Danio rerio

19 known processes

tpp1

tripeptidyl peptidase I

(Aliases: wu:fa01b09,fa01b09,im:7149243,cln2)

tpp1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sensory organ development GO:0007423 393 0.525
eye development GO:0001654 277 0.487
sensory organ morphogenesis GO:0090596 200 0.380
neurological system process GO:0050877 62 0.371
Mouse
response to chemical GO:0042221 320 0.325
regulation of multicellular organismal development GO:2000026 223 0.242
localization of cell GO:0051674 244 0.200
transport GO:0006810 220 0.193
camera type eye development GO:0043010 222 0.181
larval development GO:0002164 2 0.178
retina development in camera type eye GO:0060041 146 0.170
membrane repolarization GO:0086009 2 0.164
regulation of multicellular organismal process GO:0051239 277 0.159
retina layer formation GO:0010842 24 0.139
cell motility GO:0048870 244 0.134
establishment of localization GO:0051234 244 0.130
embryo development ending in birth or egg hatching GO:0009792 271 0.127
response to drug GO:0042493 3 0.125
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.125
generation of neurons GO:0048699 385 0.118
locomotion GO:0040011 313 0.104
fin morphogenesis GO:0033334 53 0.101
organelle organization GO:0006996 227 0.099
Mouse
cellular component movement GO:0006928 335 0.099
regulation of biological quality GO:0065008 263 0.094
neural retina development GO:0003407 49 0.092
establishment of epithelial cell polarity GO:0090162 2 0.091
cellular component assembly GO:0022607 170 0.091
regulation of anatomical structure morphogenesis GO:0022603 130 0.090
embryonic organ development GO:0048568 381 0.089
regulation of developmental process GO:0050793 247 0.084
neural crest cell migration GO:0001755 42 0.078
single organism organelle organization GO:1902589 199 0.077
cell morphogenesis involved in differentiation GO:0000904 195 0.074
pigmentation GO:0043473 85 0.070
phagocytosis GO:0006909 3 0.069
cell migration GO:0016477 237 0.069
pectoral fin development GO:0033339 50 0.068
cellular component morphogenesis GO:0032989 336 0.068
lipid storage GO:0019915 1 0.064
heterocycle metabolic process GO:0046483 290 0.064
single organism metabolic process GO:0044710 217 0.064
developmental cell growth GO:0048588 52 0.064
death GO:0016265 121 0.063
growth GO:0040007 174 0.061
embryonic organ morphogenesis GO:0048562 274 0.061
multicellular organism growth GO:0035264 4 0.059
cell cycle g1 s phase transition GO:0044843 1 0.058
brain development GO:0007420 293 0.058
cellular nitrogen compound metabolic process GO:0034641 290 0.058
cell projection organization GO:0030030 284 0.058
eye morphogenesis GO:0048592 144 0.057
golgi vesicle transport GO:0048193 3 0.056
nucleocytoplasmic transport GO:0006913 4 0.056
fin development GO:0033333 77 0.054
modification dependent macromolecule catabolic process GO:0043632 3 0.054
cytoskeleton organization GO:0007010 96 0.053
ameboidal type cell migration GO:0001667 143 0.052
nuclear transport GO:0051169 4 0.052
positive regulation of transport GO:0051050 2 0.051
regulation of signaling GO:0023051 235 0.049
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.049
axonogenesis GO:0007409 152 0.048
negative regulation of biological process GO:0048519 304 0.047
sensory system development GO:0048880 76 0.047
cellular response to chemical stimulus GO:0070887 157 0.046
negative regulation of cellular process GO:0048523 283 0.045
outflow tract morphogenesis GO:0003151 1 0.045
nucleobase containing compound metabolic process GO:0006139 274 0.045
action potential GO:0001508 19 0.045
organic cyclic compound metabolic process GO:1901360 301 0.045
establishment of protein localization to organelle GO:0072594 4 0.045
retinal ganglion cell axon guidance GO:0031290 35 0.045
cellular component biogenesis GO:0044085 178 0.045
axon development GO:0061564 166 0.044
cell death GO:0008219 121 0.044
neuromast development GO:0048884 46 0.044
heart development GO:0007507 313 0.044
neuron differentiation GO:0030182 353 0.044
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.044
cellular macromolecule metabolic process GO:0044260 391 0.043
positive regulation of metabolic process GO:0009893 108 0.043
neuron projection development GO:0031175 180 0.042
