The network for 'vitamin a metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

vitamin a metabolic process

The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene.

Drosophila melanogaster
Name Description Probability Func Analog Organism
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
gnat1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 0.407
gnat2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 0.298
zgc:56548 zgc:56548 0.251
rgrb retinal G protein coupled receptor b 0.151
crx cone-rod homeobox 0.147
arr3a arrestin 3a, retinal (X-arrestin) 0.093
zgc:73359 zgc:73359 0.088
pmelb premelanosome protein b 0.085
polr2d polymerase (RNA) II (DNA directed) polypeptide D 0.078
gnb3b guanine nucleotide binding protein (G protein), beta polypeptide 3b 0.059
irbp interphotoreceptor retinoid-binding protein 0.053
aldob aldolase b, fructose-bisphosphate 0.047
otx5 orthodenticle homolog 5 0.046
pp pyrophosphatase (inorganic) 0.042
hprt1 hypoxanthine phosphoribosyltransferase 1 0.036
rbp4l retinol binding protein 4, like 0.033
b2m beta-2-microglobulin 0.032
tyrp1b tyrosinase-related protein 1b 0.032
gngt1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.032
rho rhodopsin 0.031
hps1 Hermansky-Pudlak syndrome 1 0.027
m17 IL-6 subfamily cytokine M17 0.027
rlbp1a retinaldehyde binding protein 1a 0.027
syt5a synaptotagmin Va 0.025
pgrmc1 progesterone receptor membrane component 1 0.024
srd5a2a steroid-5-alpha-reductase, alpha polypeptide 2a 0.024
rcv1 recoverin 0.020
col5a3 collagen, type V, alpha 3 0.018
gpr182 G protein-coupled receptor 182 0.018
slc25a3a solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3a 0.017
gnpda1 glucosamine-6-phosphate deaminase 1 0.017
cyp3c1 cytochrome P450, family 3, subfamily c, polypeptide 1 0.017
rhoaa ras homolog gene family, member Aa 0.017
fhl2b four and a half LIM domains 2b 0.017
zgc:92116 zgc:92116 0.017
pde6c phosphodiesterase 6C, cGMP-specific, cone, alpha prime 0.016
gnrhr4 gonadotropin releasing hormone receptor 4 0.016
pklr pyruvate kinase, liver and RBC 0.016
stra6 stimulated by retinoic acid gene 6 homolog (mouse) 0.016
pah phenylalanine hydroxylase 0.016
dct dopachrome tautomerase 0.016
rdh5 retinol dehydrogenase 5 (11-cis/9-cis) 0.016
itgb1b.1 integrin, beta 1b.1 0.016
inhbb inhibin, beta B 0.015
ucp1 uncoupling protein 1 0.015
si:ch211-93f2.1 si:ch211-93f2.1 0.015
fabp11b fatty acid binding protein 11b 0.014
rdh12 retinol dehydrogenase 12 (all-trans and 9-cis) 0.014
mst1 macrophage stimulating 1 (hepatocyte growth factor-like) 0.014
rbp4 retinol binding protein 4, plasma 0.014
tsku tsukushi small leucine rich proteoglycan homolog (Xenopus laevis) 0.014
tbp TATA box binding protein 0.013
zgc:56085 zgc:56085 0.013
zgc:64161 zgc:64161 0.013
angptl3 angiopoietin-like 3 0.013
scp2 sterol carrier protein 2 0.013
ocrl oculocerebrorenal syndrome of Lowe 0.013
cyp4v2 cytochrome P450, family 4, subfamily V, polypeptide 2 0.013
ldhbb lactate dehydrogenase Bb 0.012
agxta alanine-glyoxylate aminotransferase a 0.012
zgc:85939 zgc:85939 0.012
rbp2a retinol binding protein 2a, cellular 0.011
fah fumarylacetoacetate hydrolase (fumarylacetoacetase) 0.011
arl3l2 ADP-ribosylation factor-like 3, like 2 0.011
zgc:56326 zgc:56326 0.011
bactin2 bactin2 0.011
zgc:92406 zgc:92406 0.011
s100a10a S100 calcium binding protein A10a 0.010
zgc:161979 zgc:161979 0.010
zgc:113518 zgc:113518 0.010
rlbp1b retinaldehyde binding protein 1b 0.010
sb:cb1058 sb:cb1058 0.010
nr5a5 nuclear receptor subfamily 5, group A, member 5 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Rho rhodopsin 0.960
Lhx3 LIM homeobox protein 3 0.389
Cacna1f calcium channel, voltage-dependent, alpha 1F subunit 0.375
D930020E02Rik RIKEN cDNA D930020E02 gene 0.366
Rpe65 retinal pigment epithelium 65 0.132
Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) 0.108
Gucy2e guanylate cyclase 2e 0.074
Lrat lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) 0.071
Prph2 peripherin 2 0.066
Gcm1 glial cells missing homolog 1 (Drosophila) 0.058
Pde6g phosphodiesterase 6G, cGMP-specific, rod, gamma 0.057
Pitx2 paired-like homeodomain transcription factor 2 0.053
Ppef2 protein phosphatase, EF hand calcium-binding domain 2 0.051
Rhox6 reproductive homeobox 6 0.047
Tulp1 tubby like protein 1 0.045
Tssk2 testis-specific serine kinase 2 0.044
C8b complement component 8, beta polypeptide 0.040
Smc1b structural maintenance of chromosomes 1B 0.035
Rs1 retinoschisis (X-linked, juvenile) 1 (human) 0.033
Sult1c1 sulfotransferase family, cytosolic, 1C, member 1 0.033
Azgp1 alpha-2-glycoprotein 1, zinc 0.032
C1qtnf5 C1q and tumor necrosis factor related protein 5 0.032
Best2 bestrophin 2 0.030
Grk1 G protein-coupled receptor kinase 1 0.030
Rbp3 retinol binding protein 3, interstitial 0.029
Theg testicular haploid expressed gene 0.028
Gzmm granzyme M (lymphocyte met-ase 1) 0.027
Onecut3 one cut domain, family member 3 0.026
Zfp42 zinc finger protein 42 0.026
Rgr retinal G protein coupled receptor 0.026
Ldhc lactate dehydrogenase C 0.023
AI118078 expressed sequence AI118078 0.023
Pou1f1 POU domain, class 1, transcription factor 1 0.023
Vsx2 visual system homeobox 2 0.022
Cnga3 cyclic nucleotide gated channel alpha 3 0.021
Kcnv2 potassium channel, subfamily V, member 2 0.021
Mesp1 mesoderm posterior 1 0.021
Myo7b myosin VIIB 0.021
Rbp1 retinol binding protein 1, cellular 0.021
Foxh1 forkhead box H1 0.020
Klk1b8 kallikrein 1-related peptidase b8 0.020
Nlrp6 NLR family, pyrin domain containing 6 0.020
Adam2 a disintegrin and metallopeptidase domain 2 0.019
Esx1 extraembryonic, spermatogenesis, homeobox 1 0.019
Prop1 paired like homeodomain factor 1 0.019
Nkx2-6 NK2 transcription factor related, locus 6 (Drosophila) 0.019
Avp arginine vasopressin 0.018
Rp1 retinitis pigmentosa 1 (human) 0.018
Dscaml1 Down syndrome cell adhesion molecule-like 1 0.018
Tg thyroglobulin 0.018
Speer3 spermatogenesis associated glutamate (E)-rich protein 3 0.017
Asgr2 asialoglycoprotein receptor 2 0.017
Stra6 stimulated by retinoic acid gene 6 0.017
Pax4 paired box gene 4 0.017
Hesx1 homeobox gene expressed in ES cells 0.017
Spdef SAM pointed domain containing ets transcription factor 0.017
Akp3 alkaline phosphatase 3, intestine, not Mn requiring 0.016
Etv2 ets variant gene 2 0.016
Clcnka chloride channel Ka 0.016
Abcc6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 0.016
Guca1a guanylate cyclase activator 1a (retina) 0.015
Klf17 Kruppel-like factor 17 0.015
F12 coagulation factor XII (Hageman factor) 0.015
