The network for 'anatomical structure maturation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

anatomical structure maturation

A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state.

Drosophila melanogaster
Name Description Probability Func Analog Organism
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.592
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.502
COPB1 coatomer protein complex, subunit beta 1 0.476
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.384
MSN moesin 0.343
FSTL1 follistatin-like 1 0.321
BMPR1A bone morphogenetic protein receptor, type IA 0.271
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.255
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.215
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.201
CSH2 chorionic somatomammotropin hormone 2 0.198
PSEN1 presenilin 1 0.174
MAML1 mastermind-like 1 (Drosophila) 0.174
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.139
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.105
RND1 Rho family GTPase 1 0.104
FLNC filamin C, gamma 0.103
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.096
SPEN spen homolog, transcriptional regulator (Drosophila) 0.085
GH1 growth hormone 1 0.080
APP amyloid beta (A4) precursor protein 0.078
FLNB filamin B, beta 0.077
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.075
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 0.062
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.054
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.052
UTRN utrophin 0.046
SETD8 SET domain containing (lysine methyltransferase) 8 0.045
PTPRC protein tyrosine phosphatase, receptor type, C 0.042
ATXN1L ataxin 1-like 0.040
JUP junction plakoglobin 0.039
PLXND1 plexin D1 0.036
ATF4 activating transcription factor 4 (tax-responsive enhancer element B67) 0.036
ITGB1BP3 integrin beta 1 binding protein 3 0.034
TGFB3 transforming growth factor, beta 3 0.033
DSG2 desmoglein 2 0.033
CTNND1 catenin (cadherin-associated protein), delta 1 0.031
RUNX1 runt-related transcription factor 1 0.031
DMD dystrophin 0.031
ENG endoglin 0.029
GATA2 GATA binding protein 2 0.026
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.026
APC adenomatous polyposis coli 0.026
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.025
IGF2R insulin-like growth factor 2 receptor 0.024
TGFB1 transforming growth factor, beta 1 0.023
APH1A anterior pharynx defective 1 homolog A (C. elegans) 0.023
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 0.023
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 0.022
NCOR2 nuclear receptor corepressor 2 0.022
TIMP2 TIMP metallopeptidase inhibitor 2 0.020
CDK5 cyclin-dependent kinase 5 0.020
PKP4 plakophilin 4 0.020
SLC3A2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 0.018
TUBB2B tubulin, beta 2B 0.018
CSHL1 chorionic somatomammotropin hormone-like 1 0.018
ATXN1 ataxin 1 0.018
JUN jun proto-oncogene 0.016
ATF3 activating transcription factor 3 0.016
PDX1 pancreatic and duodenal homeobox 1 0.016
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.015
SORBS1 sorbin and SH3 domain containing 1 0.015
DCTN1 dynactin 1 0.014
ARHGAP22 Rho GTPase activating protein 22 0.014
TGFBR1 transforming growth factor, beta receptor 1 0.014
BTRC beta-transducin repeat containing 0.014
ARHGAP1 Rho GTPase activating protein 1 0.014
PLXNB2 plexin B2 0.014
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.013
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.013
JAG1 jagged 1 0.013
TCF4 transcription factor 4 0.012
GLIS2 GLIS family zinc finger 2 0.012
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.012
FGFR2 fibroblast growth factor receptor 2 0.012
DBP D site of albumin promoter (albumin D-box) binding protein 0.012
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.012
SH3RF1 SH3 domain containing ring finger 1 0.011
GH2 growth hormone 2 0.011
NOTCH1 notch 1 0.010
BMP2 bone morphogenetic protein 2 0.010
THBS2 thrombospondin 2 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Hr hairless 0.878
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.842
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.743
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.694
Notch1 Notch gene homolog 1 (Drosophila) 0.662
Prrx1 paired related homeobox 1 0.578
Pax3 paired box gene 3 0.553
Fgf8 fibroblast growth factor 8 0.530
Wnt3a wingless-related MMTV integration site 3A 0.507
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.485
Fgfr3 fibroblast growth factor receptor 3 0.462
Dll1 delta-like 1 (Drosophila) 0.453
Zfpm2 zinc finger protein, multitype 2 0.448
Msx1 homeobox, msh-like 1 0.442
Ctnnb1 catenin (cadherin associated protein), beta 1 0.432
Gata6 GATA binding protein 6 0.428
Fat4 FAT tumor suppressor homolog 4 (Drosophila) 0.394
Hand1 heart and neural crest derivatives expressed transcript 1 0.382
Smad3 MAD homolog 3 (Drosophila) 0.374
Ednra endothelin receptor type A 0.367
Plat plasminogen activator, tissue 0.348
Csf1 colony stimulating factor 1 (macrophage) 0.346
Plxna1 plexin A1 0.320
Stra6 stimulated by retinoic acid gene 6 0.281
Epha4 Eph receptor A4 0.275
Dsg4 desmoglein 4 0.272
Ephb2 Eph receptor B2 0.268
Wnt6 wingless-related MMTV integration site 6 0.264
Psen1 presenilin 1 0.262
Rxra retinoid X receptor alpha 0.239
Fgfr2 fibroblast growth factor receptor 2 0.238
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.222
Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 0.215
Prrx2 paired related homeobox 2 0.210
Foxc1 forkhead box C1 0.209
Dlx5 distal-less homeobox 5 0.208
Smpd3 sphingomyelin phosphodiesterase 3, neutral 0.206
Lef1 lymphoid enhancer binding factor 1 0.194
Fbn1 fibrillin 1 0.192
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.183
Pou3f3 POU domain, class 3, transcription factor 3 0.181
Apc2 adenomatosis polyposis coli 2 0.173
Lama5 laminin, alpha 5 0.171
Notch2 Notch gene homolog 2 (Drosophila) 0.170
Cav1 caveolin 1, caveolae protein 0.166
Cdx1 caudal type homeobox 1 0.163
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.161
Ptgs2 prostaglandin-endoperoxide synthase 2 0.161
Ppfia4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.161
Tacr1 tachykinin receptor 1 0.158
Unc5c unc-5 homolog C (C. elegans) 0.158
Bcl2 B-cell leukemia/lymphoma 2 0.158
Lhx1 LIM homeobox protein 1 0.156
Alx4 aristaless-like homeobox 4 0.153
Col1a1 collagen, type I, alpha 1 0.152
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.150
Gli3 GLI-Kruppel family member GLI3 0.150
Ctsl cathepsin L 0.149
Ror1 receptor tyrosine kinase-like orphan receptor 1 0.147
Epha1 Eph receptor A1 0.147
Esr1 estrogen receptor 1 (alpha) 0.144
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.143
Msx3 homeobox, msh-like 3 0.141
Dchs1 dachsous 1 (Drosophila) 0.139
Gdnf glial cell line derived neurotrophic factor 0.138
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.134
Pax8 paired box gene 8 0.133
Psen2 presenilin 2 0.133
Pnoc prepronociceptin 0.129
Sox10 SRY-box containing gene 10 0.123
Grin2d glutamate receptor, ionotropic, NMDA2D (epsilon 4) 0.118
Kit kit oncogene 0.116
Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 0.115
Fgf15 fibroblast growth factor 15 0.115
Hoxa2 homeobox A2 0.114
Thrb thyroid hormone receptor beta 0.114
Pard3 par-3 (partitioning defective 3) homolog (C. elegans) 0.114
Tal1 T-cell acute lymphocytic leukemia 1 0.113
Vegfa vascular endothelial growth factor A 0.112
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.110
Sox9 SRY-box containing gene 9 0.110
Axl AXL receptor tyrosine kinase 0.107
Zic4 zinc finger protein of the cerebellum 4 0.107
Jag2 jagged 2 0.104
Tbx3 T-box 3 0.102
Gja1 gap junction protein, alpha 1 0.101
Axin2 axin2 0.100
Tgfbr2 transforming growth factor, beta receptor II 0.099
