Danio rerio

12 known processes

ttpa

tocopherol (alpha) transfer protein (ataxia (Friedreich-like) with vitamin E deficiency)

(Aliases: wu:fd44e05,zgc:66361)

ttpa biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of cellular process GO:0048523 283 0.162
Mouse
organonitrogen compound metabolic process GO:1901564 74 0.152
organic substance biosynthetic process GO:1901576 289 0.143
embryonic organ morphogenesis GO:0048562 274 0.126
morphogenesis of an epithelium GO:0002009 333 0.122
maintenance of location GO:0051235 4 0.118
larval development GO:0002164 2 0.118
generation of neurons GO:0048699 385 0.113
aging GO:0007568 2 0.110
cell morphogenesis GO:0000902 289 0.106
regulation of primary metabolic process GO:0080090 311 0.105
biosynthetic process GO:0009058 294 0.099
ion transport GO:0006811 114 0.099
cellular biosynthetic process GO:0044249 286 0.098
cellular nitrogen compound metabolic process GO:0034641 290 0.093
cellular component movement GO:0006928 335 0.093
lipid storage GO:0019915 1 0.093
organic cyclic compound biosynthetic process GO:1901362 223 0.091
regulation of multicellular organism growth GO:0040014 4 0.087
regulation of biological quality GO:0065008 263 0.081
small molecule metabolic process GO:0044281 77 0.081
Mouse
neuron differentiation GO:0030182 353 0.080
lipid metabolic process GO:0006629 52 0.079
signal transduction GO:0007165 455 0.077
multicellular organism growth GO:0035264 4 0.075
cellular aromatic compound metabolic process GO:0006725 295 0.072
amine metabolic process GO:0009308 2 0.070
response to organic substance GO:0010033 153 0.070
nitrogen compound metabolic process GO:0006807 319 0.070
digestive tract development GO:0048565 265 0.069
heart development GO:0007507 313 0.069
gene expression GO:0010467 252 0.069
embryonic organ development GO:0048568 381 0.068
Mouse
brain development GO:0007420 293 0.064
aromatic compound biosynthetic process GO:0019438 217 0.063
organic cyclic compound metabolic process GO:1901360 301 0.061
Mouse
response to chemical GO:0042221 320 0.060
Mouse
cellular amine metabolic process GO:0044106 2 0.060
developmental growth GO:0048589 166 0.059
regulation of metabolic process GO:0019222 359 0.058
ear development GO:0043583 127 0.058
alcohol biosynthetic process GO:0046165 2 0.058
blood vessel development GO:0001568 246 0.058
locomotion GO:0040011 313 0.056
neuron development GO:0048666 262 0.056
response to stress GO:0006950 263 0.056
establishment of localization GO:0051234 244 0.056
Mouse
cell projection morphogenesis GO:0048858 244 0.054
tube morphogenesis GO:0035239 349 0.054
cellular ketone metabolic process GO:0042180 11 0.054
regulation of rna biosynthetic process GO:2001141 213 0.053
single organism localization GO:1902578 225 0.053
Mouse
single organism transport GO:0044765 206 0.053
Mouse
growth GO:0040007 174 0.052
localization of cell GO:0051674 244 0.052
regulation of macromolecule metabolic process GO:0060255 317 0.051
sensory organ development GO:0007423 393 0.050
regulation of gene expression GO:0010468 265 0.049
macromolecule biosynthetic process GO:0009059 227 0.049
cell part morphogenesis GO:0032990 246 0.048
cell morphogenesis involved in differentiation GO:0000904 195 0.048
carboxylic acid metabolic process GO:0019752 22 0.047
small molecule catabolic process GO:0044282 3 0.046
central nervous system development GO:0007417 387 0.046
nucleobase containing compound biosynthetic process GO:0034654 205 0.046
cell migration GO:0016477 237 0.045
cellular component morphogenesis GO:0032989 336 0.045
positive regulation of biological process GO:0048518 253 0.044
cell motility GO:0048870 244 0.044
regulation of nitrogen compound metabolic process GO:0051171 251 0.044
digestive system development GO:0055123 289 0.043
heterocycle biosynthetic process GO:0018130 215 0.042
blood vessel morphogenesis GO:0048514 216 0.042
heterocycle metabolic process GO:0046483 290 0.041
Mouse
regulation of biosynthetic process GO:0009889 250 0.040
sensory organ morphogenesis GO:0090596 200 0.040
cellular component biogenesis GO:0044085 178 0.040
cell surface receptor signaling pathway GO:0007166 325 0.039
cell projection organization GO:0030030 284 0.039
regulation of response to stimulus GO:0048583 269 0.039
rna metabolic process GO:0016070 219 0.039
positive regulation of cellular catabolic process GO:0031331 3 0.039
cellular nitrogen compound biosynthetic process GO:0044271 218 0.038
positive regulation of catabolic process GO:0009896 4 0.038
cellular macromolecule biosynthetic process GO:0034645 224 0.037
adult behavior GO:0030534 2 0.037
lipid catabolic process GO:0016042 4 0.037
nucleobase containing compound metabolic process GO:0006139 274 0.037
regulation of signaling GO:0023051 235 0.037
carboxylic acid catabolic process GO:0046395 3 0.036
regulation of nucleic acid templated transcription GO:1903506 213 0.036
secondary metabolic process GO:0019748 3 0.036
inner ear development GO:0048839 126 0.035
cellular response to chemical stimulus GO:0070887 157 0.034
homeostatic process GO:0042592 142 0.034
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.034
response to drug GO:0042493 3 0.033
neurotransmitter transport GO:0006836 2 0.033
cellular amino acid metabolic process GO:0006520 7 0.033
neuron projection morphogenesis GO:0048812 161 0.032
regulation of rna metabolic process GO:0051252 224 0.032
neuron projection development GO:0031175 180 0.032
negative regulation of signal transduction GO:0009968 94 0.032
regulation of cellular biosynthetic process GO:0031326 245 0.032
regulation of transcription dna templated GO:0006355 213 0.031
embryonic heart tube development GO:0035050 133 0.031
synaptic growth at neuromuscular junction GO:0051124 2 0.031
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.031
transcription dna templated GO:0006351 181 0.031
cellular macromolecule metabolic process GO:0044260 391 0.031
oxoacid metabolic process GO:0043436 31 0.031
lipid biosynthetic process GO:0008610 22 0.030
single organism organelle organization GO:1902589 199 0.030
response to carbohydrate GO:0009743 3 0.030
ear morphogenesis GO:0042471 64 0.030
transport GO:0006810 220 0.030
Mouse
response to xenobiotic stimulus GO:0009410 45 0.030
negative regulation of biological process GO:0048519 304 0.030
Mouse
immune system process GO:0002376 241 0.029
determination of heart left right asymmetry GO:0061371 117 0.029
camera type eye development GO:0043010 222 0.029
regulation of multicellular organismal process GO:0051239 277 0.029
cellular response to external stimulus GO:0071496 2 0.029
positive regulation of transport GO:0051050 2 0.029
response to glucose GO:0009749 3 0.029
inner ear morphogenesis GO:0042472 63 0.029
rna biosynthetic process GO:0032774 181 0.029
regulation of cellular amino acid metabolic process GO:0006521 0 0.028
multicellular organismal response to stress GO:0033555 2 0.028
response to endogenous stimulus GO:0009719 83 0.028
cellular localization GO:0051641 97 0.027
transcription from rna polymerase ii promoter GO:0006366 80 0.027
specification of symmetry GO:0009799 204 0.027
nucleic acid templated transcription GO:0097659 181 0.027
central nervous system neuron differentiation GO:0021953 74 0.026
response to alkaloid GO:0043279 2 0.026
response to external stimulus GO:0009605 264 0.026
response to corticosteroid GO:0031960 1 0.026
epithelial cell differentiation GO:0030855 116 0.026
regulation of macromolecule biosynthetic process GO:0010556 225 0.026
oxidation reduction process GO:0055114 41 0.026
epithelial tube morphogenesis GO:0060562 148 0.025
regulation of cellular amine metabolic process GO:0033238 0 0.025
regulation of signal transduction GO:0009966 225 0.025
positive regulation of map kinase activity GO:0043406 3 0.025
negative regulation of response to stimulus GO:0048585 104 0.024
system process GO:0003008 185 0.024
digestive tract morphogenesis GO:0048546 231 0.024
single organism metabolic process GO:0044710 217 0.024
Mouse
cellular hormone metabolic process GO:0034754 19 0.024
cellular carbohydrate metabolic process GO:0044262 4 0.024
organic acid catabolic process GO:0016054 3 0.024
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.024
determination of left right symmetry GO:0007368 179 0.024
regulation of nucleoside metabolic process GO:0009118 2 0.024
organic acid metabolic process GO:0006082 31 0.024
polyol metabolic process GO:0019751 1 0.023
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.023
positive regulation of metabolic process GO:0009893 108 0.023
response to transition metal nanoparticle GO:1990267 28 0.023
macromolecule localization GO:0033036 54 0.023
regulation of circadian rhythm GO:0042752 4 0.023
hormone secretion GO:0046879 2 0.023
skeletal system development GO:0001501 181 0.023
positive regulation of cellular component biogenesis GO:0044089 3 0.023
regulation of apoptotic process GO:0042981 98 0.022
somatic muscle development GO:0007525 4 0.022
hormone metabolic process GO:0042445 19 0.022
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.022
connective tissue development GO:0061448 99 0.022
chordate embryonic development GO:0043009 271 0.022
Mouse
positive regulation of cellular metabolic process GO:0031325 94 0.022
vasculature development GO:0001944 278 0.022
determination of bilateral symmetry GO:0009855 204 0.022
regulation of synapse assembly GO:0051963 3 0.022
stem cell proliferation GO:0072089 4 0.022
response to nutrient GO:0007584 3 0.022
positive regulation of cellular process GO:0048522 201 0.021
positive regulation of cell cycle GO:0045787 3 0.021
muscle structure development GO:0061061 196 0.021
stem cell maintenance GO:0019827 4 0.021
establishment of localization in cell GO:0051649 77 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.021
positive regulation of cellular amine metabolic process GO:0033240 0 0.021
gtp metabolic process GO:0046039 4 0.021
regulation of developmental process GO:0050793 247 0.021
Mouse
forebrain development GO:0030900 96 0.021
regulation of hormone levels GO:0010817 21 0.021
regulation of cell communication GO:0010646 232 0.021
response to glucocorticoid GO:0051384 1 0.021
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.021
eye development GO:0001654 277 0.021
terpenoid metabolic process GO:0006721 15 0.021
embryonic heart tube morphogenesis GO:0003143 108 0.021
pectoral fin development GO:0033339 50 0.021
cell substrate adhesion GO:0031589 4 0.021
protein import GO:0017038 3 0.021
axonogenesis GO:0007409 152 0.020
regulation of cellular ketone metabolic process GO:0010565 7 0.020
carbohydrate biosynthetic process GO:0016051 1 0.020
single organism biosynthetic process GO:0044711 71 0.020
fin development GO:0033333 77 0.020
protein targeting to nucleus GO:0044744 3 0.020
response to hexose GO:0009746 3 0.020
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.020
mesenchyme development GO:0060485 127 0.020
muscle cell development GO:0055001 115 0.020
gastrulation GO:0007369 208 0.020
cellular lipid metabolic process GO:0044255 36 0.020
alcohol metabolic process GO:0006066 11 0.020
regulation of wound healing GO:0061041 2 0.019
melanin metabolic process GO:0006582 2 0.019
hepaticobiliary system development GO:0061008 98 0.019
autophagy GO:0006914 4 0.019
regulation of cytokine production GO:0001817 3 0.019
cellular lipid catabolic process GO:0044242 3 0.019
heart looping GO:0001947 94 0.019
macromolecular complex assembly GO:0065003 35 0.019
guanosine containing compound metabolic process GO:1901068 4 0.019
cellular component disassembly GO:0022411 1 0.019
response to monosaccharide GO:0034284 3 0.019
nuclear transport GO:0051169 4 0.019
phagocytosis GO:0006909 3 0.019
protein metabolic process GO:0019538 183 0.019
otic vesicle development GO:0071599 42 0.019
purine nucleoside monophosphate catabolic process GO:0009128 4 0.019
fatty acid transport GO:0015908 1 0.018
regulation of localization GO:0032879 104 0.018
heart morphogenesis GO:0003007 156 0.018
establishment of protein localization to organelle GO:0072594 4 0.018
regulation of purine nucleotide catabolic process GO:0033121 2 0.018
lipid homeostasis GO:0055088 3 0.018
regulation of developmental growth GO:0048638 38 0.018
angiogenesis GO:0001525 158 0.018
cellular response to endogenous stimulus GO:0071495 68 0.018
response to light stimulus GO:0009416 46 0.018
actin filament based movement GO:0030048 1 0.018
pancreas development GO:0031016 84 0.018
head development GO:0060322 303 0.018
xenobiotic metabolic process GO:0006805 4 0.018
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.017
nucleic acid metabolic process GO:0090304 244 0.017
nuclear import GO:0051170 3 0.017
regulation of nucleotide catabolic process GO:0030811 2 0.017
response to abiotic stimulus GO:0009628 122 0.017
axon development GO:0061564 166 0.017
protein localization to nucleus GO:0034504 3 0.017
regulation of protein transport GO:0051223 3 0.017
regulation of protein catabolic process GO:0042176 1 0.017
regulation of protein targeting GO:1903533 2 0.017
negative regulation of gene expression GO:0010629 65 0.017
gtp catabolic process GO:0006184 2 0.017
regulation of microtubule cytoskeleton organization GO:0070507 3 0.017
catecholamine metabolic process GO:0006584 2 0.017
regulation of inflammatory response GO:0050727 2 0.017
organelle organization GO:0006996 227 0.017
regulation of metal ion transport GO:0010959 4 0.017
enzyme linked receptor protein signaling pathway GO:0007167 106 0.017
neuroblast proliferation GO:0007405 2 0.017
single organism nuclear import GO:1902593 3 0.016
liver development GO:0001889 96 0.016
cellular response to organic substance GO:0071310 105 0.016
hormone transport GO:0009914 2 0.016
extrinsic apoptotic signaling pathway GO:0097191 3 0.016
neurological system process GO:0050877 62 0.016
regulation of jak stat cascade GO:0046425 3 0.016
regulation of cellular metabolic process GO:0031323 320 0.016
negative regulation of cell communication GO:0010648 96 0.016
sequestering of calcium ion GO:0051208 3 0.016
innate immune response GO:0045087 13 0.016
germ line stem cell maintenance GO:0030718 2 0.016
cognition GO:0050890 1 0.016
regulation of programmed cell death GO:0043067 101 0.015
cartilage development GO:0051216 96 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.015
transmembrane transport GO:0055085 120 0.015
camera type eye morphogenesis GO:0048593 108 0.015
regulation of blood pressure GO:0008217 1 0.015
peptidyl serine phosphorylation GO:0018105 1 0.015
negative regulation of multicellular organismal process GO:0051241 69 0.015
cellular respiration GO:0045333 3 0.015
atp catabolic process GO:0006200 4 0.015
chemical homeostasis GO:0048878 49 0.015
negative regulation of developmental process GO:0051093 65 0.015
Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.015
regulation of protein binding GO:0043393 3 0.015
cellular response to extracellular stimulus GO:0031668 2 0.015
regulation of establishment of protein localization GO:0070201 4 0.015