Apom apolipoprotein M 0.014
Psca prostate stem cell antigen 0.014
Lrriq4 leucine-rich repeats and IQ motif containing 4 0.014
Stag3 stromal antigen 3 0.014
Sag retinal S-antigen 0.013
Ctrc chymotrypsin C (caldecrin) 0.013
Naa11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 0.013
Klk1b1 kallikrein 1-related peptidase b1 0.013
Esrrb estrogen related receptor, beta 0.013
Il13 interleukin 13 0.013
Msx2 homeobox, msh-like 2 0.013
Crtam cytotoxic and regulatory T cell molecule 0.013
Cd46 CD46 antigen, complement regulatory protein 0.013
Cga glycoprotein hormones, alpha subunit 0.013
Mbl2 mannose-binding lectin (protein C) 2 0.012
F2 coagulation factor II 0.012
Ang2 angiogenin, ribonuclease A family, member 2 0.012
Soat2 sterol O-acyltransferase 2 0.012
Cdhr5 cadherin-related family member 5 0.012
Gckr glucokinase regulatory protein 0.012
Tsx testis specific X-linked gene 0.012
Pcp2 Purkinje cell protein 2 (L7) 0.012
Pde6c phosphodiesterase 6C, cGMP specific, cone, alpha prime 0.012
BC100451 cDNA sequence BC100451 0.012
Phlda2 pleckstrin homology-like domain, family A, member 2 0.012
Stk30 serine/threonine kinase 30 0.012
Thrb thyroid hormone receptor beta 0.012
Hao1 hydroxyacid oxidase 1, liver 0.012
Cuzd1 CUB and zona pellucida-like domains 1 0.012
Guca2b guanylate cyclase activator 2b (retina) 0.011
Mep1b meprin 1 beta 0.011
Lhx4 LIM homeobox protein 4 0.011
Bmp8b bone morphogenetic protein 8b 0.011
Gsc goosecoid homeobox 0.011
Galr2 galanin receptor 2 0.011
Treh trehalase (brush-border membrane glycoprotein) 0.011
Lrrc46 leucine rich repeat containing 46 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ppara peroxisome proliferator activated receptor alpha 0.716
Fgf1 fibroblast growth factor 1 0.342
Ceacam1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.341
Foxe3 forkhead box E3 0.321
Foxe1 forkhead box E1 (thyroid transcription factor 2) 0.244
P2ry4 pyrimidinergic receptor P2Y, G-protein coupled, 4 0.225
Mef2d myocyte enhancer factor 2D 0.198
Acot12 acyl-CoA thioesterase 12 0.197
Ptprh protein tyrosine phosphatase, receptor type, H 0.168
Hnf4a hepatocyte nuclear factor 4, alpha 0.166
Slc22a1 solute carrier family 22 (organic cation transporter), member 1 0.162
Synpo synaptopodin 0.129
Trib1 tribbles homolog 1 (Drosophila) 0.124
Crybb1 crystallin, beta B1 0.119
Slc23a1 solute carrier family 23 (nucleobase transporters), member 1 0.115
Il1r1 interleukin 1 receptor, type I 0.110
Cda cytidine deaminase 0.103
Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 0.102
Gja5 gap junction protein, alpha 5 0.091
Ugt2a1 UDP glucuronosyltransferase 2 family, polypeptide A1 0.079
Fcer2 Fc fragment of IgE, low affinity II, receptor for (CD23) 0.059
Acox2 acyl-Coenzyme A oxidase 2, branched chain 0.056
Pou3f2 POU class 3 homeobox 2 0.056
Nr1i2 nuclear receptor subfamily 1, group I, member 2 0.055
Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 0.055
Dhdpsl dihydrodipicolinate synthase-like, mitochondrial 0.053
Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 0.048
Mucdhl mucin and cadherin like 0.045
Apoa5 apolipoprotein A-V 0.044
Naaladl1 N-acetylated alpha-linked acidic dipeptidase-like 1 0.044
Vdr vitamin D (1,25- dihydroxyvitamin D3) receptor 0.041
Xpnpep2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 0.041
Sult1b1 sulfotransferase family, cytosolic, 1B, member 1 0.040
Igfals insulin-like growth factor binding protein, acid labile subunit 0.040
Mlxipl MLX interacting protein-like 0.039
Pdk4 pyruvate dehydrogenase kinase, isozyme 4 0.039
Tpo thyroid peroxidase 0.039
F2rl1 coagulation factor II (thrombin) receptor-like 1 0.037
Bcl2l2 Bcl2-like 2 0.037
A1cf APOBEC1 complementation factor 0.037
Clcn5 chloride channel 5 0.035
Hipk3 homeodomain interacting protein kinase 3 0.035
Hnf1b HNF1 homeobox B 0.033
Cldn7 claudin 7 0.033
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.033
Scn5a sodium channel, voltage-gated, type V, alpha subunit 0.032
Bche butyrylcholinesterase 0.032
Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 0.031
Dao D-amino-acid oxidase 0.031
Mettl7b methyltransferase like 7B 0.029
Abcc6 ATP-binding cassette, subfamily C (CFTR/MRP), member 6 0.029
Nmu neuromedin U 0.029
Ces1c carboxylesterase 1C 0.028
Hrg histidine-rich glycoprotein 0.028
Tas2r118 taste receptor, type 2, member 118 0.028
Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 0.028
Tef thyrotrophic embryonic factor 0.028
Zbp1 Z-DNA binding protein 1 0.027
Ush1c Usher syndrome 1C homolog (human) 0.027
Fosl2 fos-like antigen 2 0.026
Tff3 trefoil factor 3, intestinal 0.026
Ehhadh enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase 0.026
Rdh2 retinol dehydrogenase 2 0.025
Crp C-reactive protein, pentraxin-related 0.024
Pitx3 paired-like homeodomain 3 0.024
Abcb11 ATP-binding cassette, subfamily B (MDR/TAP), member 11 0.023
Slc5a1 solute carrier family 5 (sodium/glucose cotransporter), member 1 0.023
Mstn myostatin 0.022
Ppy pancreatic polypeptide 0.022
Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 0.021
Pdp2 pyruvate dehyrogenase phosphatase catalytic subunit 2 0.021
Espn espin 0.021
Ppard peroxisome proliferator-activated receptor delta 0.021
RGD1304644 similar to RIKEN cDNA 2310046K01 0.021
Acox3 acyl-Coenzyme A oxidase 3, pristanoyl 0.020
Fdxr ferredoxin reductase 0.020
Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 0.019
Olr1362 olfactory receptor 1362 0.019
Foxa3 forkhead box A3 0.019
Gucy2e guanylate cyclase 2E 0.019
Galnt5 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5) 0.018
Cox8b cytochrome c oxidase, subunit VIIIb 0.018
Acacb acetyl-Coenzyme A carboxylase beta 0.018
Galnt10 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) 0.018
Sult1e1 sulfotransferase family 1E, estrogen-preferring, member 1 0.018
Smad6 SMAD family member 6 0.018
Cdh17 cadherin 17 0.018
Aqp7 aquaporin 7 0.018
Drd4 dopamine receptor D4 0.018
Nr5a2 nuclear receptor subfamily 5, group A, member 2 0.017
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.017
Thrb thyroid hormone receptor beta 0.017
RGD1306750 LOC362451 0.017
Edn2 endothelin 2 0.017
Nr1i3 nuclear receptor subfamily 1, group I, member 3 0.016
Sdcbp2 syndecan binding protein (syntenin) 2 0.016
LOC100360169 rCG21044-like 0.016
Pla2g2c phospholipase A2, group IIC 0.016
Serpina3m serine (or cysteine) proteinase inhibitor, clade A, member 3M 0.016
UST4r integral membrane transport protein UST4r 0.016
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism