Danio rerio

0 known processes

xrn1

5'-3' exoribonuclease 1

(Aliases: MGC63635,wu:fk92c07,zgc:63635)

xrn1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.316
chordate embryonic development GO:0043009 271 0.231
single organism nuclear import GO:1902593 3 0.213
cellular macromolecule metabolic process GO:0044260 391 0.180
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.173
organelle assembly GO:0070925 110 0.157
embryonic skeletal system development GO:0048706 97 0.149
nucleocytoplasmic transport GO:0006913 4 0.131
protein import into nucleus GO:0006606 3 0.125
ubiquitin dependent protein catabolic process GO:0006511 3 0.100
establishment of localization GO:0051234 244 0.093
modification dependent macromolecule catabolic process GO:0043632 3 0.093
cellular protein catabolic process GO:0044257 4 0.091
nuclear transport GO:0051169 4 0.091
protein localization to nucleus GO:0034504 3 0.090
protein targeting to nucleus GO:0044744 3 0.089
aging GO:0007568 2 0.087
skeletal system development GO:0001501 181 0.084
positive regulation of catabolic process GO:0009896 4 0.083
cellular biosynthetic process GO:0044249 286 0.081
embryonic organ morphogenesis GO:0048562 274 0.076
transport GO:0006810 220 0.072
regulation of multicellular organism growth GO:0040014 4 0.072
heart development GO:0007507 313 0.070
negative regulation of protein phosphorylation GO:0001933 4 0.068
proteasomal protein catabolic process GO:0010498 2 0.066
embryo development ending in birth or egg hatching GO:0009792 271 0.066
negative regulation of protein kinase activity GO:0006469 4 0.064
meiotic nuclear division GO:0007126 4 0.060
cellular nitrogen compound metabolic process GO:0034641 290 0.060
regulation of multicellular organismal process GO:0051239 277 0.058
modification dependent protein catabolic process GO:0019941 3 0.058
embryonic cranial skeleton morphogenesis GO:0048701 90 0.056
establishment of protein localization to organelle GO:0072594 4 0.053
synaptic vesicle transport GO:0048489 1 0.050
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.050
embryonic skeletal system morphogenesis GO:0048704 93 0.049
embryonic organ development GO:0048568 381 0.049
cellular macromolecule biosynthetic process GO:0034645 224 0.048
heterocycle biosynthetic process GO:0018130 215 0.048
nuclear import GO:0051170 3 0.047
regulation of establishment of protein localization GO:0070201 4 0.046
regulation of synapse organization GO:0050807 3 0.045
regulation of stem cell differentiation GO:2000736 4 0.043
skeletal system morphogenesis GO:0048705 102 0.043
regulation of rna biosynthetic process GO:2001141 213 0.042
regulation of reproductive process GO:2000241 4 0.042
single organism localization GO:1902578 225 0.042
apoptotic process involved in development GO:1902742 2 0.042
regulation of biological quality GO:0065008 263 0.042
nucleic acid metabolic process GO:0090304 244 0.041
synaptic growth at neuromuscular junction GO:0051124 2 0.041
positive regulation of cellular catabolic process GO:0031331 3 0.041
cellular nitrogen compound biosynthetic process GO:0044271 218 0.040
single organism transport GO:0044765 206 0.040
embryonic viscerocranium morphogenesis GO:0048703 52 0.040
extrinsic apoptotic signaling pathway GO:0097191 3 0.040
negative regulation of kinase activity GO:0033673 4 0.039
cellular component movement GO:0006928 335 0.038
protein import GO:0017038 3 0.038
establishment of synaptic vesicle localization GO:0097480 1 0.037
gtp catabolic process GO:0006184 2 0.037
heterocycle metabolic process GO:0046483 290 0.036
stem cell maintenance GO:0019827 4 0.036
regulation of localization GO:0032879 104 0.036
regulation of nucleocytoplasmic transport GO:0046822 2 0.036
response to stress GO:0006950 263 0.035
cellular localization GO:0051641 97 0.035
