Danio rerio

0 known processes

wipi2

WD repeat domain, phosphoinositide interacting 2

(Aliases: zgc:92576)

wipi2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.274
cellular macromolecule metabolic process GO:0044260 391 0.168
modification dependent protein catabolic process GO:0019941 3 0.132
morphogenesis of an epithelium GO:0002009 333 0.131
single organism metabolic process GO:0044710 217 0.119
aging GO:0007568 2 0.098
modification dependent macromolecule catabolic process GO:0043632 3 0.096
cellular component assembly GO:0022607 170 0.095
meiotic nuclear division GO:0007126 4 0.087
regulation of cellular ketone metabolic process GO:0010565 7 0.078
autophagy GO:0006914 4 0.074
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.063
response to stress GO:0006950 263 0.061
cellular ketone metabolic process GO:0042180 11 0.060
regulation of primary metabolic process GO:0080090 311 0.059
regulation of biosynthetic process GO:0009889 250 0.057
cellular response to external stimulus GO:0071496 2 0.055
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.054
establishment of protein localization to organelle GO:0072594 4 0.051
ubiquitin dependent protein catabolic process GO:0006511 3 0.050
cellular response to nutrient levels GO:0031669 2 0.050
cellular aromatic compound metabolic process GO:0006725 295 0.047
negative regulation of biological process GO:0048519 304 0.046
cellular response to starvation GO:0009267 1 0.046
central nervous system development GO:0007417 387 0.046
cellular response to extracellular stimulus GO:0031668 2 0.045
nitrogen compound metabolic process GO:0006807 319 0.045
macroautophagy GO:0016236 1 0.044
cellular protein catabolic process GO:0044257 4 0.044
regulation of cellular metabolic process GO:0031323 320 0.044
guanosine containing compound metabolic process GO:1901068 4 0.043
maintenance of location GO:0051235 4 0.042
phagocytosis GO:0006909 3 0.042
organelle organization GO:0006996 227 0.041
proteasomal protein catabolic process GO:0010498 2 0.041
cellular component biogenesis GO:0044085 178 0.041
response to uv GO:0009411 3 0.041
lateral inhibition GO:0046331 1 0.040
digestive tract morphogenesis GO:0048546 231 0.039
regulation of meiotic cell cycle GO:0051445 1 0.039
protein metabolic process GO:0019538 183 0.039
cellular carbohydrate metabolic process GO:0044262 4 0.039
cellular protein metabolic process GO:0044267 129 0.038
protein import GO:0017038 3 0.037
regulation of nitrogen compound metabolic process GO:0051171 251 0.037
meiotic cell cycle process GO:1903046 3 0.036
sister chromatid cohesion GO:0007062 2 0.035
negative regulation of cellular process GO:0048523 283 0.035
multicellular organism growth GO:0035264 4 0.035
lipid storage GO:0019915 1 0.034
negative regulation of protein phosphorylation GO:0001933 4 0.034
cellular catabolic process GO:0044248 27 0.034
positive regulation of transport GO:0051050 2 0.034
signal transduction GO:0007165 455 0.033
positive regulation of catabolic process GO:0009896 4 0.033
cellular protein modification process GO:0006464 100 0.032
response to biotic stimulus GO:0009607 97 0.032
localization within membrane GO:0051668 1 0.032
cell surface receptor signaling pathway GO:0007166 325 0.031
post embryonic organ development GO:0048569 4 0.031
regulation of multicellular organism growth GO:0040014 4 0.031
dna templated transcription elongation GO:0006354 3 0.031
convergent extension GO:0060026 118 0.031
regulation of carbohydrate metabolic process GO:0006109 4 0.031
cellular component morphogenesis GO:0032989 336 0.030
embryonic organ development GO:0048568 381 0.029
regulation of protein targeting GO:1903533 2 0.029
regulation of epithelial cell proliferation GO:0050678 3 0.029
response to organic substance GO:0010033 153 0.028
determination of left right symmetry GO:0007368 179 0.028
wnt signaling pathway GO:0016055 80 0.028
regulation of stem cell proliferation GO:0072091 2 0.028
digestive system development GO:0055123 289 0.028
g2 dna damage checkpoint GO:0031572 3 0.028
response to topologically incorrect protein GO:0035966 2 0.028
odontogenesis of dentin containing tooth GO:0042475 1 0.027
organic acid metabolic process GO:0006082 31 0.027
female sex differentiation GO:0046660 4 0.027
regulation of nucleocytoplasmic transport GO:0046822 2 0.027
cellular amine metabolic process GO:0044106 2 0.027
golgi vesicle transport GO:0048193 3 0.026
regulation of biological quality GO:0065008 263 0.026
regulation of protein localization to nucleus GO:1900180 2 0.026
stem cell division GO:0017145 1 0.026
meiosis i GO:0007127 1 0.026
heart morphogenesis GO:0003007 156 0.026
tissue remodeling GO:0048771 4 0.026
determination of bilateral symmetry GO:0009855 204 0.025
regulation of rna metabolic process GO:0051252 224 0.025
macromolecule modification GO:0043412 111 0.025
cell substrate adhesion GO:0031589 4 0.025
protein k48 linked ubiquitination GO:0070936 1 0.025
liver development GO:0001889 96 0.025
organelle assembly GO:0070925 110 0.025
single organism biosynthetic process GO:0044711 71 0.024
tube morphogenesis GO:0035239 349 0.024
regulation of cell shape GO:0008360 1 0.024
organic cyclic compound metabolic process GO:1901360 301 0.024
small molecule metabolic process GO:0044281 77 0.024
adult behavior GO:0030534 2 0.024
meiotic chromosome segregation GO:0045132 3 0.024
cellular response to radiation GO:0071478 4 0.024
cell projection morphogenesis GO:0048858 244 0.024
localization of cell GO:0051674 244 0.024
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.024
nuclear import GO:0051170 3 0.024
cytokinesis GO:0000910 3 0.024
cellular response to light stimulus GO:0071482 4 0.023
cell motility GO:0048870 244 0.023
regulation of tube size GO:0035150 2 0.023
cell migration GO:0016477 237 0.023
response to virus GO:0009615 21 0.023
oxoacid metabolic process GO:0043436 31 0.023
positive regulation of stem cell proliferation GO:2000648 1 0.023
heterocycle metabolic process GO:0046483 290 0.023
cellular component movement GO:0006928 335 0.023
positive regulation of cell cycle GO:0045787 3 0.023
er to golgi vesicle mediated transport GO:0006888 1 0.023
single organism nuclear import GO:1902593 3 0.023
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.022
regulation of cellular amino acid metabolic process GO:0006521 0 0.022
heart looping GO:0001947 94 0.022
protein localization to nucleus GO:0034504 3 0.022
cell projection organization GO:0030030 284 0.022
gastrulation GO:0007369 208 0.022
lipid homeostasis GO:0055088 3 0.022
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.022
regulation of response to biotic stimulus GO:0002831 2 0.022
gtp catabolic process GO:0006184 2 0.021
regulation of developmental process GO:0050793 247 0.021
embryonic heart tube morphogenesis GO:0003143 108 0.021
response to vitamin GO:0033273 3 0.021
cellular amino acid metabolic process GO:0006520 7 0.021
gtp metabolic process GO:0046039 4 0.021
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.021
chromosome organization involved in meiosis GO:0070192 1 0.021
mitochondrion organization GO:0007005 4 0.021
digestive tract development GO:0048565 265 0.021
regulation of protein catabolic process GO:0042176 1 0.021
neurotransmitter transport GO:0006836 2 0.020
carbohydrate biosynthetic process GO:0016051 1 0.020
cellular nitrogen compound metabolic process GO:0034641 290 0.020
regulation of neuronal synaptic plasticity GO:0048168 1 0.020
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.020
negative regulation of epithelial cell proliferation GO:0050680 1 0.020
cellular biosynthetic process GO:0044249 286 0.020
brain development GO:0007420 293 0.020
amine metabolic process GO:0009308 2 0.020
specification of symmetry GO:0009799 204 0.020
protein import into nucleus GO:0006606 3 0.019
primary neural tube formation GO:0014020 1 0.019
single organism organelle organization GO:1902589 199 0.019
response to chemical GO:0042221 320 0.019
stem cell proliferation GO:0072089 4 0.019
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 1 0.019
response to external stimulus GO:0009605 264 0.019
developmental growth GO:0048589 166 0.019
regulation of cellular biosynthetic process GO:0031326 245 0.019
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.019
cellular response to chemical stimulus GO:0070887 157 0.019
protein modification process GO:0036211 100 0.018
mitotic sister chromatid segregation GO:0000070 6 0.018
regulation of fatty acid metabolic process GO:0019217 1 0.018
regulation of organ growth GO:0046620 3 0.018
embryonic organ morphogenesis GO:0048562 274 0.018
double strand break repair via homologous recombination GO:0000724 1 0.018
regulation of jak stat cascade GO:0046425 3 0.018
regulation of blood vessel size GO:0050880 2 0.018
vacuolar transport GO:0007034 2 0.018
lipid metabolic process GO:0006629 52 0.018
regulation of transcription dna templated GO:0006355 213 0.018
nucleobase containing compound metabolic process GO:0006139 274 0.018
cell morphogenesis GO:0000902 289 0.017
protein polyubiquitination GO:0000209 4 0.017
organic cyclic compound biosynthetic process GO:1901362 223 0.017
regulation of synaptic plasticity GO:0048167 1 0.017
secondary metabolic process GO:0019748 3 0.017
phosphate containing compound metabolic process GO:0006796 108 0.017
g1 s transition of mitotic cell cycle GO:0000082 1 0.017
neuron differentiation GO:0030182 353 0.017
cell matrix adhesion GO:0007160 4 0.017
protein acylation GO:0043543 3 0.017
nucleocytoplasmic transport GO:0006913 4 0.017
regulation of protein import into nucleus GO:0042306 2 0.017
regulation of establishment of protein localization GO:0070201 4 0.017
camera type eye development GO:0043010 222 0.017
cell cycle g1 s phase transition GO:0044843 1 0.017
catabolic process GO:0009056 32 0.017
nucleobase containing compound biosynthetic process GO:0034654 205 0.016
rna metabolic process GO:0016070 219 0.016
response to nutrient GO:0007584 3 0.016
regulation of production of molecular mediator of immune response GO:0002700 1 0.016
protein targeting to nucleus GO:0044744 3 0.016
neurotransmitter secretion GO:0007269 2 0.016
alcohol biosynthetic process GO:0046165 2 0.016
regulation of signaling GO:0023051 235 0.016
regulation of reproductive process GO:2000241 4 0.016
organonitrogen compound metabolic process GO:1901564 74 0.016
cell part morphogenesis GO:0032990 246 0.016
regulation of protein transport GO:0051223 3 0.016
growth GO:0040007 174 0.016
protein homooligomerization GO:0051260 3 0.016
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.016
protein modification by small protein removal GO:0070646 1 0.016
gene expression GO:0010467 252 0.016
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.016
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.016
head development GO:0060322 303 0.016
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.016
regulation of intracellular protein transport GO:0033157 3 0.016
embryo development ending in birth or egg hatching GO:0009792 271 0.016
tube closure GO:0060606 1 0.015
positive regulation of biological process GO:0048518 253 0.015
defense response to virus GO:0051607 10 0.015
synaptic growth at neuromuscular junction GO:0051124 2 0.015
regulation of binding GO:0051098 3 0.015
cellular response to oxygen levels GO:0071453 1 0.015
regulation of protein binding GO:0043393 3 0.015
stem cell maintenance GO:0019827 4 0.015
muscle cell differentiation GO:0042692 139 0.015
regulation of cytoplasmic transport GO:1903649 4 0.015
single organism localization GO:1902578 225 0.015
circulatory system process GO:0003013 87 0.015
cellular response to stress GO:0033554 62 0.015
triglyceride homeostasis GO:0070328 2 0.015
regulation of neural precursor cell proliferation GO:2000177 3 0.015
developmental growth involved in morphogenesis GO:0060560 86 0.015
regulation of metabolic process GO:0019222 359 0.015
germ line stem cell maintenance GO:0030718 2 0.015
peptidyl lysine acetylation GO:0018394 2 0.015
cellular lipid metabolic process GO:0044255 36 0.015
response to nicotine GO:0035094 2 0.015
inositol lipid mediated signaling GO:0048017 2 0.014
