IMP
Process View
The network for 'spinal cord motor neuron differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
spinal cord motor neuron differentiation
The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.
| Name | Description | Probability | Func Analog Organism |
|---|
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Danio rerio
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| tbx2b | T-box 2b | 0.952 | |
| gli2a | GLI-Kruppel family member GLI2a | 0.938 | |
| prdm1a | PR domain containing 1a, with ZNF domain | 0.924 | |
| shha | sonic hedgehog a | 0.900 | |
| pax6a | paired box gene 6a | 0.871 | |
| nkx2.2a | NK2 transcription factor related 2a | 0.869 | |
| olig2 | oligodendrocyte lineage transcription factor 2 | 0.831 | |
| isl1 | islet1 | 0.788 | |
| dla | deltaA | 0.741 | |
| notch1a | notch homolog 1a | 0.721 | |
| ascl1a | achaete-scute complex-like 1a (Drosophila) | 0.720 | |
| dld | deltaD | 0.685 | |
| dcc | deleted in colorectal carcinoma | 0.653 | |
| pax2a | paired box gene 2a | 0.572 | |
| eya1 | eyes absent homolog 1 | 0.475 | |
| rx3 | retinal homeobox gene 3 | 0.430 | |
| tbx1 | T-box 1 | 0.426 | |
| tll1 | tolloid-like 1 | 0.408 | |
| lhx5 | LIM homeobox 5 | 0.392 | |
| otx2 | orthodenticle homolog 2 | 0.368 | |
| lhx2b | LIM homeobox 2b | 0.350 | |
| hnf1ba | HNF1 homeobox Ba | 0.319 | |
| mnx1 | motor neuron and pancreas homeobox 1 | 0.313 | |
| tbx16 | T-box gene 16 | 0.308 | |
| ntla | no tail a | 0.308 | |
| fgf3 | fibroblast growth factor 3 | 0.300 | |
| cdx4 | caudal type homeo box transcription factor 4 | 0.295 | |
| ndr2 | nodal-related 2 | 0.281 | |
| flh | floating head | 0.271 | |
| chd | chordin | 0.257 | |
| trpm7 | transient receptor potential cation channel, subfamily M, member 7 | 0.252 | |
| gata2a | GATA-binding protein 2a | 0.245 | |
| mib | mind bomb | 0.235 | |
| gbx1 | gastrulation brain homeobox 1 | 0.234 | |
| fgf10a | fibroblast growth factor 10a | 0.230 | |
| jag1b | jagged 1b | 0.228 | |
| hoxd11a | homeo box D11a | 0.228 | |
| hlxb9lb | homeo box HB9 like b | 0.222 | |
| meis3 | myeloid ecotropic viral integration site 3 | 0.213 | |
| hlxb9la | homeo box HB9 like a | 0.203 | |
| barhl2 | BarH-like 2 | 0.196 | |
| tbx20 | T-box 20 | 0.193 | |
| isl2a | islet2a | 0.191 | |
| dlb | deltaB | 0.191 | |
| chrna6 | cholinergic receptor, nicotinic, alpha 6 | 0.182 | |
| fn1 | fibronectin 1 | 0.171 | |
| sox10 | SRY-box containing gene 10 | 0.170 | |
| dlx6a | distal-less homeobox gene 6a | 0.165 | |
| olig4 | oligodendrocyte transcription factor 4 | 0.161 | |
| foxp2 | forkhead box P2 | 0.152 | |
| ptch1 | patched 1 | 0.151 | |
| tfap2a | transcription factor AP-2 alpha | 0.143 | |
| inab | internexin neuronal intermediate filament protein, alpha b | 0.141 | |
| tal2 | T-cell acute lymphocytic leukemia 2 | 0.141 | |
| her7 | hairy and enhancer of split related-7 | 0.136 | |
| apc | adenomatosis polyposis coli | 0.136 | |
| pou5f1 | POU domain, class 5, transcription factor 1 | 0.134 | |
| lhx1a | LIM homeobox 1a | 0.132 | |
| sox32 | SRY-box containing gene 32 | 0.127 | |
| tbx5a | T-box 5a | 0.127 | |
| evx1 | even-skipped homeobox 1 | 0.120 | |
| foxd3 | forkhead box D3 | 0.120 | |
| ascl1b | achaete-scute complex-like 1b (Drosophila) | 0.120 | |
| foxa1 | forkhead box A1 | 0.119 | |
| lhx3 | LIM homeobox 3 | 0.117 | |
| eng2b | engrailed 2b | 0.115 | |
| neurog1 | neurogenin 1 | 0.114 | |
