Danio rerio

0 known processes

xrn2

5'-3' exoribonuclease 2

(Aliases: zgc:55717,wu:fb38g12,wu:fj53d06)

xrn2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of mrna splicing via spliceosome GO:0048024 3 0.699
regulation of mrna processing GO:0050684 3 0.592
larval development GO:0002164 2 0.376
alternative mrna splicing via spliceosome GO:0000380 1 0.326
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.306
gene expression GO:0010467 252 0.233
mrna processing GO:0006397 14 0.171
regulation of meiotic cell cycle GO:0051445 1 0.141
generation of neurons GO:0048699 385 0.130
meiotic nuclear division GO:0007126 4 0.129
mrna splicing via spliceosome GO:0000398 10 0.129
cellular nitrogen compound metabolic process GO:0034641 290 0.124
cellular macromolecule metabolic process GO:0044260 391 0.122
rna splicing GO:0008380 16 0.121
regulation of nitrogen compound metabolic process GO:0051171 251 0.114
regulation of gene expression GO:0010468 265 0.103
nitrogen compound metabolic process GO:0006807 319 0.098
rna metabolic process GO:0016070 219 0.094
aging GO:0007568 2 0.087
rna processing GO:0006396 25 0.086
response to external biotic stimulus GO:0043207 97 0.085
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 4 0.085
nucleobase containing compound metabolic process GO:0006139 274 0.084
organic cyclic compound metabolic process GO:1901360 301 0.082
response to stress GO:0006950 263 0.079
nucleic acid metabolic process GO:0090304 244 0.078
negative regulation of biological process GO:0048519 304 0.077
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 10 0.071
cellular aromatic compound metabolic process GO:0006725 295 0.067
nucleocytoplasmic transport GO:0006913 4 0.066
programmed cell death GO:0012501 119 0.066
locomotion GO:0040011 313 0.063
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.059
regulation of primary metabolic process GO:0080090 311 0.058
negative regulation of cellular process GO:0048523 283 0.058
rna localization GO:0006403 4 0.057
cellular macromolecule biosynthetic process GO:0034645 224 0.056
macromolecule biosynthetic process GO:0009059 227 0.056
regulation of rna metabolic process GO:0051252 224 0.054
rna transport GO:0050658 2 0.053
biosynthetic process GO:0009058 294 0.053
nuclear transport GO:0051169 4 0.053
embryo development ending in birth or egg hatching GO:0009792 271 0.051
multi organism reproductive process GO:0044703 36 0.050
response to external stimulus GO:0009605 264 0.050
regulation of cell death GO:0010941 103 0.049
response to biotic stimulus GO:0009607 97 0.049
heterocycle metabolic process GO:0046483 290 0.048
positive regulation of map kinase activity GO:0043406 3 0.048
protein localization to nucleus GO:0034504 3 0.047
cellular component movement GO:0006928 335 0.047
regulation of cytokine production GO:0001817 3 0.046
apoptotic process GO:0006915 116 0.045
establishment of localization GO:0051234 244 0.045
regulation of cellular metabolic process GO:0031323 320 0.045
gamete generation GO:0007276 33 0.044
regulation of cell differentiation GO:0045595 142 0.043
protein targeting to nucleus GO:0044744 3 0.043
mrna metabolic process GO:0016071 20 0.043
multicellular organism growth GO:0035264 4 0.042
positive regulation of cellular component biogenesis GO:0044089 3 0.042
autophagy GO:0006914 4 0.042
epithelial tube morphogenesis GO:0060562 148 0.041
establishment of protein localization to organelle GO:0072594 4 0.038
regulation of response to stimulus GO:0048583 269 0.037
cellular biosynthetic process GO:0044249 286 0.037
regulation of macromolecule metabolic process GO:0060255 317 0.037
regulation of metabolic process GO:0019222 359 0.037
sensory organ development GO:0007423 393 0.037
cell migration GO:0016477 237 0.037
axon development GO:0061564 166 0.036
regulation of cellular biosynthetic process GO:0031326 245 0.036
cellular nitrogen compound biosynthetic process GO:0044271 218 0.036
purine nucleoside monophosphate catabolic process GO:0009128 4 0.036
regulation of biological quality GO:0065008 263 0.036
nucleic acid templated transcription GO:0097659 181 0.035
cell death GO:0008219 121 0.035
protein import into nucleus GO:0006606 3 0.035
single organism nuclear import GO:1902593 3 0.035
cellular response to external stimulus GO:0071496 2 0.034
establishment of rna localization GO:0051236 3 0.034
female gonad development GO:0008585 4 0.034
regulation of nucleocytoplasmic transport GO:0046822 2 0.033
response to drug GO:0042493 3 0.033
multi organism process GO:0051704 134 0.033
translational initiation GO:0006413 3 0.032
cellular response to dsrna GO:0071359 1 0.032
chordate embryonic development GO:0043009 271 0.032
response to chemical GO:0042221 320 0.032
stem cell maintenance GO:0019827 4 0.032
nucleic acid transport GO:0050657 2 0.032
regulation of protein transport GO:0051223 3 0.031
development of primary female sexual characteristics GO:0046545 4 0.031
rna export from nucleus GO:0006405 1 0.031
multicellular organismal reproductive process GO:0048609 35 0.031
synaptic growth at neuromuscular junction GO:0051124 2 0.031
localization of cell GO:0051674 244 0.031
transcription dna templated GO:0006351 181 0.030
signal transduction GO:0007165 455 0.030
nuclear import GO:0051170 3 0.030
female sex differentiation GO:0046660 4 0.030
regulation of response to nutrient levels GO:0032107 1 0.029
regulation of rna splicing GO:0043484 8 0.029
mrna stabilization GO:0048255 4 0.029
neuron differentiation GO:0030182 353 0.028
macromolecular complex subunit organization GO:0043933 74 0.027
regulation of protein targeting GO:1903533 2 0.027
rna stabilization GO:0043489 4 0.027
cell projection organization GO:0030030 284 0.027
rna splicing via transesterification reactions GO:0000375 10 0.026
positive regulation of transport GO:0051050 2 0.026
regulation of macromolecule biosynthetic process GO:0010556 225 0.026
cell projection morphogenesis GO:0048858 244 0.026
regulation of establishment of protein localization GO:0070201 4 0.026
response to uv GO:0009411 3 0.026
negative regulation of cytokine production GO:0001818 1 0.025
regulation of growth rate GO:0040009 1 0.025
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.025
regulation of reproductive process GO:2000241 4 0.025
phagocytosis GO:0006909 3 0.025
regulation of multicellular organismal development GO:2000026 223 0.025
proteasomal protein catabolic process GO:0010498 2 0.025
regulation of multicellular organism growth GO:0040014 4 0.024
negative regulation of defense response GO:0031348 2 0.024
chemotaxis GO:0006935 104 0.024
response to virus GO:0009615 21 0.024
cell part morphogenesis GO:0032990 246 0.024
positive regulation of catabolic process GO:0009896 4 0.024
regulation of response to stress GO:0080134 36 0.024
positive regulation of biosynthetic process GO:0009891 68 0.024
regulation of protein localization to nucleus GO:1900180 2 0.024
negative regulation of kinase activity GO:0033673 4 0.024
cell motility GO:0048870 244 0.024
organelle organization GO:0006996 227 0.024
protein import GO:0017038 3 0.024
regulation of programmed cell death GO:0043067 101 0.023
regulation of translational initiation GO:0006446 1 0.023
system process GO:0003008 185 0.023
mrna transport GO:0051028 2 0.023
death GO:0016265 121 0.023
neuron development GO:0048666 262 0.023
regulation of transcription dna templated GO:0006355 213 0.023
protein metabolic process GO:0019538 183 0.023
regulation of stem cell differentiation GO:2000736 4 0.022
cellular response to extracellular stimulus GO:0031668 2 0.022
positive regulation of biological process GO:0048518 253 0.022
regulation of cytoplasmic transport GO:1903649 4 0.022
positive regulation of cell cycle GO:0045787 3 0.022