guanosine containing compound catabolic process GO:1901069 2 0.014
regulation of mesenchymal cell proliferation GO:0010464 1 0.014
acylglycerol homeostasis GO:0055090 2 0.014
macromolecule biosynthetic process GO:0009059 227 0.014
heart development GO:0007507 313 0.014
monocarboxylic acid catabolic process GO:0072329 3 0.014
female gonad development GO:0008585 4 0.014
regulation of dna recombination GO:0000018 2 0.014
negative regulation of metabolic process GO:0009892 86 0.014
regulation of stem cell differentiation GO:2000736 4 0.014
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.014
regulation of synapse organization GO:0050807 3 0.014
heart contraction GO:0060047 71 0.014
membrane invagination GO:0010324 1 0.014
negative regulation of kinase activity GO:0033673 4 0.014
protein heterooligomerization GO:0051291 1 0.014
nuclear transport GO:0051169 4 0.014
phosphatidylinositol mediated signaling GO:0048015 2 0.014
cell aging GO:0007569 2 0.014
development of primary female sexual characteristics GO:0046545 4 0.013
endoplasmic reticulum unfolded protein response GO:0030968 2 0.013
positive regulation of cellular catabolic process GO:0031331 3 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.013
positive regulation of blood circulation GO:1903524 2 0.013
regulation of cell communication GO:0010646 232 0.013
macromolecular complex subunit organization GO:0043933 74 0.013
positive regulation of chromosome organization GO:2001252 1 0.013
intracellular mrna localization GO:0008298 1 0.013
proteolysis GO:0006508 38 0.013
regulation of cellular amine metabolic process GO:0033238 0 0.013
neuron development GO:0048666 262 0.013
positive regulation of cellular amine metabolic process GO:0033240 0 0.013
negative regulation of protein kinase activity GO:0006469 4 0.013
lipid oxidation GO:0034440 1 0.013
i kappab kinase nf kappab signaling GO:0007249 4 0.013
positive regulation of secretion GO:0051047 1 0.013
response to unfolded protein GO:0006986 2 0.013
regulation of neurotransmitter secretion GO:0046928 1 0.013
response to alkaloid GO:0043279 2 0.013
ameboidal type cell migration GO:0001667 143 0.013
regulation of cellular response to growth factor stimulus GO:0090287 35 0.013
mesenchymal cell proliferation GO:0010463 1 0.013
defense response GO:0006952 47 0.013
phosphorus metabolic process GO:0006793 109 0.013
organic acid catabolic process GO:0016054 3 0.013
alternative mrna splicing via spliceosome GO:0000380 1 0.013
response to drug GO:0042493 3 0.012
fatty acid catabolic process GO:0009062 1 0.012
mitotic g2 dna damage checkpoint GO:0007095 3 0.012
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.012
regulation of erk1 and erk2 cascade GO:0070372 4 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
regulation of signal transduction GO:0009966 225 0.012
regulation of bone mineralization GO:0030500 2 0.012
rna localization GO:0006403 4 0.012
multicellular organismal metabolic process GO:0044236 2 0.012
cartilage development GO:0051216 96 0.012
establishment of epithelial cell polarity GO:0090162 2 0.012
regulation of gene expression GO:0010468 265 0.012
embryonic skeletal joint development GO:0072498 3 0.012
cellular response to organic substance GO:0071310 105 0.012
neuromuscular process controlling balance GO:0050885 3 0.012
positive regulation of cellular component biogenesis GO:0044089 3 0.012
endosome to lysosome transport GO:0008333 1 0.012
recombinational repair GO:0000725 1 0.012
negative regulation of stem cell differentiation GO:2000737 2 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.012
regulation of metal ion transport GO:0010959 4 0.012
somatic stem cell maintenance GO:0035019 1 0.012
dorsal ventral pattern formation GO:0009953 125 0.012
embryonic hemopoiesis GO:0035162 53 0.012
regulation of mrna splicing via spliceosome GO:0048024 3 0.012
regulation of mrna processing GO:0050684 3 0.012
negative regulation of defense response GO:0031348 2 0.012
protein acetylation GO:0006473 2 0.012
establishment of localization in cell GO:0051649 77 0.012
germ line stem cell division GO:0042078 1 0.011
double strand break repair GO:0006302 3 0.011
regulation of dendrite development GO:0050773 3 0.011
phagosome maturation GO:0090382 1 0.011
cytoplasm organization GO:0007028 4 0.011
gland development GO:0048732 143 0.011
carboxylic acid metabolic process GO:0019752 22 0.011
cellular response to hypoxia GO:0071456 1 0.011
organelle localization GO:0051640 49 0.011
mitotic nuclear division GO:0007067 18 0.011
spindle assembly GO:0051225 2 0.011
blood circulation GO:0008015 87 0.011
positive regulation of cell division GO:0051781 2 0.011
fin development GO:0033333 77 0.011
mitotic cell cycle GO:0000278 64 0.011
organic substance biosynthetic process GO:1901576 289 0.011
hepaticobiliary system development GO:0061008 98 0.011
regulation of response to cytokine stimulus GO:0060759 3 0.011
positive regulation of dna metabolic process GO:0051054 1 0.011
neuronal stem cell maintenance GO:0097150 2 0.011
protein modification by small protein conjugation or removal GO:0070647 14 0.011
centrosome cycle GO:0007098 1 0.011
synapsis GO:0007129 1 0.011
apoptotic process involved in development GO:1902742 2 0.011
regulation of chromosome segregation GO:0051983 1 0.011
response to other organism GO:0051707 97 0.011
regulation of receptor activity GO:0010469 2 0.011
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.011
osteoclast differentiation GO:0030316 1 0.011
cellular response to decreased oxygen levels GO:0036294 1 0.011
macromolecular complex disassembly GO:0032984 1 0.011
negative regulation of mapk cascade GO:0043409 4 0.011
negative regulation of chromosome organization GO:2001251 1 0.011
thermosensory behavior GO:0040040 1 0.011
regulation of rna biosynthetic process GO:2001141 213 0.011
regulation of neurotransmitter transport GO:0051588 1 0.011
immune system process GO:0002376 241 0.011
regulation of multicellular organismal process GO:0051239 277 0.011
positive regulation of stress activated mapk cascade GO:0032874 3 0.011
biosynthetic process GO:0009058 294 0.011
positive regulation of apoptotic signaling pathway GO:2001235 1 0.011
neuroblast proliferation GO:0007405 2 0.011
sequestering of metal ion GO:0051238 3 0.010
single organism cellular localization GO:1902580 46 0.010
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.010
transport GO:0006810 220 0.010
regulation of macromolecule metabolic process GO:0060255 317 0.010
intracellular transport GO:0046907 32 0.010
leukocyte homeostasis GO:0001776 2 0.010
peptide metabolic process GO:0006518 1 0.010
rna biosynthetic process GO:0032774 181 0.010
rna polyadenylation GO:0043631 2 0.010
pathway restricted smad protein phosphorylation GO:0060389 1 0.010
axis elongation GO:0003401 31 0.010
activation of mapk activity GO:0000187 3 0.010
male meiosis GO:0007140 2 0.010
spindle assembly involved in mitosis GO:0090307 1 0.010
regulation of gtp catabolic process GO:0033124 2 0.010
exocytosis GO:0006887 1 0.010
blood vessel morphogenesis GO:0048514 216 0.010
negative regulation of immune response GO:0050777 2 0.010
positive regulation of map kinase activity GO:0043406 3 0.010
cellular response to unfolded protein GO:0034620 2 0.010
establishment of protein localization to vacuole GO:0072666 1 0.010
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.010
response to light stimulus GO:0009416 46 0.010
internal protein amino acid acetylation GO:0006475 2 0.010
endocrine hormone secretion GO:0060986 2 0.010
vacuole organization GO:0007033 9 0.010

wipi2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.026
disease of anatomical entity DOID:7 0 0.026
nervous system disease DOID:863 0 0.019
cancer DOID:162 0 0.017
organ system cancer DOID:0050686 0 0.017
musculoskeletal system disease DOID:17 0 0.016
cardiovascular system disease DOID:1287 0 0.013
muscle tissue disease DOID:66 0 0.013
intrinsic cardiomyopathy DOID:0060036 0 0.013
cardiomyopathy DOID:0050700 0 0.013
myopathy DOID:423 0 0.013
muscular disease DOID:0080000 0 0.013
heart disease DOID:114 0 0.013
disease of metabolism DOID:0014667 0 0.012