cellular component assembly GO:0022607 170 0.015
macromolecular complex disassembly GO:0032984 1 0.015
nucleoside monophosphate catabolic process GO:0009125 4 0.015
regulation of anatomical structure morphogenesis GO:0022603 130 0.015
protein import into nucleus GO:0006606 3 0.015
cell death GO:0008219 121 0.015
programmed cell death GO:0012501 119 0.014
embryo development ending in birth or egg hatching GO:0009792 271 0.014
Mouse
regulation of synapse organization GO:0050807 3 0.014
gland development GO:0048732 143 0.014
nucleocytoplasmic transport GO:0006913 4 0.014
cellular biogenic amine metabolic process GO:0006576 2 0.014
appendage development GO:0048736 80 0.014
taxis GO:0042330 109 0.014
regulation of growth GO:0040008 42 0.014
regulation of autophagy GO:0010506 3 0.014
catabolic process GO:0009056 32 0.014
cellular response to xenobiotic stimulus GO:0071466 35 0.014
monocarboxylic acid catabolic process GO:0072329 3 0.014
neurotransmitter secretion GO:0007269 2 0.014
fin morphogenesis GO:0033334 53 0.014
protein complex disassembly GO:0043241 1 0.014
fatty acid oxidation GO:0019395 1 0.014
circadian sleep wake cycle GO:0042745 2 0.014
cellular modified amino acid metabolic process GO:0006575 3 0.014
regulation of protein localization to nucleus GO:1900180 2 0.014
mesenchymal cell differentiation GO:0048762 87 0.014
activation of mapk activity GO:0000187 3 0.014
tissue regeneration GO:0042246 74 0.014
regulation of epithelial cell proliferation GO:0050678 3 0.014
regulation of nervous system development GO:0051960 90 0.014
regulation of binding GO:0051098 3 0.014
response to organic cyclic compound GO:0014070 51 0.014
cellular response to starvation GO:0009267 1 0.014
regulation of dna replication GO:0006275 3 0.014
dopamine metabolic process GO:0042417 2 0.013
ribonucleoside monophosphate catabolic process GO:0009158 4 0.013
negative regulation of cellular metabolic process GO:0031324 77 0.013
muscle organ development GO:0007517 101 0.013
macromolecular complex subunit organization GO:0043933 74 0.013
regulation of multicellular organismal development GO:2000026 223 0.013
regulation of protein import into nucleus GO:0042306 2 0.013
peptidyl serine modification GO:0018209 2 0.013
outflow tract morphogenesis GO:0003151 1 0.013
death GO:0016265 121 0.013
positive regulation of nucleotide catabolic process GO:0030813 1 0.013
muscle cell differentiation GO:0042692 139 0.013
organic substance transport GO:0071702 58 0.013
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.013
protein localization to plasma membrane GO:0072659 1 0.013
positive regulation of nucleic acid templated transcription GO:1903508 57 0.013
modification dependent macromolecule catabolic process GO:0043632 3 0.013
sensory perception of chemical stimulus GO:0007606 3 0.013
protein stabilization GO:0050821 2 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.013
negative regulation of signaling GO:0023057 96 0.013
negative regulation of cell death GO:0060548 60 0.013
cellular protein modification process GO:0006464 100 0.013
regulation of ion transmembrane transporter activity GO:0032412 2 0.013
cell projection assembly GO:0030031 64 0.013
positive regulation of jak stat cascade GO:0046427 2 0.013
striated muscle tissue development GO:0014706 110 0.012
negative regulation of macromolecule metabolic process GO:0010605 76 0.012
isoprenoid metabolic process GO:0006720 15 0.012
erk1 and erk2 cascade GO:0070371 4 0.012
phosphate containing compound metabolic process GO:0006796 108 0.012
organic substance catabolic process GO:1901575 28 0.012
behavior GO:0007610 74 0.012
eye morphogenesis GO:0048592 144 0.012
regulation of protein complex assembly GO:0043254 3 0.012
reproduction GO:0000003 40 0.012
small molecule biosynthetic process GO:0044283 16 0.012
toxin metabolic process GO:0009404 1 0.012
fatty acid beta oxidation GO:0006635 1 0.012
multi organism process GO:0051704 134 0.012
mitochondrial transport GO:0006839 2 0.012
positive regulation of nucleoside metabolic process GO:0045979 1 0.012
regulation of dendrite development GO:0050773 3 0.012
regulation of cell differentiation GO:0045595 142 0.011
Mouse
stem cell development GO:0048864 82 0.011
positive regulation of transcription dna templated GO:0045893 57 0.011
nerve development GO:0021675 45 0.011
protein localization GO:0008104 40 0.011
regulation of cell activation GO:0050865 1 0.011
regulation of cell development GO:0060284 100 0.011
Mouse
exocrine pancreas development GO:0031017 28 0.011
development of primary female sexual characteristics GO:0046545 4 0.011
guanosine containing compound catabolic process GO:1901069 2 0.011
retinoid metabolic process GO:0001523 15 0.011
regulation of blood vessel size GO:0050880 2 0.011
skin development GO:0043588 54 0.011
phosphorus metabolic process GO:0006793 109 0.011
cation transport GO:0006812 81 0.011
positive regulation of rna metabolic process GO:0051254 59 0.011
negative regulation of biosynthetic process GO:0009890 55 0.011
positive regulation of response to stimulus GO:0048584 80 0.011
regulation of response to stress GO:0080134 36 0.011
ovulation cycle GO:0042698 2 0.011
ameboidal type cell migration GO:0001667 143 0.011
regionalization GO:0003002 274 0.011
striated muscle cell differentiation GO:0051146 129 0.011
pectoral fin morphogenesis GO:0035138 29 0.011
regulation of cytoplasmic transport GO:1903649 4 0.011
striated muscle cell development GO:0055002 108 0.011
negative regulation of metabolic process GO:0009892 86 0.011
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.011
chemotaxis GO:0006935 104 0.011
cation transmembrane transport GO:0098655 65 0.011
blood circulation GO:0008015 87 0.011
regulation of cell death GO:0010941 103 0.011
negative regulation of apoptotic process GO:0043066 55 0.011
fatty acid catabolic process GO:0009062 1 0.011
positive regulation of lipid metabolic process GO:0045834 1 0.011
dicarboxylic acid metabolic process GO:0043648 1 0.011
diterpenoid metabolic process GO:0016101 15 0.011
lipid oxidation GO:0034440 1 0.011
developmental programmed cell death GO:0010623 4 0.011
cellular aldehyde metabolic process GO:0006081 4 0.010
response to lipid GO:0033993 60 0.010
response to wounding GO:0009611 116 0.010
circulatory system process GO:0003013 87 0.010
positive regulation of cell activation GO:0050867 1 0.010
hormone biosynthetic process GO:0042446 3 0.010
response to food GO:0032094 1 0.010
regulation of intracellular protein transport GO:0033157 3 0.010
negative regulation of protein phosphorylation GO:0001933 4 0.010
regulation of organ growth GO:0046620 3 0.010
calcium ion import GO:0070509 4 0.010
wound healing GO:0042060 90 0.010
response to steroid hormone GO:0048545 35 0.010
protein homooligomerization GO:0051260 3 0.010
cellular response to nutrient levels GO:0031669 2 0.010
regulation of transmembrane transporter activity GO:0022898 2 0.010
hindbrain development GO:0030902 91 0.010
cellular response to decreased oxygen levels GO:0036294 1 0.010
cell migration involved in gastrulation GO:0042074 79 0.010
negative regulation of cytokine production GO:0001818 1 0.010

ttpa disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.040
disease of metabolism DOID:0014667 0 0.026
inherited metabolic disorder DOID:655 0 0.022
nervous system disease DOID:863 0 0.018
disease of cellular proliferation DOID:14566 0 0.015
cancer DOID:162 0 0.014
cardiovascular system disease DOID:1287 0 0.014
organ system cancer DOID:0050686 0 0.014
sensory system disease DOID:0050155 0 0.012