transport GO:0015833 1 0.012
Mouse
cellular nitrogen compound biosynthetic process GO:0044271 218 0.012
Mouse
regulation of protein binding GO:0043393 3 0.012
carbohydrate homeostasis GO:0033500 1 0.012
estrogen metabolic process GO:0008210 2 0.012
leukocyte mediated cytotoxicity GO:0001909 1 0.012
regulation of cellular biosynthetic process GO:0031326 245 0.012
Mouse
cell morphogenesis involved in differentiation GO:0000904 195 0.012
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.012
somite development GO:0061053 96 0.012
multicellular organismal signaling GO:0035637 22 0.012
protein heterooligomerization GO:0051291 1 0.012
negative regulation of defense response GO:0031348 2 0.012
smooth muscle contraction GO:0006939 2 0.012
membrane invagination GO:0010324 1 0.012
Fly
macromolecular complex disassembly GO:0032984 1 0.012
anterior posterior pattern specification GO:0009952 152 0.012
membrane repolarization GO:0086009 2 0.012
neuron development GO:0048666 262 0.012
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.012
regulation of calcium ion transport GO:0051924 2 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.012
positive regulation of cell adhesion GO:0045785 1 0.012
regulation of membrane potential GO:0042391 23 0.012
Rat
regulation of leukocyte mediated immunity GO:0002703 1 0.012
Mouse
zymogen activation GO:0031638 3 0.012
Mouse
regulation of multicellular organismal metabolic process GO:0044246 2 0.012
convergent extension GO:0060026 118 0.012
hormone secretion GO:0046879 2 0.011
regulation of cysteine type endopeptidase activity GO:2000116 21 0.011
Mouse
positive regulation of apoptotic process GO:0043065 29 0.011
Zebrafish Mouse Rat
cellular response to reactive oxygen species GO:0034614 2 0.011
dorsal ventral pattern formation GO:0009953 125 0.011
positive regulation of inflammatory response GO:0050729 1 0.011
Mouse Rat
regulation of ion transmembrane transporter activity GO:0032412 2 0.011
embryonic cranial skeleton morphogenesis GO:0048701 90 0.011
negative regulation of metabolic process GO:0009892 86 0.011
Mouse
cellular localization GO:0051641 97 0.011
Mouse
positive regulation of apoptotic signaling pathway GO:2001235 1 0.011
Zebrafish
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.011
digestive system development GO:0055123 289 0.011
negative regulation of protein transport GO:0051224 3 0.011
regulation of blood circulation GO:1903522 32 0.011
regulation of growth rate GO:0040009 1 0.011
regulation of anatomical structure morphogenesis GO:0022603 130 0.011
Mouse
positive regulation of gene expression GO:0010628 71 0.011
Mouse
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.011
actin mediated cell contraction GO:0070252 1 0.011
embryonic hemopoiesis GO:0035162 53 0.011
response to alkaloid GO:0043279 2 0.011
response to mechanical stimulus GO:0009612 24 0.011
Rat
internal protein amino acid acetylation GO:0006475 2 0.011

tnfb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.037
disease of cellular proliferation DOID:14566 0 0.029
cancer DOID:162 0 0.029
organ system cancer DOID:0050686 0 0.029
disease of metabolism DOID:0014667 0 0.014
nervous system disease DOID:863 0 0.013