Danio rerio

0 known processes

txnrd1

thioredoxin reductase 1

(Aliases: TrxR1,cb682,wu:fb83a08,fb83a08)

txnrd1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dicarboxylic acid metabolic process GO:0043648 1 0.500
larval development GO:0002164 2 0.445
cellular response to topologically incorrect protein GO:0035967 2 0.382
aging GO:0007568 2 0.320
cellular nitrogen compound metabolic process GO:0034641 290 0.297
regulation of cellular metabolic process GO:0031323 320 0.260
organelle organization GO:0006996 227 0.203
organic cyclic compound metabolic process GO:1901360 301 0.192
cellular aromatic compound metabolic process GO:0006725 295 0.185
organonitrogen compound metabolic process GO:1901564 74 0.170
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.166
nucleobase containing compound metabolic process GO:0006139 274 0.165
locomotion GO:0040011 313 0.153
protein modification process GO:0036211 100 0.142
negative regulation of cellular process GO:0048523 283 0.140
cell death GO:0008219 121 0.139
protein import GO:0017038 3 0.137
death GO:0016265 121 0.135
embryo development ending in birth or egg hatching GO:0009792 271 0.134
small molecule metabolic process GO:0044281 77 0.133
cellular modified amino acid metabolic process GO:0006575 3 0.131
regulation of metabolic process GO:0019222 359 0.128
alpha amino acid metabolic process GO:1901605 3 0.127
single organism localization GO:1902578 225 0.123
apoptotic process GO:0006915 116 0.122
nitrogen compound metabolic process GO:0006807 319 0.120
negative regulation of biological process GO:0048519 304 0.116
cellular protein metabolic process GO:0044267 129 0.115
endoplasmic reticulum unfolded protein response GO:0030968 2 0.113
cell part morphogenesis GO:0032990 246 0.103
response to drug GO:0042493 3 0.099
atp catabolic process GO:0006200 4 0.092
positive regulation of transport GO:0051050 2 0.087
proteolysis GO:0006508 38 0.086
mitochondrion organization GO:0007005 4 0.086
nucleotide metabolic process GO:0009117 28 0.086
cellular protein modification process GO:0006464 100 0.085
er nucleus signaling pathway GO:0006984 2 0.085
cellular response to unfolded protein GO:0034620 2 0.084
oxoacid metabolic process GO:0043436 31 0.084
cellular amino acid metabolic process GO:0006520 7 0.083
programmed cell death GO:0012501 119 0.081
response to topologically incorrect protein GO:0035966 2 0.078
regulation of cell death GO:0010941 103 0.077
neuron development GO:0048666 262 0.076
response to stress GO:0006950 263 0.075
regulation of biological quality GO:0065008 263 0.075
establishment of localization GO:0051234 244 0.073
cellular component morphogenesis GO:0032989 336 0.072
signal transduction GO:0007165 455 0.071
nuclear import GO:0051170 3 0.070
cytokinesis GO:0000910 3 0.069
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.069
phosphate containing compound metabolic process GO:0006796 108 0.069
carboxylic acid metabolic process GO:0019752 22 0.068
transport GO:0006810 220 0.068
establishment of localization in cell GO:0051649 77 0.068
cellular macromolecule metabolic process GO:0044260 391 0.067
gtp catabolic process GO:0006184 2 0.067
single organism organelle organization GO:1902589 199 0.067
extrinsic apoptotic signaling pathway GO:0097191 3 0.067
macromolecule modification GO:0043412 111 0.067
modification dependent macromolecule catabolic process GO:0043632 3 0.066
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.065
heterocycle metabolic process GO:0046483 290 0.063
gtp metabolic process GO:0046039 4 0.063
neuron differentiation GO:0030182 353 0.061
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.061
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.061
protein metabolic process GO:0019538 183 0.061
ovulation cycle GO:0042698 2 0.060
negative regulation of kinase activity GO:0033673 4 0.060
response to unfolded protein GO:0006986 2 0.059
positive regulation of cellular process GO:0048522 201 0.059
cell projection organization GO:0030030 284 0.059
protein polymerization GO:0051258 4 0.058
cellular response to external stimulus GO:0071496 2 0.058
cellular amide metabolic process GO:0043603 4 0.057
organic acid metabolic process GO:0006082 31 0.057
multi organism process GO:0051704 134 0.056
cellular component biogenesis GO:0044085 178 0.055
cellular response to nutrient levels GO:0031669 2 0.055
proteasomal protein catabolic process GO:0010498 2 0.055
purine nucleoside monophosphate catabolic process GO:0009128 4 0.054
modification dependent protein catabolic process GO:0019941 3 0.053
maintenance of location GO:0051235 4 0.053
meiotic nuclear division GO:0007126 4 0.053
organic cyclic compound biosynthetic process GO:1901362 223 0.052
cellular component assembly GO:0022607 170 0.052
response to other organism GO:0051707 97 0.052
negative regulation of sequestering of calcium ion GO:0051283 4 0.051
regulation of intracellular protein transport GO:0033157 3 0.051
ribonucleoside monophosphate catabolic process GO:0009158 4 0.050
purine ribonucleotide metabolic process GO:0009150 27 0.049
regulation of signaling GO:0023051 235 0.048
cell morphogenesis GO:0000902 289 0.047
cellular protein catabolic process GO:0044257 4 0.046
response to biotic stimulus GO:0009607 97 0.045
cytoskeleton dependent cytokinesis GO:0061640 3 0.045
aromatic compound biosynthetic process GO:0019438 217 0.045
single organism intracellular transport GO:1902582 25 0.044
cellular component movement GO:0006928 335 0.044
cell motility GO:0048870 244 0.044
establishment of protein localization to organelle GO:0072594 4 0.044
heterocycle biosynthetic process GO:0018130 215 0.041
regulation of gene expression GO:0010468 265 0.041
regulation of protein complex assembly GO:0043254 3 0.041
regulation of programmed cell death GO:0043067 101 0.040
negative regulation of protein complex assembly GO:0031333 1 0.040
protein acetylation GO:0006473 2 0.040
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.040
regulation of apoptotic process GO:0042981 98 0.040
positive regulation of cellular catabolic process GO:0031331 3 0.040
regulation of cellular amine metabolic process GO:0033238 0 0.039
positive regulation of biological process GO:0048518 253 0.039
ubiquitin dependent protein catabolic process GO:0006511 3 0.039
eye development GO:0001654 277 0.038
cellular protein complex assembly GO:0043623 19 0.038
sensory organ development GO:0007423 393 0.038
cell projection morphogenesis GO:0048858 244 0.038
nucleic acid metabolic process GO:0090304 244 0.038
phagocytosis GO:0006909 3 0.038
single organism transport GO:0044765 206 0.037
response to external stimulus GO:0009605 264 0.037
phosphorus metabolic process GO:0006793 109 0.037
negative regulation of signaling GO:0023057 96 0.036
carbohydrate derivative metabolic process GO:1901135 61 0.036
small molecule catabolic process GO:0044282 3 0.036
reproduction GO:0000003 40 0.035
regulation of tube size GO:0035150 2 0.035
multicellular organism growth GO:0035264 4 0.035
cellular nitrogen compound biosynthetic process GO:0044271 218 0.035
regulation of protein transport GO:0051223 3 0.034
negative regulation of protein kinase activity GO:0006469 4 0.034
positive regulation of catabolic process GO:0009896 4 0.034
lipid storage GO:0019915 1 0.034
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.033
biosynthetic process GO:0009058 294 0.033
nucleobase containing small molecule metabolic process GO:0055086 32 0.033
ribonucleotide biosynthetic process GO:0009260 20 0.033
amine metabolic process GO:0009308 2 0.033
purine containing compound metabolic process GO:0072521 29 0.032
regulation of nitrogen compound metabolic process GO:0051171 251 0.032
nucleoside monophosphate catabolic process GO:0009125 4 0.031
post golgi vesicle mediated transport GO:0006892 1 0.031
cellular response to extracellular stimulus GO:0031668 2 0.030
regulation of metal ion transport GO:0010959 4 0.030
single organism metabolic process GO:0044710 217 0.030
regulation of catalytic activity GO:0050790 55 0.030
positive regulation of map kinase activity GO:0043406 3 0.030
cellular biosynthetic process GO:0044249 286 0.030
cellular catabolic process GO:0044248 27 0.029
regulation of response to stimulus GO:0048583 269 0.029
axon development GO:0061564 166 0.029
macromolecule catabolic process GO:0009057 15 0.028
cellular localization GO:0051641 97 0.027
nucleocytoplasmic transport GO:0006913 4 0.027
response to temperature stimulus GO:0009266 15 0.027