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.034
regulation of purine nucleotide catabolic process GO:0033121 2 0.033
cartilage development GO:0051216 96 0.033
response to topologically incorrect protein GO:0035966 2 0.033
response to external stimulus GO:0009605 264 0.033
mitochondrion organization GO:0007005 4 0.032
adult behavior GO:0030534 2 0.032
regulation of synapse assembly GO:0051963 3 0.032
regulation of circadian rhythm GO:0042752 4 0.032
synaptic vesicle localization GO:0097479 1 0.032
regulation of macromolecule metabolic process GO:0060255 317 0.031
locomotor rhythm GO:0045475 3 0.031
regulation of intracellular protein transport GO:0033157 3 0.031
cellular response to nutrient levels GO:0031669 2 0.031
sensory organ development GO:0007423 393 0.030
embryonic heart tube development GO:0035050 133 0.030
regulation of protein targeting GO:1903533 2 0.030
protein complex localization GO:0031503 1 0.030
cell surface receptor signaling pathway GO:0007166 325 0.030
regulation of developmental process GO:0050793 247 0.029
regulation of cell communication GO:0010646 232 0.029
positive regulation of transport GO:0051050 2 0.029
entrainment of circadian clock GO:0009649 2 0.028
locomotion GO:0040011 313 0.028
lipid storage GO:0019915 1 0.028
phagocytosis GO:0006909 3 0.028
connective tissue development GO:0061448 99 0.028
regulation of protein transport GO:0051223 3 0.028
response to other organism GO:0051707 97 0.027
positive regulation of nucleoside metabolic process GO:0045979 1 0.027
gene expression GO:0010467 252 0.027
er nucleus signaling pathway GO:0006984 2 0.026
peptidyl serine modification GO:0018209 2 0.026
organic cyclic compound metabolic process GO:1901360 301 0.026
specification of symmetry GO:0009799 204 0.026
determination of left right symmetry GO:0007368 179 0.026
phosphate containing compound metabolic process GO:0006796 108 0.025
regulation of nucleoside metabolic process GO:0009118 2 0.025
regulation of protein localization to nucleus GO:1900180 2 0.025
regulation of metabolic process GO:0019222 359 0.025
production of molecular mediator of immune response GO:0002440 2 0.025
negative regulation of biological process GO:0048519 304 0.025
multicellular organism growth GO:0035264 4 0.025
response to external biotic stimulus GO:0043207 97 0.025
central nervous system development GO:0007417 387 0.024
regulation of cellular biosynthetic process GO:0031326 245 0.024
embryonic heart tube morphogenesis GO:0003143 108 0.024
erk1 and erk2 cascade GO:0070371 4 0.024
regulation of cytoplasmic transport GO:1903649 4 0.024
gtp metabolic process GO:0046039 4 0.024
peptidyl serine phosphorylation GO:0018105 1 0.023
protein metabolic process GO:0019538 183 0.023
meiotic cell cycle process GO:1903046 3 0.023
positive regulation of gtp catabolic process GO:0033126 1 0.023
regulation of gtp catabolic process GO:0033124 2 0.023
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.023
amine metabolic process GO:0009308 2 0.023
positive regulation of biological process GO:0048518 253 0.023
immune system process GO:0002376 241 0.023
response to biotic stimulus GO:0009607 97 0.022
cell motility GO:0048870 244 0.022
regulation of protein import into nucleus GO:0042306 2 0.022
regulation of epithelial cell proliferation GO:0050678 3 0.022
positive regulation of nucleotide catabolic process GO:0030813 1 0.022
response to chemical GO:0042221 320 0.021
establishment of rna localization GO:0051236 3 0.021
embryonic skeletal joint morphogenesis GO:0060272 3 0.021
positive regulation of muscle cell differentiation GO:0051149 1 0.021
negative regulation of multicellular organismal process GO:0051241 69 0.021
negative regulation of nuclear division GO:0051784 3 0.021
response to drug GO:0042493 3 0.021
enzyme linked receptor protein signaling pathway GO:0007167 106 0.021
single organism organelle organization GO:1902589 199 0.021
somitogenesis GO:0001756 87 0.021
regulation of nucleotide catabolic process GO:0030811 2 0.021
negative regulation of mapk cascade GO:0043409 4 0.020
cellular response to chemical stimulus GO:0070887 157 0.020
regulation of cytokine production GO:0001817 3 0.020
b cell activation GO:0042113 2 0.020
positive regulation of cellular component biogenesis GO:0044089 3 0.020
protein dephosphorylation GO:0006470 3 0.020
cellular response to starvation GO:0009267 1 0.020
regulation of gtpase activity GO:0043087 2 0.020
cell cycle arrest GO:0007050 1 0.020
organic substance biosynthetic process GO:1901576 289 0.020
negative regulation of developmental process GO:0051093 65 0.020
defense response GO:0006952 47 0.020
determination of bilateral symmetry GO:0009855 204 0.020
neurotransmitter secretion GO:0007269 2 0.020
heart morphogenesis GO:0003007 156 0.020
regulation of cellular metabolic process GO:0031323 320 0.020
positive regulation of map kinase activity GO:0043406 3 0.020
response to organic substance GO:0010033 153 0.020
defense response to other organism GO:0098542 33 0.019
protein stabilization GO:0050821 2 0.019
stem cell development GO:0048864 82 0.019
neurotransmitter transport GO:0006836 2 0.019
membrane invagination GO:0010324 1 0.019
regulation of protein catabolic process GO:0042176 1 0.019
stem cell proliferation GO:0072089 4 0.019
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.019
brain development GO:0007420 293 0.019
golgi vesicle transport GO:0048193 3 0.019
guanosine containing compound catabolic process GO:1901069 2 0.018
regulation of cellular amine metabolic process GO:0033238 0 0.018
stem cell differentiation GO:0048863 117 0.018
angiogenesis GO:0001525 158 0.018
biosynthetic process GO:0009058 294 0.018
cellular component morphogenesis GO:0032989 336 0.018
nitrogen compound metabolic process GO:0006807 319 0.018
negative regulation of defense response GO:0031348 2 0.018
organic substance transport GO:0071702 58 0.018
establishment of vesicle localization GO:0051650 24 0.017
maintenance of location GO:0051235 4 0.017
macromolecule localization GO:0033036 54 0.017
meiosis i GO:0007127 1 0.017
negative regulation of synapse assembly GO:0051964 2 0.017
catabolic process GO:0009056 32 0.017
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.017
renal tubule morphogenesis GO:0061333 1 0.017
regulation of programmed cell death GO:0043067 101 0.017
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 1 0.017
regulation of organelle assembly GO:1902115 4 0.017
synaptic vesicle endocytosis GO:0048488 1 0.017
cellular response to extracellular stimulus GO:0031668 2 0.017
post golgi vesicle mediated transport GO:0006892 1 0.017
organelle fusion GO:0048284 3 0.017
guanosine containing compound metabolic process GO:1901068 4 0.017
rna metabolic process GO:0016070 219 0.017
vesicle localization GO:0051648 27 0.017
nucleobase containing compound biosynthetic process GO:0034654 205 0.017
blood vessel morphogenesis GO:0048514 216 0.017
muscle cell differentiation GO:0042692 139 0.016
regulation of cellular protein catabolic process GO:1903362 1 0.016
response to unfolded protein GO:0006986 2 0.016
determination of heart left right asymmetry GO:0061371 117 0.016
negative regulation of programmed cell death GO:0043069 58 0.016
cellular response to external stimulus GO:0071496 2 0.016
regulation of catalytic activity GO:0050790 55 0.016
regulation of carbohydrate metabolic process GO:0006109 4 0.016
signal transduction GO:0007165 455 0.016
regulation of protein complex assembly GO:0043254 3 0.016
endoplasmic reticulum unfolded protein response GO:0030968 2 0.016
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.016
cellular macromolecule catabolic process GO:0044265 12 0.016
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.016
regulation of epithelial to mesenchymal transition GO:0010717 3 0.016
cellular amide metabolic process GO:0043603 4 0.016
protein secretion GO:0009306 1 0.015
mitochondrial transport GO:0006839 2 0.015
negative regulation of reproductive process GO:2000242 3 0.015
regulation of response to stimulus GO:0048583 269 0.015
tube morphogenesis GO:0035239 349 0.015
compound eye development GO:0048749 2 0.015
regulation of cell activation GO:0050865 1 0.015
generation of neurons GO:0048699 385 0.015
macromolecule biosynthetic process GO:0009059 227 0.015
negative regulation of cellular process GO:0048523 283 0.015
organonitrogen compound metabolic process GO:1901564 74 0.015
negative regulation of molecular function GO:0044092 23 0.015
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.015
cell morphogenesis GO:0000902 289 0.015
neuron development GO:0048666 262 0.015
negative regulation of epithelial cell proliferation GO:0050680 1 0.015
negative regulation of catabolic process GO:0009895 3 0.015
epithelial tube morphogenesis GO:0060562 148 0.014
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.014
cellular amino acid metabolic process GO:0006520 7 0.014
cellular aromatic compound metabolic process GO:0006725 295 0.014
ameboidal type cell migration GO:0001667 143 0.014
cell death in response to oxidative stress GO:0036473 2 0.014
organic acid metabolic process GO:0006082 31 0.014
localization of cell GO:0051674 244 0.014
regulation of molecular function GO:0065009 70 0.014
synaptic target recognition GO:0008039 1 0.014
mesenchyme development GO:0060485 127 0.014
immune system development GO:0002520 191 0.014
positive regulation of cell cycle GO:0045787 3 0.014
regulation of synaptic plasticity GO:0048167 1 0.014
rna 3 end processing GO:0031123 2 0.014
cellular response to topologically incorrect protein GO:0035967 2 0.014
heart looping GO:0001947 94 0.014
cell migration involved in heart development GO:0060973 22 0.014
morphogenesis of an epithelium GO:0002009 333 0.014
cognition GO:0050890 1 0.014
head development GO:0060322 303 0.014
positive regulation of oocyte development GO:0060282 1 0.014
hematopoietic or lymphoid organ development GO:0048534 191 0.014
rna localization GO:0006403 4 0.014
regulation of binding GO:0051098 3 0.014
regulation of translational initiation GO:0006446 1 0.014
single organism cellular localization GO:1902580 46 0.013
positive regulation of gtpase activity GO:0043547 1 0.013
positive regulation of apoptotic signaling pathway GO:2001235 1 0.013
regulation of erk1 and erk2 cascade GO:0070372 4 0.013
negative regulation of cell communication GO:0010648 96 0.013
regulation of primary metabolic process GO:0080090 311 0.013
negative regulation of stem cell differentiation GO:2000737 2 0.013
negative regulation of cytoplasmic transport GO:1903650 2 0.013
cytoskeleton organization GO:0007010 96 0.013
regulation of cellular component movement GO:0051270 55 0.013
oxoacid metabolic process GO:0043436 31 0.013
muscle structure development GO:0061061 196 0.013
regulation of response to biotic stimulus GO:0002831 2 0.013
negative regulation of cell differentiation GO:0045596 46 0.013
developmental programmed cell death GO:0010623 4 0.013
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.013
neuron remodeling GO:0016322 1 0.012
regulation of cellular component organization GO:0051128 86 0.012
negative regulation of catalytic activity GO:0043086 21 0.012
striated muscle cell development GO:0055002 108 0.012
macroautophagy GO:0016236 1 0.012
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.012
cellular amine metabolic process GO:0044106 2 0.012
cellular catabolic process GO:0044248 27 0.012
negative regulation of sequestering of calcium ion GO:0051283 4 0.012
translational initiation GO:0006413 3 0.012
neuron differentiation GO:0030182 353 0.012
regulation of signaling GO:0023051 235 0.012
phosphorus metabolic process GO:0006793 109 0.012
regulation of stem cell proliferation GO:0072091 2 0.012
cellular component assembly GO:0022607 170 0.012
programmed cell death GO:0012501 119 0.012
vasculature development GO:0001944 278 0.012
regulation of gene expression GO:0010468 265 0.012
regulation of dendrite development GO:0050773 3 0.012
regulation of ras gtpase activity GO:0032318 2 0.012
regulation of cell shape GO:0008360 1 0.012
establishment of localization in cell GO:0051649 77 0.012
neuronal stem cell maintenance GO:0097150 2 0.012
organelle organization GO:0006996 227 0.012
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.012
developmental growth GO:0048589 166 0.012
nuclear division GO:0000280 23 0.012
centrosome cycle GO:0007098 1 0.012
intracellular mrna localization GO:0008298 1 0.012
transcription from rna polymerase ii promoter GO:0006366 80 0.012
regulation of biosynthetic process GO:0009889 250 0.012
maternal determination of anterior posterior axis embryo GO:0008358 4 0.012
system process GO:0003008 185 0.011
response to light stimulus GO:0009416 46 0.011
negative regulation of multi organism process GO:0043901 3 0.011
peptide transport GO:0015833 1 0.011
multi organism process GO:0051704 134 0.011
mrna export from nucleus GO:0006406 1 0.011
lateral inhibition GO:0046331 1 0.011
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 22 0.011
protein phosphorylation GO:0006468 47 0.011
phagocytosis engulfment GO:0006911 1 0.011
single organism membrane fusion GO:0044801 2 0.011
negative regulation of innate immune response GO:0045824 2 0.011
single organism metabolic process GO:0044710 217 0.011
cellular response to stress GO:0033554 62 0.011
phosphorylation GO:0016310 69 0.011
positive regulation of immune effector process GO:0002699 3 0.011
liver development GO:0001889 96 0.011
post embryonic organ development GO:0048569 4 0.011
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.011
nucleobase containing compound metabolic process GO:0006139 274 0.011
cellular protein modification process GO:0006464 100 0.011
immune effector process GO:0002252 23 0.011
water homeostasis GO:0030104 4 0.011
rna biosynthetic process GO:0032774 181 0.011
glial cell proliferation GO:0014009 4 0.011
regulation of cell projection assembly GO:0060491 4 0.011
negative regulation of intracellular transport GO:0032387 3 0.010
mrna transport GO:0051028 2 0.010
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.010
cellular component biogenesis GO:0044085 178 0.010
cellular protein metabolic process GO:0044267 129 0.010
gastrulation GO:0007369 208 0.010
germ line stem cell maintenance GO:0030718 2 0.010
regulation of mrna processing GO:0050684 3 0.010
carboxylic acid metabolic process GO:0019752 22 0.010
regulation of response to oxidative stress GO:1902882 2 0.010
somatic stem cell maintenance GO:0035019 1 0.010
blood vessel development GO:0001568 246 0.010
positive regulation of cell division GO:0051781 2 0.010
tissue remodeling GO:0048771 4 0.010
negative regulation of response to stimulus GO:0048585 104 0.010
anterior posterior pattern specification GO:0009952 152 0.010

xrn1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 0 0.046
muscular disease DOID:0080000 0 0.046
disease of anatomical entity DOID:7 0 0.046
musculoskeletal system disease DOID:17 0 0.046
muscle tissue disease DOID:66 0 0.046
disease of metabolism DOID:0014667 0 0.017
heart disease DOID:114 0 0.010
cardiomyopathy DOID:0050700 0 0.010
intrinsic cardiomyopathy DOID:0060036 0 0.010
cardiovascular system disease DOID:1287 0 0.010