The network for 'regulation of lymphocyte activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of lymphocyte activation

Any process that modulates the frequency, rate or extent of lymphocyte activation.

Drosophila melanogaster
Name Description Probability Func Analog Organism
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
LCK lymphocyte-specific protein tyrosine kinase 0.992
TRAF1 TNF receptor-associated factor 1 0.982
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.970
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.964
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.957
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.949
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.947
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.945
CD2 CD2 molecule 0.936
SH3KBP1 SH3-domain kinase binding protein 1 0.935
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.908
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.904
BIRC3 baculoviral IAP repeat containing 3 0.903
FAS Fas (TNF receptor superfamily, member 6) 0.898
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.891
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.873
FGFR2 fibroblast growth factor receptor 2 0.863
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.862
IL4R interleukin 4 receptor 0.827
CFLAR CASP8 and FADD-like apoptosis regulator 0.811
CD80 CD80 molecule 0.809
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.796
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.796
CCR7 chemokine (C-C motif) receptor 7 0.756
IL1R1 interleukin 1 receptor, type I 0.751
SYK spleen tyrosine kinase 0.751
HLA-DMA major histocompatibility complex, class II, DM alpha 0.742
IL2RG interleukin 2 receptor, gamma 0.740
HLA-DRA major histocompatibility complex, class II, DR alpha 0.738
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.712
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.709
SH2D1A SH2 domain containing 1A 0.699
CXCL9 chemokine (C-X-C motif) ligand 9 0.688
B2M beta-2-microglobulin 0.675
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.665
PTPRC protein tyrosine phosphatase, receptor type, C 0.661
PTK2 PTK2 protein tyrosine kinase 2 0.658
BCL2 B-cell CLL/lymphoma 2 0.637
CCL22 chemokine (C-C motif) ligand 22 0.627
HLA-A major histocompatibility complex, class I, A 0.626
HLA-F major histocompatibility complex, class I, F 0.615
IRAK1 interleukin-1 receptor-associated kinase 1 0.590
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.578
PLCG1 phospholipase C, gamma 1 0.573
HCK hemopoietic cell kinase 0.572
TGIF1 TGFB-induced factor homeobox 1 0.572
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.566
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.565
EGFR epidermal growth factor receptor 0.561
ICAM1 intercellular adhesion molecule 1 0.547
GRB2 growth factor receptor-bound protein 2 0.545
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.531
IRF4 interferon regulatory factor 4 0.516
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.516
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.516
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.505
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.503
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.503
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.502
RIPK2 receptor-interacting serine-threonine kinase 2 0.493
IL2RB interleukin 2 receptor, beta 0.493
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.492
HLA-B major histocompatibility complex, class I, B 0.482
FASLG Fas ligand (TNF superfamily, member 6) 0.477
CD247 CD247 molecule 0.475
VAV1 vav 1 guanine nucleotide exchange factor 0.469
CARD11 caspase recruitment domain family, member 11 0.466
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.459
SLA Src-like-adaptor 0.454
CD6 CD6 molecule 0.445
STAT4 signal transducer and activator of transcription 4 0.440
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.439
CD86 CD86 molecule 0.416
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.405
GAB1 GRB2-associated binding protein 1 0.393
PILRA paired immunoglobin-like type 2 receptor alpha 0.393
HLA-E major histocompatibility complex, class I, E 0.377
TRAF2 TNF receptor-associated factor 2 0.377
HLA-G major histocompatibility complex, class I, G 0.375
SLAMF1 signaling lymphocytic activation molecule family member 1 0.369
ABI1 abl-interactor 1 0.361
IL10RA interleukin 10 receptor, alpha 0.360
CD1C CD1c molecule 0.358
SMAD7 SMAD family member 7 0.356
JAK1 Janus kinase 1 0.355
CXCR6 chemokine (C-X-C motif) receptor 6 0.351
HLA-DMB major histocompatibility complex, class II, DM beta 0.342
CAV1 caveolin 1, caveolae protein, 22kDa 0.336
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.327
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.323
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.321
CD3G CD3g molecule, gamma (CD3-TCR complex) 0.317
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.298
SIGLEC7 sialic acid binding Ig-like lectin 7 0.294
IL16 interleukin 16 (lymphocyte chemoattractant factor) 0.293
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.284
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.280
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.274
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.272
CD2AP CD2-associated protein 0.270
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Mus musculus
Name Description Probability Func Analog Organism
Tlr4 toll-like receptor 4 0.995
Cd40 CD40 antigen 0.995
Stat3 signal transducer and activator of transcription 3 0.992
Rnf2 ring finger protein 2 0.989
Ccr2 chemokine (C-C motif) receptor 2 0.988
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.987
Lck lymphocyte protein tyrosine kinase 0.983
Icos inducible T-cell co-stimulator 0.979
Cd19 CD19 antigen 0.978
Jak2 Janus kinase 2 0.967
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.962
Pax2 paired box gene 2 0.955
Ptprc protein tyrosine phosphatase, receptor type, C 0.951
Tnf tumor necrosis factor 0.951
Lepr leptin receptor 0.946
Ccr7 chemokine (C-C motif) receptor 7 0.945
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.941
Efnb2 ephrin B2 0.927
Il1b interleukin 1 beta 0.914
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.900
Fgfr2 fibroblast growth factor receptor 2 0.899
Lat linker for activation of T cells 0.897
Fyn Fyn proto-oncogene 0.891
Wt1 Wilms tumor 1 homolog 0.881
Casp1 caspase 1 0.878
Ar androgen receptor 0.878
Ikzf1 IKAROS family zinc finger 1 0.877
Tgfb1 transforming growth factor, beta 1 0.876
Il27ra interleukin 27 receptor, alpha 0.873
Lyz2 lysozyme 2 0.873
Grb2 growth factor receptor bound protein 2 0.870
Slamf1 signaling lymphocytic activation molecule family member 1 0.863
Btk Bruton agammaglobulinemia tyrosine kinase 0.853
Cd28 CD28 antigen 0.850
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.844
Fas Fas (TNF receptor superfamily member 6) 0.844
Fasl Fas ligand (TNF superfamily, member 6) 0.841
Csf1 colony stimulating factor 1 (macrophage) 0.838
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.833
Ifng interferon gamma 0.828
Pdcd1 programmed cell death 1 0.816
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.815
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.813
Cd86 CD86 antigen 0.812
Traf6 TNF receptor-associated factor 6 0.807
Rb1 retinoblastoma 1 0.801
Il1r1 interleukin 1 receptor, type I 0.792
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.792
Sh2d2a SH2 domain protein 2A 0.786
Vangl2 vang-like 2 (van gogh, Drosophila) 0.781
Il2rb interleukin 2 receptor, beta chain 0.776
Stat6 signal transducer and activator of transcription 6 0.776
Il7r interleukin 7 receptor 0.776
Ltb lymphotoxin B 0.771
Cbl Casitas B-lineage lymphoma 0.770
Lta lymphotoxin A 0.763
Clec4n C-type lectin domain family 4, member n 0.762
Mmp9 matrix metallopeptidase 9 0.757
Ccr6 chemokine (C-C motif) receptor 6 0.756
Gli3 GLI-Kruppel family member GLI3 0.753
Cd180 CD180 antigen 0.750
Cd7 CD7 antigen 0.744
Il2rg interleukin 2 receptor, gamma chain 0.736
Sfpi1 SFFV proviral integration 1 0.731
Nckap1l NCK associated protein 1 like 0.729
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.729
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.727
Spib Spi-B transcription factor (Spi-1/PU.1 related) 0.727
Birc3 baculoviral IAP repeat-containing 3 0.727
Il10ra interleukin 10 receptor, alpha 0.719
Prf1 perforin 1 (pore forming protein) 0.718
Stat5b signal transducer and activator of transcription 5B 0.716
Klra9 killer cell lectin-like receptor subfamily A, member 9 0.714
Rarg retinoic acid receptor, gamma 0.711
Adora2a adenosine A2a receptor 0.711
H2-Aa histocompatibility 2, class II antigen A, alpha 0.709
Myd88 myeloid differentiation primary response gene 88 0.707
Tbx3 T-box 3 0.703
Stat5a signal transducer and activator of transcription 5A 0.698
Batf basic leucine zipper transcription factor, ATF-like 0.691
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.691
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.679
Tbx21 T-box 21 0.679
Zeb1 zinc finger E-box binding homeobox 1 0.676
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.676
Axl AXL receptor tyrosine kinase 0.675
Itgb2 integrin beta 2 0.673
Cd96 CD96 antigen 0.671
Ccr9 chemokine (C-C motif) receptor 9 0.667
Igh immunoglobulin heavy chain complex 0.664
Ccl5 chemokine (C-C motif) ligand 5 0.663
Blk B lymphoid kinase 0.656
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.654
Clec4d C-type lectin domain family 4, member d 0.653
