Danio rerio

0 known processes

ucp2

uncoupling protein 2

(Aliases: MGC76853,cb74,MGC65762)

ucp2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
system process GO:0003008 185 0.296
cellular response to nutrient levels GO:0031669 2 0.195
Rat
response to organic substance GO:0010033 153 0.188
Zebrafish Rat
organic acid metabolic process GO:0006082 31 0.140
organonitrogen compound metabolic process GO:1901564 74 0.138
carboxylic acid metabolic process GO:0019752 22 0.135
regulation of response to oxidative stress GO:1902882 2 0.130
multicellular organismal macromolecule metabolic process GO:0044259 2 0.117
response to glucocorticoid GO:0051384 1 0.108
cellular response to external stimulus GO:0071496 2 0.106
Rat
collagen metabolic process GO:0032963 2 0.104
small molecule metabolic process GO:0044281 77 0.101
immune system process GO:0002376 241 0.094
multicellular organismal metabolic process GO:0044236 2 0.084
sphingolipid biosynthetic process GO:0030148 2 0.083
cellular response to starvation GO:0009267 1 0.080
Rat
oxoacid metabolic process GO:0043436 31 0.078
nuclear import GO:0051170 3 0.077
response to corticosteroid GO:0031960 1 0.077
aging GO:0007568 2 0.077
Rat
response to endogenous stimulus GO:0009719 83 0.077
Zebrafish Rat
larval development GO:0002164 2 0.075
response to carbohydrate GO:0009743 3 0.071
Rat
blood vessel development GO:0001568 246 0.069
cell surface receptor signaling pathway GO:0007166 325 0.066
adult behavior GO:0030534 2 0.066
establishment of protein localization to organelle GO:0072594 4 0.065
protein targeting to nucleus GO:0044744 3 0.064
cellular response to extracellular stimulus GO:0031668 2 0.064
Rat
regulation of cellular response to oxidative stress GO:1900407 2 0.064
positive regulation of transport GO:0051050 2 0.060
response to drug GO:0042493 3 0.060
single organism organelle organization GO:1902589 199 0.059
single organism localization GO:1902578 225 0.058
Rat
mitochondrion organization GO:0007005 4 0.058
cellular response to chemical stimulus GO:0070887 157 0.055
Zebrafish Rat
cell death in response to oxidative stress GO:0036473 2 0.055
single organism metabolic process GO:0044710 217 0.053
response to organic cyclic compound GO:0014070 51 0.051
Zebrafish
regulation of epithelial cell proliferation GO:0050678 3 0.051
response to monosaccharide GO:0034284 3 0.050
Rat
protein import into nucleus GO:0006606 3 0.049
negative regulation of biological process GO:0048519 304 0.048
Rat
regulation of cellular ketone metabolic process GO:0010565 7 0.047
nuclear transport GO:0051169 4 0.046
nucleocytoplasmic transport GO:0006913 4 0.044
autophagy GO:0006914 4 0.044
regulation of multicellular organism growth GO:0040014 4 0.044
response to steroid hormone GO:0048545 35 0.044
Zebrafish
cognition GO:0050890 1 0.044
catabolic process GO:0009056 32 0.042
response to hexose GO:0009746 3 0.041
Rat
membrane lipid biosynthetic process GO:0046467 2 0.040
regulation of nucleotide catabolic process GO:0030811 2 0.040
single organism biosynthetic process GO:0044711 71 0.039
single organism nuclear import GO:1902593 3 0.039
cofactor metabolic process GO:0051186 15 0.039
regulation of cellular amino acid metabolic process GO:0006521 0 0.038
response to stress GO:0006950 263 0.038
Rat
regulation of protein transport GO:0051223 3 0.038
response to hormone GO:0009725 48 0.037
Zebrafish Rat
cellular amino acid metabolic process GO:0006520 7 0.037
regulation of cytokine production GO:0001817 3 0.037
regulation of carbohydrate metabolic process GO:0006109 4 0.036
cell migration GO:0016477 237 0.036
response to transition metal nanoparticle GO:1990267 28 0.035
cellular component movement GO:0006928 335 0.035
response to alkaloid GO:0043279 2 0.035
cell substrate adhesion GO:0031589 4 0.034
regulation of heart growth GO:0060420 2 0.032
cellular carbohydrate metabolic process GO:0044262 4 0.032
cellular response to organic substance GO:0071310 105 0.032
Zebrafish Rat
response to biotic stimulus GO:0009607 97 0.031
regulation of establishment of protein localization GO:0070201 4 0.031
nucleoside monophosphate catabolic process GO:0009125 4 0.031
biosynthetic process GO:0009058 294 0.031
hydrogen peroxide metabolic process GO:0042743 2 0.029
response to ketone GO:1901654 1 0.029
blood vessel morphogenesis GO:0048514 216 0.029
response to nutrient GO:0007584 3 0.028
locomotion GO:0040011 313 0.028
protein import GO:0017038 3 0.028
multi organism process GO:0051704 134 0.028
Rat
positive regulation of catabolic process GO:0009896 4 0.028
regulation of system process GO:0044057 40 0.027
carbohydrate derivative metabolic process GO:1901135 61 0.027
protein localization to nucleus GO:0034504 3 0.027
regulation of muscle contraction GO:0006937 3 0.027
regulation of metal ion transport GO:0010959 4 0.026
multicellular organism growth GO:0035264 4 0.026
response to lipid GO:0033993 60 0.026
Zebrafish Rat
cellular macromolecule metabolic process GO:0044260 391 0.026
regulation of production of molecular mediator of immune response GO:0002700 1 0.026
gtp metabolic process GO:0046039 4 0.025
heart contraction GO:0060047 71 0.025
regulation of bone mineralization GO:0030500 2 0.025
guanosine containing compound metabolic process GO:1901068 4 0.025
cellular response to oxygen levels GO:0071453 1 0.025
response to external stimulus GO:0009605 264 0.024
Rat
negative regulation of heart contraction GO:0045822 2 0.024
nitric oxide biosynthetic process GO:0006809 2 0.024
regulation of tube size GO:0035150 2 0.024
regulation of protein complex assembly GO:0043254 3 0.023
cell death GO:0008219 121 0.022
Rat
ameboidal type cell migration GO:0001667 143 0.022
carboxylic acid catabolic process GO:0046395 3 0.022
alpha amino acid metabolic process GO:1901605 3 0.022
death GO:0016265 121 0.022
Rat
positive regulation of cellular catabolic process GO:0031331 3 0.022
organelle organization GO:0006996 227 0.022
extrinsic apoptotic signaling pathway GO:0097191 3 0.022
cell morphogenesis involved in differentiation GO:0000904 195 0.022
actin filament based process GO:0030029 64 0.022
regulation of protein import into nucleus GO:0042306 2 0.022
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.022
cellular amine metabolic process GO:0044106 2 0.022
protein polymerization GO:0051258 4 0.022
response to mechanical stimulus GO:0009612 24 0.022
microtubule polymerization GO:0046785 2 0.022
cellular biosynthetic process GO:0044249 286 0.021
cellular catabolic process GO:0044248 27 0.021
establishment of localization GO:0051234 244 0.021
Rat
regionalization GO:0003002 274 0.021
regulation of gtp catabolic process GO:0033124 2 0.021
regulation of blood vessel size GO:0050880 2 0.021
regulation of cellular component organization GO:0051128 86 0.021
developmental growth GO:0048589 166 0.020
monovalent inorganic cation transport GO:0015672 42 0.020
centrosome organization GO:0051297 1 0.020
rna localization GO:0006403 4 0.020
regulation of cell shape GO:0008360 1 0.020
apical junction assembly GO:0043297 1 0.020
negative regulation of striated muscle tissue development GO:0045843 2 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.019
cell migration involved in gastrulation GO:0042074 79 0.019
single organism cellular localization GO:1902580 46 0.019
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.019
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.019
transport GO:0006810 220 0.019
Rat
modulation by virus of host morphology or physiology GO:0019048 1 0.019
protein heterooligomerization GO:0051291 1 0.019
cellular component disassembly GO:0022411 1 0.019
fat soluble vitamin metabolic process GO:0006775 4 0.019
nucleobase containing compound biosynthetic process GO:0034654 205 0.018
regulation of purine nucleotide catabolic process GO:0033121 2 0.018
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 2 0.018
regulation of protein localization to nucleus GO:1900180 2 0.018
signal transduction GO:0007165 455 0.018
regulation of transporter activity GO:0032409 2 0.018
response to chemical GO:0042221 320 0.018
Zebrafish Rat
amine metabolic process GO:0009308 2 0.018
microtubule organizing center organization GO:0031023 1 0.018
s adenosylmethionine metabolic process GO:0046500 1 0.018
regulation of membrane potential GO:0042391 23 0.018
Mouse
regulation of oxidative stress induced cell death GO:1903201 2 0.018
response to bacterium GO:0009617 58 0.017
regulation of gtpase activity GO:0043087 2 0.017
cellular lipid metabolic process GO:0044255 36 0.017
vasculature development GO:0001944 278 0.017
cellular component biogenesis GO:0044085 178 0.017
regulation of response to nutrient levels GO:0032107 1 0.017
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.017
regulation of protein polymerization GO:0032271 2 0.017
negative regulation of feeding behavior GO:2000252 2 0.017
negative regulation of signal transduction in absence of ligand GO:1901099 1 0.017
cellular ketone metabolic process GO:0042180 11 0.017
regulation of glucose import GO:0046324 1 0.017
regulation of transmembrane transporter activity GO:0022898 2 0.016
circadian sleep wake cycle sleep GO:0050802 1 0.016
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.016
negative regulation of small gtpase mediated signal transduction GO:0051058 1 0.016
phosphorylation GO:0016310 69 0.016
regulation of cytokine biosynthetic process GO:0042035 1 0.016
regulation of actin filament based process GO:0032970 9 0.016
cellular component morphogenesis GO:0032989 336 0.016
protein complex disassembly GO:0043241 1 0.016
inorganic anion transport GO:0015698 25 0.016
regulation of nucleocytoplasmic transport GO:0046822 2 0.016
positive regulation of epithelial cell proliferation GO:0050679 1 0.016
response to other organism GO:0051707 97 0.016
positive regulation of developmental process GO:0051094 50 0.015
regulation of cellular metabolic process GO:0031323 320 0.015
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.015
negative regulation of muscle tissue development GO:1901862 2 0.015
response to nitrogen compound GO:1901698 19 0.015
Rat
regulation of protein binding GO:0043393 3 0.015
posterior lateral line system development GO:0048915 46 0.015
response to dexamethasone GO:0071548 1 0.015
regulation of dendrite development GO:0050773 3 0.015
gastrulation GO:0007369 208 0.015
maintenance of location GO:0051235 4 0.015
establishment of rna localization GO:0051236 3 0.015
response to oxygen containing compound GO:1901700 55 0.015
Rat
cellular response to hormone stimulus GO:0032870 39 0.015
Zebrafish Rat
positive regulation of cellular component biogenesis GO:0044089 3 0.015
chloride transmembrane transport GO:1902476 4 0.015
positive regulation of cytokine production GO:0001819 2 0.015
establishment of protein localization to plasma membrane GO:0090002 1 0.015
cellular response to endogenous stimulus GO:0071495 68 0.015
Zebrafish Rat
positive regulation of secretion by cell GO:1903532 1 0.015
protein activation cascade GO:0072376 6 0.015
superoxide metabolic process GO:0006801 2 0.015
b cell mediated immunity GO:0019724 3 0.014
gtp catabolic process GO:0006184 2 0.014
angiogenesis GO:0001525 158 0.014
cellular response to hypoxia GO:0071456 1 0.014
cellular response to steroid hormone stimulus GO:0071383 31 0.014
Zebrafish
immunoglobulin mediated immune response GO:0016064 3 0.014
negative regulation of epithelial cell proliferation GO:0050680 1 0.014
response to amino acid GO:0043200 2 0.014
positive regulation of cellular amine metabolic process GO:0033240 0 0.014
xenobiotic metabolic process GO:0006805 4 0.014
b cell activation GO:0042113 2 0.014
positive regulation of cytoskeleton organization GO:0051495 3 0.014
organic substance biosynthetic process GO:1901576 289 0.014
cellular component assembly involved in morphogenesis GO:0010927 107 0.014
ion transmembrane transport GO:0034220 91 0.014
cellular response to decreased oxygen levels GO:0036294 1 0.014
cellular response to organic cyclic compound GO:0071407 38 0.014
Zebrafish
macromolecular complex subunit organization GO:0043933 74 0.014
response to fluid shear stress GO:0034405 2 0.013
response to glucose GO:0009749 3 0.013
Rat
regulation of macromolecule metabolic process GO:0060255 317 0.013
response to cadmium ion GO:0046686 14 0.013
ribonucleoside monophosphate catabolic process GO:0009158 4 0.013
oxidation reduction process GO:0055114 41 0.013
actin polymerization or depolymerization GO:0008154 2 0.013
regulation of intracellular protein transport GO:0033157 3 0.013
actin filament based movement GO:0030048 1 0.013
cell motility GO:0048870 244 0.013
production of molecular mediator of immune response GO:0002440 2 0.013
protein metabolic process GO:0019538 183 0.013
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.013
sensory perception of smell GO:0007608 2 0.013
growth GO:0040007 174 0.013
regulation of circadian sleep wake cycle GO:0042749 1 0.013
toxin transport GO:1901998 2 0.013
negative regulation of protein phosphorylation GO:0001933 4 0.013
mitochondrial transport GO:0006839 2 0.013
Rat
positive regulation of gtp catabolic process GO:0033126 1 0.013
negative regulation of response to stimulus GO:0048585 104 0.013
Rat
membrane hyperpolarization GO:0060081 1 0.013
gene expression GO:0010467 252 0.013
positive regulation of cell adhesion GO:0045785 1 0.012
regulation of ion transmembrane transporter activity GO:0032412 2 0.012
response to estrogen GO:0043627 27 0.012
Zebrafish
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 1 0.012
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.012
cellular extravasation GO:0045123 1 0.012
regulation of cytoskeleton organization GO:0051493 11 0.012
stem cell differentiation GO:0048863 117 0.012
response to methylmercury GO:0051597 11 0.012
positive regulation of nucleoside metabolic process GO:0045979 1 0.012
long chain fatty acid transport GO:0015909 1 0.012
cellular response to lipid GO:0071396 39 0.012
Zebrafish
cellular aldehyde metabolic process GO:0006081 4 0.012
regulation of cellular component movement GO:0051270 55 0.012
cellular protein metabolic process GO:0044267 129 0.012
tissue homeostasis GO:0001894 25 0.011
muscle cell migration GO:0014812 4 0.011
regulation of rho protein signal transduction GO:0035023 2 0.011
response to external biotic stimulus GO:0043207 97 0.011
regulation of cellular amine metabolic process GO:0033238 0 0.011
heart development GO:0007507 313 0.011
cell adhesion GO:0007155 40 0.011
positive regulation of nucleotide catabolic process GO:0030813 1 0.011
protein modification process GO:0036211 100 0.011
circadian sleep wake cycle GO:0042745 2 0.011
metal ion transport GO:0030001 58 0.011
striated muscle contraction GO:0006941 12 0.011
regulation of cytoplasmic transport GO:1903649 4 0.011
lymphocyte proliferation GO:0046651 1 0.011
negative regulation of signaling GO:0023057 96 0.011
Rat
negative regulation of dna replication GO:0008156 2 0.011
negative regulation of ras protein signal transduction GO:0046580 1 0.011
regulation of developmental process GO:0050793 247 0.011
cellular nitrogen compound biosynthetic process GO:0044271 218 0.011
regulation of striated muscle contraction GO:0006942 2 0.011
response to oxygen levels GO:0070482 25 0.010
Rat
glycerol transport GO:0015793 7 0.010
regulation of ph GO:0006885 3 0.010
pyruvate metabolic process GO:0006090 1 0.010
regulation of reactive oxygen species metabolic process GO:2000377 2 0.010
chloride transport GO:0006821 8 0.010
positive regulation of gtpase activity GO:0043547 1 0.010
negative regulation of multi organism process GO:0043901 3 0.010
aromatic compound biosynthetic process GO:0019438 217 0.010
cellular component assembly GO:0022607 170 0.010
dicarboxylic acid metabolic process GO:0043648 1 0.010

ucp2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.029
inherited metabolic disorder DOID:655 0 0.029
lysosomal storage disease DOID:3211 0 0.016
hyperinsulinemic hypoglycemia DOID:13317 0 0.012
carbohydrate metabolic disorder DOID:2978 0 0.012