The network for 'regulation of macrophage differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of macrophage differentiation

Any process that modulates the frequency, rate or extent of macrophage differentiation.

Drosophila melanogaster
Name Description Probability Func Analog Organism
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
tal1 T-cell acute lymphocytic leukemia 1 0.273
lmo2 LIM domain only 2 (rhombotin-like 1) 0.046
gata3 GATA-binding protein 3 0.038
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.028
drl draculin 0.017
irx3a iroquois homeobox protein 3a 0.017
mpped2 metallophosphoesterase domain containing 2 0.011
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Homo sapiens
Name Description Probability Func Analog Organism
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.000
C1QA complement component 1, q subcomponent, A chain 0.997
XIAP X-linked inhibitor of apoptosis 0.997
BIRC3 baculoviral IAP repeat containing 3 0.990
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.988
BIRC2 baculoviral IAP repeat containing 2 0.977
RIPK2 receptor-interacting serine-threonine kinase 2 0.968
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.940
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.735
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.733
CFLAR CASP8 and FADD-like apoptosis regulator 0.682
FAS Fas (TNF receptor superfamily, member 6) 0.671
APAF1 apoptotic peptidase activating factor 1 0.641
IL8 interleukin 8 0.617
CXCL2 chemokine (C-X-C motif) ligand 2 0.610
C1QC complement component 1, q subcomponent, C chain 0.603
TAL1 T-cell acute lymphocytic leukemia 1 0.411
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.400
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.395
TRAF1 TNF receptor-associated factor 1 0.332
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.331
RIPK3 receptor-interacting serine-threonine kinase 3 0.226
FASLG Fas ligand (TNF superfamily, member 6) 0.218
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.201
CXCL3 chemokine (C-X-C motif) ligand 3 0.176
C1QB complement component 1, q subcomponent, B chain 0.164
NLRC4 NLR family, CARD domain containing 4 0.134
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.113
GHR growth hormone receptor 0.112
DIABLO diablo, IAP-binding mitochondrial protein 0.079
CXCL11 chemokine (C-X-C motif) ligand 11 0.076
DPP4 dipeptidyl-peptidase 4 0.066
TRAF3 TNF receptor-associated factor 3 0.065
FADD Fas (TNFRSF6)-associated via death domain 0.061
UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.059
HDAC6 histone deacetylase 6 0.046
LRDD leucine-rich repeats and death domain containing 0.042
CXCL5 chemokine (C-X-C motif) ligand 5 0.040
SH2D4A SH2 domain containing 4A 0.039
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.037
CCL20 chemokine (C-C motif) ligand 20 0.036
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.034
CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.034
PF4 platelet factor 4 0.033
CXCL10 chemokine (C-X-C motif) ligand 10 0.031
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.022
CCL8 chemokine (C-C motif) ligand 8 0.022
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.020
IRF1 interferon regulatory factor 1 0.019
HBB hemoglobin, beta 0.018
IL6 interleukin 6 (interferon, beta 2) 0.018
IL1B interleukin 1, beta 0.017
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.015
CCL2 chemokine (C-C motif) ligand 2 0.014
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.014
OSMR oncostatin M receptor 0.014
UBD ubiquitin D 0.013
DBNL drebrin-like 0.013
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.012
PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B 0.012
TANK TRAF family member-associated NFKB activator 0.012
SOD2 superoxide dismutase 2, mitochondrial 0.011
RIPK4 receptor-interacting serine-threonine kinase 4 0.011
BCL2A1 BCL2-related protein A1 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Id3 inhibitor of DNA binding 3 0.859
Id1 inhibitor of DNA binding 1 0.563
Gata4 GATA binding protein 4 0.454
Stat3 signal transducer and activator of transcription 3 0.446
Fas Fas (TNF receptor superfamily member 6) 0.389
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.337
Pten phosphatase and tensin homolog 0.335
Ldb3 LIM domain binding 3 0.323
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.283
Fgd1 FYVE, RhoGEF and PH domain containing 1 0.277
Ctnnb1 catenin (cadherin associated protein), beta 1 0.273
C1qa complement component 1, q subcomponent, alpha polypeptide 0.255
Jag1 jagged 1 0.192
C1qb complement component 1, q subcomponent, beta polypeptide 0.191
Ifnar1 interferon (alpha and beta) receptor 1 0.143
Tyrobp TYRO protein tyrosine kinase binding protein 0.133
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.132
Notch1 Notch gene homolog 1 (Drosophila) 0.130
Src Rous sarcoma oncogene 0.110
Csf1r colony stimulating factor 1 receptor 0.110
Igh immunoglobulin heavy chain complex 0.101
Gata6 GATA binding protein 6 0.093
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.092
Fadd Fas (TNFRSF6)-associated via death domain 0.086
Nf1 neurofibromatosis 1 0.085
Trp53 transformation related protein 53 0.082
Kit kit oncogene 0.080
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.080
Ikzf1 IKAROS family zinc finger 1 0.078
Casp8 caspase 8 0.069
Smad6 MAD homolog 6 (Drosophila) 0.067
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.066
Rb1 retinoblastoma 1 0.065
Bmpr1a bone morphogenetic protein receptor, type 1A 0.063
Tcf3 transcription factor 3 0.062
Zfpm2 zinc finger protein, multitype 2 0.058
Apaf1 apoptotic peptidase activating factor 1 0.057
Lyz2 lysozyme 2 0.055
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.055
Hes1 hairy and enhancer of split 1 (Drosophila) 0.055
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.054
Sox4 SRY-box containing gene 4 0.052
Tcf4 transcription factor 4 0.050
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.048
Kitl kit ligand 0.047
Alox5ap arachidonate 5-lipoxygenase activating protein 0.047
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.043
Fgfr2 fibroblast growth factor receptor 2 0.042
Dll1 delta-like 1 (Drosophila) 0.041
Tal1 T-cell acute lymphocytic leukemia 1 0.038
Ripk3 receptor-interacting serine-threonine kinase 3 0.036
Tcirg1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 0.033
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.033
Fcgr2b Fc receptor, IgG, low affinity IIb 0.033
Nos3 nitric oxide synthase 3, endothelial cell 0.032
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.030
Itgb2 integrin beta 2 0.030
Rxra retinoid X receptor alpha 0.028
Col1a1 collagen, type I, alpha 1 0.028
Ifngr1 interferon gamma receptor 1 0.027
Pkdcc protein kinase domain containing, cytoplasmic 0.025
Tbx3 T-box 3 0.025
Hs1bp3 HCLS1 binding protein 3 0.024
Myo6 myosin VI 0.024
Nsf N-ethylmaleimide sensitive fusion protein 0.024
Gja1 gap junction protein, alpha 1 0.024
Traf6 TNF receptor-associated factor 6 0.024
Lef1 lymphoid enhancer binding factor 1 0.023
Fyb FYN binding protein 0.022
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.022
Cyld cylindromatosis (turban tumor syndrome) 0.022
Actn2 actinin alpha 2 0.021
Il6st interleukin 6 signal transducer 0.020
Plcd1 phospholipase C, delta 1 0.020
Fgfr3 fibroblast growth factor receptor 3 0.019
Stat6 signal transducer and activator of transcription 6 0.019
Ncoa1 nuclear receptor coactivator 1 0.019
Pparg peroxisome proliferator activated receptor gamma 0.019
Shank3 SH3/ankyrin domain gene 3 0.018
Gli3 GLI-Kruppel family member GLI3 0.018
Cfp complement factor properdin 0.018
Psen1 presenilin 1 0.017
Prkce protein kinase C, epsilon 0.017
Ly86 lymphocyte antigen 86 0.017
C3 complement component 3 0.017
Tgfb2 transforming growth factor, beta 2 0.017
H2-Aa histocompatibility 2, class II antigen A, alpha 0.017
Emx1 empty spiracles homolog 1 (Drosophila) 0.016
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.015
Bmp4 bone morphogenetic protein 4 0.015
Ctss cathepsin S 0.015
Runx1 runt related transcription factor 1 0.015
Hhex hematopoietically expressed homeobox 0.015
Sgpl1 sphingosine phosphate lyase 1 0.014
Klf3 Kruppel-like factor 3 (basic) 0.014
Pitx2 paired-like homeodomain transcription factor 2 0.014
Smad4 MAD homolog 4 (Drosophila) 0.014
Rbl1 retinoblastoma-like 1 (p107) 0.014
Yap1 yes-associated protein 1 0.013
Myd88 myeloid differentiation primary response gene 88 0.013
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism