Danio rerio

20 known processes

wnk1

WNK lysine deficient protein kinase 1

(Aliases: fc14f06,si:ch211-240l19.1,wu:fc14f06)

wnk1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
convergent extension involved in gastrulation GO:0060027 71 0.209
larval development GO:0002164 2 0.200
signal transduction GO:0007165 455 0.176
Fly
ameboidal type cell migration GO:0001667 143 0.138
sensory organ development GO:0007423 393 0.123
response to wounding GO:0009611 116 0.118
organic acid metabolic process GO:0006082 31 0.113
response to external stimulus GO:0009605 264 0.103
Fly
cell migration GO:0016477 237 0.102
cellular ketone metabolic process GO:0042180 11 0.102
cellular nitrogen compound metabolic process GO:0034641 290 0.101
cellular component movement GO:0006928 335 0.095
Fly
oxoacid metabolic process GO:0043436 31 0.093
response to chemical GO:0042221 320 0.091
Fly
regulation of fatty acid metabolic process GO:0019217 1 0.086
small molecule metabolic process GO:0044281 77 0.081
regulation of protein transport GO:0051223 3 0.079
aging GO:0007568 2 0.077
cellular macromolecule metabolic process GO:0044260 391 0.075
Fly
retina development in camera type eye GO:0060041 146 0.074
protein localization to nucleus GO:0034504 3 0.073
carboxylic acid metabolic process GO:0019752 22 0.073
cellular component assembly involved in morphogenesis GO:0010927 107 0.072
cell migration involved in gastrulation GO:0042074 79 0.072
endothelial cell fate commitment GO:0060839 3 0.071
camera type eye development GO:0043010 222 0.067
neuron neuron synaptic transmission GO:0007270 1 0.065
positive regulation of histone modification GO:0031058 1 0.065
regulation of cellular amino acid metabolic process GO:0006521 0 0.064
response to abiotic stimulus GO:0009628 122 0.064
regulation of cellular amine metabolic process GO:0033238 0 0.062
generation of neurons GO:0048699 385 0.060
Fly
response to lipid GO:0033993 60 0.060
convergent extension GO:0060026 118 0.057
single organism nuclear import GO:1902593 3 0.056
morphogenesis of an epithelium GO:0002009 333 0.056
response to glucocorticoid GO:0051384 1 0.055
embryonic organ development GO:0048568 381 0.055
organic substance biosynthetic process GO:1901576 289 0.055
muscle structure development GO:0061061 196 0.054
embryo development ending in birth or egg hatching GO:0009792 271 0.054
macromolecule modification GO:0043412 111 0.051
Fly
nucleic acid metabolic process GO:0090304 244 0.051
regulation of nitrogen compound metabolic process GO:0051171 251 0.050
maintenance of location GO:0051235 4 0.050
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.048
regulation of tube size GO:0035150 2 0.048
protein modification process GO:0036211 100 0.047
Fly
regulation of jak stat cascade GO:0046425 3 0.046
nucleocytoplasmic transport GO:0006913 4 0.045
protein import GO:0017038 3 0.045
cytokinesis GO:0000910 3 0.044
transport GO:0006810 220 0.044
regulation of cell projection assembly GO:0060491 4 0.043
tyrosine phosphorylation of stat protein GO:0007260 1 0.043
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.042
establishment of localization GO:0051234 244 0.041
astrocyte differentiation GO:0048708 1 0.040
amine metabolic process GO:0009308 2 0.040
regulation of endothelial cell proliferation GO:0001936 1 0.039
nuclear import GO:0051170 3 0.038
regulation of response to stimulus GO:0048583 269 0.038
Fly
posterior lateral line neuromast development GO:0048919 20 0.038
response to hormone GO:0009725 48 0.038
negative regulation of cellular process GO:0048523 283 0.037
spermatid differentiation GO:0048515 2 0.037
regulation of signaling GO:0023051 235 0.037
Fly
response to ketone GO:1901654 1 0.037
somite development GO:0061053 96 0.037
positive regulation of cellular component biogenesis GO:0044089 3 0.036
regulation of cellular metabolic process GO:0031323 320 0.036
muscle cell differentiation GO:0042692 139 0.036
response to corticosteroid GO:0031960 1 0.036
single organism organelle organization GO:1902589 199 0.036
cellular amine metabolic process GO:0044106 2 0.035
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.035
positive regulation of transport GO:0051050 2 0.035
immune system process GO:0002376 241 0.035
regulation of synapse organization GO:0050807 3 0.034
cellular aromatic compound metabolic process GO:0006725 295 0.034
somitogenesis GO:0001756 87 0.034
regulation of epithelial cell proliferation GO:0050678 3 0.034
cellular biosynthetic process GO:0044249 286 0.034
multicellular organism growth GO:0035264 4 0.034
neuron development GO:0048666 262 0.034
Fly
chordate embryonic development GO:0043009 271 0.034
transcription from rna polymerase iii promoter GO:0006383 1 0.033
cellular amino acid metabolic process GO:0006520 7 0.033
regulation of mrna splicing via spliceosome GO:0048024 3 0.033
multicellular organismal metabolic process GO:0044236 2 0.033
central nervous system development GO:0007417 387 0.033
response to oxygen containing compound GO:1901700 55 0.032
regulation of cellular ketone metabolic process GO:0010565 7 0.032
nuclear transport GO:0051169 4 0.032
stem cell division GO:0017145 1 0.030
protein import into nucleus GO:0006606 3 0.030
regulation of transcription from rna polymerase iii promoter GO:0006359 1 0.029
cell motility GO:0048870 244 0.029
i kappab kinase nf kappab signaling GO:0007249 4 0.029
regulation of blood vessel size GO:0050880 2 0.029
wound healing GO:0042060 90 0.029
protein dephosphorylation GO:0006470 3 0.028
single organism metabolic process GO:0044710 217 0.028
vasculature development GO:0001944 278 0.027
secondary metabolic process GO:0019748 3 0.027
response to organic substance GO:0010033 153 0.027
regulation of cytoplasmic transport GO:1903649 4 0.027
cellular response to oxygen levels GO:0071453 1 0.027
mitochondrion organization GO:0007005 4 0.027
heterocycle biosynthetic process GO:0018130 215 0.027
lateral line development GO:0048882 66 0.027
cell cycle arrest GO:0007050 1 0.027
biosynthetic process GO:0009058 294 0.026
protein targeting to nucleus GO:0044744 3 0.026
regulation of cell substrate adhesion GO:0010810 1 0.026
regulation of mrna processing GO:0050684 3 0.026
regulation of carbohydrate metabolic process GO:0006109 4 0.026
organonitrogen compound metabolic process GO:1901564 74 0.026
locomotion GO:0040011 313 0.026
Fly
cation transport GO:0006812 81 0.026
neuromast development GO:0048884 46 0.026
gene expression GO:0010467 252 0.025
nucleobase containing compound metabolic process GO:0006139 274 0.025
cellular carbohydrate metabolic process GO:0044262 4 0.025
positive regulation of catabolic process GO:0009896 4 0.025
neuron projection morphogenesis GO:0048812 161 0.025
Fly
cellular protein metabolic process GO:0044267 129 0.024
Fly
response to stress GO:0006950 263 0.024
homeostasis of number of cells GO:0048872 62 0.024
lymph vessel development GO:0001945 27 0.024
peptidyl lysine acetylation GO:0018394 2 0.024
tube morphogenesis GO:0035239 349 0.024
regulation of macromolecule metabolic process GO:0060255 317 0.023
lipid homeostasis GO:0055088 3 0.023
glial cell migration GO:0008347 3 0.023
protein acylation GO:0043543 3 0.023
negative regulation of defense response GO:0031348 2 0.023
digestive system development GO:0055123 289 0.023
meiotic nuclear division GO:0007126 4 0.023
regulation of multicellular organism growth GO:0040014 4 0.023
negative regulation of biological process GO:0048519 304 0.023
regulation of primary metabolic process GO:0080090 311 0.023
single organism localization GO:1902578 225 0.022
cellular response to chemical stimulus GO:0070887 157 0.022
organic cyclic compound biosynthetic process GO:1901362 223 0.022
stem cell proliferation GO:0072089 4 0.022
protein acetylation GO:0006473 2 0.022
negative regulation of biosynthetic process GO:0009890 55 0.022
muscle organ development GO:0007517 101 0.022
regulation of cellular component organization GO:0051128 86 0.022
mitotic cytokinesis GO:0000281 3 0.021
positive regulation of nucleoside metabolic process GO:0045979 1 0.021
sensory perception of pain GO:0019233 1 0.021
organelle organization GO:0006996 227 0.021
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.021
lateral line system development GO:0048925 76 0.021
positive regulation of muscle cell differentiation GO:0051149 1 0.021
cell projection organization GO:0030030 284 0.021
Fly
neuron differentiation GO:0030182 353 0.021
Fly
response to endogenous stimulus GO:0009719 83 0.021
myeloid cell differentiation GO:0030099 86 0.021
regulation of establishment of protein localization GO:0070201 4 0.020
notch signaling pathway GO:0007219 35 0.020
positive regulation of cellular amine metabolic process GO:0033240 0 0.020
regulation of rna metabolic process GO:0051252 224 0.020
regulation of synapse assembly GO:0051963 3 0.020
jak stat cascade GO:0007259 5 0.020
olfactory bulb development GO:0021772 4 0.019
regulation of cytokine production GO:0001817 3 0.019
gtp metabolic process GO:0046039 4 0.019
internal peptidyl lysine acetylation GO:0018393 2 0.019
lymphatic endothelial cell differentiation GO:0060836 1 0.019
cytosolic calcium ion transport GO:0060401 3 0.019
cellular nitrogen compound biosynthetic process GO:0044271 218 0.019
nitrogen compound metabolic process GO:0006807 319 0.019
cell surface receptor signaling pathway GO:0007166 325 0.019
Fly
organelle assembly GO:0070925 110 0.019
regulation of organelle assembly GO:1902115 4 0.018
negative chemotaxis GO:0050919 1 0.018
regulation of cell activation GO:0050865 1 0.018
posterior lateral line neuromast hair cell differentiation GO:0048923 8 0.018
cell part morphogenesis GO:0032990 246 0.018
Fly
hematopoietic or lymphoid organ development GO:0048534 191 0.018
regulation of cell shape GO:0008360 1 0.018
heterocycle metabolic process GO:0046483 290 0.017
regulation of cell differentiation GO:0045595 142 0.017
phagocytosis GO:0006909 3 0.017
protein secretion GO:0009306 1 0.017
cytoskeleton dependent cytokinesis GO:0061640 3 0.017
gtp catabolic process GO:0006184 2 0.017
negative regulation of cytokine production GO:0001818 1 0.017
cellular component biogenesis GO:0044085 178 0.017
establishment of protein localization to organelle GO:0072594 4 0.017
embryonic organ morphogenesis GO:0048562 274 0.017
cellular response to hypoxia GO:0071456 1 0.017
cell morphogenesis GO:0000902 289 0.017
Fly
regulation of tyrosine phosphorylation of stat protein GO:0042509 1 0.017
phosphorus metabolic process GO:0006793 109 0.017
Fly
regulation of nucleoside metabolic process GO:0009118 2 0.017
growth GO:0040007 174 0.017
organophosphate biosynthetic process GO:0090407 23 0.017
positive regulation of cellular process GO:0048522 201 0.017
Fly
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.016
positive regulation of gliogenesis GO:0014015 2 0.016
regulation of protein complex assembly GO:0043254 3 0.016
internal protein amino acid acetylation GO:0006475 2 0.016
cellular component morphogenesis GO:0032989 336 0.016
Fly
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.016
guanosine containing compound catabolic process GO:1901069 2 0.016
neuroblast differentiation GO:0014016 1 0.016
glycerolipid biosynthetic process GO:0045017 1 0.016
negative regulation of metabolic process GO:0009892 86 0.016
nucleobase containing compound biosynthetic process GO:0034654 205 0.016
positive regulation of signal transduction GO:0009967 56 0.016
Fly
regulation of multicellular organismal metabolic process GO:0044246 2 0.016
phosphate containing compound metabolic process GO:0006796 108 0.016
Fly
leukocyte activation GO:0045321 12 0.016
negative regulation of kinase activity GO:0033673 4 0.016
regulation of multicellular organismal process GO:0051239 277 0.016
posterior lateral line development GO:0048916 38 0.015
olfactory lobe development GO:0021988 4 0.015
regulation of dna replication GO:0006275 3 0.015
negative regulation of protein phosphorylation GO:0001933 4 0.015
regulation of protein localization to nucleus GO:1900180 2 0.015
skin development GO:0043588 54 0.015
regulation of stem cell proliferation GO:0072091 2 0.015
macromolecule biosynthetic process GO:0009059 227 0.015
positive regulation of secretion by cell GO:1903532 1 0.015
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.015
protein polymerization GO:0051258 4 0.015
regulation of inflammatory response GO:0050727 2 0.015
organic cyclic compound metabolic process GO:1901360 301 0.015
heart morphogenesis GO:0003007 156 0.015
regulation of glial cell differentiation GO:0045685 4 0.015
regulation of binding GO:0051098 3 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.014
hemopoiesis GO:0030097 183 0.014
regulation of filopodium assembly GO:0051489 2 0.014
circulatory system process GO:0003013 87 0.014
cellular component assembly GO:0022607 170 0.014
proteasomal protein catabolic process GO:0010498 2 0.014
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.014
regulation of cell communication GO:0010646 232 0.014
Fly
regulation of cell motility GO:2000145 46 0.014
regulation of blood coagulation GO:0030193 1 0.014
myeloid cell homeostasis GO:0002262 56 0.014
multi organism process GO:0051704 134 0.014
Worm
cellular response to organic substance GO:0071310 105 0.014
modification dependent macromolecule catabolic process GO:0043632 3 0.014
positive regulation of metabolic process GO:0009893 108 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.014
negative regulation of transcription dna templated GO:0045892 45 0.014
cellular component disassembly GO:0022411 1 0.013
heart development GO:0007507 313 0.013
intestinal absorption GO:0050892 2 0.013
aromatic compound biosynthetic process GO:0019438 217 0.013
membrane invagination GO:0010324 1 0.013
positive regulation of cell activation GO:0050867 1 0.013
immune system development GO:0002520 191 0.013
striated muscle cell development GO:0055002 108 0.013
positive regulation of cell cycle GO:0045787 3 0.013
regulation of circadian rhythm GO:0042752 4 0.013
retina layer formation GO:0010842 24 0.013
gliogenesis GO:0042063 45 0.013
regulation of cellular biosynthetic process GO:0031326 245 0.013
axonogenesis GO:0007409 152 0.013
Fly
extrinsic apoptotic signaling pathway GO:0097191 3 0.013
embryonic limb morphogenesis GO:0030326 2 0.013
cell projection morphogenesis GO:0048858 244 0.013
Fly
rna biosynthetic process GO:0032774 181 0.013
neuron projection development GO:0031175 180 0.013
Fly
neuromuscular synaptic transmission GO:0007274 2 0.013
gastrulation GO:0007369 208 0.013
cilium organization GO:0044782 71 0.013
cellular response to external stimulus GO:0071496 2 0.013
cellular response to decreased oxygen levels GO:0036294 1 0.013
developmental growth GO:0048589 166 0.013
lipid storage GO:0019915 1 0.013
blood circulation GO:0008015 87 0.013
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 1 0.013
mitotic dna integrity checkpoint GO:0044774 4 0.013
rna metabolic process GO:0016070 219 0.013
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.013
cellular protein catabolic process GO:0044257 4 0.013
sequestering of metal ion GO:0051238 3 0.013
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.013
regulation of protein import into nucleus GO:0042306 2 0.013
regulation of signal transduction GO:0009966 225 0.013
Fly
striated muscle tissue development GO:0014706 110 0.012
cellular response to hormone stimulus GO:0032870 39 0.012
regulation of organ growth GO:0046620 3 0.012
positive regulation of myeloid cell differentiation GO:0045639 2 0.012
muscle cell development GO:0055001 115 0.012
neuron projection guidance GO:0097485 86 0.012
Fly
medulla oblongata development GO:0021550 4 0.012
positive regulation of cellular catabolic process GO:0031331 3 0.012
regulation of developmental process GO:0050793 247 0.012
adherens junction organization GO:0034332 4 0.012
eye development GO:0001654 277 0.012
guanosine containing compound metabolic process GO:1901068 4 0.012
regionalization GO:0003002 274 0.012
regulation of reactive oxygen species metabolic process GO:2000377 2 0.012
single organism transport GO:0044765 206 0.012
synaptic growth at neuromuscular junction GO:0051124 2 0.012
positive regulation of jak stat cascade GO:0046427 2 0.012
spermatid development GO:0007286 2 0.012
enzyme linked receptor protein signaling pathway GO:0007167 106 0.012
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.012
phosphatidylinositol biosynthetic process GO:0006661 1 0.012
regulation of gene expression GO:0010468 265 0.012
response to carbohydrate GO:0009743 3 0.012
phagocytosis engulfment GO:0006911 1 0.012
skeletal muscle tissue development GO:0007519 67 0.012
epidermal cell differentiation GO:0009913 36 0.012
single organism reproductive process GO:0044702 40 0.012
positive regulation of protein complex assembly GO:0031334 2 0.012
peripheral nervous system neuron differentiation GO:0048934 28 0.012
cellular response to molecule of bacterial origin GO:0071219 3 0.012
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 1 0.012
stem cell maintenance GO:0019827 4 0.011
regulation of nucleocytoplasmic transport GO:0046822 2 0.011
positive regulation of chromatin modification GO:1903310 1 0.011
calcium ion transport into cytosol GO:0060402 3 0.011
localization of cell GO:0051674 244 0.011
regulation of macromolecule biosynthetic process GO:0010556 225 0.011
positive regulation of cytoskeleton organization GO:0051495 3 0.011
interspecies interaction between organisms GO:0044419 4 0.011
taxis GO:0042330 109 0.011
Fly
regulation of gtpase activity GO:0043087 2 0.011
regulation of blood pressure GO:0008217 1 0.011
synaptic transmission cholinergic GO:0007271 4 0.011
spindle assembly involved in mitosis GO:0090307 1 0.011
regulation of biological quality GO:0065008 263 0.011
monocarboxylic acid metabolic process GO:0032787 17 0.011
response to hypoxia GO:0001666 25 0.011
blood vessel morphogenesis GO:0048514 216 0.011
macromolecular complex disassembly GO:0032984 1 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.011
dorsal motor nucleus of vagus nerve development GO:0021744 4 0.011
regulation of molecular function GO:0065009 70 0.011
neuroblast proliferation GO:0007405 2 0.011
regeneration GO:0031099 91 0.011
positive regulation of gtpase activity GO:0043547 1 0.011
protein complex localization GO:0031503 1 0.011
cellular protein modification process GO:0006464 100 0.011
Fly
female meiotic division GO:0007143 2 0.011
ion transmembrane transport GO:0034220 91 0.011
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.011
cytoskeleton organization GO:0007010 96 0.010
nucleic acid templated transcription GO:0097659 181 0.010
lipid metabolic process GO:0006629 52 0.010
negative regulation of cellular metabolic process GO:0031324 77 0.010
multicellular organismal macromolecule metabolic process GO:0044259 2 0.010
membrane fusion GO:0061025 2 0.010
inositol lipid mediated signaling GO:0048017 2 0.010
positive regulation of chromosome organization GO:2001252 1 0.010
dorsal ventral pattern formation GO:0009953 125 0.010
glial cell proliferation GO:0014009 4 0.010
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.010
skeletal system development GO:0001501 181 0.010
negative regulation of epithelial cell proliferation GO:0050680 1 0.010
rho protein signal transduction GO:0007266 5 0.010
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.010
mitotic g2 dna damage checkpoint GO:0007095 3 0.010
regulation of growth rate GO:0040009 1 0.010
modification dependent protein catabolic process GO:0019941 3 0.010
homeostatic process GO:0042592 142 0.010

wnk1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.093
musculoskeletal system disease DOID:17 0 0.040
nervous system disease DOID:863 0 0.028
muscle tissue disease DOID:66 0 0.028
muscular disease DOID:0080000 0 0.028
immune system disease DOID:2914 0 0.026
myopathy DOID:423 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
cancer DOID:162 0 0.012
organ system cancer DOID:0050686 0 0.011