Danio rerio

15 known processes

top2a

topoisomerase (DNA) II alpha

(Aliases: fc08c07,MGC92574,wu:fc08c07)

top2a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
meiotic nuclear division GO:0007126 4 0.987
embryo development ending in birth or egg hatching GO:0009792 271 0.941
Worm
microtubule based process GO:0007017 60 0.913
Fly
nuclear division GO:0000280 23 0.848
Fly
macromolecule biosynthetic process GO:0009059 227 0.719
Mouse Fly
spindle assembly involved in mitosis GO:0090307 1 0.693
spindle assembly GO:0051225 2 0.551
cell cycle GO:0007049 93 0.545
Fly
meiotic chromosome segregation GO:0045132 3 0.532
spindle organization GO:0007051 5 0.514
Fly
cellular aromatic compound metabolic process GO:0006725 295 0.506
Human Mouse Fly
reproduction GO:0000003 40 0.503
Worm
mitotic cell cycle process GO:1903047 48 0.496
Fly
cilium morphogenesis GO:0060271 85 0.493
cell cycle process GO:0022402 53 0.492
Fly
larval development GO:0002164 2 0.486
Worm
regulation of meiotic cell cycle GO:0051445 1 0.486
cellular nitrogen compound metabolic process GO:0034641 290 0.450
Human Mouse Fly
nucleobase containing compound metabolic process GO:0006139 274 0.447
Human Mouse Fly
nucleus organization GO:0006997 7 0.435
regulation of multicellular organismal development GO:2000026 223 0.427
regulation of multicellular organism growth GO:0040014 4 0.418
nucleic acid metabolic process GO:0090304 244 0.400
Human Mouse Fly
meiosis i GO:0007127 1 0.382
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.356
Human Mouse Fly
regulation of biosynthetic process GO:0009889 250 0.344
Mouse Fly
microtubule organizing center organization GO:0031023 1 0.338
centrosome duplication GO:0051298 1 0.337
regulation of multicellular organismal process GO:0051239 277 0.337
nitrogen compound metabolic process GO:0006807 319 0.312
Human Mouse Fly
dna metabolic process GO:0006259 27 0.292
Human Mouse Fly
regulation of rna metabolic process GO:0051252 224 0.286
Human Mouse Fly
developmental growth GO:0048589 166 0.284
positive regulation of cell cycle GO:0045787 3 0.281
organic cyclic compound metabolic process GO:1901360 301 0.271
Human Mouse Fly
gene expression GO:0010467 252 0.252
Mouse Worm Fly
organelle fission GO:0048285 23 0.250
Fly
regulation of primary metabolic process GO:0080090 311 0.246
Human Mouse Fly
meiotic cell cycle process GO:1903046 3 0.242
regulation of gene expression GO:0010468 265 0.241
Mouse Worm Fly
positive regulation of biological process GO:0048518 253 0.238
Human Mouse
cellular nitrogen compound biosynthetic process GO:0044271 218 0.234
Mouse Fly
cellular biosynthetic process GO:0044249 286 0.223
Mouse Fly
rna metabolic process GO:0016070 219 0.221
Human Mouse Fly
organelle organization GO:0006996 227 0.214
Human Mouse Fly
cellular macromolecule metabolic process GO:0044260 391 0.205
Human Mouse Fly
positive regulation of cellular process GO:0048522 201 0.203
Human Mouse
heterocycle biosynthetic process GO:0018130 215 0.203
Mouse Fly
regulation of nucleocytoplasmic transport GO:0046822 2 0.202
mitotic nuclear division GO:0007067 18 0.202
Fly
biosynthetic process GO:0009058 294 0.200
Mouse Fly
centrosome cycle GO:0007098 1 0.199
spindle assembly involved in meiosis GO:0090306 1 0.184
mitotic dna integrity checkpoint GO:0044774 4 0.184
Fly
meiotic cell cycle GO:0051321 5 0.173
regulation of cellular biosynthetic process GO:0031326 245 0.172
Mouse Fly
cytoskeleton organization GO:0007010 96 0.169
Fly
microtubule cytoskeleton organization GO:0000226 33 0.167
Fly
developmental process involved in reproduction GO:0003006 27 0.166
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.165
Mouse
single organism metabolic process GO:0044710 217 0.165
Human Mouse Fly
oocyte maturation GO:0001556 4 0.164
positive regulation of cellular component biogenesis GO:0044089 3 0.162
mitotic spindle organization GO:0007052 5 0.158
Fly
single organism nuclear import GO:1902593 3 0.156
heterocycle metabolic process GO:0046483 290 0.154
Human Mouse Fly
cell migration GO:0016477 237 0.153
eye development GO:0001654 277 0.150
Zebrafish
rna biosynthetic process GO:0032774 181 0.149
Mouse Fly
regulation of nitrogen compound metabolic process GO:0051171 251 0.143
Human Mouse Fly
positive regulation of catabolic process GO:0009896 4 0.140
regulation of cellular metabolic process GO:0031323 320 0.140
Human Mouse Fly
digestive system development GO:0055123 289 0.139
centrosome organization GO:0051297 1 0.136
nuclear transport GO:0051169 4 0.135
mitotic cell cycle GO:0000278 64 0.129
Fly
cell death in response to oxidative stress GO:0036473 2 0.127
aromatic compound biosynthetic process GO:0019438 217 0.127
Mouse Fly
establishment of localization GO:0051234 244 0.126
Worm Fly
meiosis ii GO:0007135 1 0.119
chromosome segregation GO:0007059 12 0.119
regulation of mitotic cell cycle phase transition GO:1901990 8 0.119
Fly
multicellular organism growth GO:0035264 4 0.116
protein targeting to nucleus GO:0044744 3 0.111
nucleic acid templated transcription GO:0097659 181 0.109
Mouse Fly
regulation of rna biosynthetic process GO:2001141 213 0.108
Mouse Fly
cell motility GO:0048870 244 0.107
single organism organelle organization GO:1902589 199 0.105
Human Mouse Fly
female meiotic division GO:0007143 2 0.104
organic substance biosynthetic process GO:1901576 289 0.103
Mouse Fly
nucleus localization GO:0051647 8 0.103
nucleobase containing compound biosynthetic process GO:0034654 205 0.103
Mouse Fly
regulation of macromolecule metabolic process GO:0060255 317 0.103
Human Mouse Worm Fly
regulation of metabolic process GO:0019222 359 0.102
Human Mouse Worm Fly
nuclear import GO:0051170 3 0.101
regeneration GO:0031099 91 0.095
locomotion GO:0040011 313 0.094
Zebrafish
cytokinesis GO:0000910 3 0.093
establishment of protein localization to organelle GO:0072594 4 0.093
cytokinetic process GO:0032506 2 0.093
nuclear migration GO:0007097 3 0.093
nucleocytoplasmic transport GO:0006913 4 0.093
maturation of ssu rrna GO:0030490 1 0.092
response to stress GO:0006950 263 0.092
Human Fly
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.092
Fly
transport GO:0006810 220 0.092
Worm
cellular localization GO:0051641 97 0.091
Fly
cellular component biogenesis GO:0044085 178 0.091
regulation of protein transport GO:0051223 3 0.089
positive regulation of cellular amine metabolic process GO:0033240 0 0.087
digestive tract development GO:0048565 265 0.084
regulation of cellular response to oxidative stress GO:1900407 2 0.084
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.084
microtubule bundle formation GO:0001578 9 0.083
single organism localization GO:1902578 225 0.082
pronuclear migration GO:0035046 1 0.082
organic substance transport GO:0071702 58 0.082
regulation of histone methylation GO:0031060 3 0.082
amine metabolic process GO:0009308 2 0.081
protein complex subunit organization GO:0071822 46 0.081
Fly
positive regulation of cellular catabolic process GO:0031331 3 0.080
circulatory system process GO:0003013 87 0.079
positive regulation of cellular biosynthetic process GO:0031328 68 0.079
Mouse
transcription from rna polymerase ii promoter GO:0006366 80 0.078
Mouse
localization of cell GO:0051674 244 0.078
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.077
Human Mouse
growth GO:0040007 174 0.077
positive regulation of rna biosynthetic process GO:1902680 57 0.076
Mouse
cellular ketone metabolic process GO:0042180 11 0.076
negative regulation of biological process GO:0048519 304 0.076
Worm Fly
death GO:0016265 121 0.074
Human
neural retina development GO:0003407 49 0.074
Zebrafish
peptidyl threonine phosphorylation GO:0018107 1 0.073
regulation of cellular ketone metabolic process GO:0010565 7 0.073
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.073
cellular component assembly GO:0022607 170 0.069
cellular protein modification process GO:0006464 100 0.069
negative regulation of metabolic process GO:0009892 86 0.069
Worm Fly
cell projection organization GO:0030030 284 0.067
Zebrafish
homologous chromosome segregation GO:0045143 1 0.067
chromosome organization involved in meiosis GO:0070192 1 0.067
cellular protein metabolic process GO:0044267 129 0.065
cilium assembly GO:0042384 58 0.065
negative regulation of cellular process GO:0048523 283 0.064
Fly
response to chemical GO:0042221 320 0.064
Zebrafish
carboxylic acid metabolic process GO:0019752 22 0.064
cell cycle g2 m phase transition GO:0044839 4 0.063
regulation of catalytic activity GO:0050790 55 0.062
reciprocal meiotic recombination GO:0007131 1 0.062
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.062
organic acid metabolic process GO:0006082 31 0.062
oxoacid metabolic process GO:0043436 31 0.061
regulation of developmental process GO:0050793 247 0.060
germ cell development GO:0007281 22 0.060
spindle assembly involved in female meiosis GO:0007056 1 0.059
protein import GO:0017038 3 0.059
lateral inhibition GO:0046331 1 0.058
cytoskeleton dependent cytokinesis GO:0061640 3 0.058
negative regulation of cellular metabolic process GO:0031324 77 0.057
Fly
chordate embryonic development GO:0043009 271 0.057
auditory receptor cell fate commitment GO:0009912 4 0.056
regulation of cellular amino acid metabolic process GO:0006521 0 0.056
male meiosis GO:0007140 2 0.056
nuclear envelope organization GO:0006998 2 0.055
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.055
Fly
multi organism reproductive process GO:0044703 36 0.055
protein metabolic process GO:0019538 183 0.055
cleavage furrow formation GO:0036089 2 0.054
fertilization GO:0009566 3 0.053
meiotic spindle organization GO:0000212 1 0.052
organelle localization GO:0051640 49 0.052
Fly
eye morphogenesis GO:0048592 144 0.051
Zebrafish
camera type eye development GO:0043010 222 0.051
Zebrafish
negative regulation of cellular catabolic process GO:0031330 3 0.050
blood vessel development GO:0001568 246 0.049
organic substance catabolic process GO:1901575 28 0.049
Human Mouse Fly
regulation of cell cycle phase transition GO:1901987 8 0.049
Fly
rna 3 end processing GO:0031123 2 0.048
regulation of biological quality GO:0065008 263 0.048
regulation of establishment of protein localization GO:0070201 4 0.048
sensory organ development GO:0007423 393 0.048
Zebrafish
cell migration involved in heart development GO:0060973 22 0.048
single organism reproductive process GO:0044702 40 0.048
regulation of transcription dna templated GO:0006355 213 0.047
Mouse Fly
protein import into nucleus GO:0006606 3 0.047
morphogenesis of an epithelium GO:0002009 333 0.047
establishment of localization in cell GO:0051649 77 0.045
Fly
embryonic digestive tract morphogenesis GO:0048557 3 0.044
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.044
Mouse
development of primary sexual characteristics GO:0045137 5 0.044
microtubule polymerization or depolymerization GO:0031109 3 0.044
positive regulation of chromosome organization GO:2001252 1 0.044
cilium organization GO:0044782 71 0.044
cellular amino acid metabolic process GO:0006520 7 0.043
organic cyclic compound biosynthetic process GO:1901362 223 0.043
Mouse Fly
regulation of intracellular protein transport GO:0033157 3 0.043
hematopoietic stem cell differentiation GO:0060218 20 0.043
exocrine system development GO:0035272 28 0.042
transcription dna templated GO:0006351 181 0.042
Mouse Fly
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.041
Fly
regulation of chromatin modification GO:1903308 5 0.041
retina morphogenesis in camera type eye GO:0060042 79 0.041
Zebrafish
cellular macromolecule biosynthetic process GO:0034645 224 0.041
Mouse Fly
regulation of mitotic cell cycle GO:0007346 25 0.040
Fly
multicellular organism reproduction GO:0032504 35 0.040
response to organic substance GO:0010033 153 0.040
chromosome organization GO:0051276 31 0.040
Human Mouse Fly
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000462 1 0.039
regulation of cell cycle process GO:0010564 20 0.039
Fly
primary neural tube formation GO:0014020 1 0.039
carbohydrate derivative metabolic process GO:1901135 61 0.039
Human Mouse Fly
multicellular organismal reproductive process GO:0048609 35 0.039
protein homooligomerization GO:0051260 3 0.039
protein localization to nucleus GO:0034504 3 0.038
regulation of cell activation GO:0050865 1 0.038
microtubule depolymerization GO:0007019 1 0.038
microtubule based movement GO:0007018 33 0.038
regulation of protein complex assembly GO:0043254 3 0.038
regulation of cytoplasmic transport GO:1903649 4 0.038
negative regulation of gene expression GO:0010629 65 0.037
Worm Fly
negative regulation of apoptotic process GO:0043066 55 0.037
single organism cellular localization GO:1902580 46 0.037
vasculature development GO:0001944 278 0.037
negative regulation of nuclear division GO:0051784 3 0.036
positive regulation of transcription dna templated GO:0045893 57 0.036
Mouse
cell part morphogenesis GO:0032990 246 0.036
Zebrafish
regulation of cellular amine metabolic process GO:0033238 0 0.036
mitotic sister chromatid cohesion GO:0007064 2 0.036
cell death GO:0008219 121 0.035
Human
regulation of response to oxidative stress GO:1902882 2 0.035
regulation of protein localization to nucleus GO:1900180 2 0.035
mitotic cytokinesis GO:0000281 3 0.035
regulation of organ growth GO:0046620 3 0.035
regulation of cellular component organization GO:0051128 86 0.035
positive regulation of biosynthetic process GO:0009891 68 0.035
Mouse
single organism transport GO:0044765 206 0.035
blood vessel morphogenesis GO:0048514 216 0.035
blood circulation GO:0008015 87 0.034
modification dependent macromolecule catabolic process GO:0043632 3 0.034
heart process GO:0003015 71 0.034
intracellular transport GO:0046907 32 0.034
cell substrate adhesion GO:0031589 4 0.034
reciprocal dna recombination GO:0035825 1 0.034
establishment of vesicle localization GO:0051650 24 0.033
regulation of protein targeting GO:1903533 2 0.033
negative regulation of macromolecule metabolic process GO:0010605 76 0.033
Worm Fly
regulation of intracellular signal transduction GO:1902531 57 0.033
positive regulation of transport GO:0051050 2 0.033
small gtpase mediated signal transduction GO:0007264 8 0.033
single fertilization GO:0007338 3 0.031
regulation of gene expression epigenetic GO:0040029 11 0.031
Worm Fly
system process GO:0003008 185 0.031
negative regulation of protein transport GO:0051224 3 0.031
behavior GO:0007610 74 0.031
negative regulation of response to stimulus GO:0048585 104 0.030
regulation of protein import into nucleus GO:0042306 2 0.030
protein complex assembly GO:0006461 30 0.030
protein secretion GO:0009306 1 0.030
sexual reproduction GO:0019953 36 0.030
regulation of heart growth GO:0060420 2 0.029
positive regulation of immune effector process GO:0002699 3 0.029
regulation of protein catabolic process GO:0042176 1 0.029
positive regulation of gene expression GO:0010628 71 0.029
Mouse
cellular component disassembly GO:0022411 1 0.029
Human
regulation of establishment of planar polarity GO:0090175 4 0.029
positive regulation of protein complex assembly GO:0031334 2 0.029
phosphorus metabolic process GO:0006793 109 0.029
Human Mouse Fly
cellular component movement GO:0006928 335 0.029
Zebrafish
embryonic organ development GO:0048568 381 0.028
cell proliferation GO:0008283 80 0.028
gamete generation GO:0007276 33 0.028
intracellular signal transduction GO:0035556 85 0.028
oogenesis GO:0048477 14 0.028
neuron projection regeneration GO:0031102 16 0.028
embryonic limb morphogenesis GO:0030326 2 0.027
angiogenesis GO:0001525 158 0.027
cell projection morphogenesis GO:0048858 244 0.027
Zebrafish
regulation of nucleic acid templated transcription GO:1903506 213 0.027
Mouse Fly
eye photoreceptor cell development GO:0042462 30 0.027
head development GO:0060322 303 0.027
spermatid differentiation GO:0048515 2 0.026
organelle assembly GO:0070925 110 0.026
smooth muscle contraction GO:0006939 2 0.026
inner ear receptor cell fate commitment GO:0060120 4 0.026
proximal distal pattern formation GO:0009954 1 0.026
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.026
Mouse Fly
cellular component morphogenesis GO:0032989 336 0.026
Zebrafish
response to antibiotic GO:0046677 1 0.026
convergent extension GO:0060026 118 0.025
spinal cord development GO:0021510 46 0.025
proteasomal protein catabolic process GO:0010498 2 0.025
regulation of cell death GO:0010941 103 0.025
Human
response to topologically incorrect protein GO:0035966 2 0.025
regulation of cell cycle GO:0051726 52 0.025
Fly
positive regulation of cellular metabolic process GO:0031325 94 0.025
Human Mouse
tube morphogenesis GO:0035239 349 0.024
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.024
Human Mouse
mitotic dna damage checkpoint GO:0044773 4 0.024
Fly
endocardium morphogenesis GO:0003160 4 0.024
determination of intestine left right asymmetry GO:0071908 2 0.024
nucleoside monophosphate catabolic process GO:0009125 4 0.024
Human Mouse Fly
protein complex disassembly GO:0043241 1 0.024
cell morphogenesis GO:0000902 289 0.023
Zebrafish
embryonic organ morphogenesis GO:0048562 274 0.023
organic cyclic compound catabolic process GO:1901361 15 0.023
Human Mouse Fly
regulation of microtubule cytoskeleton organization GO:0070507 3 0.023
negative regulation of cellular biosynthetic process GO:0031327 55 0.023
Fly
sister chromatid segregation GO:0000819 6 0.023
Fly
negative regulation of catabolic process GO:0009895 3 0.023
regulation of reactive oxygen species metabolic process GO:2000377 2 0.023
response to drug GO:0042493 3 0.022
negative regulation of biosynthetic process GO:0009890 55 0.022
Fly
epithalamus development GO:0021538 10 0.022
exocrine pancreas development GO:0031017 28 0.022
regulation of peptidase activity GO:0052547 23 0.022
embryonic heart tube morphogenesis GO:0003143 108 0.022
regulation of protein depolymerization GO:1901879 1 0.022
heart morphogenesis GO:0003007 156 0.022
regulation of macromolecule biosynthetic process GO:0010556 225 0.022
Mouse Fly
cell substrate junction assembly GO:0007044 2 0.022
regulation of mrna processing GO:0050684 3 0.022
cellular response to radiation GO:0071478 4 0.021
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.021
dna modification GO:0006304 8 0.021
reproductive process GO:0022414 40 0.021
negative regulation of cell communication GO:0010648 96 0.021
neuronal stem cell maintenance GO:0097150 2 0.021
negative regulation of transcription dna templated GO:0045892 45 0.021
Fly
muscle tissue development GO:0060537 110 0.021
heart looping GO:0001947 94 0.021
positive regulation of cytoskeleton organization GO:0051495 3 0.021
gastrulation GO:0007369 208 0.021
negative regulation of cell cycle phase transition GO:1901988 5 0.021
Fly
distal tubule development GO:0072017 1 0.021
response to abiotic stimulus GO:0009628 122 0.021
atp catabolic process GO:0006200 4 0.021
Human Mouse Fly
developmental programmed cell death GO:0010623 4 0.021
nerve development GO:0021675 45 0.021
regulation of production of molecular mediator of immune response GO:0002700 1 0.020
establishment of organelle localization GO:0051656 45 0.020
Fly
bmp signaling pathway involved in heart development GO:0061312 15 0.020
dna alkylation GO:0006305 8 0.020
regulation of cell aging GO:0090342 1 0.020
neural crest cell differentiation GO:0014033 72 0.020
regulation of organelle assembly GO:1902115 4 0.020
cellular response to chemical stimulus GO:0070887 157 0.020
digestive tract morphogenesis GO:0048546 231 0.020
dna methylation or demethylation GO:0044728 8 0.020
regulation of reproductive process GO:2000241 4 0.020
regulation of localization GO:0032879 104 0.019
cellular macromolecular complex assembly GO:0034622 24 0.019
regulation of system process GO:0044057 40 0.019
regulation of programmed cell death GO:0043067 101 0.019
Human
embryonic skeletal joint development GO:0072498 3 0.019
negative regulation of chemotaxis GO:0050922 4 0.019
axonal defasciculation GO:0007414 2 0.019
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.019
response to wounding GO:0009611 116 0.019
regulation of blood circulation GO:1903522 32 0.019
golgi organization GO:0007030 1 0.019
striated muscle tissue development GO:0014706 110 0.019
regulation of chromosome segregation GO:0051983 1 0.019
autophagy GO:0006914 4 0.019
peptidyl threonine modification GO:0018210 1 0.018
cell surface receptor signaling pathway GO:0007166 325 0.018
regulation of purine nucleotide catabolic process GO:0033121 2 0.018
positive regulation of chromatin modification GO:1903310 1 0.018
organonitrogen compound metabolic process GO:1901564 74 0.018
Human Mouse Fly
heart contraction GO:0060047 71 0.018
interspecies interaction between organisms GO:0044419 4 0.017
Human
regulation of apoptotic process GO:0042981 98 0.017
Human
phosphorylation GO:0016310 69 0.017
pectoral fin development GO:0033339 50 0.017
establishment of nucleus localization GO:0040023 7 0.017
retina layer formation GO:0010842 24 0.017
Zebrafish
mesenchymal cell proliferation GO:0010463 1 0.017
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.017
Fly
spermatid development GO:0007286 2 0.017
regulation of nucleotide catabolic process GO:0030811 2 0.017
axial mesoderm formation GO:0048320 4 0.017
kidney vasculature development GO:0061440 2 0.017
cellular response to organic substance GO:0071310 105 0.017
basement membrane assembly GO:0070831 3 0.017
posttranscriptional regulation of gene expression GO:0010608 14 0.017
Worm
ras protein signal transduction GO:0007265 7 0.017
mitotic g2 dna damage checkpoint GO:0007095 3 0.016
Fly
response to uv GO:0009411 3 0.016
cellular response to unfolded protein GO:0034620 2 0.016
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.016
protein modification process GO:0036211 100 0.016
regulation of cell division GO:0051302 12 0.016
negative regulation of protein import into nucleus GO:0042308 2 0.016
regulation of developmental growth GO:0048638 38 0.016
macromolecular complex subunit organization GO:0043933 74 0.016
Fly
macromolecule modification GO:0043412 111 0.016
positive regulation of nucleoside metabolic process GO:0045979 1 0.016
regulation of cellular component size GO:0032535 30 0.016
positive regulation of macromolecule metabolic process GO:0010604 93 0.015
Human Mouse
regulation of protein maturation GO:1903317 10 0.015
regulation of anatomical structure size GO:0090066 33 0.015
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.015
regulation of cell cycle g2 m phase transition GO:1902749 4 0.015
response to steroid hormone GO:0048545 35 0.015
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.015
Human Mouse Fly
macromolecular complex assembly GO:0065003 35 0.015
female gamete generation GO:0007292 14 0.015
neural crest cell development GO:0014032 62 0.015
renal system process involved in regulation of blood volume GO:0001977 1 0.015
positive regulation of endothelial cell differentiation GO:0045603 2 0.015
sex differentiation GO:0007548 5 0.015
modification dependent protein catabolic process GO:0019941 3 0.015
positive regulation of rna metabolic process GO:0051254 59 0.015
Human Mouse
negative regulation of rna metabolic process GO:0051253 48 0.014
Fly
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.014
regulation of growth GO:0040008 42 0.014
tube closure GO:0060606 1 0.014
guanosine containing compound metabolic process GO:1901068 4 0.014
astral microtubule organization GO:0030953 1 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.014
regulation of blood pressure GO:0008217 1 0.014
negative regulation of ras protein signal transduction GO:0046580 1 0.014
protein localization GO:0008104 40 0.014
regulation of jak stat cascade GO:0046425 3 0.014
positive regulation of ras protein signal transduction GO:0046579 1 0.014
negative regulation of cellular component organization GO:0051129 16 0.014
smoothened signaling pathway GO:0007224 30 0.014
cellular response to reactive oxygen species GO:0034614 2 0.014
female meiosis chromosome segregation GO:0016321 1 0.014
regulation of molecular function GO:0065009 70 0.014
positive regulation of metabolic process GO:0009893 108 0.014
Human Mouse
olfactory bulb development GO:0021772 4 0.014
endodermal digestive tract morphogenesis GO:0061031 2 0.014
positive regulation of map kinase activity GO:0043406 3 0.014
regulation of cellular protein catabolic process GO:1903362 1 0.014
microtubule polymerization GO:0046785 2 0.013
sister chromatid cohesion GO:0007062 2 0.013
positive regulation of histone modification GO:0031058 1 0.013
regulation of oxidative stress induced cell death GO:1903201 2 0.013
retinal ganglion cell axon guidance GO:0031290 35 0.013
Zebrafish
cellular response to biotic stimulus GO:0071216 3 0.013
stem cell fate commitment GO:0048865 1 0.013
photoreceptor cell fate commitment GO:0046552 1 0.013
endocardium formation GO:0060214 1 0.013
ventral spinal cord interneuron specification GO:0021521 3 0.013
response to other organism GO:0051707 97 0.013
response to radiation GO:0009314 51 0.013
g2 m transition of mitotic cell cycle GO:0000086 4 0.013
regulation of neuron differentiation GO:0045664 56 0.013
cranial nerve development GO:0021545 42 0.013
positive regulation of nucleotide catabolic process GO:0030813 1 0.013
ribonucleoside monophosphate catabolic process GO:0009158 4 0.013
Human Mouse Fly
regulation of proteolysis GO:0030162 24 0.013
negative regulation of neuron projection regeneration GO:0070571 4 0.013
b cell activation GO:0042113 2 0.012
aging GO:0007568 2 0.012
cellular response to oxygen levels GO:0071453 1 0.012
heterophilic cell cell adhesion via plasma membrane cell adhesion molecules GO:0007157 2 0.012
single organism intracellular transport GO:1902582 25 0.012
negative regulation of protein kinase activity GO:0006469 4 0.012
maintenance of location GO:0051235 4 0.012
positive regulation of mesodermal cell fate specification GO:0048337 1 0.012
negative regulation of cell cycle GO:0045786 14 0.012
Fly
negative regulation of intracellular transport GO:0032387 3 0.012
intrinsic apoptotic signaling pathway GO:0097193 20 0.012
regionalization GO:0003002 274 0.012
negative regulation of kinase activity GO:0033673 4 0.012
regulation of cell size GO:0008361 29 0.012
developmental growth involved in morphogenesis GO:0060560 86 0.012
somatic muscle development GO:0007525 4 0.012
regulation of response to stimulus GO:0048583 269 0.012
cellular response to decreased oxygen levels GO:0036294 1 0.011
protein polymerization GO:0051258 4 0.011
macromolecular complex disassembly GO:0032984 1 0.011
lipid storage GO:0019915 1 0.011
muscle structure development GO:0061061 196 0.011
negative regulation of dna metabolic process GO:0051053 4 0.011
negative regulation of signal transduction GO:0009968 94 0.011
central nervous system development GO:0007417 387 0.011
positive regulation of nucleic acid templated transcription GO:1903508 57 0.011
Mouse
ventral spinal cord interneuron fate commitment GO:0060579 3 0.011
positive regulation of cell division GO:0051781 2 0.011
negative regulation of dna replication GO:0008156 2 0.011
histone deacetylation GO:0016575 2 0.011
cellular protein complex assembly GO:0043623 19 0.011
fin regeneration GO:0031101 51 0.011
negative regulation of chromosome organization GO:2001251 1 0.011
regulation of cell projection assembly GO:0060491 4 0.011
response to oxidative stress GO:0006979 11 0.011
negative regulation of cell death GO:0060548 60 0.011
phosphate containing compound metabolic process GO:0006796 108 0.011
Human Mouse Fly

top2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.026
disease of cellular proliferation DOID:14566 0 0.026
immune system disease DOID:2914 0 0.025
disease of anatomical entity DOID:7 0 0.025
hematopoietic system disease DOID:74 0 0.021
bone marrow disease DOID:4961 0 0.020
nervous system disease DOID:863 0 0.016
musculoskeletal system cancer DOID:0060100 0 0.011
organ system cancer DOID:0050686 0 0.011