ubiquitin dependent protein catabolic process GO:0006511 3 0.042
cellular protein catabolic process GO:0044257 4 0.041
head development GO:0060322 303 0.041
cell part morphogenesis GO:0032990 246 0.041
regulation of neuron differentiation GO:0045664 56 0.041
aging GO:0007568 2 0.041
lateral line system development GO:0048925 76 0.041
rna metabolic process GO:0016070 219 0.039
regulation of neurotransmitter transport GO:0051588 1 0.038
axon guidance GO:0007411 86 0.038
nucleic acid metabolic process GO:0090304 244 0.038
central nervous system development GO:0007417 387 0.038
cation transport GO:0006812 81 0.038
positive regulation of cellular process GO:0048522 201 0.037
ear development GO:0043583 127 0.037
phosphate containing compound metabolic process GO:0006796 108 0.037
cell morphogenesis GO:0000902 289 0.037
polarized epithelial cell differentiation GO:0030859 4 0.037
regulation of neurogenesis GO:0050767 87 0.037
positive regulation of glucose transport GO:0010828 1 0.036
cellular response to organic substance GO:0071310 105 0.036
neuron development GO:0048666 262 0.036
sympathetic nervous system development GO:0048485 3 0.035
regulation of metabolic process GO:0019222 359 0.035
single organism localization GO:1902578 225 0.035
neuron projection morphogenesis GO:0048812 161 0.035
regulation of cellular component organization GO:0051128 86 0.034
cellular response to topologically incorrect protein GO:0035967 2 0.034
response to stress GO:0006950 263 0.034
stem cell proliferation GO:0072089 4 0.034
nucleoside monophosphate catabolic process GO:0009125 4 0.034
gland development GO:0048732 143 0.033
adult behavior GO:0030534 2 0.033
nitrogen compound metabolic process GO:0006807 319 0.032
negative regulation of axon guidance GO:1902668 1 0.031
appendage morphogenesis GO:0035107 56 0.030
camera type eye morphogenesis GO:0048593 108 0.030
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.030
glial cell migration GO:0008347 3 0.030
mitotic cell cycle process GO:1903047 48 0.030
purine containing compound metabolic process GO:0072521 29 0.030
stem cell fate commitment GO:0048865 1 0.029
morphogenesis of an epithelium GO:0002009 333 0.029
regulation of multicellular organism growth GO:0040014 4 0.028
protein metabolic process GO:0019538 183 0.028
appendage development GO:0048736 80 0.028
cell projection morphogenesis GO:0048858 244 0.028
regulation of cell shape GO:0008360 1 0.028
pectoral fin morphogenesis GO:0035138 29 0.028
regulation of organ growth GO:0046620 3 0.028
skeletal system development GO:0001501 181 0.028
autophagy GO:0006914 4 0.028
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.028
circulatory system process GO:0003013 87 0.027
regulation of intracellular protein transport GO:0033157 3 0.027
regulation of cell communication GO:0010646 232 0.027
viral process GO:0016032 1 0.027
digestive system development GO:0055123 289 0.026
spindle assembly GO:0051225 2 0.026
negative regulation of cytokine mediated signaling pathway GO:0001960 2 0.026
negative regulation of programmed cell death GO:0043069 58 0.026
nerve development GO:0021675 45 0.026
epithelial cell differentiation GO:0030855 116 0.026
microtubule based process GO:0007017 60 0.026
modification dependent protein catabolic process GO:0019941 3 0.026
atp catabolic process GO:0006200 4 0.026
response to vitamin GO:0033273 3 0.026
cellular response to external stimulus GO:0071496 2 0.026
chemotaxis GO:0006935 104 0.025
cortical cytoskeleton organization GO:0030865 1 0.025
regulation of cellular protein catabolic process GO:1903362 1 0.025
positive regulation of secretion GO:0051047 1 0.025
protein polyubiquitination GO:0000209 4 0.025
regulation of nervous system development GO:0051960 90 0.024
regulation of axonogenesis GO:0050770 32 0.024
hemopoiesis GO:0030097 183 0.024
developmental growth GO:0048589 166 0.024
establishment of epithelial cell apical basal polarity GO:0045198 2 0.024
sensory perception GO:0007600 39 0.024
cellular amide metabolic process GO:0043603 4 0.024
maintenance of location GO:0051235 4 0.024
interaction with host GO:0051701 4 0.024
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.024
developmental pigmentation GO:0048066 48 0.024
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.024
g1 s transition of mitotic cell cycle GO:0000082 1 0.023
programmed cell death GO:0012501 119 0.023
establishment or maintenance of bipolar cell polarity GO:0061245 12 0.023
small molecule metabolic process GO:0044281 77 0.023
single organism transport GO:0044765 206 0.023
heterophilic cell cell adhesion via plasma membrane cell adhesion molecules GO:0007157 2 0.023
cell surface receptor signaling pathway GO:0007166 325 0.023
regulation of programmed cell death GO:0043067 101 0.023
muscle structure development GO:0061061 196 0.022
ribonucleoside monophosphate catabolic process GO:0009158 4 0.022
signal transduction GO:0007165 455 0.022
homeostatic process GO:0042592 142 0.022
cellular response to light stimulus GO:0071482 4 0.022
regulation of protein ubiquitination GO:0031396 3 0.022
response to abiotic stimulus GO:0009628 122 0.022
response to light stimulus GO:0009416 46 0.022
cellular response to endogenous stimulus GO:0071495 68 0.022
positive regulation of glucose import GO:0046326 1 0.021
establishment of apical basal cell polarity GO:0035089 2 0.021
regulation of binding GO:0051098 3 0.021
protein complex biogenesis GO:0070271 30 0.021
establishment or maintenance of cell polarity GO:0007163 29 0.021
transmembrane transport GO:0055085 120 0.021
regulation of cell death GO:0010941 103 0.021
negative regulation of axon extension involved in axon guidance GO:0048843 1 0.021
cognition GO:0050890 1 0.021
system process GO:0003008 185 0.020
Mouse
telomere organization GO:0032200 1 0.020
pigment cell differentiation GO:0050931 38 0.020
positive regulation of cell cycle GO:0045787 3 0.020
nuclear export GO:0051168 1 0.020
actin filament based process GO:0030029 64 0.020
regulation of cellular metabolic process GO:0031323 320 0.020
cellular aromatic compound metabolic process GO:0006725 295 0.020
protein polymerization GO:0051258 4 0.020
regulation of response to stimulus GO:0048583 269 0.020
telomere maintenance GO:0000723 1 0.020
organelle fusion GO:0048284 3 0.019
rna processing GO:0006396 25 0.019
cortical actin cytoskeleton organization GO:0030866 1 0.019
cellular response to oxygen containing compound GO:1901701 20 0.019
regulation of synapse organization GO:0050807 3 0.019
regeneration GO:0031099 91 0.019
response to oxygen containing compound GO:1901700 55 0.019
regulation of primary metabolic process GO:0080090 311 0.019
organelle localization GO:0051640 49 0.019
establishment of monopolar cell polarity GO:0061162 2 0.019
positive regulation of catabolic process GO:0009896 4 0.019
response to glucocorticoid GO:0051384 1 0.019
regulation of rna metabolic process GO:0051252 224 0.019
positive regulation of secretion by cell GO:1903532 1 0.019
apoptotic process GO:0006915 116 0.019
organic substance transport GO:0071702 58 0.019
single fertilization GO:0007338 3 0.019
behavior GO:0007610 74 0.019
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 1 0.019
response to endogenous stimulus GO:0009719 83 0.019
regulation of cell motility GO:2000145 46 0.018
regulation of mrna processing GO:0050684 3 0.018
organic substance biosynthetic process GO:1901576 289 0.018
cranial nerve development GO:0021545 42 0.018
neural crest cell development GO:0014032 62 0.018
toxin transport GO:1901998 2 0.018
regulation of autophagy GO:0010506 3 0.018
proteasomal protein catabolic process GO:0010498 2 0.018
inositol phosphate metabolic process GO:0043647 1 0.018
gene expression GO:0010467 252 0.018
g2 dna damage checkpoint GO:0031572 3 0.018
embryonic cranial skeleton morphogenesis GO:0048701 90 0.018
response to lipid GO:0033993 60 0.017
specification of symmetry GO:0009799 204 0.017
interspecies interaction between organisms GO:0044419 4 0.017
regulation of tube size GO:0035150 2 0.017
morphogenesis of follicular epithelium GO:0016333 1 0.017
commissural neuron axon guidance GO:0071679 3 0.017
axon extension GO:0048675 45 0.017
nucleobase containing compound biosynthetic process GO:0034654 205 0.017
axon midline choice point recognition GO:0016199 4 0.017
regulation of nucleoside metabolic process GO:0009118 2 0.017
aromatic compound biosynthetic process GO:0019438 217 0.017
post embryonic organ development GO:0048569 4 0.016
cell adhesion mediated by integrin GO:0033627 1 0.016