Cux2 cut-like homeobox 2 0.098
Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 0.097
Lmx1a LIM homeobox transcription factor 1 alpha 0.097
Nos2 nitric oxide synthase 2, inducible 0.095
Eya1 eyes absent 1 homolog (Drosophila) 0.094
Ednrb endothelin receptor type B 0.094
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.094
Wnt4 wingless-related MMTV integration site 4 0.094
Odz1 odd Oz/ten-m homolog 1 (Drosophila) 0.090
Chrd chordin 0.090
Mrc2 mannose receptor, C type 2 0.090
Wnt5a wingless-related MMTV integration site 5A 0.089
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Rattus norvegicus
Name Description Probability Func Analog Organism
Kcnc2 potassium voltage gated channel, Shaw-related subfamily, member 2 0.031
Gria4 glutamate receptor, ionotrophic, AMPA 4 0.022
Cnksr2 connector enhancer of kinase suppressor of Ras 2 0.018
Pdpn podoplanin 0.018
Atp2b3 ATPase, Ca++ transporting, plasma membrane 3 0.018
Lef1 lymphoid enhancer binding factor 1 0.018
Htr2a 5-hydroxytryptamine (serotonin) receptor 2A 0.017
Cd63 Cd63 molecule 0.016
Grm7 glutamate receptor, metabotropic 7 0.016
Gfra2 GDNF family receptor alpha 2 0.016
Elk3 ELK3, ETS-domain protein 0.014
Csf3 colony stimulating factor 3 (granulocyte) 0.014
Bmp6 bone morphogenetic protein 6 0.014
Snap91 synaptosomal-associated protein 91 0.014
Eif3e eukaryotic translation initiation factor 3, subunit E 0.014
Procr protein C receptor, endothelial 0.014
Scn3a sodium channel, voltage-gated, type III, alpha 0.014
Syt7 synaptotagmin VII 0.013
Lamp2 lysosomal-associated membrane protein 2 0.013
Gipr gastric inhibitory polypeptide receptor 0.013
Stx1b syntaxin 1B 0.013
Mcpt3 mast cell peptidase 3 0.013
Tacr3 tachykinin receptor 3 0.013
Hpcal4 hippocalcin-like 4 0.013
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.013
Camkk2 calcium/calmodulin-dependent protein kinase kinase 2, beta 0.013
RT1-DOa RT1 class II, locus DOa 0.012
Robo2 roundabout homolog 2 (Drosophila) 0.012
Npr1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) 0.012
Trpc4 transient receptor potential cation channel, subfamily C, member 4 0.012
Fgl2 fibrinogen-like 2 0.012
Andpro androgen regulated protein 0.011
Prl8a2 prolactin family 8, subfamily a, member 2 0.011
Olr1701 olfactory receptor 1701 0.011
Shank1 SH3 and multiple ankyrin repeat domains 1 0.011
Tmod2 tropomodulin 2 0.011
Prdm2 PR domain containing 2, with ZNF domain 0.011
Axl Axl receptor tyrosine kinase 0.011
Scn9a sodium channel, voltage-gated, type IX, alpha 0.011
Fgf14 fibroblast growth factor 14 0.011
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.011
Arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.011
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.011
Gja6 gap junction protein, alpha 6 0.011
Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 0.011
Uncx UNC homeobox 0.011
Stc1 stanniocalcin 1 0.011
Grm8 glutamate receptor, metabotropic 8 0.011
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.011
Mrc1 mannose receptor, C type 1 0.011
Dock6 dedicator of cytokinesis 6 0.011
Oaz3 ornithine decarboxylase antizyme 3 0.010
Pcdha13 protocadherin alpha 13 0.010
Ralb v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) 0.010
Grin3a glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.010
Kcnd3 potassium voltage-gated channel, Shal-related subfamily, member 3 0.010
Wipf1 WAS/WASL interacting protein family, member 1 0.010
Igfbp3 insulin-like growth factor binding protein 3 0.010
Mca32 mast cell antigen 32 0.010
Dlg4 discs, large homolog 4 (Drosophila) 0.010
Gnb2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.010
Shox2 short stature homeobox 2 0.010
Il6 interleukin 6 0.010
Lhx1 LIM homeobox 1 0.010
Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 0.010
Pdrg1 p53 and DNA damage regulated 1 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism