IMP
Process View
The network for 't cell costimulation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
t cell costimulation
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.
| Name | Description | Probability | Func Analog Organism |
|---|
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Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| CTLA4 | cytotoxic T-lymphocyte-associated protein 4 | 0.713 | |
| LCK | lymphocyte-specific protein tyrosine kinase | 0.096 | |
| ZAP70 | zeta-chain (TCR) associated protein kinase 70kDa | 0.091 | |
| CD247 | CD247 molecule | 0.040 | |
| CD6 | CD6 molecule | 0.038 | |
| CD80 | CD80 molecule | 0.037 | |
| BCL10 | B-cell CLL/lymphoma 10 | 0.037 | |
| EGFR | epidermal growth factor receptor | 0.025 | |
| BTN2A2 | butyrophilin, subfamily 2, member A2 | 0.024 | |
| SYK | spleen tyrosine kinase | 0.024 | |
| GRAP2 | GRB2-related adaptor protein 2 | 0.022 | |
| HLA-F | major histocompatibility complex, class I, F | 0.022 | |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | 0.020 | |
| PTPN22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | 0.018 | |
| PTPRC | protein tyrosine phosphatase, receptor type, C | 0.016 | |
| LAT | linker for activation of T cells | 0.016 | |
| PRKCDBP | protein kinase C, delta binding protein | 0.013 | |
| TGIF1 | TGFB-induced factor homeobox 1 | 0.013 | |
| CD3G | CD3g molecule, gamma (CD3-TCR complex) | 0.012 | |
| MALT1 | mucosa associated lymphoid tissue lymphoma translocation gene 1 | 0.012 | |
| CCL22 | chemokine (C-C motif) ligand 22 | 0.010 |
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Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Icos | inducible T-cell co-stimulator | 0.959 | |
| Ifng | interferon gamma | 0.916 | |
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.878 | |
| Il4 | interleukin 4 | 0.817 | |
| Pdcd1 | programmed cell death 1 | 0.795 | |
| Ltb | lymphotoxin B | 0.600 | |
| Cd7 | CD7 antigen | 0.560 | |
| Lta | lymphotoxin A | 0.552 | |
| Cxcr5 | chemokine (C-X-C motif) receptor 5 | 0.499 | |
| Cd40 | CD40 antigen | 0.434 | |
| Ccl3 | chemokine (C-C motif) ligand 3 | 0.433 | |
| Tnfrsf4 | tumor necrosis factor receptor superfamily, member 4 | 0.426 | |
| Fasl | Fas ligand (TNF superfamily, member 6) | 0.414 | |
| Klrg1 | killer cell lectin-like receptor subfamily G, member 1 | 0.403 | |
| Cd28 | CD28 antigen | 0.376 | |
| Cd6 | CD6 antigen | 0.357 | |
| Cxcl13 | chemokine (C-X-C motif) ligand 13 | 0.335 | |
| Cd3g | CD3 antigen, gamma polypeptide | 0.317 | |
| Socs1 | suppressor of cytokine signaling 1 | 0.303 | |
| Ccr5 | chemokine (C-C motif) receptor 5 | 0.300 | |
| Tbx21 | T-box 21 | 0.287 | |
| Sh2d2a | SH2 domain protein 2A | 0.283 | |
| Cd3d | CD3 antigen, delta polypeptide | 0.269 | |
| Cxcr3 | chemokine (C-X-C motif) receptor 3 | 0.264 | |
| Ccr2 | chemokine (C-C motif) receptor 2 | 0.263 | |
| Map3k14 | mitogen-activated protein kinase kinase kinase 14 | 0.256 | |
| Cd4 | CD4 antigen | 0.230 | |
| Il1b | interleukin 1 beta | 0.225 | |
| Batf | basic leucine zipper transcription factor, ATF-like | 0.222 | |
| Cd5 | CD5 antigen | 0.196 | |
| Cd8a | CD8 antigen, alpha chain | 0.193 | |
| Ubd | ubiquitin D | 0.191 | |
| Ccl7 | chemokine (C-C motif) ligand 7 | 0.185 | |
| Gzma | granzyme A | 0.185 | |
| Ctla4 | cytotoxic T-lymphocyte-associated protein 4 | 0.180 | |
| Gzmb | granzyme B | 0.179 | |
| Ikzf1 | IKAROS family zinc finger 1 | 0.173 | |
| Cd2 | CD2 antigen | 0.172 | |
| Sh2d1a | SH2 domain protein 1A | 0.170 | |
| Ccl8 | chemokine (C-C motif) ligand 8 | 0.166 | |
| Fas | Fas (TNF receptor superfamily member 6) | 0.157 | |
| Itk | IL2-inducible T-cell kinase | 0.152 | |
| Folr2 | folate receptor 2 (fetal) | 0.152 | |
| Ctsw | cathepsin W | 0.147 | |
| Igh | immunoglobulin heavy chain complex | 0.142 | |
| Klrk1 | killer cell lectin-like receptor subfamily K, member 1 | 0.138 | |
| Cd19 | CD19 antigen | 0.131 | |
| Cd96 | CD96 antigen | 0.122 | |
| Ccl4 | chemokine (C-C motif) ligand 4 | 0.119 | |
| Cd8b1 | CD8 antigen, beta chain 1 | 0.118 | |
| Sit1 | suppression inducing transmembrane adaptor 1 | 0.117 | |
| Tnfrsf9 | tumor necrosis factor receptor superfamily, member 9 | 0.114 | |
| Itgax | integrin alpha X | 0.110 | |
| Cd3e | CD3 antigen, epsilon polypeptide | 0.106 | |
| C3ar1 | complement component 3a receptor 1 | 0.100 | |
| S100a4 | S100 calcium binding protein A4 | 0.098 | |
| Ccr1 | chemokine (C-C motif) receptor 1 | 0.094 | |
| Pou2af1 | POU domain, class 2, associating factor 1 | 0.093 | |
| Gimap7 | GTPase, IMAP family member 7 | 0.091 | |
| Cd160 | CD160 antigen | 0.084 | |
| Tnf | tumor necrosis factor | 0.084 | |
| Csf2 | colony stimulating factor 2 (granulocyte-macrophage) | 0.081 | |
| Ccl22 | chemokine (C-C motif) ligand 22 | 0.080 | |
| Cxcl10 | chemokine (C-X-C motif) ligand 10 | 0.080 | |
| Cd86 | CD86 antigen | 0.078 | |
| Il27ra | interleukin 27 receptor, alpha | 0.077 | |
| Gzmk | granzyme K | 0.075 | |
| Ccl9 | chemokine (C-C motif) ligand 9 | 0.074 | |
| Xcr1 | chemokine (C motif) receptor 1 | 0.074 | |
| Klrd1 | killer cell lectin-like receptor, subfamily D, member 1 | 0.072 | |
| Ccr8 | chemokine (C-C motif) receptor 8 | 0.072 | |
| Cxcl9 | chemokine (C-X-C motif) ligand 9 | 0.068 | |
| Il2rb | interleukin 2 receptor, beta chain | 0.066 | |
| Nkg7 | natural killer cell group 7 sequence | 0.063 | |
| Gzmc | granzyme C | 0.063 | |
| Il1rn | interleukin 1 receptor antagonist | 0.063 | |
| Xcl1 | chemokine (C motif) ligand 1 | 0.061 | |
| Prdm1 | PR domain containing 1, with ZNF domain | 0.060 | |
| Ccl1 | chemokine (C-C motif) ligand 1 | 0.060 | |
| Il2ra | interleukin 2 receptor, alpha chain | 0.059 | |
| Il7 | interleukin 7 | 0.058 | |
| Crtam | cytotoxic and regulatory T cell molecule | 0.055 | |
| Il18rap | interleukin 18 receptor accessory protein | 0.055 | |
| Ccl12 | chemokine (C-C motif) ligand 12 | 0.053 | |
| Fcna | ficolin A | 0.052 | |
| Ccl5 | chemokine (C-C motif) ligand 5 | 0.052 | |
| Il21r | interleukin 21 receptor | 0.052 | |
| Zap70 | zeta-chain (TCR) associated protein kinase | 0.050 | |
| Folr4 | folate receptor 4 (delta) | 0.050 | |
| Aire | autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) | 0.048 | |
| Ikzf3 | IKAROS family zinc finger 3 | 0.046 | |
| Ccr7 | chemokine (C-C motif) receptor 7 | 0.045 | |
| Cd247 | CD247 antigen | 0.044 | |
| Klrc1 | killer cell lectin-like receptor subfamily C, member 1 | 0.043 | |
| Cst7 | cystatin F (leukocystatin) | 0.042 | |
| Irg1 | immunoresponsive gene 1 | 0.040 | |
| Slamf8 | SLAM family member 8 | 0.040 | |
| Lag3 | lymphocyte-activation gene 3 | 0.039 | |
| Klrb1b | killer cell lectin-like receptor subfamily B member 1B | 0.039 | |
| Tnfsf14 | tumor necrosis factor (ligand) superfamily, member 14 | 0.039 |
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Rattus norvegicus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Cd247 | Cd247 molecule | 0.204 | |
| Lepr | leptin receptor | 0.040 | |
| Htr1b | 5-hydroxytryptamine (serotonin) receptor 1B | 0.020 | |
| Il6 | interleukin 6 | 0.020 | |
| Cd5 | Cd5 molecule | 0.016 | |
| Pmfbp1 | polyamine modulated factor 1 binding protein 1 | 0.014 | |
| Cxcr3 | chemokine (C-X-C motif) receptor 3 | 0.014 | |
| Mmp12 | matrix metallopeptidase 12 | 0.013 | |
| Sult2a1 | sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 | 0.013 | |
| Capn8 | calpain 8 | 0.011 | |
| Mmrn1 | multimerin 1 | 0.010 | |
| Cd8b | CD8b molecule | 0.010 |