The network for 'negative regulation of lymphocyte activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of lymphocyte activation

Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation.

Drosophila melanogaster
Name Description Probability Func Analog Organism
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
B2M beta-2-microglobulin 0.749
CD80 CD80 molecule 0.500
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.302
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.298
HLA-F major histocompatibility complex, class I, F 0.279
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.245
HLA-G major histocompatibility complex, class I, G 0.244
HLA-B major histocompatibility complex, class I, B 0.240
BIRC3 baculoviral IAP repeat containing 3 0.216
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.196
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.193
HLA-A major histocompatibility complex, class I, A 0.150
HLA-DRA major histocompatibility complex, class II, DR alpha 0.148
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.119
BMPR1A bone morphogenetic protein receptor, type IA 0.100
HLA-DMA major histocompatibility complex, class II, DM alpha 0.098
CCR5 chemokine (C-C motif) receptor 5 0.084
PILRA paired immunoglobin-like type 2 receptor alpha 0.082
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.070
HLA-DMB major histocompatibility complex, class II, DM beta 0.068
HLA-E major histocompatibility complex, class I, E 0.065
HLA-C major histocompatibility complex, class I, C 0.063
CD86 CD86 molecule 0.055
CCL4 chemokine (C-C motif) ligand 4 0.055
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.054
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.049
POU3F2 POU class 3 homeobox 2 0.044
GAS6 growth arrest-specific 6 0.040
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.039
IL10 interleukin 10 0.039
CXCL9 chemokine (C-X-C motif) ligand 9 0.038
CD247 CD247 molecule 0.036
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.035
SLAMF1 signaling lymphocytic activation molecule family member 1 0.035
CCR1 chemokine (C-C motif) receptor 1 0.033
IL10RA interleukin 10 receptor, alpha 0.033
UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.032
BTN3A3 butyrophilin, subfamily 3, member A3 0.030
DPP4 dipeptidyl-peptidase 4 0.030
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.030
IL2RG interleukin 2 receptor, gamma 0.030
BTN3A1 butyrophilin, subfamily 3, member A1 0.029
GHR growth hormone receptor 0.029
FSTL1 follistatin-like 1 0.028
CSK c-src tyrosine kinase 0.028
ADAM17 ADAM metallopeptidase domain 17 0.028
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.028
CFLAR CASP8 and FADD-like apoptosis regulator 0.027
IL22RA2 interleukin 22 receptor, alpha 2 0.027
ICAM1 intercellular adhesion molecule 1 0.027
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.026
CCL8 chemokine (C-C motif) ligand 8 0.025
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.025
IL4R interleukin 4 receptor 0.025
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.024
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.024
BTN3A2 butyrophilin, subfamily 3, member A2 0.024
TFF1 trefoil factor 1 0.022
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.022
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.022
CCL2 chemokine (C-C motif) ligand 2 0.021
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.021
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.020
APAF1 apoptotic peptidase activating factor 1 0.019
IL6 interleukin 6 (interferon, beta 2) 0.019
IL15RA interleukin 15 receptor, alpha 0.019
IL4 interleukin 4 0.019
PBK PDZ binding kinase 0.019
EPOR erythropoietin receptor 0.019
CXCL10 chemokine (C-X-C motif) ligand 10 0.019
CCL13 chemokine (C-C motif) ligand 13 0.019
PAX3 paired box 3 0.018
CCR7 chemokine (C-C motif) receptor 7 0.018
SOCS1 suppressor of cytokine signaling 1 0.018
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.017
FASLG Fas ligand (TNF superfamily, member 6) 0.017
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.017
IL8 interleukin 8 0.017
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.017
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.017
THOC5 THO complex 5 0.016
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.016
LAT linker for activation of T cells 0.016
IFNG interferon, gamma 0.016
IL1B interleukin 1, beta 0.016
IL22RA1 interleukin 22 receptor, alpha 1 0.016
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.016
CD40 CD40 molecule, TNF receptor superfamily member 5 0.016
CCR4 chemokine (C-C motif) receptor 4 0.016
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.015
TNF tumor necrosis factor 0.015
CD33 CD33 molecule 0.015
HK3 hexokinase 3 (white cell) 0.015
ENG endoglin 0.014
SIGLEC7 sialic acid binding Ig-like lectin 7 0.014
SMAD7 SMAD family member 7 0.014
CD28 CD28 molecule 0.014
GAB1 GRB2-associated binding protein 1 0.014
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.014
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.014
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Mus musculus
Name Description Probability Func Analog Organism
Stat3 signal transducer and activator of transcription 3 0.931
Axl AXL receptor tyrosine kinase 0.917
Foxp3 forkhead box P3 0.912
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.875
Nf1 neurofibromatosis 1 0.865
Was Wiskott-Aldrich syndrome homolog (human) 0.847
Rc3h1 RING CCCH (C3H) domains 1 0.835
Zeb1 zinc finger E-box binding homeobox 1 0.822
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.821
Prf1 perforin 1 (pore forming protein) 0.791
Id3 inhibitor of DNA binding 3 0.761
H2-Aa histocompatibility 2, class II antigen A, alpha 0.757
Vangl2 vang-like 2 (van gogh, Drosophila) 0.746
Rb1 retinoblastoma 1 0.745
Plcg1 phospholipase C, gamma 1 0.737
Cbl Casitas B-lineage lymphoma 0.728
Pdcd1 programmed cell death 1 0.723
Cd19 CD19 antigen 0.711
Traf6 TNF receptor-associated factor 6 0.684
Id1 inhibitor of DNA binding 1 0.669
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.661
Cd40 CD40 antigen 0.658
Gli2 GLI-Kruppel family member GLI2 0.648
Sfrp2 secreted frizzled-related protein 2 0.625
Tnip1 TNFAIP3 interacting protein 1 0.599
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.592
Il10 interleukin 10 0.573
Myd88 myeloid differentiation primary response gene 88 0.570
Dlg4 discs, large homolog 4 (Drosophila) 0.565
Ccr7 chemokine (C-C motif) receptor 7 0.563
Irf1 interferon regulatory factor 1 0.541
Cd80 CD80 antigen 0.539
Clec4e C-type lectin domain family 4, member e 0.513
Mdm2 transformed mouse 3T3 cell double minute 2 0.512
Stat6 signal transducer and activator of transcription 6 0.508
Nlrp3 NLR family, pyrin domain containing 3 0.506
Casp8 caspase 8 0.505
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.498
Pten phosphatase and tensin homolog 0.492
Meox2 mesenchyme homeobox 2 0.477
Cd28 CD28 antigen 0.477
Ptch1 patched homolog 1 0.472
C1qb complement component 1, q subcomponent, beta polypeptide 0.468
Aire autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) 0.453
Igh immunoglobulin heavy chain complex 0.448
Prkcd protein kinase C, delta 0.439
Traf2 TNF receptor-associated factor 2 0.427
Fyn Fyn proto-oncogene 0.423
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.423
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.403
Ccl24 chemokine (C-C motif) ligand 24 0.402
Bcl3 B-cell leukemia/lymphoma 3 0.392
Ikbkg inhibitor of kappaB kinase gamma 0.383
Fgf10 fibroblast growth factor 10 0.381
Ifng interferon gamma 0.380
Itsn1 intersectin 1 (SH3 domain protein 1A) 0.372
Hif1a hypoxia inducible factor 1, alpha subunit 0.362
Kdr kinase insert domain protein receptor 0.361
Il2rb interleukin 2 receptor, beta chain 0.360
Foxc1 forkhead box C1 0.357
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.352
Jak2 Janus kinase 2 0.348
Vegfa vascular endothelial growth factor A 0.345
Lyz2 lysozyme 2 0.338
Ifnb1 interferon beta 1, fibroblast 0.338
Tyro3 TYRO3 protein tyrosine kinase 3 0.338
Pou2af1 POU domain, class 2, associating factor 1 0.335
Stat5a signal transducer and activator of transcription 5A 0.321
Kitl kit ligand 0.314
Itgb2 integrin beta 2 0.312
Ciita class II transactivator 0.312
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.303
Cd4 CD4 antigen 0.297
Rbl1 retinoblastoma-like 1 (p107) 0.297
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.296
Fasl Fas ligand (TNF superfamily, member 6) 0.291
Stat2 signal transducer and activator of transcription 2 0.290
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.286
Tcirg1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 0.280
Spib Spi-B transcription factor (Spi-1/PU.1 related) 0.277
Gli3 GLI-Kruppel family member GLI3 0.276
Il10ra interleukin 10 receptor, alpha 0.275
Hhex hematopoietically expressed homeobox 0.271
Mefv Mediterranean fever 0.270
Pax3 paired box gene 3 0.270
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.267
Fgfr2 fibroblast growth factor receptor 2 0.267
Il27ra interleukin 27 receptor, alpha 0.265
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.261
Il6st interleukin 6 signal transducer 0.255
Sprr2k small proline-rich protein 2K 0.254
Irf8 interferon regulatory factor 8 0.242
C3ar1 complement component 3a receptor 1 0.241
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.240
Dlg1 discs, large homolog 1 (Drosophila) 0.237
Fas Fas (TNF receptor superfamily member 6) 0.225
Flt4 FMS-like tyrosine kinase 4 0.225
Ticam1 toll-like receptor adaptor molecule 1 0.223
Grb2 growth factor receptor bound protein 2 0.219
Ccl22 chemokine (C-C motif) ligand 22 0.218
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-Db1 RT1 class II, locus Db1 0.947
RT1-Da RT1 class II, locus Da 0.940
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.930
RT1-Ba RT1 class II, locus Ba 0.887
RT1-Bb RT1 class II, locus Bb 0.616
RT1-DMb RT1 class II, locus DMb 0.591
Cd37 CD37 molecule 0.073
Cd2 Cd2 molecule 0.063
RT1-DMa RT1 class II, locus DMa 0.062
Pld4 phospholipase D family, member 4 0.048
Lyz2 lysozyme 2 0.034
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.026
Fgfr2 fibroblast growth factor receptor 2 0.025
Aif1 allograft inflammatory factor 1 0.018
C1qb complement component 1, q subcomponent, B chain 0.017
Scamp2 secretory carrier membrane protein 2 0.017
Inpp5d inositol polyphosphate-5-phosphatase D 0.016
C1qc complement component 1, q subcomponent, C chain 0.013
Laptm5 lysosomal protein transmembrane 5 0.013
Top1 topoisomerase (DNA) I 0.013
Slc15a3 solute carrier family 15, member 3 0.013
Lcp1 lymphocyte cytosolic protein 1 0.011
Il2rg interleukin 2 receptor, gamma 0.010
Cd3d CD3 molecule, delta 0.010
Prkch protein kinase C, eta 0.010
Alox5ap arachidonate 5-lipoxygenase activating protein 0.010
Aebp1 AE binding protein 1 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism