Danio rerio

20 known processes

ucp1

uncoupling protein 1

(Aliases: zgc:77603,wu:fb62c08,UCPx,fb62c08,MGC55824,UCP3,ucp4,zgc:55824)

ucp1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of biological quality GO:0065008 263 0.538
aging GO:0007568 2 0.501
carboxylic acid catabolic process GO:0046395 3 0.448
regulation of response to stimulus GO:0048583 269 0.369
organic acid catabolic process GO:0016054 3 0.350
small molecule metabolic process GO:0044281 77 0.272
cellular carbohydrate metabolic process GO:0044262 4 0.264
positive regulation of biological process GO:0048518 253 0.262
regulation of multicellular organism growth GO:0040014 4 0.241
multicellular organism growth GO:0035264 4 0.241
single organism transport GO:0044765 206 0.223
Mouse
carboxylic acid metabolic process GO:0019752 22 0.218
organic acid metabolic process GO:0006082 31 0.207
cellular lipid metabolic process GO:0044255 36 0.199
protein activation cascade GO:0072376 6 0.179
response to hexose GO:0009746 3 0.178
response to glucose GO:0009749 3 0.171
lipid catabolic process GO:0016042 4 0.169
cellular response to chemical stimulus GO:0070887 157 0.158
regulation of signaling GO:0023051 235 0.154
cell substrate adhesion GO:0031589 4 0.151
hindbrain development GO:0030902 91 0.145
transport GO:0006810 220 0.145
Mouse
cellular biosynthetic process GO:0044249 286 0.143
Mouse
monocarboxylic acid catabolic process GO:0072329 3 0.137
primary amino compound metabolic process GO:1901160 1 0.122
neuron differentiation GO:0030182 353 0.121
negative regulation of biological process GO:0048519 304 0.119
ion transport GO:0006811 114 0.113
Mouse
regulation of cell communication GO:0010646 232 0.106
cellular amino acid biosynthetic process GO:0008652 2 0.103
negative regulation of cellular process GO:0048523 283 0.103
response to monosaccharide GO:0034284 3 0.099
response to vitamin GO:0033273 3 0.090
response to stress GO:0006950 263 0.090
central nervous system development GO:0007417 387 0.090
blood coagulation fibrin clot formation GO:0072378 3 0.086
cell migration GO:0016477 237 0.086
single organism metabolic process GO:0044710 217 0.085
cellular response to organic substance GO:0071310 105 0.084
single organism localization GO:1902578 225 0.083
Mouse
biosynthetic process GO:0009058 294 0.082
Mouse
alpha amino acid metabolic process GO:1901605 3 0.082
lipid metabolic process GO:0006629 52 0.082
cellular amine metabolic process GO:0044106 2 0.080
cellular response to lipid GO:0071396 39 0.080
brain development GO:0007420 293 0.076
cellular localization GO:0051641 97 0.074
response to vitamin b3 GO:0033552 2 0.073
organic substance biosynthetic process GO:1901576 289 0.072
Mouse
macromolecular complex subunit organization GO:0043933 74 0.072
positive regulation of transport GO:0051050 2 0.072
hormone transport GO:0009914 2 0.071
oxoacid metabolic process GO:0043436 31 0.071
striated muscle cell differentiation GO:0051146 129 0.071
signal transduction GO:0007165 455 0.068
developmental growth GO:0048589 166 0.068
establishment of localization GO:0051234 244 0.068
Mouse
insulin like growth factor receptor signaling pathway GO:0048009 4 0.068
amine metabolic process GO:0009308 2 0.067
response to nutrient GO:0007584 3 0.066
maintenance of location GO:0051235 4 0.065
regulation of multicellular organismal process GO:0051239 277 0.064
small molecule catabolic process GO:0044282 3 0.063
fatty acid catabolic process GO:0009062 1 0.063
primary amino compound biosynthetic process GO:1901162 1 0.062
organic cyclic compound metabolic process GO:1901360 301 0.062
Mouse
taurine metabolic process GO:0019530 1 0.062
cellular ketone metabolic process GO:0042180 11 0.060
muscle cell differentiation GO:0042692 139 0.059
muscle structure development GO:0061061 196 0.059
cellular macromolecule metabolic process GO:0044260 391 0.057
Mouse
cellular macromolecule biosynthetic process GO:0034645 224 0.056
Mouse
protein metabolic process GO:0019538 183 0.055
fatty acid metabolic process GO:0006631 5 0.054
regulation of cellular amino acid metabolic process GO:0006521 0 0.054
hormone mediated signaling pathway GO:0009755 9 0.053
regulation of cellular ketone metabolic process GO:0010565 7 0.053
anion transport GO:0006820 38 0.053
cell death GO:0008219 121 0.052
regulation of nitrogen compound metabolic process GO:0051171 251 0.051
Mouse
cellular component assembly GO:0022607 170 0.051
cellular amino acid metabolic process GO:0006520 7 0.050
organonitrogen compound metabolic process GO:1901564 74 0.050
intracellular receptor signaling pathway GO:0030522 30 0.049
larval development GO:0002164 2 0.049
generation of neurons GO:0048699 385 0.048
serotonin biosynthetic process GO:0042427 1 0.047
response to steroid hormone GO:0048545 35 0.047
response to endogenous stimulus GO:0009719 83 0.047
striated muscle cell development GO:0055002 108 0.047
growth GO:0040007 174 0.046
organic substance transport GO:0071702 58 0.046
phosphatidylinositol mediated signaling GO:0048015 2 0.044
long chain fatty acid transport GO:0015909 1 0.043
positive regulation of multicellular organismal process GO:0051240 52 0.042
response to lipid GO:0033993 60 0.041
macromolecule biosynthetic process GO:0009059 227 0.041
Mouse
cellular response to organic cyclic compound GO:0071407 38 0.040
neuron neuron synaptic transmission GO:0007270 1 0.040
response to chemical GO:0042221 320 0.039
lipid storage GO:0019915 1 0.039
heart development GO:0007507 313 0.038
serotonin metabolic process GO:0042428 1 0.038
branched chain amino acid metabolic process GO:0009081 1 0.038
fatty acid oxidation GO:0019395 1 0.038
cellular nitrogen compound biosynthetic process GO:0044271 218 0.037
Mouse
response to estrogen GO:0043627 27 0.037
head development GO:0060322 303 0.037
regulation of developmental process GO:0050793 247 0.036
actomyosin structure organization GO:0031032 53 0.035
protein complex assembly GO:0006461 30 0.035
regulation of signal transduction GO:0009966 225 0.035
energy reserve metabolic process GO:0006112 2 0.035
regulation of gene expression GO:0010468 265 0.034
Mouse
nitrogen compound metabolic process GO:0006807 319 0.034
Mouse
cerebellar granular layer formation GO:0021684 3 0.034
macromolecular complex assembly GO:0065003 35 0.032
regulation of fatty acid metabolic process GO:0019217 1 0.032
hormone secretion GO:0046879 2 0.032
regulation of programmed cell death GO:0043067 101 0.032
response to hormone GO:0009725 48 0.030
neuroblast proliferation GO:0007405 2 0.030
cellular macromolecular complex assembly GO:0034622 24 0.030
cellular component morphogenesis GO:0032989 336 0.030
positive regulation of cell adhesion GO:0045785 1 0.030
actin cytoskeleton organization GO:0030036 63 0.030
positive regulation of metabolic process GO:0009893 108 0.029
cellular lipid catabolic process GO:0044242 3 0.029
response to carbohydrate GO:0009743 3 0.029
regulation of hormone levels GO:0010817 21 0.028
negative regulation of cell death GO:0060548 60 0.028
muscle cell development GO:0055001 115 0.028
regulation of macromolecule metabolic process GO:0060255 317 0.028
Mouse
tyrosine metabolic process GO:0006570 1 0.028
negative regulation of response to stimulus GO:0048585 104 0.027
cell surface receptor signaling pathway GO:0007166 325 0.027
fatty acid transport GO:0015908 1 0.026
negative regulation of macromolecule metabolic process GO:0010605 76 0.026
apoptotic process GO:0006915 116 0.026
cell matrix adhesion GO:0007160 4 0.026
cellular nitrogen compound metabolic process GO:0034641 290 0.026
Mouse
nucleobase containing compound biosynthetic process GO:0034654 205 0.026
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.026
embryonic organ development GO:0048568 381 0.025
system process GO:0003008 185 0.025
single organism organelle organization GO:1902589 199 0.025
enzyme linked receptor protein signaling pathway GO:0007167 106 0.025
positive regulation of response to stimulus GO:0048584 80 0.025
transcription from rna polymerase ii promoter GO:0006366 80 0.025
Mouse
negative regulation of dna replication GO:0008156 2 0.025
actin filament based process GO:0030029 64 0.024
regulation of primary metabolic process GO:0080090 311 0.024
Mouse
regulation of hormone secretion GO:0046883 2 0.024
regulation of macromolecule biosynthetic process GO:0010556 225 0.024
Mouse
cellular response to estrogen stimulus GO:0071391 24 0.024
adult behavior GO:0030534 2 0.024
response to organic cyclic compound GO:0014070 51 0.024
immune system development GO:0002520 191 0.024
lipid oxidation GO:0034440 1 0.024
regulation of carbohydrate metabolic process GO:0006109 4 0.023
response to alkaloid GO:0043279 2 0.023
response to methanol GO:0033986 4 0.023
regulation of cellular amine metabolic process GO:0033238 0 0.023
negative regulation of feeding behavior GO:2000252 2 0.023
regulation of localization GO:0032879 104 0.022
reproduction GO:0000003 40 0.022
regulation of synapse assembly GO:0051963 3 0.022
regulation of cell substrate adhesion GO:0010810 1 0.022
regulation of cellular metabolic process GO:0031323 320 0.022
Mouse
indole containing compound metabolic process GO:0042430 2 0.022
organelle organization GO:0006996 227 0.021
cellular biogenic amine metabolic process GO:0006576 2 0.021
positive regulation of cellular process GO:0048522 201 0.021
multicellular organismal response to stress GO:0033555 2 0.021
positive regulation of catabolic process GO:0009896 4 0.021
fat soluble vitamin metabolic process GO:0006775 4 0.021
regulation of blood vessel size GO:0050880 2 0.020
stem cell proliferation GO:0072089 4 0.020
positive regulation of cellular amine metabolic process GO:0033240 0 0.020
neuron development GO:0048666 262 0.020
localization of cell GO:0051674 244 0.020
establishment of localization in cell GO:0051649 77 0.020
organic cyclic compound biosynthetic process GO:1901362 223 0.020
Mouse
cellular protein metabolic process GO:0044267 129 0.020
circadian sleep wake cycle GO:0042745 2 0.019
regulation of cell death GO:0010941 103 0.019
heterocycle metabolic process GO:0046483 290 0.019
Mouse
cellular response to methanol GO:0071405 4 0.019
cytoskeleton organization GO:0007010 96 0.019
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.019
rna metabolic process GO:0016070 219 0.019
Mouse
multi organism cellular process GO:0044764 2 0.019
carboxylic acid biosynthetic process GO:0046394 12 0.019
catecholamine biosynthetic process GO:0042423 2 0.019
organelle assembly GO:0070925 110 0.018
positive regulation of cell substrate adhesion GO:0010811 1 0.018
neurotransmitter transport GO:0006836 2 0.018
protein localization to plasma membrane GO:0072659 1 0.018
organic hydroxy compound transport GO:0015850 14 0.018
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.018
negative regulation of programmed cell death GO:0043069 58 0.018
circadian sleep wake cycle process GO:0022410 2 0.018
positive regulation of developmental process GO:0051094 50 0.018
myofibril assembly GO:0030239 48 0.017
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.017
response to glucocorticoid GO:0051384 1 0.017
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.017
programmed cell death GO:0012501 119 0.017
cellular response to steroid hormone stimulus GO:0071383 31 0.017
carbohydrate biosynthetic process GO:0016051 1 0.017
regulation of stem cell proliferation GO:0072091 2 0.017
cellular response to starvation GO:0009267 1 0.017
intracellular signal transduction GO:0035556 85 0.017
peptide transport GO:0015833 1 0.017
aromatic amino acid family metabolic process GO:0009072 1 0.017
negative regulation of signaling GO:0023057 96 0.017
inositol lipid mediated signaling GO:0048017 2 0.016
response to organic substance GO:0010033 153 0.016
embryonic organ morphogenesis GO:0048562 274 0.016
carbon dioxide transport GO:0015670 3 0.016
nucleic acid metabolic process GO:0090304 244 0.016
Mouse
negative regulation of gene expression GO:0010629 65 0.016
positive regulation of lipid metabolic process GO:0045834 1 0.016
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.016
cellular response to xenobiotic stimulus GO:0071466 35 0.015
vitamin a metabolic process GO:0006776 1 0.015
positive regulation of cellular catabolic process GO:0031331 3 0.015
cellular response to hormone stimulus GO:0032870 39 0.015
protein complex subunit organization GO:0071822 46 0.015
response to drug GO:0042493 3 0.015
alcohol biosynthetic process GO:0046165 2 0.015
positive regulation of protein kinase b signaling GO:0051897 1 0.015
regulation of apoptotic process GO:0042981 98 0.015
macromolecule localization GO:0033036 54 0.015
negative regulation of apoptotic process GO:0043066 55 0.015
oxidation reduction process GO:0055114 41 0.014
response to acidic ph GO:0010447 2 0.014
carbohydrate derivative metabolic process GO:1901135 61 0.014
mitochondrial transport GO:0006839 2 0.014
cell morphogenesis GO:0000902 289 0.014
regulation of circadian rhythm GO:0042752 4 0.014
regulation of metabolic process GO:0019222 359 0.014
Mouse
cell part morphogenesis GO:0032990 246 0.014
regulation of insulin like growth factor receptor signaling pathway GO:0043567 1 0.014
cellular response to external stimulus GO:0071496 2 0.014
cell cell signaling GO:0007267 52 0.014
cellular component biogenesis GO:0044085 178 0.014
steroid hormone mediated signaling pathway GO:0043401 9 0.013
immune system process GO:0002376 241 0.013
respiratory electron transport chain GO:0022904 2 0.013
response to abiotic stimulus GO:0009628 122 0.013
organ regeneration GO:0031100 1 0.013
regulation of dna replication GO:0006275 3 0.013
electron transport chain GO:0022900 2 0.013
endosomal transport GO:0016197 2 0.013
cognition GO:0050890 1 0.013
response to nutrient levels GO:0031667 10 0.013
hindbrain morphogenesis GO:0021575 22 0.013
pyruvate metabolic process GO:0006090 1 0.013
polyol metabolic process GO:0019751 1 0.013
positive regulation of cellular metabolic process GO:0031325 94 0.013
positive regulation of jak stat cascade GO:0046427 2 0.013
response to external stimulus GO:0009605 264 0.013
response to corticosteroid GO:0031960 1 0.013
blood vessel development GO:0001568 246 0.013
dopamine biosynthetic process GO:0042416 2 0.013
gene expression GO:0010467 252 0.012
Mouse
catechol containing compound biosynthetic process GO:0009713 2 0.012
embryonic heart tube morphogenesis GO:0003143 108 0.012
response to food GO:0032094 1 0.012
cell morphogenesis involved in differentiation GO:0000904 195 0.012
regulation of cell shape GO:0008360 1 0.012
transcription dna templated GO:0006351 181 0.012
Mouse
negative regulation of cell differentiation GO:0045596 46 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.012
endothelial cell development GO:0001885 12 0.012
heterocycle biosynthetic process GO:0018130 215 0.012
Mouse
receptor internalization GO:0031623 2 0.012
gtp metabolic process GO:0046039 4 0.012
cellular response to extracellular stimulus GO:0031668 2 0.012
cellular aromatic compound metabolic process GO:0006725 295 0.011
Mouse
sensory organ development GO:0007423 393 0.011
regulation of rna metabolic process GO:0051252 224 0.011
Mouse
protein polymerization GO:0051258 4 0.011
regulation of circadian sleep wake cycle GO:0042749 1 0.011
regulation of nucleic acid templated transcription GO:1903506 213 0.011
Mouse
multicellular organismal metabolic process GO:0044236 2 0.011
negative regulation of cellular metabolic process GO:0031324 77 0.011
eye development GO:0001654 277 0.011
cellular response to hypoxia GO:0071456 1 0.011
regulation of protein transport GO:0051223 3 0.011
positive regulation of secretion GO:0051047 1 0.011
cellular component assembly involved in morphogenesis GO:0010927 107 0.011
cellular component disassembly GO:0022411 1 0.011
monoamine transport GO:0015844 1 0.011
cerebellar granular layer morphogenesis GO:0021683 3 0.011
organic acid biosynthetic process GO:0016053 12 0.010
response to oxygen containing compound GO:1901700 55 0.010
digestive tract mesoderm development GO:0007502 1 0.010
embryonic heart tube development GO:0035050 133 0.010
nucleobase containing compound metabolic process GO:0006139 274 0.010
Mouse
regulation of tube size GO:0035150 2 0.010
positive regulation of cell cycle GO:0045787 3 0.010
cellular amide metabolic process GO:0043603 4 0.010
connective tissue development GO:0061448 99 0.010
cerebellar granular layer development GO:0021681 3 0.010
response to decreased oxygen levels GO:0036293 25 0.010
negative regulation of defense response GO:0031348 2 0.010
protein homooligomerization GO:0051260 3 0.010
negative regulation of multi organism process GO:0043901 3 0.010

ucp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.026
lipid metabolism disorder DOID:3146 0 0.026
inherited metabolic disorder DOID:655 0 0.026