nuclear transport GO:0051169 4 0.027
regulation of primary metabolic process GO:0080090 311 0.027
organic acid catabolic process GO:0016054 3 0.027
negative regulation of cellular metabolic process GO:0031324 77 0.027
purine ribonucleoside metabolic process GO:0046128 10 0.027
regulation of nucleotide catabolic process GO:0030811 2 0.027
single organism nuclear import GO:1902593 3 0.027
generation of neurons GO:0048699 385 0.027
regulation of peptidase activity GO:0052547 23 0.027
regulation of protein polymerization GO:0032271 2 0.026
response to external biotic stimulus GO:0043207 97 0.026
nucleic acid templated transcription GO:0097659 181 0.026
regulation of molecular function GO:0065009 70 0.026
carbohydrate derivative biosynthetic process GO:1901137 43 0.026
catabolic process GO:0009056 32 0.026
negative regulation of mapk cascade GO:0043409 4 0.026
cellular amino acid biosynthetic process GO:0008652 2 0.026
macromolecular complex subunit organization GO:0043933 74 0.025
positive regulation of cellular amine metabolic process GO:0033240 0 0.025
endocytosis GO:0006897 16 0.025
regulation of multicellular organism growth GO:0040014 4 0.025
negative regulation of metabolic process GO:0009892 86 0.025
negative regulation of cell communication GO:0010648 96 0.024
guanosine containing compound catabolic process GO:1901069 2 0.024
mitochondrial transport GO:0006839 2 0.024
endosomal transport GO:0016197 2 0.024
fatty acid biosynthetic process GO:0006633 4 0.024
ribose phosphate metabolic process GO:0019693 27 0.024
phosphorylation GO:0016310 69 0.024
organic substance catabolic process GO:1901575 28 0.024
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.024
regulation of cytoplasmic transport GO:1903649 4 0.023
guanosine containing compound metabolic process GO:1901068 4 0.023
regulation of cytokine production GO:0001817 3 0.023
protein dephosphorylation GO:0006470 3 0.023
regulation of protein targeting GO:1903533 2 0.023
nucleoside phosphate metabolic process GO:0006753 28 0.022
regulation of anatomical structure size GO:0090066 33 0.022
regulation of jun kinase activity GO:0043506 3 0.022
regulation of establishment of protein localization GO:0070201 4 0.022
organic substance biosynthetic process GO:1901576 289 0.022
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.022
protein complex biogenesis GO:0070271 30 0.021
cell cycle GO:0007049 93 0.021
organophosphate metabolic process GO:0019637 37 0.021
single organism cellular localization GO:1902580 46 0.021
regulation of protein catabolic process GO:0042176 1 0.021
response to oxidative stress GO:0006979 11 0.021
regulation of purine nucleotide catabolic process GO:0033121 2 0.021
organelle fusion GO:0048284 3 0.021
zymogen activation GO:0031638 3 0.021
protein stabilization GO:0050821 2 0.020
positive regulation of macromolecule metabolic process GO:0010604 93 0.020
neuron projection morphogenesis GO:0048812 161 0.020
female sex differentiation GO:0046660 4 0.020
negative regulation of protein phosphorylation GO:0001933 4 0.020
gamete generation GO:0007276 33 0.020
regulation of blood pressure GO:0008217 1 0.020
regulation of localization GO:0032879 104 0.020
intracellular signal transduction GO:0035556 85 0.020
regulation of cellular component organization GO:0051128 86 0.019
regulation of macromolecule metabolic process GO:0060255 317 0.019
neuron projection development GO:0031175 180 0.019
compound eye development GO:0048749 2 0.019
protein phosphorylation GO:0006468 47 0.018
cell morphogenesis involved in differentiation GO:0000904 195 0.018
positive regulation of catalytic activity GO:0043085 25 0.018
response to chemical GO:0042221 320 0.018
multicellular organismal reproductive process GO:0048609 35 0.018
negative regulation of signal transduction GO:0009968 94 0.018
regulation of rna metabolic process GO:0051252 224 0.018
spindle assembly GO:0051225 2 0.018
meiotic cell cycle process GO:1903046 3 0.018
response to uv GO:0009411 3 0.018
rna biosynthetic process GO:0032774 181 0.018
regulation of cell communication GO:0010646 232 0.017
positive regulation of apoptotic signaling pathway GO:2001235 1 0.017
protein targeting to nucleus GO:0044744 3 0.017
regulation of nucleocytoplasmic transport GO:0046822 2 0.017
negative regulation of cell death GO:0060548 60 0.017
regulation of mrna processing GO:0050684 3 0.017
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.016
mitochondrion morphogenesis GO:0070584 2 0.016
lipid catabolic process GO:0016042 4 0.016
ribonucleotide metabolic process GO:0009259 27 0.016
localization of cell GO:0051674 244 0.016
regulation of multicellular organismal process GO:0051239 277 0.016
membrane fusion GO:0061025 2 0.016
single fertilization GO:0007338 3 0.016
deoxyribonucleotide biosynthetic process GO:0009263 1 0.015
immune response GO:0006955 28 0.015
peptidyl serine phosphorylation GO:0018105 1 0.015
regulation of blood vessel size GO:0050880 2 0.015
cell aging GO:0007569 2 0.015
regulation of nucleoside metabolic process GO:0009118 2 0.015
macromolecular complex assembly GO:0065003 35 0.015
regulation of stem cell differentiation GO:2000736 4 0.015
gene expression GO:0010467 252 0.015
aromatic compound catabolic process GO:0019439 15 0.015
regulation of signal transduction GO:0009966 225 0.015
cellular response to starvation GO:0009267 1 0.015
cell migration GO:0016477 237 0.015
negative regulation of macromolecule metabolic process GO:0010605 76 0.015
cellular response to chemical stimulus GO:0070887 157 0.015
regulation of cellular ketone metabolic process GO:0010565 7 0.014
single organism biosynthetic process GO:0044711 71 0.014
response to nutrient GO:0007584 3 0.014
protein modification by small protein removal GO:0070646 1 0.014
peptidyl serine modification GO:0018209 2 0.014
ovulation cycle process GO:0022602 2 0.014
development of primary female sexual characteristics GO:0046545 4 0.014
negative regulation of apoptotic process GO:0043066 55 0.014
response to hydrogen peroxide GO:0042542 3 0.014
transcription dna templated GO:0006351 181 0.014
toxin transport GO:1901998 2 0.014
nucleoside phosphate biosynthetic process GO:1901293 21 0.014
regulation of protein localization to nucleus GO:1900180 2 0.014
regulation of transporter activity GO:0032409 2 0.014
regulation of nucleic acid templated transcription GO:1903506 213 0.014
cell cycle process GO:0022402 53 0.014
growth GO:0040007 174 0.014
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.014
microtubule polymerization GO:0046785 2 0.014
regulation of meiotic cell cycle GO:0051445 1 0.014
response to mechanical stimulus GO:0009612 24 0.014
positive regulation of molecular function GO:0044093 33 0.014
positive regulation of protein complex assembly GO:0031334 2 0.013
internal peptidyl lysine acetylation GO:0018393 2 0.013
vesicle mediated transport GO:0016192 22 0.013
response to oxygen radical GO:0000305 2 0.013
regulation of protein ubiquitination GO:0031396 3 0.013
ribonucleoside metabolic process GO:0009119 11 0.013
chemical homeostasis GO:0048878 49 0.013
positive regulation of cellular metabolic process GO:0031325 94 0.013
protein localization GO:0008104 40 0.013
system process GO:0003008 185 0.013
long chain fatty acid biosynthetic process GO:0042759 1 0.013
regulation of cellular biosynthetic process GO:0031326 245 0.013
stem cell division GO:0017145 1 0.013
cellular response to organic substance GO:0071310 105 0.013
regulation of biosynthetic process GO:0009889 250 0.013
positive regulation of apoptotic process GO:0043065 29 0.013
regulation of endopeptidase activity GO:0052548 23 0.013
rna metabolic process GO:0016070 219 0.013
mitotic cytokinesis GO:0000281 3 0.013
regulation of cellular amino acid metabolic process GO:0006521 0 0.013
protein import into nucleus GO:0006606 3 0.013
reproductive process GO:0022414 40 0.013
cofactor metabolic process GO:0051186 15 0.013
internal protein amino acid acetylation GO:0006475 2 0.013
regulation of cellular protein metabolic process GO:0032268 52 0.013
deoxyribonucleotide metabolic process GO:0009262 1 0.013
nuclear export GO:0051168 1 0.013
cortical cytoskeleton organization GO:0030865 1 0.012
regulation of locomotion GO:0040012 55 0.012
multicellular organism reproduction GO:0032504 35 0.012
positive regulation of nucleoside metabolic process GO:0045979 1 0.012
positive regulation of secretion GO:0051047 1 0.012
circulatory system process GO:0003013 87 0.012
response to organic substance GO:0010033 153 0.012
defense response to fungus GO:0050832 2 0.012
cellular response to stress GO:0033554 62 0.012
protein localization to nucleus GO:0034504 3 0.012
protein secretion GO:0009306 1 0.012
positive regulation of metabolic process GO:0009893 108 0.012
cellular response to reactive oxygen species GO:0034614 2 0.012
response to carbohydrate GO:0009743 3 0.012
regulation of cell activation GO:0050865 1 0.012
receptor mediated endocytosis GO:0006898 6 0.012
organelle localization GO:0051640 49 0.012
positive regulation of gtp catabolic process GO:0033126 1 0.012
axonogenesis GO:0007409 152 0.012
hydrogen peroxide metabolic process GO:0042743 2 0.012
carbohydrate biosynthetic process GO:0016051 1 0.012
b cell mediated immunity GO:0019724 3 0.012
homeostatic process GO:0042592 142 0.012
regulation of response to stress GO:0080134 36 0.012
protein homooligomerization GO:0051260 3 0.012
regulation of hydrolase activity GO:0051336 28 0.012
positive regulation of cell death GO:0010942 29 0.012
developmental growth GO:0048589 166 0.012
digestive system development GO:0055123 289 0.012
apoptotic signaling pathway GO:0097190 23 0.012
mitotic cell cycle GO:0000278 64 0.012
protein complex subunit organization GO:0071822 46 0.012
rna localization GO:0006403 4 0.011
organic substance transport GO:0071702 58 0.011
cellular component disassembly GO:0022411 1 0.011
activation of mapk activity GO:0000187 3 0.011
regulation of neurotransmitter secretion GO:0046928 1 0.011
nucleobase containing compound catabolic process GO:0034655 15 0.011
positive regulation of wound healing GO:0090303 1 0.011
regulation of macromolecule biosynthetic process GO:0010556 225 0.011
membrane invagination GO:0010324 1 0.011
nucleoside biosynthetic process GO:0009163 2 0.011
response to glucose GO:0009749 3 0.011
synaptic vesicle transport GO:0048489 1 0.011
negative regulation of programmed cell death GO:0043069 58 0.011
transmembrane transport GO:0055085 120 0.011
negative regulation of response to stimulus GO:0048585 104 0.011
response to alkaloid GO:0043279 2 0.011
fatty acid oxidation GO:0019395 1 0.011
negative regulation of organelle organization GO:0010639 4 0.011
positive regulation of cell cycle GO:0045787 3 0.011
purine nucleotide metabolic process GO:0006163 27 0.011
response to hexose GO:0009746 3 0.011
macromolecule biosynthetic process GO:0009059 227 0.011
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.011
response to monosaccharide GO:0034284 3 0.011
positive regulation of cellular component biogenesis GO:0044089 3 0.011
lipid homeostasis GO:0055088 3 0.011
b cell activation GO:0042113 2 0.011
cell type specific apoptotic process GO:0097285 22 0.011
somatic muscle development GO:0007525 4 0.011
response to alcohol GO:0097305 14 0.011
nuclear migration GO:0007097 3 0.011
ion homeostasis GO:0050801 41 0.011
cellular macromolecule localization GO:0070727 21 0.011
male gamete generation GO:0048232 7 0.011
neurotransmitter secretion GO:0007269 2 0.011
spermatogenesis GO:0007283 7 0.011
microtubule based process GO:0007017 60 0.010
mononuclear cell proliferation GO:0032943 1 0.010
tube morphogenesis GO:0035239 349 0.010
cellular component maintenance GO:0043954 3 0.010
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 20 0.010
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.010
positive regulation of leukocyte mediated immunity GO:0002705 1 0.010
defense response GO:0006952 47 0.010
protein modification by small protein conjugation or removal GO:0070647 14 0.010
peptide metabolic process GO:0006518 1 0.010
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.010
sister chromatid cohesion GO:0007062 2 0.010
neurotransmitter transport GO:0006836 2 0.010
protein complex assembly GO:0006461 30 0.010

txnrd1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.072
nervous system disease DOID:863 0 0.032
cancer DOID:162 0 0.021
disease of cellular proliferation DOID:14566 0 0.021
disease of metabolism DOID:0014667 0 0.017
inherited metabolic disorder DOID:655 0 0.017
organ system cancer DOID:0050686 0 0.015
musculoskeletal system disease DOID:17 0 0.011
amino acid metabolic disorder DOID:9252 0 0.010