| irx4b | iroquois homeobox protein 4b | 0.111 | |
| irx1b | iroquois homeobox protein 1, b | 0.111 | |
| nr2e1 | nuclear receptor subfamily 2, group E, member 1 | 0.111 | |
| vsx1 | visual system homeobox 1 homolog, chx10-like | 0.105 | |
| six3a | sine oculis homeobox homolog 3a | 0.103 | |
| osr2 | odd-skipped related 2 (Drosophila) | 0.100 | |
| hoxa9b | homeo box A9b | 0.097 | |
| ptch2 | patched 2 | 0.094 | |
| drd2a | dopamine receptor D2a | 0.093 | |
| prickle1b | prickle homolog 1 (Drosophila) b | 0.093 | |
| nkx1.2la | NK1 transcription factor related 2-like,a | 0.092 | |
| dlx2a | distal-less homeobox gene 2a | 0.092 | |
| foxg1a | forkhead box G1a | 0.090 | |
| fzd5 | frizzled homolog 5 | 0.087 | |
| traf4a | tnf receptor-associated factor 4a | 0.086 | |
| foxa2 | forkhead box A2 | 0.086 | |
| hoxd12a | homeo box D12a | 0.086 | |
| hoxa13b | homeo box A13b | 0.085 | |
| gata3 | GATA-binding protein 3 | 0.082 | |
| fezf2 | FEZ family zinc finger 2 | 0.081 | |
| irx4a | iroquois homeobox protein 4a | 0.080 | |
| vsx2 | visual system homeobox 2 | 0.080 | |
| otpb | orthopedia homolog b | 0.077 | |
| wnt2ba | wingless-type MMTV integration site family, member 2Ba | 0.073 | |
| gata6 | GATA-binding protein 6 | 0.069 | |
| runx1 | runt-related transcription factor 1 | 0.069 | |
| pcdh18b | protocadherin 18b | 0.066 | |
| adcyap1r1 | adenylate cyclase activating polypeptide 1 (pituitary) receptor type I | 0.064 | |
| onecut1 | one cut domain, family member 1 | 0.063 | |
| fgf20a | fibroblast growth factor 20a | 0.063 | |
| gfra1b | gdnf family receptor alpha 1b | 0.061 | |
| gli1 | GLI-Kruppel family member 1 | 0.061 | |
| mpp5a | membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a) | 0.060 |
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Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Shh | sonic hedgehog | 1.000 | |
| Otx2 | orthodenticle homolog 2 (Drosophila) | 1.000 | |
| Gli3 | GLI-Kruppel family member GLI3 | 1.000 | |
| Pax3 | paired box gene 3 | 1.000 | |
| Fgfr2 | fibroblast growth factor receptor 2 | 0.999 | |
| Pax6 | paired box gene 6 | 0.999 | |
| Msx1 | homeobox, msh-like 1 | 0.999 | |
| Foxg1 | forkhead box G1 | 0.998 | |
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 0.998 | |
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.998 | |
| Gli2 | GLI-Kruppel family member GLI2 | 0.997 | |
| Sox2 | SRY-box containing gene 2 | 0.997 | |
| Pax2 | paired box gene 2 | 0.996 | |
| Pitx1 | paired-like homeodomain transcription factor 1 | 0.995 | |
| Pitx2 | paired-like homeodomain transcription factor 2 | 0.994 | |
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 0.994 | |
| Chrd | chordin | 0.990 | |
| Eya1 | eyes absent 1 homolog (Drosophila) | 0.990 | |
| Nkx2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 0.989 | |
| Fgfr1 | fibroblast growth factor receptor 1 | 0.983 | |
| Ptch1 | patched homolog 1 | 0.982 | |
| Prrx1 | paired related homeobox 1 | 0.981 | |
| Sox9 | SRY-box containing gene 9 | 0.980 | |
| Emx1 | empty spiracles homolog 1 (Drosophila) | 0.980 | |
| Fgf8 | fibroblast growth factor 8 | 0.980 | |
| Sox11 | SRY-box containing gene 11 | 0.976 | |
| Hand2 | heart and neural crest derivatives expressed transcript 2 | 0.975 | |
| Emx2 | empty spiracles homolog 2 (Drosophila) | 0.973 | |
| Dlx5 | distal-less homeobox 5 | 0.971 | |
| Tcfap2a | transcription factor AP-2, alpha | 0.969 | |
| Foxc1 | forkhead box C1 | 0.967 | |
| Foxc2 | forkhead box C2 | 0.962 | |
| Nog | noggin | 0.950 | |
| Gbx2 | gastrulation brain homeobox 2 | 0.949 | |
| Bmp4 | bone morphogenetic protein 4 | 0.942 | |
| Tbx1 | T-box 1 | 0.937 | |
| Meox2 | mesenchyme homeobox 2 | 0.929 | |
| Tbx3 | T-box 3 | 0.915 | |
| Chd7 | chromodomain helicase DNA binding protein 7 | 0.882 | |
| Fgf10 | fibroblast growth factor 10 | 0.854 | |
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.841 | |
| Phox2b | paired-like homeobox 2b | 0.806 | |
| Vangl2 | vang-like 2 (van gogh, Drosophila) | 0.803 | |
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.788 | |
| Nodal | nodal | 0.783 | |
| Alx4 | aristaless-like homeobox 4 | 0.775 | |
| Hoxd10 | homeobox D10 | 0.770 | |
| Hes1 | hairy and enhancer of split 1 (Drosophila) | 0.764 | |
| Bmp7 | bone morphogenetic protein 7 | 0.762 | |
| Nkx2-2 | NK2 transcription factor related, locus 2 (Drosophila) | 0.745 | |
| Jag1 | jagged 1 | 0.731 | |
| Hoxa10 | homeobox A10 | 0.731 | |
| Wt1 | Wilms tumor 1 homolog | 0.720 | |
| Pbx1 | pre B-cell leukemia transcription factor 1 | 0.710 | |
| Fgf3 | fibroblast growth factor 3 | 0.708 | |
| Lhx3 | LIM homeobox protein 3 | 0.691 | |
| Ret | ret proto-oncogene | 0.680 | |
| En1 | engrailed 1 | 0.676 | |
| Nr5a1 | nuclear receptor subfamily 5, group A, member 1 | 0.672 | |
| Hes5 | hairy and enhancer of split 5 (Drosophila) | 0.669 | |
| Ascl1 | achaete-scute complex homolog 1 (Drosophila) | 0.667 | |
| Smo | smoothened homolog (Drosophila) | 0.648 | |
| Hoxd3 | homeobox D3 | 0.647 | |
| Insm1 | insulinoma-associated 1 | 0.639 | |
| Six4 | sine oculis-related homeobox 4 homolog (Drosophila) | 0.636 | |
| Lhx1 | LIM homeobox protein 1 | 0.625 | |
| Mks1 | Meckel syndrome, type 1 | 0.597 | |
| Mycn | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.596 | |
| Hoxa1 | homeobox A1 | 0.591 | |
| Neurog2 | neurogenin 2 | 0.573 | |
| Uncx | UNC homeobox | 0.555 | |
| Fgfr3 | fibroblast growth factor receptor 3 | 0.540 | |
| Dll1 | delta-like 1 (Drosophila) | 0.533 | |
| Msx2 | homeobox, msh-like 2 | 0.515 | |
| Otx1 | orthodenticle homolog 1 (Drosophila) | 0.514 | |
| Gsc | goosecoid homeobox | 0.506 | |
| Pdgfra | platelet derived growth factor receptor, alpha polypeptide | 0.504 | |
| Sall4 | sal-like 4 (Drosophila) | 0.503 | |
| Hoxd9 | homeobox D9 | 0.479 | |
| Hoxc4 | homeobox C4 | 0.476 | |
| En2 | engrailed 2 | 0.468 | |
| Sox3 | SRY-box containing gene 3 | 0.461 | |
| Ddx60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.446 | |
| Tlx3 | T-cell leukemia, homeobox 3 | 0.444 | |
| Tcf15 | transcription factor 15 | 0.432 | |
| Hoxa11 | homeobox A11 | 0.421 | |
| Zic3 | zinc finger protein of the cerebellum 3 | 0.411 | |
| Gata3 | GATA binding protein 3 | 0.409 | |
| Hoxa9 | homeobox A9 | 0.408 | |
| Hoxd13 | homeobox D13 | 0.407 | |
| Sox17 | SRY-box containing gene 17 | 0.395 | |
| Tbx15 | T-box 15 | 0.384 | |
| Hoxc6 | homeobox C6 | 0.375 | |
| Wnt6 | wingless-related MMTV integration site 6 | 0.361 | |
| Dll4 | delta-like 4 (Drosophila) | 0.361 | |
| Ptf1a | pancreas specific transcription factor, 1a | 0.356 | |
| Bdnf | brain derived neurotrophic factor | 0.348 | |
| Gata4 | GATA binding protein 4 | 0.344 | |
| Grb10 | growth factor receptor bound protein 10 | 0.333 | |
| Rbpj | recombination signal binding protein for immunoglobulin kappa J region | 0.330 |