Danio rerio

9 known processes

ube2nb

ubiquitin-conjugating enzyme E2Nb

(Aliases: zgc:63901,MGC63901,ube2nl)

ube2nb biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of cellular process GO:0048523 283 0.404
signal transduction GO:0007165 455 0.387
Fly
nucleobase containing compound metabolic process GO:0006139 274 0.349
regulation of primary metabolic process GO:0080090 311 0.328
Fly
cell surface receptor signaling pathway GO:0007166 325 0.324
macromolecule biosynthetic process GO:0009059 227 0.316
regulation of biological quality GO:0065008 263 0.315
cell motility GO:0048870 244 0.313
alternative mrna splicing via spliceosome GO:0000380 1 0.300
cellular macromolecule biosynthetic process GO:0034645 224 0.296
regulation of metabolic process GO:0019222 359 0.292
Fly
mrna splicing via spliceosome GO:0000398 10 0.287
nucleic acid metabolic process GO:0090304 244 0.263
regulation of multicellular organismal process GO:0051239 277 0.243
Fly
negative regulation of biological process GO:0048519 304 0.228
cell morphogenesis GO:0000902 289 0.226
Fly
regulation of gene expression GO:0010468 265 0.220
embryo development ending in birth or egg hatching GO:0009792 271 0.212
Worm
regulation of rna metabolic process GO:0051252 224 0.207
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.202
larval development GO:0002164 2 0.200
regulation of signal transduction GO:0009966 225 0.186
Fly
regulation of rna biosynthetic process GO:2001141 213 0.175
spliceosomal snrnp assembly GO:0000387 2 0.172
regulation of macromolecule metabolic process GO:0060255 317 0.171
Fly
regulation of anatomical structure morphogenesis GO:0022603 130 0.170
regulation of mrna splicing via spliceosome GO:0048024 3 0.169
regulation of macromolecule biosynthetic process GO:0010556 225 0.169
organelle organization GO:0006996 227 0.164
regulation of signaling GO:0023051 235 0.158
Fly
cell migration GO:0016477 237 0.157
regulation of nucleic acid templated transcription GO:1903506 213 0.156
cellular macromolecule metabolic process GO:0044260 391 0.144
Zebrafish Worm Fly
cell projection organization GO:0030030 284 0.143
Fly
localization of cell GO:0051674 244 0.141
cellular nitrogen compound biosynthetic process GO:0044271 218 0.140
negative regulation of metabolic process GO:0009892 86 0.137
nitrogen compound metabolic process GO:0006807 319 0.136
rna metabolic process GO:0016070 219 0.132
regulation of transcription dna templated GO:0006355 213 0.132
response to stress GO:0006950 263 0.128
nucleobase containing compound biosynthetic process GO:0034654 205 0.121
regulation of cellular metabolic process GO:0031323 320 0.116
Fly
gene expression GO:0010467 252 0.115
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 10 0.115
positive regulation of metabolic process GO:0009893 108 0.113
Fly
cellular biosynthetic process GO:0044249 286 0.110
cellular component biogenesis GO:0044085 178 0.109
Fly
organic cyclic compound biosynthetic process GO:1901362 223 0.109
cellular aromatic compound metabolic process GO:0006725 295 0.108
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.106
rna splicing GO:0008380 16 0.105
protein acetylation GO:0006473 2 0.105
regulation of cell differentiation GO:0045595 142 0.104
cellular component movement GO:0006928 335 0.103
protein metabolic process GO:0019538 183 0.099
Zebrafish Worm Fly
biosynthetic process GO:0009058 294 0.099
regulation of nitrogen compound metabolic process GO:0051171 251 0.098
cellular component assembly GO:0022607 170 0.097
Fly
heterocycle biosynthetic process GO:0018130 215 0.096
single organism metabolic process GO:0044710 217 0.095
Fly
nuclear transport GO:0051169 4 0.095
response to chemical GO:0042221 320 0.093
Fly
cellular component morphogenesis GO:0032989 336 0.092
Fly
i kappab kinase nf kappab signaling GO:0007249 4 0.090
negative regulation of macromolecule metabolic process GO:0010605 76 0.089
regulation of cellular component organization GO:0051128 86 0.088
rna biosynthetic process GO:0032774 181 0.088
meiotic nuclear division GO:0007126 4 0.087
organic cyclic compound metabolic process GO:1901360 301 0.085
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.083
regulation of embryonic development GO:0045995 47 0.082
Fly
negative regulation of gene expression GO:0010629 65 0.081
regulation of protein ubiquitination GO:0031396 3 0.081
Fly
heterocycle metabolic process GO:0046483 290 0.080
phagocytosis GO:0006909 3 0.080
cellular protein metabolic process GO:0044267 129 0.077
Zebrafish Worm Fly
neuron projection morphogenesis GO:0048812 161 0.076
Fly
nucleic acid templated transcription GO:0097659 181 0.075
cellular nitrogen compound metabolic process GO:0034641 290 0.074
mitotic g2 dna damage checkpoint GO:0007095 3 0.072
regulation of biosynthetic process GO:0009889 250 0.071
cell cycle GO:0007049 93 0.071
Fly
anterior posterior pattern specification GO:0009952 152 0.071
regulation of cellular biosynthetic process GO:0031326 245 0.071
protein localization to nucleus GO:0034504 3 0.070
dorsal ventral pattern formation GO:0009953 125 0.070
regulation of multicellular organismal development GO:2000026 223 0.069
Fly
cognition GO:0050890 1 0.069
positive regulation of dna metabolic process GO:0051054 1 0.068
nucleocytoplasmic transport GO:0006913 4 0.067
protein modification process GO:0036211 100 0.066
Zebrafish Worm Fly
cellular ketone metabolic process GO:0042180 11 0.066
locomotion GO:0040011 313 0.065
multi organism process GO:0051704 134 0.065
cell morphogenesis involved in differentiation GO:0000904 195 0.064
Fly
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.064
Fly
organic substance biosynthetic process GO:1901576 289 0.064
aging GO:0007568 2 0.063
axonogenesis GO:0007409 152 0.062
Fly
single organism reproductive process GO:0044702 40 0.062
regulation of cell cycle GO:0051726 52 0.061
Fly
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.061
spliceosomal complex assembly GO:0000245 1 0.061
transcription dna templated GO:0006351 181 0.060
cellular protein modification process GO:0006464 100 0.060
Zebrafish Worm Fly
neuron differentiation GO:0030182 353 0.059
Fly
stem cell maintenance GO:0019827 4 0.059
regulation of meiotic cell cycle GO:0051445 1 0.059
neuron development GO:0048666 262 0.058
Fly
protein acylation GO:0043543 3 0.057
cell proliferation GO:0008283 80 0.056
negative regulation of cellular metabolic process GO:0031324 77 0.055
positive regulation of biological process GO:0048518 253 0.054
Fly
regulation of mitotic cell cycle embryonic GO:0009794 2 0.053
Fly
heart development GO:0007507 313 0.051
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.050
enzyme linked receptor protein signaling pathway GO:0007167 106 0.049
internal peptidyl lysine acetylation GO:0018393 2 0.049
regulation of cell shape GO:0008360 1 0.049
chordate embryonic development GO:0043009 271 0.049
positive regulation of cellular process GO:0048522 201 0.048
Fly
spermatid development GO:0007286 2 0.048
cellular localization GO:0051641 97 0.048
Worm
transport GO:0006810 220 0.047
amine metabolic process GO:0009308 2 0.046
regulation of cell development GO:0060284 100 0.045
stem cell differentiation GO:0048863 117 0.045
regulation of stem cell differentiation GO:2000736 4 0.044
aromatic compound biosynthetic process GO:0019438 217 0.044
developmental process involved in reproduction GO:0003006 27 0.044
regulation of mrna processing GO:0050684 3 0.043
mitotic cell cycle embryonic GO:0045448 2 0.043
Fly
regulation of epithelial cell proliferation GO:0050678 3 0.043
macromolecular complex subunit organization GO:0043933 74 0.043
rna localization GO:0006403 4 0.043
adult behavior GO:0030534 2 0.042
Fly
regulation of cell death GO:0010941 103 0.042
Fly
growth GO:0040007 174 0.041
Fly
recombinational repair GO:0000725 1 0.041
cytokinesis GO:0000910 3 0.041
regulation of response to stimulus GO:0048583 269 0.041
Fly
positive regulation of response to stimulus GO:0048584 80 0.041
Fly
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.041
single organism nuclear import GO:1902593 3 0.040
stem cell development GO:0048864 82 0.040
regulation of cell proliferation GO:0042127 37 0.040
regulation of cellular amino acid metabolic process GO:0006521 0 0.039
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.039
cellular response to endogenous stimulus GO:0071495 68 0.039
intracellular signal transduction GO:0035556 85 0.039
Fly
regulation of synapse assembly GO:0051963 3 0.039
regulation of phosphorus metabolic process GO:0051174 43 0.038
Fly
regulation of cellular amine metabolic process GO:0033238 0 0.038
stem cell proliferation GO:0072089 4 0.038
response to endogenous stimulus GO:0009719 83 0.038
maintenance of location GO:0051235 4 0.038
pronuclear migration GO:0035046 1 0.038
regulation of localization GO:0032879 104 0.037
Worm
synaptic growth at neuromuscular junction GO:0051124 2 0.037
Fly
mitotic dna integrity checkpoint GO:0044774 4 0.037
oxoacid metabolic process GO:0043436 31 0.037
internal protein amino acid acetylation GO:0006475 2 0.036
cellular component disassembly GO:0022411 1 0.036
hemopoiesis GO:0030097 183 0.035
negative regulation of signaling GO:0023057 96 0.035
death GO:0016265 121 0.035
Fly
cellular response to chemical stimulus GO:0070887 157 0.035
peptidyl lysine acetylation GO:0018394 2 0.035
negative regulation of signal transduction GO:0009968 94 0.035
regulation of cellular ketone metabolic process GO:0010565 7 0.034
regulation of cell communication GO:0010646 232 0.034
Fly
mesenchyme development GO:0060485 127 0.034
regulation of developmental process GO:0050793 247 0.033
Fly
positive regulation of cell cycle GO:0045787 3 0.033
Fly
chromatin modification GO:0016568 21 0.033
cell part morphogenesis GO:0032990 246 0.033
Fly
autophagy GO:0006914 4 0.032
mrna processing GO:0006397 14 0.032
regulation of cell morphogenesis GO:0022604 42 0.032
phosphorylation GO:0016310 69 0.030
Fly
homeostatic process GO:0042592 142 0.030
regulation of catalytic activity GO:0050790 55 0.030
meiotic cell cycle process GO:1903046 3 0.030
double strand break repair via homologous recombination GO:0000724 1 0.029
cellular amine metabolic process GO:0044106 2 0.029
system process GO:0003008 185 0.029
negative regulation of transcription dna templated GO:0045892 45 0.029
modification dependent macromolecule catabolic process GO:0043632 3 0.029
organic acid metabolic process GO:0006082 31 0.029
cell projection morphogenesis GO:0048858 244 0.029
Fly
embryonic organ morphogenesis GO:0048562 274 0.029
eye development GO:0001654 277 0.028
segmentation GO:0035282 97 0.028
ubiquitin dependent protein catabolic process GO:0006511 3 0.028
histone modification GO:0016570 20 0.027
cell division GO:0051301 20 0.027
single organism localization GO:1902578 225 0.027
generation of neurons GO:0048699 385 0.027
Fly
establishment of localization GO:0051234 244 0.026
sex determination GO:0007530 1 0.026
nuclear import GO:0051170 3 0.026
pole plasm assembly GO:0007315 4 0.026
ion transport GO:0006811 114 0.026
macromolecule modification GO:0043412 111 0.026
Zebrafish Worm Fly
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.025
neuroblast proliferation GO:0007405 2 0.025
regulation of organelle organization GO:0033043 29 0.025
immune system development GO:0002520 191 0.025
cellular response to organic substance GO:0071310 105 0.025
carboxylic acid metabolic process GO:0019752 22 0.024
mitotic dna damage checkpoint GO:0044773 4 0.024
macromolecular complex assembly GO:0065003 35 0.024
spermatid differentiation GO:0048515 2 0.024
membrane invagination GO:0010324 1 0.024
modification dependent protein catabolic process GO:0019941 3 0.024
intracellular mrna localization GO:0008298 1 0.024
dna metabolic process GO:0006259 27 0.023
nuclear division GO:0000280 23 0.023
immune system process GO:0002376 241 0.023
ribonucleoprotein complex biogenesis GO:0022613 13 0.023
protein complex disassembly GO:0043241 1 0.023
regulation of receptor activity GO:0010469 2 0.023
behavior GO:0007610 74 0.023
Fly
regulation of synapse organization GO:0050807 3 0.023
digestive tract development GO:0048565 265 0.022
single organism transport GO:0044765 206 0.022
establishment of protein localization to organelle GO:0072594 4 0.022
cellular response to growth factor stimulus GO:0071363 39 0.022
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.022
Fly
protein targeting to nucleus GO:0044744 3 0.022
double strand break repair GO:0006302 3 0.022
neuron projection development GO:0031175 180 0.021
Fly
regulation of cellular protein metabolic process GO:0032268 52 0.021
Fly
multi organism reproductive process GO:0044703 36 0.021
digestive system development GO:0055123 289 0.021
positive regulation of cell communication GO:0010647 56 0.020
Fly
fertilization GO:0009566 3 0.020
negative regulation of response to stimulus GO:0048585 104 0.020
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.020
negative regulation of locomotion GO:0040013 18 0.020
positive regulation of developmental process GO:0051094 50 0.020
Fly
phosphate containing compound metabolic process GO:0006796 108 0.020
Fly
gland development GO:0048732 143 0.020
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.019
axis specification GO:0009798 43 0.019
negative regulation of rna splicing GO:0033119 1 0.019
sexual reproduction GO:0019953 36 0.019
cell aging GO:0007569 2 0.019
rna 3 end processing GO:0031123 2 0.019
regulation of protein complex assembly GO:0043254 3 0.019
hematopoietic or lymphoid organ development GO:0048534 191 0.019
synapse organization GO:0050808 21 0.019
Fly
single organism cellular localization GO:1902580 46 0.019
negative regulation of cell communication GO:0010648 96 0.018
regulation of phosphorylation GO:0042325 26 0.018
Fly
maternal determination of anterior posterior axis embryo GO:0008358 4 0.018
chemotaxis GO:0006935 104 0.018
reproduction GO:0000003 40 0.018
positive regulation of cellular amine metabolic process GO:0033240 0 0.018
mitotic g2 m transition checkpoint GO:0044818 3 0.018
regulation of molecular function GO:0065009 70 0.018
establishment of cell polarity GO:0030010 18 0.018
cellular response to dna damage stimulus GO:0006974 24 0.018
small molecule metabolic process GO:0044281 77 0.018
camera type eye development GO:0043010 222 0.018
phosphorus metabolic process GO:0006793 109 0.018
Fly
macromolecule localization GO:0033036 54 0.018
Worm
single organism organelle organization GO:1902589 199 0.018
oocyte anterior posterior axis specification GO:0007314 4 0.017
phagocytosis engulfment GO:0006911 1 0.017
protein dephosphorylation GO:0006470 3 0.017
positive regulation of transport GO:0051050 2 0.017
cellular amino acid metabolic process GO:0006520 7 0.017
transcription from rna polymerase ii promoter GO:0006366 80 0.017
regulation of stem cell proliferation GO:0072091 2 0.017
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.017
mesenchymal cell development GO:0014031 78 0.017
mapk cascade GO:0000165 18 0.017
Fly
negative regulation of cell development GO:0010721 26 0.017
photoreceptor cell morphogenesis GO:0008594 1 0.016
Fly
chromosome organization GO:0051276 31 0.016
g2 dna damage checkpoint GO:0031572 3 0.016
digestive tract morphogenesis GO:0048546 231 0.016
ras protein signal transduction GO:0007265 7 0.016
regionalization GO:0003002 274 0.016
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.016
regulation of rna splicing GO:0043484 8 0.016
single fertilization GO:0007338 3 0.016
regulation of transporter activity GO:0032409 2 0.016
cellular macromolecular complex assembly GO:0034622 24 0.016
response to drug GO:0042493 3 0.016
Fly
morphogenesis of an epithelium GO:0002009 333 0.016
protein import GO:0017038 3 0.016
regulation of cell cycle process GO:0010564 20 0.016
regulation of protein metabolic process GO:0051246 56 0.016
Fly
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.015
protein homooligomerization GO:0051260 3 0.015
positive regulation of molecular function GO:0044093 33 0.015
regulation of dendrite development GO:0050773 3 0.015
cell maturation GO:0048469 23 0.015
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 4 0.015
dna catabolic process GO:0006308 1 0.015
embryonic organ development GO:0048568 381 0.015
negative regulation of ras protein signal transduction GO:0046580 1 0.015
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.015
negative regulation of synapse assembly GO:0051964 2 0.015
regulation of cellular response to growth factor stimulus GO:0090287 35 0.015
protein stabilization GO:0050821 2 0.015
multicellular organismal reproductive process GO:0048609 35 0.015
mesenchymal cell differentiation GO:0048762 87 0.015
reproductive process GO:0022414 40 0.015
negative regulation of phosphate metabolic process GO:0045936 13 0.014
cytoplasm organization GO:0007028 4 0.014
skin development GO:0043588 54 0.014
regulation of oocyte development GO:0060281 3 0.014
positive regulation of chromosome organization GO:2001252 1 0.014
developmental maturation GO:0021700 34 0.014
Fly
cellular response to external stimulus GO:0071496 2 0.014
regulation of protein modification process GO:0031399 29 0.014
Fly
cytoskeleton dependent cytokinesis GO:0061640 3 0.014
positive regulation of chromatin modification GO:1903310 1 0.014
small gtpase mediated signal transduction GO:0007264 8 0.014
central nervous system development GO:0007417 387 0.014
protein k63 linked ubiquitination GO:0070534 2 0.014
multicellular organism growth GO:0035264 4 0.014
ameboidal type cell migration GO:0001667 143 0.014
cellular protein catabolic process GO:0044257 4 0.014
lateral inhibition GO:0046331 1 0.014
locomotory behavior GO:0007626 34 0.013
Fly
response to growth factor GO:0070848 39 0.013
epithelial cell differentiation GO:0030855 116 0.013
positive regulation of signaling GO:0023056 56 0.013
Fly
positive regulation of protein metabolic process GO:0051247 23 0.013
Fly
mrna transport GO:0051028 2 0.013
mitochondrion organization GO:0007005 4 0.013
blood vessel morphogenesis GO:0048514 216 0.013
negative regulation of cell death GO:0060548 60 0.013
regulation of erk1 and erk2 cascade GO:0070372 4 0.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.013
covalent chromatin modification GO:0016569 20 0.013
neuromuscular synaptic transmission GO:0007274 2 0.013
negative regulation of cell differentiation GO:0045596 46 0.013
regulation of cytoplasmic transport GO:1903649 4 0.013
ribonucleoprotein complex subunit organization GO:0071826 8 0.013
positive regulation of ras protein signal transduction GO:0046579 1 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.013
negative regulation of protein phosphorylation GO:0001933 4 0.013
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.013
Fly
negative regulation of developmental process GO:0051093 65 0.012
regulation of reproductive process GO:2000241 4 0.012
proteolysis GO:0006508 38 0.012
negative regulation of rna metabolic process GO:0051253 48 0.012
regulation of cytokine production GO:0001817 3 0.012
response to glucocorticoid GO:0051384 1 0.012
negative regulation of cellular protein metabolic process GO:0032269 16 0.012
actin polymerization or depolymerization GO:0008154 2 0.012
multicellular organismal homeostasis GO:0048871 29 0.012
mitotic cell cycle GO:0000278 64 0.012
Fly
cellular macromolecule localization GO:0070727 21 0.012
Worm
meiotic chromosome segregation GO:0045132 3 0.012
response to organic substance GO:0010033 153 0.012
negative regulation of multicellular organismal process GO:0051241 69 0.012
response to hormone GO:0009725 48 0.012
regulation of phosphate metabolic process GO:0019220 43 0.012
Fly
vasculature development GO:0001944 278 0.012
negative regulation of mrna metabolic process GO:1903312 3 0.012
regulation of establishment of protein localization GO:0070201 4 0.012
apoptotic process GO:0006915 116 0.012
stem cell division GO:0017145 1 0.012
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.012
protein polymerization GO:0051258 4 0.012
cellular response to stress GO:0033554 62 0.012
positive regulation of catabolic process GO:0009896 4 0.012
programmed cell death GO:0012501 119 0.012
positive regulation of epithelial cell proliferation GO:0050679 1 0.012
somite development GO:0061053 96 0.011
macromolecular complex disassembly GO:0032984 1 0.011
cell fate commitment GO:0045165 99 0.011
mrna 3 end processing GO:0031124 2 0.011
cell adhesion GO:0007155 40 0.011
positive regulation of histone modification GO:0031058 1 0.011
anterior posterior axis specification GO:0009948 20 0.011
protein complex subunit organization GO:0071822 46 0.011
positive regulation of cellular component biogenesis GO:0044089 3 0.011
regulation of protein catabolic process GO:0042176 1 0.011
regulation of locomotion GO:0040012 55 0.011
multicellular organism reproduction GO:0032504 35 0.011
retina development in camera type eye GO:0060041 146 0.011
sensory organ development GO:0007423 393 0.011
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.011
establishment or maintenance of cell polarity GO:0007163 29 0.011
protein import into nucleus GO:0006606 3 0.011
rna transport GO:0050658 2 0.011
response to abiotic stimulus GO:0009628 122 0.011
g2 m transition of mitotic cell cycle GO:0000086 4 0.011
negative regulation of cell morphogenesis involved in differentiation GO:0010771 8 0.011
erk1 and erk2 cascade GO:0070371 4 0.010
positive regulation of macromolecule metabolic process GO:0010604 93 0.010
Fly
positive regulation of multicellular organismal process GO:0051240 52 0.010
Fly
nucleic acid transport GO:0050657 2 0.010
positive regulation of mrna splicing via spliceosome GO:0048026 1 0.010
regulation of protein complex disassembly GO:0043244 1 0.010
specification of symmetry GO:0009799 204 0.010
establishment of rna localization GO:0051236 3 0.010
mrna metabolic process GO:0016071 20 0.010
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.010
homeostasis of number of cells GO:0048872 62 0.010

ube2nb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.014
disease of metabolism DOID:0014667 0 0.013
myopathy DOID:423 0 0.013
muscular disease DOID:0080000 0 0.013
musculoskeletal system disease DOID:17 0 0.013
muscle tissue disease DOID:66 0 0.013