regulation of mitotic cell cycle GO:0007346 25 0.016
stem cell maintenance GO:0019827 4 0.016
actin cytoskeleton organization GO:0030036 63 0.016
positive regulation of translation GO:0045727 1 0.016
cellular component disassembly GO:0022411 1 0.016
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.016
neuron projection guidance GO:0097485 86 0.016
regulation of signal transduction GO:0009966 225 0.016
regulation of glucose import GO:0046324 1 0.016
i kappab kinase nf kappab signaling GO:0007249 4 0.016
vasculature development GO:0001944 278 0.016
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.016
mesenchymal cell development GO:0014031 78 0.016
protein import GO:0017038 3 0.016
lamellipodium assembly GO:0030032 1 0.016
cellular amine metabolic process GO:0044106 2 0.016
retina morphogenesis in camera type eye GO:0060042 79 0.016
heterocycle biosynthetic process GO:0018130 215 0.015
purine nucleoside monophosphate catabolic process GO:0009128 4 0.015
regulation of membrane potential GO:0042391 23 0.015
response to nutrient GO:0007584 3 0.015
inner ear development GO:0048839 126 0.015
regulation of extent of cell growth GO:0061387 29 0.015
small molecule catabolic process GO:0044282 3 0.015
protein complex subunit organization GO:0071822 46 0.015
response to organic substance GO:0010033 153 0.015
response to external stimulus GO:0009605 264 0.015
glucose import GO:0046323 2 0.015
regulation of cell development GO:0060284 100 0.015
embryonic skeletal joint development GO:0072498 3 0.015
tissue regeneration GO:0042246 74 0.015
mrna transport GO:0051028 2 0.015
protein complex disassembly GO:0043241 1 0.015
positive regulation of cell matrix adhesion GO:0001954 1 0.015
rna 3 end processing GO:0031123 2 0.015
exocytosis GO:0006887 1 0.015
cellular response to hormone stimulus GO:0032870 39 0.015
midbrain development GO:0030901 28 0.015
multi organism cellular process GO:0044764 2 0.015
pancreas development GO:0031016 84 0.015
hindbrain development GO:0030902 91 0.015
cartilage condensation GO:0001502 3 0.015
tube closure GO:0060606 1 0.014
neural tube development GO:0021915 62 0.014
protein complex assembly GO:0006461 30 0.014
primary neural tube formation GO:0014020 1 0.014
melanin metabolic process GO:0006582 2 0.014
cellular carbohydrate metabolic process GO:0044262 4 0.014
gtp metabolic process GO:0046039 4 0.014
negative regulation of apoptotic process GO:0043066 55 0.014
cellular response to extracellular stimulus GO:0031668 2 0.014
cell growth GO:0016049 57 0.014
neural nucleus development GO:0048857 15 0.014
neuroblast proliferation GO:0007405 2 0.014
establishment of localization in cell GO:0051649 77 0.014
endosome organization GO:0007032 2 0.014
synaptic vesicle recycling GO:0036465 1 0.014
negative regulation of signal transduction GO:0009968 94 0.014
central nervous system neuron differentiation GO:0021953 74 0.014
regulation of cellular ketone metabolic process GO:0010565 7 0.014
regulation of cell size GO:0008361 29 0.014
myelination of anterior lateral line nerve axons GO:0048914 3 0.014
neuron neuron synaptic transmission GO:0007270 1 0.014
ion transport GO:0006811 114 0.014
organonitrogen compound metabolic process GO:1901564 74 0.014
single organism membrane organization GO:0044802 20 0.013
positive regulation of cellular catabolic process GO:0031331 3 0.013
skeletal system morphogenesis GO:0048705 102 0.013
response to radiation GO:0009314 51 0.013
regulation of locomotion GO:0040012 55 0.013
mitotic g2 dna damage checkpoint GO:0007095 3 0.013
amine metabolic process GO:0009308 2 0.013
mrna export from nucleus GO:0006406 1 0.013
immune system process GO:0002376 241 0.013
cellular response to starvation GO:0009267 1 0.013
renal filtration GO:0097205 10 0.013
single organism membrane fusion GO:0044801 2 0.013
organic acid metabolic process GO:0006082 31 0.013
determination of bilateral symmetry GO:0009855 204 0.013
lamellipodium organization GO:0097581 1 0.013
negative regulation of signal transduction in absence of ligand GO:1901099 1 0.013
tube morphogenesis GO:0035239 349 0.013
cellular biosynthetic process GO:0044249 286 0.013
endosomal transport GO:0016197 2 0.013
response to ketone GO:1901654 1 0.013
regulation of cell activation GO:0050865 1 0.013
female gonad development GO:0008585 4 0.013
anatomical structure arrangement GO:0048532 2 0.013
startle response GO:0001964 4 0.013
regulation of apoptotic process GO:0042981 98 0.013
cell matrix adhesion GO:0007160 4 0.012
odontogenesis of dentin containing tooth GO:0042475 1 0.012
regulation of developmental growth GO:0048638 38 0.012
cell cycle process GO:0022402 53 0.012
epithelial tube morphogenesis GO:0060562 148 0.012
cellular ketone metabolic process GO:0042180 11 0.012
response to corticosteroid GO:0031960 1 0.012
regulation of cytokine production GO:0001817 3 0.012
regulation of glucose transport GO:0010827 1 0.012
centrosome cycle GO:0007098 1 0.012
cell adhesion GO:0007155 40 0.012
membrane organization GO:0061024 21 0.012
wound healing GO:0042060 90 0.012
single organism nuclear import GO:1902593 3 0.012
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.012
positive regulation of chromosome organization GO:2001252 1 0.012
inorganic ion transmembrane transport GO:0098660 57 0.012
developmental growth involved in morphogenesis GO:0060560 86 0.012
positive regulation of map kinase activity GO:0043406 3 0.012
mesodermal cell migration GO:0008078 12 0.012
embryonic skeletal joint morphogenesis GO:0060272 3 0.012
polyol metabolic process GO:0019751 1 0.012
anterior lateral line nerve glial cell development GO:0048939 3 0.012
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.012
sensory neuron axon guidance GO:0097374 3 0.012
organelle assembly GO:0070925 110 0.012
exocrine system development GO:0035272 28 0.012
heart morphogenesis GO:0003007 156 0.011
regulation of protein catabolic process GO:0042176 1 0.011
mrna 3 end processing GO:0031124 2 0.011
regulation of protein binding GO:0043393 3 0.011
modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051817 4 0.011
negative regulation of stem cell differentiation GO:2000737 2 0.011
response to alcohol GO:0097305 14 0.011
regulation of rna biosynthetic process GO:2001141 213 0.011
negative regulation of macromolecule metabolic process GO:0010605 76 0.011
negative regulation of gene expression GO:0010629 65 0.011
multicellular organismal signaling GO:0035637 22 0.011
regulation of growth GO:0040008 42 0.011
regulation of protein complex assembly GO:0043254 3 0.011
cellular response to stress GO:0033554 62 0.011
regulation of gene expression GO:0010468 265 0.011
nuclear import GO:0051170 3 0.011
regulation of dendrite morphogenesis GO:0048814 3 0.011
ribonucleoprotein complex biogenesis GO:0022613 13 0.011
meiotic chromosome segregation GO:0045132 3 0.011
neuromuscular synaptic transmission GO:0007274 2 0.011
negative regulation of cell death GO:0060548 60 0.011
cardiac conduction GO:0061337 3 0.011
axon ensheathment in central nervous system GO:0032291 2 0.011
cellular protein modification process GO:0006464 100 0.011
central nervous system myelination GO:0022010 2 0.011
mitotic dna damage checkpoint GO:0044773 4 0.011
anterior lateral line nerve glial cell differentiation GO:0048913 3 0.010
macromolecular complex assembly GO:0065003 35 0.010
leukocyte proliferation GO:0070661 1 0.010
enzyme linked receptor protein signaling pathway GO:0007167 106 0.010
myelination GO:0042552 18 0.010
regulation of nitrogen compound metabolic process GO:0051171 251 0.010
regulation of cell differentiation GO:0045595 142 0.010
regulation of synaptic plasticity GO:0048167 1 0.010
cellular localization GO:0051641 97 0.010
organic substance catabolic process GO:1901575 28 0.010
digestive tract development GO:0048565 265 0.010
positive regulation of cell adhesion GO:0045785 1 0.010
macromolecular complex subunit organization GO:0043933 74 0.010
stem cell development GO:0048864 82 0.010
photoreceptor cell differentiation GO:0046530 55 0.010
cellular response to nutrient levels GO:0031669 2 0.010
regulation of cellular amino acid metabolic process GO:0006521 0 0.010
purine nucleotide metabolic process GO:0006163 27 0.010
centrosome organization GO:0051297 1 0.010

tpp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.121
nervous system disease DOID:863 0 0.047
musculoskeletal system disease DOID:17 0 0.014
muscular disease DOID:0080000 0 0.011
muscle tissue disease DOID:66 0 0.011
disease of cellular proliferation DOID:14566 0 0.010