Danio rerio

32 known processes

ttnb

titin b

(Aliases: si:dZ167C3.1,ttnl,im:6911926,TTN,hm:zeh1256r,si:dz249n21.1,wu:fc09a12)

ttnb biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ventricular cardiac myofibril assembly GO:0055005 4 0.909
striated muscle cell development GO:0055002 108 0.795
cellular component assembly GO:0022607 170 0.757
muscle cell differentiation GO:0042692 139 0.739
striated muscle cell differentiation GO:0051146 129 0.730
cellular component assembly involved in morphogenesis GO:0010927 107 0.726
somitogenesis GO:0001756 87 0.654
heart process GO:0003015 71 0.632
muscle cell development GO:0055001 115 0.589
actin cytoskeleton organization GO:0030036 63 0.506
muscle structure development GO:0061061 196 0.496
heart development GO:0007507 313 0.489
cardiac muscle cell differentiation GO:0055007 30 0.468
sarcomere organization GO:0045214 26 0.465
cellular component biogenesis GO:0044085 178 0.450
system process GO:0003008 185 0.440
cardiac muscle tissue development GO:0048738 48 0.397
neuron differentiation GO:0030182 353 0.360
organic substance biosynthetic process GO:1901576 289 0.342
myofibril assembly GO:0030239 48 0.337
neuron development GO:0048666 262 0.311
circulatory system process GO:0003013 87 0.295
cardiac muscle fiber development GO:0048739 3 0.280
cellular component morphogenesis GO:0032989 336 0.273
cardiac cell development GO:0055006 21 0.271
actomyosin structure organization GO:0031032 53 0.267
muscle system process GO:0003012 20 0.264
blood circulation GO:0008015 87 0.244
nitrogen compound metabolic process GO:0006807 319 0.241
actin filament based process GO:0030029 64 0.237
neuron projection development GO:0031175 180 0.220
anterior posterior pattern specification GO:0009952 152 0.188
ventricular cardiac muscle cell differentiation GO:0055012 6 0.178
somite development GO:0061053 96 0.174
skeletal muscle organ development GO:0060538 78 0.164
segmentation GO:0035282 97 0.162
heart morphogenesis GO:0003007 156 0.151
alternative mrna splicing via spliceosome GO:0000380 1 0.150
organophosphate biosynthetic process GO:0090407 23 0.148
cellular biosynthetic process GO:0044249 286 0.143
determination of bilateral symmetry GO:0009855 204 0.138
specification of symmetry GO:0009799 204 0.137
regulation of macromolecule metabolic process GO:0060255 317 0.137
organonitrogen compound metabolic process GO:1901564 74 0.136
embryo development ending in birth or egg hatching GO:0009792 271 0.136
single organism organelle organization GO:1902589 199 0.130
fatty acid catabolic process GO:0009062 1 0.130
regulation of ion transmembrane transporter activity GO:0032412 2 0.129
regulation of muscle contraction GO:0006937 3 0.128
cardiocyte differentiation GO:0035051 44 0.126
anatomical structure homeostasis GO:0060249 36 0.121
organelle organization GO:0006996 227 0.118
cell projection morphogenesis GO:0048858 244 0.116
striated muscle tissue development GO:0014706 110 0.115
pyruvate metabolic process GO:0006090 1 0.115
heart valve formation GO:0003188 4 0.114
negative regulation of biological process GO:0048519 304 0.111
chordate embryonic development GO:0043009 271 0.107
regulation of metabolic process GO:0019222 359 0.103
cellular aromatic compound metabolic process GO:0006725 295 0.101
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.098
immune system development GO:0002520 191 0.089
lipid storage GO:0019915 1 0.088
regulation of blood circulation GO:1903522 32 0.086
regulation of gene expression GO:0010468 265 0.084
behavior GO:0007610 74 0.083
neuromuscular synaptic transmission GO:0007274 2 0.082
regulation of heart contraction GO:0008016 32 0.082
aging GO:0007568 2 0.081
larval development GO:0002164 2 0.080
biological adhesion GO:0022610 40 0.078
cardiac muscle cell development GO:0055013 20 0.075
organic acid metabolic process GO:0006082 31 0.071
regulation of transmembrane transporter activity GO:0022898 2 0.068
organic cyclic compound biosynthetic process GO:1901362 223 0.064
single organism biosynthetic process GO:0044711 71 0.063
calcium ion homeostasis GO:0055074 19 0.063
regionalization GO:0003002 274 0.062
forebrain midbrain boundary formation GO:0021905 1 0.062
oogenesis GO:0048477 14 0.062
maintenance of location GO:0051235 4 0.060
muscle organ development GO:0007517 101 0.058
cell part morphogenesis GO:0032990 246 0.058
development of primary female sexual characteristics GO:0046545 4 0.058
positive regulation of biological process GO:0048518 253 0.057
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.055
generation of neurons GO:0048699 385 0.055
organic cyclic compound metabolic process GO:1901360 301 0.054
small molecule catabolic process GO:0044282 3 0.054
oxoacid metabolic process GO:0043436 31 0.053
cell projection organization GO:0030030 284 0.052
digestive system development GO:0055123 289 0.052
regulation of system process GO:0044057 40 0.052
determination of left right symmetry GO:0007368 179 0.051
positive regulation of blood circulation GO:1903524 2 0.051
muscle contraction GO:0006936 18 0.050
cardiac ventricle formation GO:0003211 1 0.050
cellular response to hormone stimulus GO:0032870 39 0.049
regulation of transporter activity GO:0032409 2 0.048
heart looping GO:0001947 94 0.048
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.047
carboxylic acid metabolic process GO:0019752 22 0.046
positive regulation of heart contraction GO:0045823 2 0.046
heart contraction GO:0060047 71 0.045
stem cell differentiation GO:0048863 117 0.044
positive regulation of transport GO:0051050 2 0.043
regulation of cellular component organization GO:0051128 86 0.043
ventricular cardiac muscle tissue development GO:0003229 3 0.041
cellular nitrogen compound metabolic process GO:0034641 290 0.040
heterocycle metabolic process GO:0046483 290 0.040
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.040
regulation of response to stimulus GO:0048583 269 0.040
regulation of cell communication GO:0010646 232 0.039
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.039
cellular nitrogen compound biosynthetic process GO:0044271 218 0.039
regulation of primary metabolic process GO:0080090 311 0.038
cytoskeleton organization GO:0007010 96 0.038
muscle organ morphogenesis GO:0048644 8 0.038
female gamete generation GO:0007292 14 0.038
cell morphogenesis GO:0000902 289 0.037
limb bud formation GO:0060174 2 0.036
immune system process GO:0002376 241 0.036
embryonic organ development GO:0048568 381 0.036
adult behavior GO:0030534 2 0.036
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.035
locomotion GO:0040011 313 0.034
cell morphogenesis involved in differentiation GO:0000904 195 0.034
somatic muscle development GO:0007525 4 0.033
axonogenesis GO:0007409 152 0.033
biosynthetic process GO:0009058 294 0.033
mitotic cell cycle process GO:1903047 48 0.032
regulation of purine nucleotide catabolic process GO:0033121 2 0.032
regulation of blood pressure GO:0008217 1 0.032
cellular lipid catabolic process GO:0044242 3 0.032
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.032
regulation of multicellular organismal process GO:0051239 277 0.031
regulation of tube size GO:0035150 2 0.031
lateral line system development GO:0048925 76 0.031
small molecule metabolic process GO:0044281 77 0.031
cell projection assembly GO:0030031 64 0.031
gene expression GO:0010467 252 0.030
rna metabolic process GO:0016070 219 0.030
embryonic organ morphogenesis GO:0048562 274 0.030
regulation of cellular biosynthetic process GO:0031326 245 0.030
patterning of blood vessels GO:0001569 15 0.029
cellular macromolecule biosynthetic process GO:0034645 224 0.029
macromolecule biosynthetic process GO:0009059 227 0.029
multi organism process GO:0051704 134 0.029
response to endogenous stimulus GO:0009719 83 0.028
regulation of signal transduction GO:0009966 225 0.028
response to organic substance GO:0010033 153 0.028
purine nucleoside monophosphate catabolic process GO:0009128 4 0.028
regulation of synapse organization GO:0050807 3 0.028
er nucleus signaling pathway GO:0006984 2 0.027
nucleobase containing compound metabolic process GO:0006139 274 0.027
response to external stimulus GO:0009605 264 0.027
endocardial cushion formation GO:0003272 2 0.027
regulation of cell matrix adhesion GO:0001952 1 0.026
regulation of anatomical structure morphogenesis GO:0022603 130 0.026
cellular lipid metabolic process GO:0044255 36 0.026
cardiac chamber formation GO:0003207 4 0.026
cellular protein metabolic process GO:0044267 129 0.026
fatty acid beta oxidation GO:0006635 1 0.026
monocarboxylic acid catabolic process GO:0072329 3 0.026
regulation of programmed cell death GO:0043067 101 0.026
positive regulation of metabolic process GO:0009893 108 0.026
regulation of nucleotide catabolic process GO:0030811 2 0.025
muscle fiber development GO:0048747 52 0.025
hemopoiesis GO:0030097 183 0.025
atp catabolic process GO:0006200 4 0.025
cellular response to unfolded protein GO:0034620 2 0.025
post embryonic organ development GO:0048569 4 0.025
response to unfolded protein GO:0006986 2 0.025
regulation of cardiac muscle contraction GO:0055117 2 0.025
cardiac muscle tissue morphogenesis GO:0055008 7 0.024
wound healing GO:0042060 90 0.024
establishment of localization GO:0051234 244 0.024
purine containing compound metabolic process GO:0072521 29 0.024
brain development GO:0007420 293 0.024
nephron tubule epithelial cell differentiation GO:0072160 1 0.024
hematopoietic or lymphoid organ development GO:0048534 191 0.023
germ cell development GO:0007281 22 0.023
mesoderm development GO:0007498 88 0.023
organophosphate metabolic process GO:0019637 37 0.023
cell substrate adhesion GO:0031589 4 0.023
sensory organ development GO:0007423 393 0.023
positive regulation of skeletal muscle tissue development GO:0048643 1 0.023
cellular response to chemical stimulus GO:0070887 157 0.023
endocardial cushion morphogenesis GO:0003203 3 0.023
heterocycle biosynthetic process GO:0018130 215 0.022
muscle tissue development GO:0060537 110 0.022
endoplasmic reticulum unfolded protein response GO:0030968 2 0.022
positive regulation of muscle cell differentiation GO:0051149 1 0.022
regulation of cytoplasmic transport GO:1903649 4 0.022
fertilization GO:0009566 3 0.022
negative regulation of cellular process GO:0048523 283 0.022
sequestering of metal ion GO:0051238 3 0.022
venous blood vessel morphogenesis GO:0048845 3 0.022
regulation of biosynthetic process GO:0009889 250 0.021
response to stress GO:0006950 263 0.021
organelle assembly GO:0070925 110 0.021
lipid oxidation GO:0034440 1 0.021
regulation of metal ion transport GO:0010959 4 0.020
developmental growth GO:0048589 166 0.020
cognition GO:0050890 1 0.020
eye development GO:0001654 277 0.020
connective tissue development GO:0061448 99 0.019
protein metabolic process GO:0019538 183 0.019
regulation of blood vessel size GO:0050880 2 0.018
lymphoid lineage cell migration GO:0097534 4 0.018
cell adhesion GO:0007155 40 0.018
sex determination GO:0007530 1 0.018
cellular amino acid metabolic process GO:0006520 7 0.018
regulation of sequestering of calcium ion GO:0051282 4 0.018
rna biosynthetic process GO:0032774 181 0.018
cellular calcium ion homeostasis GO:0006874 13 0.018
determination of heart left right asymmetry GO:0061371 117 0.018
regulation of nucleoside metabolic process GO:0009118 2 0.018
neuron projection morphogenesis GO:0048812 161 0.018
regulation of protein binding GO:0043393 3 0.018
nucleocytoplasmic transport GO:0006913 4 0.018
synaptic growth at neuromuscular junction GO:0051124 2 0.017
regulation of biological quality GO:0065008 263 0.017
organic acid catabolic process GO:0016054 3 0.017
nucleic acid metabolic process GO:0090304 244 0.017
nucleoside monophosphate catabolic process GO:0009125 4 0.017
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.017
pigmentation GO:0043473 85 0.017
purine ribonucleotide metabolic process GO:0009150 27 0.017
phosphorus metabolic process GO:0006793 109 0.017
lipid metabolic process GO:0006629 52 0.016
axonal fasciculation GO:0007413 11 0.016
single organism reproductive process GO:0044702 40 0.016
establishment of protein localization to plasma membrane GO:0090002 1 0.016
signal transduction GO:0007165 455 0.016
regulation of calcium ion transport GO:0051924 2 0.016
single organism transport GO:0044765 206 0.016
multi organism reproductive process GO:0044703 36 0.016
ear development GO:0043583 127 0.015
ventricular cardiac muscle cell development GO:0055015 5 0.015
nucleobase containing compound biosynthetic process GO:0034654 205 0.015
negative regulation of translation GO:0017148 1 0.015
developmental maturation GO:0021700 34 0.015
regulation of signaling GO:0023051 235 0.015
nucleobase containing compound transport GO:0015931 2 0.015
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.015
single organism metabolic process GO:0044710 217 0.015
intracellular signal transduction GO:0035556 85 0.015
response to wounding GO:0009611 116 0.015
circadian sleep wake cycle GO:0042745 2 0.014
positive regulation of cellular amine metabolic process GO:0033240 0 0.014
purine nucleotide metabolic process GO:0006163 27 0.014
growth GO:0040007 174 0.014
sensory system development GO:0048880 76 0.014
carboxylic acid catabolic process GO:0046395 3 0.014
organonitrogen compound biosynthetic process GO:1901566 47 0.014
epithelial tube morphogenesis GO:0060562 148 0.014
morphogenesis of an epithelium GO:0002009 333 0.014
calcium mediated signaling GO:0019722 2 0.014
mesenchyme development GO:0060485 127 0.014
programmed cell death GO:0012501 119 0.014
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.014
regulation of apoptotic process GO:0042981 98 0.013
fatty acid oxidation GO:0019395 1 0.013
regulation of cellular metabolic process GO:0031323 320 0.013
morphogenesis of an epithelial sheet GO:0002011 49 0.013
establishment of epithelial cell polarity GO:0090162 2 0.013
cellular protein modification process GO:0006464 100 0.013
skeletal muscle tissue development GO:0007519 67 0.013
cellular response to extracellular stimulus GO:0031668 2 0.013
water homeostasis GO:0030104 4 0.013
regulation of catalytic activity GO:0050790 55 0.013
cellular modified amino acid metabolic process GO:0006575 3 0.013
central nervous system development GO:0007417 387 0.013
axon development GO:0061564 166 0.013
regulation of reproductive process GO:2000241 4 0.013
cell matrix adhesion GO:0007160 4 0.013
response to amino acid GO:0043200 2 0.013
cell motility GO:0048870 244 0.013
regulation of cell projection assembly GO:0060491 4 0.012
taxis GO:0042330 109 0.012
cellular component movement GO:0006928 335 0.012
camera type eye morphogenesis GO:0048593 108 0.012
regulation of cell shape GO:0008360 1 0.012
sequestering of calcium ion GO:0051208 3 0.012
lymphoid lineage cell migration into thymus GO:0097535 4 0.012
sexual reproduction GO:0019953 36 0.012
fibril organization GO:0097435 1 0.012
regulation of circadian rhythm GO:0042752 4 0.012
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.012
regulation of cell activation GO:0050865 1 0.012
response to glucocorticoid GO:0051384 1 0.012
vasculature development GO:0001944 278 0.012
positive regulation of cellular catabolic process GO:0031331 3 0.012
single organism nuclear import GO:1902593 3 0.012
regulation of binding GO:0051098 3 0.012
regulation of macromolecule biosynthetic process GO:0010556 225 0.011
cardiac muscle cell contraction GO:0086003 1 0.011
phosphate containing compound metabolic process GO:0006796 108 0.011
protein localization to nucleus GO:0034504 3 0.011
regulation of nitrogen compound metabolic process GO:0051171 251 0.011
protein complex subunit organization GO:0071822 46 0.011
digestive tract development GO:0048565 265 0.011
response to corticosteroid GO:0031960 1 0.011
ribonucleoside monophosphate catabolic process GO:0009158 4 0.011
skeletal muscle fiber development GO:0048741 35 0.011
single organism carbohydrate metabolic process GO:0044723 12 0.011
establishment of protein localization to organelle GO:0072594 4 0.011
homeostasis of number of cells GO:0048872 62 0.011
embryonic heart tube morphogenesis GO:0003143 108 0.011
macromolecule modification GO:0043412 111 0.011
cellular amine metabolic process GO:0044106 2 0.011
regulation of molecular function GO:0065009 70 0.011
phagocytosis engulfment GO:0006911 1 0.011
nuclear import GO:0051170 3 0.011
positive regulation of cellular metabolic process GO:0031325 94 0.010
regulation of multicellular organism growth GO:0040014 4 0.010
cell cycle GO:0007049 93 0.010
skeletal muscle thin filament assembly GO:0030240 4 0.010
cellular response to topologically incorrect protein GO:0035967 2 0.010
oocyte development GO:0048599 14 0.010
homeostatic process GO:0042592 142 0.010

ttnb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.187
myopathy DOID:423 0 0.145
muscular disease DOID:0080000 0 0.145
heart disease DOID:114 0 0.145
cardiomyopathy DOID:0050700 0 0.145
cardiovascular system disease DOID:1287 0 0.145
musculoskeletal system disease DOID:17 0 0.145
muscle tissue disease DOID:66 0 0.145
nervous system disease DOID:863 0 0.011
large intestine cancer DOID:5672 0 0.010
colon cancer DOID:219 0 0.010
gastrointestinal system cancer DOID:3119 0 0.010
intestinal cancer DOID:10155 0 0.010
cancer DOID:162 0 0.010
disease of cellular proliferation DOID:14566 0 0.010
organ system cancer DOID:0050686 0 0.010
colorectal cancer DOID:9256 0 0.010