regulation of multicellular organismal process GO:0051239 277 0.022
dorsal ventral pattern formation GO:0009953 125 0.022
nuclear export GO:0051168 1 0.022
regulation of neural precursor cell proliferation GO:2000177 3 0.022
organic substance biosynthetic process GO:1901576 289 0.022
meiotic cell cycle process GO:1903046 3 0.022
regulation of response to biotic stimulus GO:0002831 2 0.021
single organism metabolic process GO:0044710 217 0.021
modification dependent macromolecule catabolic process GO:0043632 3 0.021
embryonic organ morphogenesis GO:0048562 274 0.021
macroautophagy GO:0016236 1 0.021
lipid storage GO:0019915 1 0.021
cellular amine metabolic process GO:0044106 2 0.020
regulation of cellular amine metabolic process GO:0033238 0 0.020
dna templated transcription elongation GO:0006354 3 0.020
negative regulation of cell death GO:0060548 60 0.020
positive regulation of cellular catabolic process GO:0031331 3 0.020
regulation of protein import into nucleus GO:0042306 2 0.020
regulation of signaling GO:0023051 235 0.020
immune effector process GO:0002252 23 0.020
defense response to other organism GO:0098542 33 0.020
tube morphogenesis GO:0035239 349 0.020
positive regulation of cellular process GO:0048522 201 0.019
positive regulation of cellular amine metabolic process GO:0033240 0 0.019
negative regulation of response to stimulus GO:0048585 104 0.019
neuron projection morphogenesis GO:0048812 161 0.019
regulation of cell activation GO:0050865 1 0.019
modification dependent protein catabolic process GO:0019941 3 0.019
positive regulation of nucleic acid templated transcription GO:1903508 57 0.019
regulation of locomotion GO:0040012 55 0.019
regulation of autophagy GO:0010506 3 0.019
transcription from rna polymerase ii promoter GO:0006366 80 0.019
nucleobase containing compound transport GO:0015931 2 0.019
taxis GO:0042330 109 0.018
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.018
regulation of mrna metabolic process GO:1903311 6 0.018
regulation of mrna stability GO:0043488 4 0.018
compound eye development GO:0048749 2 0.018
regulation of synapse assembly GO:0051963 3 0.018
negative regulation of metabolic process GO:0009892 86 0.018
regulation of response to extracellular stimulus GO:0032104 1 0.018
rna biosynthetic process GO:0032774 181 0.017
transport GO:0006810 220 0.017
negative regulation of stem cell differentiation GO:2000737 2 0.017
cell morphogenesis GO:0000902 289 0.017
single organism organelle organization GO:1902589 199 0.017
amine metabolic process GO:0009308 2 0.017
carboxylic acid metabolic process GO:0019752 22 0.017
meiotic chromosome segregation GO:0045132 3 0.017
defense response GO:0006952 47 0.017
negative regulation of macromolecule metabolic process GO:0010605 76 0.017
negative regulation of gene expression GO:0010629 65 0.017
immune system process GO:0002376 241 0.017
negative regulation of protein phosphorylation GO:0001933 4 0.017
lamellipodium assembly GO:0030032 1 0.017
regulation of cellular amino acid metabolic process GO:0006521 0 0.016
axon guidance GO:0007411 86 0.016
cellular response to starvation GO:0009267 1 0.016
negative regulation of programmed cell death GO:0043069 58 0.016
outflow tract morphogenesis GO:0003151 1 0.016
regionalization GO:0003002 274 0.016
regulation of apoptotic process GO:0042981 98 0.016
negative regulation of translation GO:0017148 1 0.015
neuron projection development GO:0031175 180 0.015
regulation of jun kinase activity GO:0043506 3 0.015
sequestering of metal ion GO:0051238 3 0.015
regulation of jak stat cascade GO:0046425 3 0.015
cellular amino acid metabolic process GO:0006520 7 0.015
determination of bilateral symmetry GO:0009855 204 0.015
positive regulation of cell activation GO:0050867 1 0.015
positive regulation of rna biosynthetic process GO:1902680 57 0.015
negative regulation of cellular metabolic process GO:0031324 77 0.015
cell cycle g1 s phase transition GO:0044843 1 0.015
g2 dna damage checkpoint GO:0031572 3 0.015
positive regulation of jun kinase activity GO:0043507 2 0.015
positive regulation of cell communication GO:0010647 56 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.015
ribonucleoside monophosphate catabolic process GO:0009158 4 0.015
regulation of cell communication GO:0010646 232 0.015
immune system development GO:0002520 191 0.015
germ cell development GO:0007281 22 0.015
lamellipodium organization GO:0097581 1 0.015
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.014
positive regulation of metabolic process GO:0009893 108 0.014
thermosensory behavior GO:0040040 1 0.014
specification of symmetry GO:0009799 204 0.014
embryonic organ development GO:0048568 381 0.014
morphogenesis of an epithelium GO:0002009 333 0.014
nucleobase containing compound biosynthetic process GO:0034654 205 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.014
aromatic compound biosynthetic process GO:0019438 217 0.014
regulation of organelle assembly GO:1902115 4 0.014
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.014
maintenance of location GO:0051235 4 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.014
cellular component morphogenesis GO:0032989 336 0.014
negative regulation of rna splicing GO:0033119 1 0.014
dsrna fragmentation GO:0031050 1 0.014
regulation of defense response to virus GO:0050688 2 0.014
organelle assembly GO:0070925 110 0.013
negative regulation of apoptotic process GO:0043066 55 0.013
axonogenesis GO:0007409 152 0.013
mitochondrion organization GO:0007005 4 0.013
protein dephosphorylation GO:0006470 3 0.013
oxoacid metabolic process GO:0043436 31 0.013
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.013
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.013
cellular protein metabolic process GO:0044267 129 0.013
spliceosomal complex assembly GO:0000245 1 0.013
erk1 and erk2 cascade GO:0070371 4 0.013
positive regulation of developmental process GO:0051094 50 0.013
cellular protein catabolic process GO:0044257 4 0.013
regulation of nucleic acid templated transcription GO:1903506 213 0.013
cellular component disassembly GO:0022411 1 0.013
eye development GO:0001654 277 0.013
positive regulation of rna metabolic process GO:0051254 59 0.013
organic cyclic compound biosynthetic process GO:1901362 223 0.013
determination of left right symmetry GO:0007368 179 0.013
regulation of protein complex disassembly GO:0043244 1 0.013
behavior GO:0007610 74 0.013
regulation of stem cell proliferation GO:0072091 2 0.013
organonitrogen compound metabolic process GO:1901564 74 0.013
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.013
cytokinesis GO:0000910 3 0.013
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.012
synaptic target recognition GO:0008039 1 0.012
regulation of biosynthetic process GO:0009889 250 0.012
central nervous system development GO:0007417 387 0.012
neurotransmitter transport GO:0006836 2 0.012
negative regulation of mrna splicing via spliceosome GO:0048025 1 0.012
stem cell proliferation GO:0072089 4 0.012
activation of mapk activity GO:0000187 3 0.012
phosphorus metabolic process GO:0006793 109 0.012
reproduction GO:0000003 40 0.012
positive regulation of cytokine production GO:0001819 2 0.012
mesenchyme development GO:0060485 127 0.012
intracellular signal transduction GO:0035556 85 0.012
regulation of intracellular protein transport GO:0033157 3 0.012
positive regulation of immune effector process GO:0002699 3 0.012
ubiquitin dependent protein catabolic process GO:0006511 3 0.012
protein complex disassembly GO:0043241 1 0.012
heart morphogenesis GO:0003007 156 0.012
cellular response to nutrient levels GO:0031669 2 0.012
positive regulation of gene expression GO:0010628 71 0.012
regulation of cellular component movement GO:0051270 55 0.012
wnt signaling pathway GO:0016055 80 0.012
regulation of protein metabolic process GO:0051246 56 0.012
positive regulation of cellular biosynthetic process GO:0031328 68 0.012
g1 s transition of mitotic cell cycle GO:0000082 1 0.012
cellular component assembly GO:0022607 170 0.012
regulation of localization GO:0032879 104 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
negative regulation of cytokine mediated signaling pathway GO:0001960 2 0.012
growth GO:0040007 174 0.012
response to other organism GO:0051707 97 0.012
mrna export from nucleus GO:0006406 1 0.012
ribosomal small subunit biogenesis GO:0042274 2 0.012
negative regulation of mrna processing GO:0050686 1 0.012
regulation of binding GO:0051098 3 0.012
antimicrobial humoral response GO:0019730 2 0.012
negative regulation of multi organism process GO:0043901 3 0.012
cell fate commitment GO:0045165 99 0.012
sexual reproduction GO:0019953 36 0.012
posttranscriptional regulation of gene expression GO:0010608 14 0.012
interspecies interaction between organisms GO:0044419 4 0.012
positive regulation of secretion GO:0051047 1 0.011
gene silencing by mirna GO:0035195 3 0.011
response to corticosteroid GO:0031960 1 0.011
negative chemotaxis GO:0050919 1 0.011
specification of organ identity GO:0010092 2 0.011
cell cycle GO:0007049 93 0.011
muscle structure development GO:0061061 196 0.011
regulation of signal transduction GO:0009966 225 0.011
positive regulation of translation GO:0045727 1 0.011
cell matrix adhesion GO:0007160 4 0.011
multi organism cellular process GO:0044764 2 0.011
retina development in camera type eye GO:0060041 146 0.011
cell aging GO:0007569 2 0.011
regulation of cell shape GO:0008360 1 0.011
cognition GO:0050890 1 0.011
skeletal system development GO:0001501 181 0.011
blood vessel morphogenesis GO:0048514 216 0.011
rna 3 end processing GO:0031123 2 0.011
hepaticobiliary system development GO:0061008 98 0.011
response to lipid GO:0033993 60 0.011
golgi vesicle transport GO:0048193 3 0.011
negative regulation of cell communication GO:0010648 96 0.011
cell projection assembly GO:0030031 64 0.011
cellular macromolecular complex assembly GO:0034622 24 0.011
positive regulation of epithelial cell proliferation GO:0050679 1 0.011
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.011
positive regulation of stress activated mapk cascade GO:0032874 3 0.011
camera type eye development GO:0043010 222 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.011
blood vessel development GO:0001568 246 0.010
microtubule based process GO:0007017 60 0.010
vasculature development GO:0001944 278 0.010
response to organic substance GO:0010033 153 0.010
cellular ketone metabolic process GO:0042180 11 0.010
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.010
stem cell differentiation GO:0048863 117 0.010
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.010
protein homooligomerization GO:0051260 3 0.010
reproductive process GO:0022414 40 0.010
gtp catabolic process GO:0006184 2 0.010
positive regulation of leukocyte differentiation GO:1902107 1 0.010
response to wounding GO:0009611 116 0.010
locomotor rhythm GO:0045475 3 0.010
response to ketone GO:1901654 1 0.010
establishment of epithelial cell polarity GO:0090162 2 0.010
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.010
stem cell division GO:0017145 1 0.010
viral process GO:0016032 1 0.010
regulation of cell motility GO:2000145 46 0.010

xrn2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.026
musculoskeletal system disease DOID:17 0 0.021
myopathy DOID:423 0 0.017
muscular disease DOID:0080000 0 0.017
muscle tissue disease DOID:66 0 0.017
cancer DOID:162 0 0.014
disease of cellular proliferation DOID:14566 0 0.014
nervous system disease DOID:863 0 0.012