Smad6 MAD homolog 6 (Drosophila) 0.651
Rxra retinoid X receptor alpha 0.650
Nlrp3 NLR family, pyrin domain containing 3 0.647
Ccl2 chemokine (C-C motif) ligand 2 0.646
Plcg1 phospholipase C, gamma 1 0.645
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.641
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cd247 Cd247 molecule 0.246
Cd2 Cd2 molecule 0.151
Cd37 CD37 molecule 0.111
Ptprc protein tyrosine phosphatase, receptor type, C 0.066
RT1-Da RT1 class II, locus Da 0.063
Cd4 Cd4 molecule 0.058
Cd5 Cd5 molecule 0.055
Ciita class II, major histocompatibility complex, transactivator 0.051
Laptm5 lysosomal protein transmembrane 5 0.048
Ctss cathepsin S 0.048
Gzmk granzyme K 0.042
Spn sialophorin 0.041
Casp1 caspase 1 0.039
Grin2a glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.034
Ccr5 chemokine (C-C motif) receptor 5 0.034
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.031
Fcgr2a Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.029
Cxcr3 chemokine (C-X-C motif) receptor 3 0.029
Il1r1 interleukin 1 receptor, type I 0.028
Mmp10 matrix metallopeptidase 10 0.028
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.027
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.027
Il9r interleukin 9 receptor 0.026
Il2rb interleukin 2 receptor, beta 0.026
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.025
Inpp5d inositol polyphosphate-5-phosphatase D 0.025
Hck hemopoietic cell kinase 0.024
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.024
Alox5ap arachidonate 5-lipoxygenase activating protein 0.023
Tas2r123 taste receptor, type 2, member 123 0.023
Itgad integrin, alpha D 0.023
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.022
RT1-DMb RT1 class II, locus DMb 0.022
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.022
Lat linker for activation of T cells 0.022
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.022
Il6st interleukin 6 signal transducer 0.021
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.021
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.021
LOC100364854 similar to RIKEN cDNA A430107P09 gene-like 0.021
Mcpt2 mast cell protease 2 0.021
RT1-DMa RT1 class II, locus DMa 0.020
Map4k1 mitogen activated protein kinase kinase kinase kinase 1 0.020
Itgb7 integrin, beta 7 0.020
Vip vasoactive intestinal peptide 0.020
Anpep alanyl (membrane) aminopeptidase 0.020
Cd44 Cd44 molecule 0.019
Prrx1 paired related homeobox 1 0.019
Scn11a sodium channel, voltage-gated, type XI, alpha 0.019
Alox5 arachidonate 5-lipoxygenase 0.019
Lcp2 lymphocyte cytosolic protein 2 0.018
Calcr calcitonin receptor 0.018
Tcrb T-cell receptor beta chain 0.018
Slfn2 schlafen 2 0.017
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.017
Nkg7 natural killer cell group 7 sequence 0.017
C1qb complement component 1, q subcomponent, B chain 0.017
Flt1 FMS-related tyrosine kinase 1 0.017
Anxa2 annexin A2 0.017
Socs3 suppressor of cytokine signaling 3 0.017
Ccr2 chemokine (C-C motif) receptor 2 0.016
Gja4 gap junction protein, alpha 4 0.016
Lef1 lymphoid enhancer binding factor 1 0.016
Cd3g CD3 molecule, gamma 0.016
Csf1 colony stimulating factor 1 (macrophage) 0.016
Kcns1 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 0.016
Pth parathyroid hormone 0.016
Cacng1 calcium channel, voltage-dependent, gamma subunit 1 0.015
Icam1 intercellular adhesion molecule 1 0.015
Kcnv1 potassium channel, subfamily V, member 1 0.015
Reg3g regenerating islet-derived 3 gamma 0.015
Cd53 Cd53 molecule 0.015
Rac1 ras-related C3 botulinum toxin substrate 1 0.015
Mylk2 myosin light chain kinase 2 0.015
Svs1 seminal vesicle secretory protein 1 0.015
Podxl podocalyxin-like 0.015
Cd86 CD86 molecule 0.015
Ralbp1 ralA binding protein 1 0.015
Scp2 sterol carrier protein 2 0.015
Bin2 bridging integrator 2 0.015
Il6 interleukin 6 0.014
Serpinb1a serine (or cysteine) proteinase inhibitor, clade B, member 1a 0.014
Stat6 signal transducer and activator of transcription 6 0.014
Cfp complement factor properdin 0.014
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.014
Ccl4 chemokine (C-C motif) ligand 4 0.014
Il1b interleukin 1 beta 0.014
Ddr2 discoidin domain receptor tyrosine kinase 2 0.014
Cxcl3 chemokine (C-X-C motif) ligand 3 0.014
LOC100361706 lambda-chain C1-region-like 0.014
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.014
Fgfr2 fibroblast growth factor receptor 2 0.014
Kl Klotho 0.014
Arhgap25 Rho GTPase activating protein 25 0.014
Plcg2 phospholipase C, gamma 2 0.013
Tgfbr3 transforming growth factor, beta receptor III 0.013
Psbpc2 prostatic steroid-binding protein C2 0.013
Wipf1 WAS/WASL interacting protein family, member 1 0.013
Cd200r1 CD200 receptor 1 0.013
Sell selectin L 0.013
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism