Danio rerio

39 known processes

vcl

vinculin

(Aliases: im:6902790,hm:zehn2160)

vcl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
aging GO:0007568 2 0.133
adherens junction organization GO:0034332 4 0.130
regulation of mrna processing GO:0050684 3 0.105
ameboidal type cell migration GO:0001667 143 0.100
cellular macromolecule metabolic process GO:0044260 391 0.086
leukocyte proliferation GO:0070661 1 0.078
response to carbohydrate GO:0009743 3 0.073
regulation of blood vessel size GO:0050880 2 0.070
protein import into nucleus GO:0006606 3 0.070
heart development GO:0007507 313 0.070
sensory organ development GO:0007423 393 0.069
eye development GO:0001654 277 0.068
maintenance of epithelial cell apical basal polarity GO:0045199 5 0.068
retina development in camera type eye GO:0060041 146 0.065
response to hexose GO:0009746 3 0.065
actin cytoskeleton organization GO:0030036 63 0.063
nitrogen compound metabolic process GO:0006807 319 0.063
cytoskeleton organization GO:0007010 96 0.060
mononuclear cell proliferation GO:0032943 1 0.058
regulation of tube size GO:0035150 2 0.058
regulation of mrna catabolic process GO:0061013 3 0.056
nucleic acid templated transcription GO:0097659 181 0.056
cell surface receptor signaling pathway GO:0007166 325 0.056
modification dependent protein catabolic process GO:0019941 3 0.055
nuclear migration GO:0007097 3 0.055
actomyosin structure organization GO:0031032 53 0.053
organic substance biosynthetic process GO:1901576 289 0.053
cellular component movement GO:0006928 335 0.053
regulation of glucose transport GO:0010827 1 0.051
regulation of protein transport GO:0051223 3 0.050
multicellular organism growth GO:0035264 4 0.050
immune system process GO:0002376 241 0.049
camera type eye development GO:0043010 222 0.049
morphogenesis of an epithelium GO:0002009 333 0.049
protein localization to nucleus GO:0034504 3 0.049
positive regulation of catabolic process GO:0009896 4 0.048
response to nutrient GO:0007584 3 0.048
positive regulation of cellular catabolic process GO:0031331 3 0.048
nuclear import GO:0051170 3 0.048
medulla oblongata development GO:0021550 4 0.047
regulation of glucose import GO:0046324 1 0.046
protein import GO:0017038 3 0.045
rna 3 end processing GO:0031123 2 0.044
response to monosaccharide GO:0034284 3 0.044
positive regulation of transport GO:0051050 2 0.043
regulation of cell projection assembly GO:0060491 4 0.043
stem cell proliferation GO:0072089 4 0.042
response to drug GO:0042493 3 0.042
neuroblast proliferation GO:0007405 2 0.041
regulation of cytokine production GO:0001817 3 0.041
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.041
establishment of protein localization to organelle GO:0072594 4 0.040
regulation of intracellular protein transport GO:0033157 3 0.040
cellular component assembly GO:0022607 170 0.039
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.039
regulation of wound healing GO:0061041 2 0.038
response to glucose GO:0009749 3 0.038
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.037
single organism metabolic process GO:0044710 217 0.037
positive regulation of cellular component biogenesis GO:0044089 3 0.037
regulation of filopodium assembly GO:0051489 2 0.037
nucleocytoplasmic transport GO:0006913 4 0.037
vasculature development GO:0001944 278 0.036
adherens junction maintenance GO:0034334 2 0.036
regulation of cytoplasmic transport GO:1903649 4 0.036
muscle cell development GO:0055001 115 0.036
regulation of cell substrate adhesion GO:0010810 1 0.036
system process GO:0003008 185 0.036
maintenance of location GO:0051235 4 0.035
regulation of establishment of protein localization GO:0070201 4 0.035
embryonic heart tube development GO:0035050 133 0.035
modification dependent macromolecule catabolic process GO:0043632 3 0.034
actin filament based process GO:0030029 64 0.034
response to stress GO:0006950 263 0.034
larval development GO:0002164 2 0.034
regulation of cell shape GO:0008360 1 0.034
smooth muscle contraction GO:0006939 2 0.034
gene expression GO:0010467 252 0.034
heterocycle metabolic process GO:0046483 290 0.034
cellular aromatic compound metabolic process GO:0006725 295 0.034
macromolecule biosynthetic process GO:0009059 227 0.033
positive regulation of glucose transport GO:0010828 1 0.033
regeneration GO:0031099 91 0.033
regulation of signal transduction GO:0009966 225 0.032
cellular protein catabolic process GO:0044257 4 0.032
myofibril assembly GO:0030239 48 0.032
regulation of macromolecule biosynthetic process GO:0010556 225 0.032
heterocycle biosynthetic process GO:0018130 215 0.032
single organism organelle organization GO:1902589 199 0.032
regulation of nucleocytoplasmic transport GO:0046822 2 0.032
regulation of myotube differentiation GO:0010830 2 0.032
biosynthetic process GO:0009058 294 0.031
establishment or maintenance of bipolar cell polarity GO:0061245 12 0.031
glucose import GO:0046323 2 0.030
autophagy GO:0006914 4 0.030
camera type eye morphogenesis GO:0048593 108 0.029
cell matrix adhesion GO:0007160 4 0.029
positive regulation of secretion by cell GO:1903532 1 0.029
single organism nuclear import GO:1902593 3 0.029
regulation of protein catabolic process GO:0042176 1 0.029
transcription dna templated GO:0006351 181 0.029
actin polymerization or depolymerization GO:0008154 2 0.029
dorsal motor nucleus of vagus nerve development GO:0021744 4 0.029
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.028
mrna catabolic process GO:0006402 6 0.028
lymphocyte proliferation GO:0046651 1 0.028
immune system development GO:0002520 191 0.028
cell migration involved in sprouting angiogenesis GO:0002042 8 0.028
establishment or maintenance of polarity of embryonic epithelium GO:0016332 2 0.028
positive regulation of cytokine production GO:0001819 2 0.028
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 11 0.028
regulation of protein localization to nucleus GO:1900180 2 0.028
signal transduction GO:0007165 455 0.028
regulation of protein targeting GO:1903533 2 0.028
regulation of protein ubiquitination GO:0031396 3 0.028
protein targeting to nucleus GO:0044744 3 0.027
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.027
regulation of multicellular organism growth GO:0040014 4 0.027
blood vessel morphogenesis GO:0048514 216 0.027
positive regulation of cell substrate adhesion GO:0010811 1 0.027
cell junction maintenance GO:0034331 2 0.027
regulation of cell migration involved in sprouting angiogenesis GO:0090049 3 0.027
cellular biosynthetic process GO:0044249 286 0.027
cellular amino acid metabolic process GO:0006520 7 0.027
regulation of gene expression GO:0010468 265 0.027
sensory organ morphogenesis GO:0090596 200 0.026
positive regulation of cell activation GO:0050867 1 0.026
positive regulation of macromolecule metabolic process GO:0010604 93 0.026
digestive tract mesoderm development GO:0007502 1 0.026
i kappab kinase nf kappab signaling GO:0007249 4 0.026
regulation of nitrogen compound metabolic process GO:0051171 251 0.026
maintenance of cell polarity GO:0030011 5 0.026
ubiquitin dependent protein catabolic process GO:0006511 3 0.025
rna biosynthetic process GO:0032774 181 0.025
embryonic organ development GO:0048568 381 0.025
tube morphogenesis GO:0035239 349 0.024
organelle assembly GO:0070925 110 0.024
protein complex localization GO:0031503 1 0.024
blood vessel development GO:0001568 246 0.024
regulation of transcription dna templated GO:0006355 213 0.024
regulation of signaling GO:0023051 235 0.024
somatic muscle development GO:0007525 4 0.024
positive regulation of cell cycle GO:0045787 3 0.024
nucleobase containing compound biosynthetic process GO:0034654 205 0.024
cell cycle g2 m phase transition GO:0044839 4 0.024
regulation of biosynthetic process GO:0009889 250 0.024
eye morphogenesis GO:0048592 144 0.024
rna metabolic process GO:0016070 219 0.023
regulation of primary metabolic process GO:0080090 311 0.023
carboxylic acid metabolic process GO:0019752 22 0.023
localization of cell GO:0051674 244 0.023
establishment or maintenance of apical basal cell polarity GO:0035088 12 0.023
myotube differentiation GO:0014902 45 0.023
negative regulation of apoptotic process GO:0043066 55 0.023
g2 m transition of mitotic cell cycle GO:0000086 4 0.022
cell motility GO:0048870 244 0.022
embryo development ending in birth or egg hatching GO:0009792 271 0.022
negative regulation of signal transduction GO:0009968 94 0.022
blood circulation GO:0008015 87 0.022
angiogenesis GO:0001525 158 0.022
specification of symmetry GO:0009799 204 0.022
negative regulation of protein phosphorylation GO:0001933 4 0.022
nucleic acid metabolic process GO:0090304 244 0.022
positive regulation of cytoskeleton organization GO:0051495 3 0.022
single organism localization GO:1902578 225 0.022
positive regulation of cell adhesion GO:0045785 1 0.022
positive regulation of muscle cell differentiation GO:0051149 1 0.021
striated muscle cell differentiation GO:0051146 129 0.021
regulation of rna biosynthetic process GO:2001141 213 0.021
regulation of biological quality GO:0065008 263 0.021
sprouting angiogenesis GO:0002040 53 0.021
organelle organization GO:0006996 227 0.021
cell projection organization GO:0030030 284 0.021
cell migration GO:0016477 237 0.021
organic cyclic compound metabolic process GO:1901360 301 0.021
odontogenesis of dentin containing tooth GO:0042475 1 0.021
mrna 3 end processing GO:0031124 2 0.021
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.021
positive regulation of secretion GO:0051047 1 0.020
circulatory system process GO:0003013 87 0.020
convergent extension GO:0060026 118 0.020
nucleobase containing compound metabolic process GO:0006139 274 0.020
response to hormone GO:0009725 48 0.020
regulation of apoptotic process GO:0042981 98 0.020
response to external stimulus GO:0009605 264 0.020
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.020
regulation of cellular biosynthetic process GO:0031326 245 0.020
determination of bilateral symmetry GO:0009855 204 0.020
organonitrogen compound metabolic process GO:1901564 74 0.020
chondrocyte development GO:0002063 4 0.020
positive regulation of glucose import GO:0046326 1 0.019
regulation of cell matrix adhesion GO:0001952 1 0.019
negative regulation of biological process GO:0048519 304 0.019
aromatic compound biosynthetic process GO:0019438 217 0.019
cellular component biogenesis GO:0044085 178 0.019
organic acid metabolic process GO:0006082 31 0.019
nuclear transport GO:0051169 4 0.018
digestive tract morphogenesis GO:0048546 231 0.018
macromolecule catabolic process GO:0009057 15 0.018
regulation of organ growth GO:0046620 3 0.018
histone h3 k4 methylation GO:0051568 2 0.018
response to abiotic stimulus GO:0009628 122 0.018
oxoacid metabolic process GO:0043436 31 0.018
cellular component maintenance GO:0043954 3 0.018
protein modification process GO:0036211 100 0.018
peptide transport GO:0015833 1 0.018
hematopoietic or lymphoid organ development GO:0048534 191 0.017
cellular response to extracellular stimulus GO:0031668 2 0.017
cellular response to external stimulus GO:0071496 2 0.017
protein metabolic process GO:0019538 183 0.017
muscle structure development GO:0061061 196 0.017
retina morphogenesis in camera type eye GO:0060042 79 0.017
regionalization GO:0003002 274 0.017
meiotic nuclear division GO:0007126 4 0.017
regulation of wnt signaling pathway GO:0030111 53 0.017
macromolecular complex subunit organization GO:0043933 74 0.017
cellular nitrogen compound metabolic process GO:0034641 290 0.017
central nervous system development GO:0007417 387 0.017
response to chemical GO:0042221 320 0.017
synaptic growth at neuromuscular junction GO:0051124 2 0.017
cellular component assembly involved in morphogenesis GO:0010927 107 0.017
negative regulation of signaling GO:0023057 96 0.017
cell death GO:0008219 121 0.017
dna templated transcription elongation GO:0006354 3 0.017
microtubule based process GO:0007017 60 0.017
establishment of spindle localization GO:0051293 12 0.016
regulation of reproductive process GO:2000241 4 0.016
proteasomal protein catabolic process GO:0010498 2 0.016
regulation of response to stimulus GO:0048583 269 0.016
regulation of protein import into nucleus GO:0042306 2 0.016
hemopoiesis GO:0030097 183 0.016
determination of left right symmetry GO:0007368 179 0.016
cell projection assembly GO:0030031 64 0.016
mrna metabolic process GO:0016071 20 0.016
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.016
regulation of blood circulation GO:1903522 32 0.016
head development GO:0060322 303 0.016
negative regulation of protein kinase activity GO:0006469 4 0.016
organic cyclic compound biosynthetic process GO:1901362 223 0.016
protein heterooligomerization GO:0051291 1 0.016
epithelial tube morphogenesis GO:0060562 148 0.016
death GO:0016265 121 0.016
regulation of skeletal muscle fiber development GO:0048742 2 0.016
cellular protein metabolic process GO:0044267 129 0.016
regulation of cell motility GO:2000145 46 0.016
neural nucleus development GO:0048857 15 0.015
regulation of multicellular organismal process GO:0051239 277 0.015
protein secretion GO:0009306 1 0.015
mitochondrion organization GO:0007005 4 0.015
regulation of blood coagulation GO:0030193 1 0.015
convergent extension involved in gastrulation GO:0060027 71 0.015
regulation of cellular protein catabolic process GO:1903362 1 0.015
single organism cellular localization GO:1902580 46 0.015
cellular response to organic substance GO:0071310 105 0.015
phagocytosis GO:0006909 3 0.015
growth GO:0040007 174 0.015
meiotic chromosome segregation GO:0045132 3 0.015
cell cell junction maintenance GO:0045217 1 0.015
response to temperature stimulus GO:0009266 15 0.015
mesoderm development GO:0007498 88 0.015
lipid catabolic process GO:0016042 4 0.015
hindbrain development GO:0030902 91 0.015
embryonic hemopoiesis GO:0035162 53 0.015
regulation of muscle contraction GO:0006937 3 0.014
embryonic skeletal joint development GO:0072498 3 0.014
neuron differentiation GO:0030182 353 0.014
digestive tract development GO:0048565 265 0.014
regulation of cellular component movement GO:0051270 55 0.014
positive regulation of nucleoside metabolic process GO:0045979 1 0.014
cell cycle g1 s phase transition GO:0044843 1 0.014
regulation of cellular metabolic process GO:0031323 320 0.014
phagocytosis engulfment GO:0006911 1 0.014
wound healing GO:0042060 90 0.014
spermatid development GO:0007286 2 0.014
negative regulation of programmed cell death GO:0043069 58 0.014
cellular component morphogenesis GO:0032989 336 0.014
regulation of rho protein signal transduction GO:0035023 2 0.014
positive regulation of translation GO:0045727 1 0.014
cellular ketone metabolic process GO:0042180 11 0.014
enzyme linked receptor protein signaling pathway GO:0007167 106 0.014
cellular nitrogen compound biosynthetic process GO:0044271 218 0.014
intracellular signal transduction GO:0035556 85 0.013
small molecule metabolic process GO:0044281 77 0.013
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.013
negative regulation of response to stimulus GO:0048585 104 0.013
microtubule organizing center organization GO:0031023 1 0.013
gtp metabolic process GO:0046039 4 0.013
cellular component disassembly GO:0022411 1 0.013
regulation of metabolic process GO:0019222 359 0.013
negative regulation of mapk cascade GO:0043409 4 0.013
meiotic cell cycle process GO:1903046 3 0.013
heart morphogenesis GO:0003007 156 0.013
rna processing GO:0006396 25 0.013
protein polymerization GO:0051258 4 0.013
glycoprotein metabolic process GO:0009100 23 0.013
negative regulation of cell death GO:0060548 60 0.013
nucleoside monophosphate catabolic process GO:0009125 4 0.013
striated muscle cell development GO:0055002 108 0.013
translational initiation GO:0006413 3 0.013
protein localization to plasma membrane GO:0072659 1 0.013
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.013
ribonucleoprotein complex biogenesis GO:0022613 13 0.013
negative regulation of kinase activity GO:0033673 4 0.013
amine metabolic process GO:0009308 2 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.013
regulation of inflammatory response GO:0050727 2 0.013
cell migration involved in gastrulation GO:0042074 79 0.013
response to endogenous stimulus GO:0009719 83 0.012
brain development GO:0007420 293 0.012
hemostasis GO:0007599 13 0.012
cellular carbohydrate metabolic process GO:0044262 4 0.012
chordate embryonic development GO:0043009 271 0.012
regulation of nucleoside metabolic process GO:0009118 2 0.012
gastrulation GO:0007369 208 0.012
regulation of cell activation GO:0050865 1 0.012
gtp catabolic process GO:0006184 2 0.012
cellular macromolecule biosynthetic process GO:0034645 224 0.012
negative regulation of cellular process GO:0048523 283 0.012
regulation of epithelial cell proliferation GO:0050678 3 0.012
positive regulation of biological process GO:0048518 253 0.012
negative regulation of reproductive process GO:2000242 3 0.012
sleep GO:0030431 1 0.012
cellular amine metabolic process GO:0044106 2 0.012
regulation of cell death GO:0010941 103 0.012
regulation of cellular amine metabolic process GO:0033238 0 0.012
protein complex disassembly GO:0043241 1 0.012
b cell activation GO:0042113 2 0.012
synaptic target recognition GO:0008039 1 0.012
membrane invagination GO:0010324 1 0.012
establishment of organelle localization GO:0051656 45 0.012
negative regulation of synapse assembly GO:0051964 2 0.012
neurotransmitter transport GO:0006836 2 0.012
skeletal system development GO:0001501 181 0.012
guanosine containing compound metabolic process GO:1901068 4 0.012
skeletal muscle tissue development GO:0007519 67 0.012
positive regulation of striated muscle cell differentiation GO:0051155 1 0.012
spermatid differentiation GO:0048515 2 0.012
regulation of hemostasis GO:1900046 1 0.012
regulation of rna metabolic process GO:0051252 224 0.012
actin filament polymerization GO:0030041 2 0.012
compound eye development GO:0048749 2 0.011
regulation of anatomical structure morphogenesis GO:0022603 130 0.011
innervation GO:0060384 3 0.011
carbohydrate biosynthetic process GO:0016051 1 0.011
positive regulation of protein kinase b signaling GO:0051897 1 0.011
negative chemotaxis GO:0050919 1 0.011
regulation of skeletal muscle tissue development GO:0048641 4 0.011
positive regulation of muscle tissue development GO:1901863 1 0.011
lipid storage GO:0019915 1 0.011
somite development GO:0061053 96 0.011
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.011
startle response GO:0001964 4 0.011
heart looping GO:0001947 94 0.011
secondary metabolic process GO:0019748 3 0.011
nerve development GO:0021675 45 0.011
single organism transport GO:0044765 206 0.011
atp catabolic process GO:0006200 4 0.011
regulation of reactive oxygen species metabolic process GO:2000377 2 0.011
cell substrate junction assembly GO:0007044 2 0.011
regulation of macromolecule metabolic process GO:0060255 317 0.011
regulation of gtpase activity GO:0043087 2 0.011
cell part morphogenesis GO:0032990 246 0.011
cellular protein modification process GO:0006464 100 0.011
macromolecular complex disassembly GO:0032984 1 0.011
transport GO:0006810 220 0.011
cellular response to chemical stimulus GO:0070887 157 0.011
regulation of actin filament based movement GO:1903115 1 0.011
regulation of mrna splicing via spliceosome GO:0048024 3 0.011
determination of heart left right asymmetry GO:0061371 117 0.011
digestive system development GO:0055123 289 0.011
response to light stimulus GO:0009416 46 0.011
positive regulation of nucleotide catabolic process GO:0030813 1 0.011
regulation of cell communication GO:0010646 232 0.011
muscle cell migration GO:0014812 4 0.010
embryonic skeletal joint morphogenesis GO:0060272 3 0.010
mrna processing GO:0006397 14 0.010
cellular response to hypoxia GO:0071456 1 0.010
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.010
macromolecule modification GO:0043412 111 0.010
proteolysis GO:0006508 38 0.010
regulation of anatomical structure size GO:0090066 33 0.010
regulation of cellular ketone metabolic process GO:0010565 7 0.010
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.010
guanosine containing compound catabolic process GO:1901069 2 0.010
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 1 0.010
apoptotic process GO:0006915 116 0.010
tissue regeneration GO:0042246 74 0.010
positive regulation of striated muscle tissue development GO:0045844 1 0.010
organelle localization GO:0051640 49 0.010
homeostatic process GO:0042592 142 0.010
nuclear transcribed mrna catabolic process GO:0000956 4 0.010
positive regulation of cell matrix adhesion GO:0001954 1 0.010
positive regulation of cellular process GO:0048522 201 0.010
developmental growth GO:0048589 166 0.010
viral process GO:0016032 1 0.010
regulation of cardiac muscle contraction GO:0055117 2 0.010
post embryonic organ development GO:0048569 4 0.010
regulation of nucleotide catabolic process GO:0030811 2 0.010
embryonic skeletal system development GO:0048706 97 0.010
ras protein signal transduction GO:0007265 7 0.010

vcl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.030
muscular disease DOID:0080000 0 0.021
musculoskeletal system disease DOID:17 0 0.021
disease of cellular proliferation DOID:14566 0 0.013
cancer DOID:162 0 0.013
organ system cancer DOID:0050686 0 0.013
myopathy DOID:423 0 0.013
muscle tissue disease DOID:66 0 0.013
eye and adnexa disease DOID:1492 0 0.012
eye disease DOID:5614 0 0.012
nervous system disease DOID:863 0 0.012
sensory system disease DOID:0050155 0 0.012