Danio rerio

103 known processes

tp63

tumor protein p63

(Aliases: p63,id:ibd3516,MGC192897,wu:fk85h07,DNp63,wu:fk88b02,tp73l,wu:fc89f04)

tp63 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
skin development GO:0043588 54 0.993
skeletal system development GO:0001501 181 0.983
Zebrafish Mouse
embryonic organ development GO:0048568 381 0.973
Zebrafish
epidermis development GO:0008544 48 0.947
chordate embryonic development GO:0043009 271 0.940
Zebrafish
cranial ganglion development GO:0061550 3 0.911
otic vesicle morphogenesis GO:0071600 34 0.906
epidermal cell differentiation GO:0009913 36 0.878
Mouse
embryo development ending in birth or egg hatching GO:0009792 271 0.877
Zebrafish Worm
regionalization GO:0003002 274 0.877
Mouse
epithelial cell differentiation GO:0030855 116 0.870
Mouse
cell motility GO:0048870 244 0.869
blood vessel development GO:0001568 246 0.821
Zebrafish
positive regulation of biological process GO:0048518 253 0.814
Human Zebrafish Mouse Fly
skeletal system morphogenesis GO:0048705 102 0.807
Zebrafish
morphogenesis of an epithelium GO:0002009 333 0.786
tube morphogenesis GO:0035239 349 0.781
Mouse
sympathetic nervous system development GO:0048485 3 0.778
Mouse
gastrulation GO:0007369 208 0.771
digestive system development GO:0055123 289 0.765
Mouse
cartilage development GO:0051216 96 0.754
regulation of multicellular organismal process GO:0051239 277 0.752
Human Zebrafish Mouse Fly
digestive tract development GO:0048565 265 0.725
Mouse
immune system process GO:0002376 241 0.724
Zebrafish
regulation of epithelial cell proliferation GO:0050678 3 0.717
Mouse
formation of primary germ layer GO:0001704 62 0.698
brain development GO:0007420 293 0.694
cellular component movement GO:0006928 335 0.687
embryonic cranial skeleton morphogenesis GO:0048701 90 0.667
Zebrafish
embryonic organ morphogenesis GO:0048562 274 0.666
Zebrafish
embryonic skeletal system development GO:0048706 97 0.665
Zebrafish
ectodermal placode formation GO:0060788 26 0.645
specification of symmetry GO:0009799 204 0.641
ear development GO:0043583 127 0.627
regulation of metabolic process GO:0019222 359 0.626
appendage morphogenesis GO:0035107 56 0.623
Mouse
pectoral fin development GO:0033339 50 0.622
gland development GO:0048732 143 0.615
Mouse
otic vesicle formation GO:0030916 27 0.611
neural crest cell development GO:0014032 62 0.601
cellular aromatic compound metabolic process GO:0006725 295 0.598
blood vessel morphogenesis GO:0048514 216 0.585
Zebrafish
multicellular organismal water homeostasis GO:0050891 1 0.579
Mouse
positive regulation of biosynthetic process GO:0009891 68 0.576
Human Zebrafish Mouse Fly
otic vesicle development GO:0071599 42 0.574
mesenchyme development GO:0060485 127 0.573
cell fate specification GO:0001708 68 0.572
heart development GO:0007507 313 0.567
cell migration GO:0016477 237 0.563
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.561
cell projection organization GO:0030030 284 0.560
wound healing GO:0042060 90 0.553
Fly
neuron differentiation GO:0030182 353 0.552
Fly
embryonic skeletal system morphogenesis GO:0048704 93 0.544
Zebrafish
immune system development GO:0002520 191 0.542
Zebrafish
response to external stimulus GO:0009605 264 0.538
Worm Fly
localization of cell GO:0051674 244 0.537
regulation of immune system process GO:0002682 34 0.535
connective tissue development GO:0061448 99 0.531
regulation of multicellular organismal development GO:2000026 223 0.518
Zebrafish Mouse Fly
death GO:0016265 121 0.511
neuron projection guidance GO:0097485 86 0.507
hematopoietic or lymphoid organ development GO:0048534 191 0.504
Zebrafish
neural crest cell differentiation GO:0014033 72 0.489
negative regulation of multicellular organismal process GO:0051241 69 0.487
Zebrafish Mouse Fly
negative regulation of biological process GO:0048519 304 0.485
angiogenesis GO:0001525 158 0.478
Zebrafish
locomotion GO:0040011 313 0.477
cell proliferation GO:0008283 80 0.476
Mouse Fly
keratinocyte differentiation GO:0030216 0 0.476
Mouse
retina morphogenesis in camera type eye GO:0060042 79 0.475
somite development GO:0061053 96 0.473
water homeostasis GO:0030104 4 0.461
Mouse
positive regulation of rna metabolic process GO:0051254 59 0.455
Human Zebrafish Mouse Fly
camera type eye development GO:0043010 222 0.450
central nervous system myelin formation GO:0032289 1 0.445
positive regulation of epithelial cell proliferation GO:0050679 1 0.445
Mouse
response to wounding GO:0009611 116 0.436
Fly
morphogenesis of an epithelial sheet GO:0002011 49 0.432
eye development GO:0001654 277 0.422
determination of bilateral symmetry GO:0009855 204 0.419
otic placode formation GO:0043049 23 0.417
regulation of establishment of protein localization GO:0070201 4 0.414
Fly
programmed cell death GO:0012501 119 0.410
appendage development GO:0048736 80 0.409
Mouse
inner ear morphogenesis GO:0042472 63 0.408
growth GO:0040007 174 0.398
Fly
sensory organ morphogenesis GO:0090596 200 0.391
mesoderm morphogenesis GO:0048332 51 0.390
regulation of biological quality GO:0065008 263 0.383
Zebrafish Mouse
aromatic compound biosynthetic process GO:0019438 217 0.382
myelination GO:0042552 18 0.381
regulation of biosynthetic process GO:0009889 250 0.374
regeneration GO:0031099 91 0.371
Fly
heart morphogenesis GO:0003007 156 0.371
epidermal cell fate specification GO:0009957 4 0.364
inner ear development GO:0048839 126 0.363
regulation of response to stimulus GO:0048583 269 0.362
Human Mouse Fly
regulation of cell proliferation GO:0042127 37 0.351
Mouse Fly
ear morphogenesis GO:0042471 64 0.350
cell fate commitment GO:0045165 99 0.349
t cell activation GO:0042110 6 0.349
response to stress GO:0006950 263 0.347
muscle cell differentiation GO:0042692 139 0.345
epithelial cell development GO:0002064 42 0.344
Mouse
forebrain development GO:0030900 96 0.342
ectodermal placode development GO:0071696 37 0.339
sensory organ development GO:0007423 393 0.339
endocrine system development GO:0035270 65 0.337
protein targeting to nucleus GO:0044744 3 0.332
Fly
homeostatic process GO:0042592 142 0.332
Zebrafish Mouse
response to mechanical stimulus GO:0009612 24 0.322
hatching gland development GO:0048785 3 0.314
eye morphogenesis GO:0048592 144 0.314
neuron projection morphogenesis GO:0048812 161 0.307
hemopoiesis GO:0030097 183 0.306
Zebrafish
mesenchymal cell differentiation GO:0048762 87 0.306
regulation of anatomical structure morphogenesis GO:0022603 130 0.305
Zebrafish
muscle structure development GO:0061061 196 0.300
determination of dorsal ventral asymmetry GO:0048262 34 0.299
signal transduction GO:0007165 455 0.298
organic cyclic compound metabolic process GO:1901360 301 0.297
fin morphogenesis GO:0033334 53 0.295
germ line stem cell maintenance GO:0030718 2 0.294
mesenchymal cell development GO:0014031 78 0.293
cardiac muscle tissue development GO:0048738 48 0.292
cell morphogenesis GO:0000902 289 0.286
regulation of programmed cell death GO:0043067 101 0.285
Human Zebrafish Mouse Fly
negative regulation of epithelial cell proliferation GO:0050680 1 0.282
regulation of water loss via skin GO:0033561 1 0.276
Mouse
embryonic viscerocranium morphogenesis GO:0048703 52 0.275
regulation of cell death GO:0010941 103 0.274
Human Zebrafish Mouse Fly
developmental growth GO:0048589 166 0.274
Fly
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.272
larval development GO:0002164 2 0.270
Worm
mesodermal cell differentiation GO:0048333 21 0.269
cellular macromolecule metabolic process GO:0044260 391 0.268
stem cell differentiation GO:0048863 117 0.266
Fly
ectodermal placode morphogenesis GO:0071697 32 0.265
negative regulation of response to stimulus GO:0048585 104 0.263
Human
positive regulation of cellular process GO:0048522 201 0.261
Human Zebrafish Mouse Fly
positive regulation of cellular component biogenesis GO:0044089 3 0.259
cellular biosynthetic process GO:0044249 286 0.251
peripheral nervous system development GO:0007422 55 0.248
epiboly GO:0090504 41 0.247
regulation of macromolecule metabolic process GO:0060255 317 0.245
cellular nitrogen compound metabolic process GO:0034641 290 0.244
cell projection assembly GO:0030031 64 0.244
endoderm development GO:0007492 49 0.240
regulation of cellular metabolic process GO:0031323 320 0.239
heterocycle metabolic process GO:0046483 290 0.238
determination of left right symmetry GO:0007368 179 0.236
metal ion transport GO:0030001 58 0.233
organic substance biosynthetic process GO:1901576 289 0.230
somitogenesis GO:0001756 87 0.229
pigmentation GO:0043473 85 0.228
cartilage development involved in endochondral bone morphogenesis GO:0060351 8 0.227
cellular component morphogenesis GO:0032989 336 0.226
cellular nitrogen compound biosynthetic process GO:0044271 218 0.224
cell death GO:0008219 121 0.222
floor plate development GO:0033504 15 0.219
pectoral fin morphogenesis GO:0035138 29 0.219
synaptic growth at neuromuscular junction GO:0051124 2 0.219
taxis GO:0042330 109 0.214
cellular lipid metabolic process GO:0044255 36 0.212
Fly
regulation of synapse assembly GO:0051963 3 0.212
lens development in camera type eye GO:0002088 22 0.211
calcium ion import GO:0070509 4 0.211
nitrogen compound metabolic process GO:0006807 319 0.206
ectoderm formation GO:0001705 2 0.202
regulation of macromolecule biosynthetic process GO:0010556 225 0.202
organic cyclic compound biosynthetic process GO:1901362 223 0.201
renal system development GO:0072001 94 0.200
Mouse
eye field cell fate commitment involved in camera type eye formation GO:0060898 3 0.197
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.196
Human Zebrafish Mouse Fly
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.196
Mouse
odontogenesis of dentin containing tooth GO:0042475 1 0.190
Mouse
forebrain neuron fate commitment GO:0021877 1 0.189
cell morphogenesis involved in differentiation GO:0000904 195 0.188
retina homeostasis GO:0001895 12 0.187
single organism reproductive process GO:0044702 40 0.187
Zebrafish Mouse Fly
head morphogenesis GO:0060323 8 0.184
regulation of nitrogen compound metabolic process GO:0051171 251 0.181
fin development GO:0033333 77 0.180
notochord development GO:0030903 54 0.178
regulation of gene expression GO:0010468 265 0.178
neural crest formation GO:0014029 14 0.177
cranial nerve development GO:0021545 42 0.176
negative regulation of wnt signaling pathway GO:0030178 30 0.173
stem cell maintenance GO:0019827 4 0.172
cardiocyte differentiation GO:0035051 44 0.172
heart looping GO:0001947 94 0.170
ameboidal type cell migration GO:0001667 143 0.170
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.168
Fly
neuroepithelial cell differentiation GO:0060563 26 0.165
defense response GO:0006952 47 0.163
positive regulation of macromolecule metabolic process GO:0010604 93 0.160
Human Zebrafish Mouse Fly
regulation of inflammatory response GO:0050727 2 0.160
regulation of response to external stimulus GO:0032101 31 0.159
Fly
melanocyte differentiation GO:0030318 26 0.159
response to abiotic stimulus GO:0009628 122 0.159
Zebrafish Worm Fly
embryonic limb morphogenesis GO:0030326 2 0.158
Mouse
camera type eye morphogenesis GO:0048593 108 0.156
endodermal cell fate specification GO:0001714 17 0.156
regulation of multicellular organism growth GO:0040014 4 0.154
Fly
regulation of developmental process GO:0050793 247 0.149
Human Zebrafish Mouse Fly
pigment cell differentiation GO:0050931 38 0.149
neural tube development GO:0021915 62 0.148
positive regulation of cellular metabolic process GO:0031325 94 0.148
Human Zebrafish Mouse Fly
rna metabolic process GO:0016070 219 0.147
vasculature development GO:0001944 278 0.146
Zebrafish
positive regulation of transport GO:0051050 2 0.144
neuron projection development GO:0031175 180 0.143
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.143
biosynthetic process GO:0009058 294 0.143
gastrulation with mouth forming second GO:0001702 44 0.142
response to organic substance GO:0010033 153 0.141
Zebrafish
generation of neurons GO:0048699 385 0.139
Fly
inner ear receptor cell differentiation GO:0060113 29 0.138
vasculogenesis GO:0001570 41 0.138
biological adhesion GO:0022610 40 0.137
regulation of wound healing GO:0061041 2 0.136
nucleic acid metabolic process GO:0090304 244 0.136
embryonic camera type eye morphogenesis GO:0048596 19 0.133
macromolecular complex subunit organization GO:0043933 74 0.132
Human Mouse
convergent extension GO:0060026 118 0.132
negative regulation of cell differentiation GO:0045596 46 0.131
Mouse Fly
positive regulation of nervous system development GO:0051962 25 0.130
muscle cell development GO:0055001 115 0.129
determination of heart left right asymmetry GO:0061371 117 0.129
neural crest cell migration GO:0001755 42 0.129
response to other organism GO:0051707 97 0.129
head development GO:0060322 303 0.129
digestive tract morphogenesis GO:0048546 231 0.128
Mouse
cell projection morphogenesis GO:0048858 244 0.126
pituitary gland development GO:0021983 16 0.125
negative regulation of signaling GO:0023057 96 0.124
central nervous system development GO:0007417 387 0.123
gene expression GO:0010467 252 0.123
developmental pigmentation GO:0048066 48 0.123
stem cell development GO:0048864 82 0.122
tissue regeneration GO:0042246 74 0.121
Fly
ectodermal cell fate specification GO:0001715 2 0.121
regulation of body fluid levels GO:0050878 16 0.121
Mouse
regulation of synapse organization GO:0050807 3 0.120
regulation of nervous system development GO:0051960 90 0.120
Fly
wnt signaling pathway GO:0016055 80 0.120
negative regulation of gastrulation GO:2000542 11 0.117
multicellular organism growth GO:0035264 4 0.117
Fly
nucleobase containing compound biosynthetic process GO:0034654 205 0.117
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.113
positive regulation of rna biosynthetic process GO:1902680 57 0.113
Human Zebrafish Mouse Fly
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.111
response to glucocorticoid GO:0051384 1 0.110
myelin assembly GO:0032288 1 0.110
hematopoietic progenitor cell differentiation GO:0002244 23 0.109
cell substrate adhesion GO:0031589 4 0.108
immune response GO:0006955 28 0.108
pharyngeal system development GO:0060037 18 0.108
regulation of catenin import into nucleus GO:0035412 2 0.108
regulation of cytokine production GO:0001817 3 0.108
endoderm formation GO:0001706 29 0.107
cellular component assembly involved in morphogenesis GO:0010927 107 0.107
response to growth factor GO:0070848 39 0.106
regulation of response to stress GO:0080134 36 0.106
Human Fly
motor neuron axon guidance GO:0008045 23 0.105
striated muscle tissue development GO:0014706 110 0.105
ion transport GO:0006811 114 0.105
regulation of cell activation GO:0050865 1 0.105
lens morphogenesis in camera type eye GO:0002089 7 0.104
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.103
embryonic heart tube development GO:0035050 133 0.103
regulation of cell cycle GO:0051726 52 0.103
Human Zebrafish Fly
organelle organization GO:0006996 227 0.103
Mouse Worm Fly
fin regeneration GO:0031101 51 0.102
regulation of epidermis development GO:0045682 2 0.101
Mouse
cation transport GO:0006812 81 0.100
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.100
Human Zebrafish Mouse Fly
pancreas development GO:0031016 84 0.100
lateral line ganglion development GO:0048890 2 0.100
mesoderm development GO:0007498 88 0.100
Mouse
endodermal cell differentiation GO:0035987 19 0.099
sensory system development GO:0048880 76 0.099
semicircular canal development GO:0060872 24 0.098
cell cell signaling involved in cell fate commitment GO:0045168 12 0.098
guanosine containing compound catabolic process GO:1901069 2 0.096
heart field specification GO:0003128 1 0.094
regulation of cell communication GO:0010646 232 0.093
Human Mouse Fly
regulation of protein targeting GO:1903533 2 0.093
Fly
pharyngeal muscle development GO:0043282 4 0.093
heterocycle biosynthetic process GO:0018130 215 0.093
positive regulation of protein complex assembly GO:0031334 2 0.092
hair cell differentiation GO:0035315 32 0.092
convergent extension involved in gastrulation GO:0060027 71 0.091
negative regulation of cell communication GO:0010648 96 0.091
embryonic camera type eye development GO:0031076 29 0.091
regulation of nucleic acid templated transcription GO:1903506 213 0.090
muscle tissue development GO:0060537 110 0.089
Mouse
gamete generation GO:0007276 33 0.089
Zebrafish Fly
neural plate regionalization GO:0060897 10 0.089
embryonic heart tube morphogenesis GO:0003143 108 0.088
lymphocyte activation GO:0046649 10 0.088
negative regulation of signal transduction GO:0009968 94 0.087
gtp metabolic process GO:0046039 4 0.086
regulation of vasculature development GO:1901342 33 0.086
Zebrafish
inner ear receptor cell fate commitment GO:0060120 4 0.085
reproduction GO:0000003 40 0.084
Zebrafish Worm Fly
ribonucleotide metabolic process GO:0009259 27 0.083
regulation of cell differentiation GO:0045595 142 0.083
Human Mouse Fly
regulation of primary metabolic process GO:0080090 311 0.083
extrinsic apoptotic signaling pathway GO:0097191 3 0.082
anterior posterior pattern specification GO:0009952 152 0.082
epithelial cell proliferation GO:0050673 17 0.082
Mouse
mesodermal cell fate commitment GO:0001710 14 0.082
olfactory placode development GO:0071698 12 0.082
regulation of ectodermal cell fate specification GO:0042665 2 0.081
cell part morphogenesis GO:0032990 246 0.081
regulation of wnt signaling pathway involved in heart development GO:0003307 2 0.081
post embryonic morphogenesis GO:0009886 4 0.081
endothelial cell differentiation GO:0045446 20 0.081
phagocytosis GO:0006909 3 0.080
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.080
Human Zebrafish Mouse Fly
mesoderm formation GO:0001707 43 0.080
central nervous system myelination GO:0022010 2 0.080
negative regulation of developmental process GO:0051093 65 0.079
Human Zebrafish Mouse Fly
positive regulation of multicellular organismal process GO:0051240 52 0.079
Human Fly
regulation of neuron differentiation GO:0045664 56 0.079
Fly
enzyme linked receptor protein signaling pathway GO:0007167 106 0.079
Fly
cellular macromolecule biosynthetic process GO:0034645 224 0.079
striated muscle cell differentiation GO:0051146 129 0.079
nuclear import GO:0051170 3 0.078
Fly
regulation of gastrulation GO:0010470 24 0.078
establishment of endothelial barrier GO:0061028 3 0.077
positive regulation of metabolic process GO:0009893 108 0.077
Human Zebrafish Mouse Fly
negative regulation of embryonic development GO:0045992 11 0.076
response to corticosteroid GO:0031960 1 0.076
somatic stem cell maintenance GO:0035019 1 0.075
hepaticobiliary system development GO:0061008 98 0.075
nucleobase containing compound metabolic process GO:0006139 274 0.075
single organism organelle organization GO:1902589 199 0.074
Fly
germ cell migration GO:0008354 8 0.074
aorta development GO:0035904 4 0.073
definitive hemopoiesis GO:0060216 18 0.072
Zebrafish
lateral inhibition GO:0046331 1 0.072
chondrocyte development GO:0002063 4 0.072
axon development GO:0061564 166 0.070
protein acetylation GO:0006473 2 0.070
oxoacid metabolic process GO:0043436 31 0.070
nucleocytoplasmic transport GO:0006913 4 0.069
Fly
canonical wnt signaling pathway involved in heart development GO:0061316 1 0.068
regulation of signal transduction GO:0009966 225 0.068
Human Mouse Fly
positive regulation of cell differentiation GO:0045597 30 0.068
Human
cellular component biogenesis GO:0044085 178 0.068
Human
embryonic retina morphogenesis in camera type eye GO:0060059 22 0.067
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.067
protein import into nucleus GO:0006606 3 0.067
Fly
lateral line system development GO:0048925 76 0.067
regulation of cellular component movement GO:0051270 55 0.067
cell surface receptor signaling pathway GO:0007166 325 0.067
Human Mouse Fly
membrane invagination GO:0010324 1 0.067
regulation of ectoderm development GO:2000383 2 0.066
dorsal ventral pattern formation GO:0009953 125 0.066
embryonic pectoral fin morphogenesis GO:0035118 24 0.066
positive regulation of protein kinase b signaling GO:0051897 1 0.066
ventricular cardiac muscle tissue development GO:0003229 3 0.065
retina development in camera type eye GO:0060041 146 0.065
nuclear transport GO:0051169 4 0.065
Fly
regulation of cell fate specification GO:0042659 20 0.065
endothelium development GO:0003158 25 0.065
regulation of rho protein signal transduction GO:0035023 2 0.063
cell migration involved in gastrulation GO:0042074 79 0.062
ectoderm development GO:0007398 9 0.062
regulation of embryonic development GO:0045995 47 0.062
medial fin development GO:0033338 16 0.062
oligodendrocyte differentiation GO:0048709 23 0.062
chemotaxis GO:0006935 104 0.061
photoreceptor cell differentiation GO:0046530 55 0.061
Fly
multicellular organismal homeostasis GO:0048871 29 0.060
Zebrafish
cell migration involved in heart development GO:0060973 22 0.060
auditory receptor cell fate commitment GO:0009912 4 0.060
regulation of cytoplasmic transport GO:1903649 4 0.060
Fly
epithelial cell migration GO:0010631 25 0.059
nose development GO:0043584 3 0.059
regulation of cell development GO:0060284 100 0.059
Fly
positive regulation of cell motility GO:2000147 11 0.058
regulation of locomotion GO:0040012 55 0.058
aging GO:0007568 2 0.058
Human Mouse Worm Fly
nucleic acid templated transcription GO:0097659 181 0.058
regulation of epithelial to mesenchymal transition GO:0010717 3 0.058
regulation of signaling GO:0023051 235 0.056
Human Mouse Fly
bone morphogenesis GO:0060349 11 0.056
regulation of protein transport GO:0051223 3 0.056
Fly
hindbrain development GO:0030902 91 0.056
cellular response to organic substance GO:0071310 105 0.056
regulation of gtpase activity GO:0043087 2 0.056
embryonic eye morphogenesis GO:0048048 30 0.056
endochondral bone morphogenesis GO:0060350 8 0.056
glial cell fate commitment GO:0021781 6 0.055
leukocyte differentiation GO:0002521 25 0.055
regulation of nucleoside metabolic process GO:0009118 2 0.055
regulation of cell shape GO:0008360 1 0.055
striated muscle cell development GO:0055002 108 0.054
neuron development GO:0048666 262 0.054
mesodermal cell fate specification GO:0007501 12 0.054
axon guidance GO:0007411 86 0.054
epithelial cell morphogenesis GO:0003382 2 0.054
regulation of insulin like growth factor receptor signaling pathway GO:0043567 1 0.054
Fly
axis specification GO:0009798 43 0.054
regulation of cellular amine metabolic process GO:0033238 0 0.053
detection of mechanical stimulus GO:0050982 11 0.053
cell proliferation involved in heart morphogenesis GO:0061323 2 0.053
cell cycle GO:0007049 93 0.053
Human Zebrafish Worm Fly
protein import GO:0017038 3 0.052
Fly
regulation of stem cell differentiation GO:2000736 4 0.051
lymphocyte differentiation GO:0030098 9 0.051
regulation of blood coagulation GO:0030193 1 0.051
regulation of intracellular protein transport GO:0033157 3 0.051
Fly
positive regulation of protein polymerization GO:0032273 2 0.051
regulation of apoptotic process GO:0042981 98 0.051
Human Zebrafish Mouse Fly
guanosine containing compound metabolic process GO:1901068 4 0.051
negative regulation of canonical wnt signaling pathway GO:0090090 21 0.050
cell activation GO:0001775 16 0.050
regulation of cellular amino acid metabolic process GO:0006521 0 0.050
cell growth GO:0016049 57 0.050
oligodendrocyte cell fate commitment GO:0021779 5 0.050
determination of pancreatic left right asymmetry GO:0035469 11 0.050
regulation of endothelial cell proliferation GO:0001936 1 0.049
regulation of cellular component size GO:0032535 30 0.049
kidney development GO:0001822 92 0.049
neuron fate commitment GO:0048663 26 0.049
positive regulation of apoptotic process GO:0043065 29 0.049
Human Zebrafish Mouse Fly
regulation of mesoderm development GO:2000380 11 0.049
Mouse
liver development GO:0001889 96 0.049
negative regulation of mitosis GO:0045839 3 0.048
neural plate anterior posterior regionalization GO:0021999 8 0.048
response to oxygen containing compound GO:1901700 55 0.048
muscle organ development GO:0007517 101 0.048
glial cell differentiation GO:0010001 42 0.048
primitive hemopoiesis GO:0060215 27 0.047
regulation of purine nucleotide catabolic process GO:0033121 2 0.047
regulation of autophagy GO:0010506 3 0.047
Fly
establishment of protein localization to organelle GO:0072594 4 0.047
Fly
tissue homeostasis GO:0001894 25 0.046
Zebrafish
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.046
Fly
negative regulation of wnt signaling pathway involved in heart development GO:0003308 2 0.046
response to chemical GO:0042221 320 0.046
Zebrafish
actin filament based process GO:0030029 64 0.045
embryonic appendage morphogenesis GO:0035113 30 0.045
Mouse
regulation of wnt signaling pathway GO:0030111 53 0.045
positive regulation of cellular biosynthetic process GO:0031328 68 0.045
Human Zebrafish Mouse Fly
cell adhesion GO:0007155 40 0.045
apoptotic process involved in development GO:1902742 2 0.045
neural plate pattern specification GO:0060896 12 0.045
atrioventricular valve formation GO:0003190 3 0.045
organonitrogen compound metabolic process GO:1901564 74 0.044
carboxylic acid metabolic process GO:0019752 22 0.044
negative regulation of endothelial cell migration GO:0010596 1 0.044
response to carbohydrate GO:0009743 3 0.043
cellular response to stress GO:0033554 62 0.043
lipid oxidation GO:0034440 1 0.043
system process GO:0003008 185 0.043
Zebrafish
negative regulation of neuron differentiation GO:0045665 10 0.043
Fly
phagocytosis engulfment GO:0006911 1 0.043
positive regulation of nucleic acid templated transcription GO:1903508 57 0.043
Human Zebrafish Mouse Fly
positive regulation of translation GO:0045727 1 0.043
negative regulation of cellular process GO:0048523 283 0.043
regulation of cellular biosynthetic process GO:0031326 245 0.043
eye photoreceptor cell development GO:0042462 30 0.043
lymph vessel development GO:0001945 27 0.043
response to bacterium GO:0009617 58 0.043
heart valve formation GO:0003188 4 0.042
transcription from rna polymerase ii promoter GO:0006366 80 0.042
Human Mouse Fly
germ cell development GO:0007281 22 0.042
Fly
positive regulation of cellular component movement GO:0051272 11 0.042
cellular protein modification process GO:0006464 100 0.042
developmental cell growth GO:0048588 52 0.041
regulation of skeletal muscle tissue development GO:0048641 4 0.041
mechanoreceptor differentiation GO:0042490 37 0.041
internal peptidyl lysine acetylation GO:0018393 2 0.040
endothelial cell migration GO:0043542 19 0.040
small molecule metabolic process GO:0044281 77 0.040
blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043 4 0.040
gtp catabolic process GO:0006184 2 0.040
response to biotic stimulus GO:0009607 97 0.039
apoptotic process involved in morphogenesis GO:0060561 2 0.039
lateral line nerve glial cell development GO:0048937 6 0.039

tp63 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.160
integumentary system disease DOID:16 0 0.160
reproductive organ cancer DOID:193 0 0.092
female reproductive organ cancer DOID:120 0 0.092
cancer DOID:162 0 0.092
disease of cellular proliferation DOID:14566 0 0.092
organ system cancer DOID:0050686 0 0.092
bone development disease DOID:0080006 0 0.046
bone disease DOID:0080001 0 0.046
musculoskeletal system disease DOID:17 0 0.046
connective tissue disease DOID:65 0 0.046