The network for 'somatic muscle development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

somatic muscle development

The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle.

Mus musculus
Name Description Probability Func Analog Organism
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
aldo-1 Protein ALDO-1 0.062
egl-13 Protein EGL-13 0.057
unc-15 Protein UNC-15 0.050
T21B6.3 Protein T21B6.3 0.044
emb-9 Protein EMB-9 0.042
myo-3 Protein MYO-3 0.042
unc-73 Protein UNC-73 0.037
vab-3 Protein VAB-3 0.036
F35A5.1 Protein F35A5.1 0.028
ncx-2 Protein NCX-2 0.028
pat-12 Protein PAT-12 0.027
alh-8 Protein ALH-8 0.027
K10D6.4 Protein K10D6.4 0.023
F46H5.3 Protein F46H5.3 0.023
pha-4 Protein PHA-4 0.023
K07E3.4 Protein K07E3.4 0.022
cwn-1 Protein CWN-1 0.022
vab-23 Protein VAB-23 0.021
tni-4 Protein TNI-4 0.021
CELE_Y53F4B.9 Protein Y53F4B.9 0.020
T12D8.9 Protein T12D8.9 0.020
tnt-4 Protein TNT-4 0.020
T22B11.4 Protein T22B11.4 0.020
camt-1 Protein CAMT-1 0.020
dig-1 Protein DIG-1 0.019
myo-2 Protein MYO-2 0.018
let-2 Protein LET-2 0.018
C53C9.2 Protein C53C9.2 0.018
ogt-1 Protein OGT-1 0.018
T25F10.6 Protein T25F10.6 0.018
egl-30 Protein EGL-30 0.018
R03H10.2 Protein R03H10.2 0.017
klp-19 Protein KLP-19 0.017
fln-2 Protein FLN-2 0.017
tag-241 Protein TAG-241 0.017
phat-4 Protein PHAT-4 0.017
unc-54 Protein UNC-54 0.017
unc-95 Protein UNC-95 0.017
sup-12 Protein SUP-12 0.016
ubr-1 Protein UBR-1 0.016
egl-8 Protein EGL-8 0.016
skn-1 Protein SKN-1 0.016
lin-7 Protein LIN-7 0.016
sorb-1 Protein SORB-1 0.016
T05F1.2 Protein T05F1.2 0.016
ztf-19 Protein ZTF-19 0.016
egl-18 Protein EGL-18 0.016
smg-1 Protein SMG-1 0.016
C50E3.5 Protein C50E3.5 0.015
T13C2.3 Protein T13C2.3 0.015
fkh-7 Protein FKH-7 0.015
Y45G5AM.6 Protein Y45G5AM.6 0.015
dim-1 Protein DIM-1 0.015
K09A9.6 Protein K09A9.6 0.015
col-43 Protein COL-43 0.015
egl-38 Protein EGL-38 0.015
mes-3 Protein MES-3 0.015
gly-13 Protein GLY-13 0.015
twk-18 Protein TWK-18 0.015
ifg-1 Protein IFG-1 0.015
cpna-2 Protein CPNA-2 0.015
mup-2 Protein MUP-2 0.014
zyx-1 Protein ZYX-1 0.014
egl-36 Protein EGL-36 0.014
nhr-107 Protein NHR-107 0.014
ZC449.5 Protein ZC449.5 0.014
dgk-4 Protein DGK-4 0.014
sel-1 Protein SEL-1 0.014
T19D12.2 Protein T19D12.2 0.014
lin-9 Protein LIN-9 0.014
let-268 Protein LET-268 0.014
F21C10.7 Protein F21C10.7 0.014
lig-1 Protein LIG-1 0.014
F18H3.4 Protein F18H3.4 0.014
mig-38 Protein MIG-38 0.014
unc-43 Protein UNC-43 0.014
myo-5 Protein MYO-5 0.014
C18B2.3 Protein C18B2.3 0.013
mdh-2 Protein MDH-2 0.013
ZK662.2 Protein ZK662.2 0.013
csq-1 Protein CSQ-1 0.013
czw-1 Protein CZW-1 0.013
syd-2 Protein SYD-2 0.013
elt-6 Protein ELT-6 0.013
F44B9.2 Protein F44B9.2 0.013
pde-2 Protein PDE-2 0.013
gly-6 Protein GLY-6 0.013
epi-1 Protein EPI-1 0.013
sax-7 Protein SAX-7 0.013
math-24 Protein MATH-24 0.013
lin-29 Protein LIN-29 0.013
gcl-1 Protein GCL-1 0.013
idhb-1 Protein IDHB-1 0.013
F47B7.7 Protein F47B7.7 0.013
lin-59 Protein LIN-59 0.013
pat-10 Protein PAT-10 0.013
nhr-154 Protein NHR-154 0.013
nob-1 Protein NOB-1 0.012
pqn-22 Protein PQN-22 0.012
C36E8.1 Protein C36E8.1 0.012
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Danio rerio
Name Description Probability Func Analog Organism
smyhc2 slow myosin heavy chain 2 0.907
myf5 myogenic factor 5 0.894
eng2a engrailed 2a 0.881
myhz2 myosin, heavy polypeptide 2, fast muscle specific 0.872
myhz1.1 myosin, heavy polypeptide 1.1, skeletal muscle 0.853
six1b sine oculis homeobox homolog 1b 0.812
myhz1.2 myosin, heavy polypeptide 1.2, skeletal muscle 0.790
mef2d myocyte enhancer factor 2d 0.689
smyd1b SET and MYND domain containing 1b 0.652
tnni1b troponin I, skeletal, slow b 0.573
LOC100149148 novel protein similar to myosin heavy chain 4 (myhc4) 0.572
sgcd sarcoglycan, delta (dystrophin-associated glycoprotein) 0.568
tnni2a.4 troponin I, skeletal, fast 2a.4 0.557
tnni1al troponin I, skeletal, slow like 0.551
musk muscle, skeletal, receptor tyrosine kinase 0.490
smyhc1l slow myosin heavy chain 1, like 0.462
tbx2b T-box 2b 0.416
lama4 laminin, alpha 4 0.413
unc45b unc-45 homolog B (C. elegans) 0.410
pcdh19 protocadherin 19 0.387
flot2a flotillin 2a 0.374
myod1 myogenic differentiation 1 0.339
tnnc1b troponin C type 1b (slow) 0.337
rbfox1l RNA binding protein, fox-1 homolog (C. elegans) 1-like 0.329
lbx2 ladybird homeobox homolog 2 (Drosophila) 0.304
tbx1 T-box 1 0.303
tbx2a T-box gene 2a 0.301
pcdh8 protocadherin 8 0.271
smyhc1 slow myosin heavy chain 1 0.268
eomesa eomesodermin homolog a 0.267
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.264
tnnt1 troponin T1, skeletal, slow 0.260
her1 hairy-related 1 0.251
ttna titin a 0.245
gro1 groucho 1 0.236
ryr1b ryanodine receptor 1b (skeletal) 0.227
hbbe1.1 hemoglobin beta embryonic-1.1 0.220
tgfb3 transforming growth factor, beta 3 0.216
has2 hyaluronan synthase 2 0.210
sema3aa semaphorin 3aa 0.198
ankrd6 ankyrin repeat domain 6 0.198
rest RE1-silencing transcription factor 0.189
fgf8b fibroblast growth factor 8 b 0.188
vdra vitamin D receptor a 0.187
myhc4 myosin heavy chain 4 0.178
flot1b flotillin 1b 0.173
spry4 sprouty (Drosophila) homolog 4 0.170
tbx16 T-box gene 16 0.169
tead3a TEA domain family member 3 a 0.168
cftr cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) 0.161
egr1 early growth response 1 0.157
znfl2a zinc finger-like gene 2a 0.154
pdlim7 PDZ and LIM domain 7 0.154
pacsin3 protein kinase C and casein kinase substrate in neurons 3 0.149
eng2b engrailed 2b 0.148
rxrbb retinoid x receptor, beta b 0.147
emx3 empty spiracles homeobox 3 0.147
vmhc ventricular myosin heavy chain 0.145
zeb1 zinc finger E-box binding homeobox 1 0.143
actn2 actinin, alpha 2 0.139
si:dkey-97i18.2 si:dkey-97i18.2 0.136
popdc2 popeye domain containing 2 0.133
frem3 Fras1 related extracellular matrix 3 0.126
zbtb4 zinc finger and BTB domain containing 4 0.126
fgfr4 fibroblast growth factor receptor 4 0.126
pgk1 phosphoglycerate kinase 1 0.124
zgc:64133 zgc:64133 0.123
msgn1 mesogenin 1 0.119
gro2 groucho 2 0.118
h1m linker histone H1M 0.118
mespa mesoderm posterior a 0.117
slc4a1a solute carrier family 4, anion exchanger, member 1a 0.117
ptprf protein tyrosine phosphatase, receptor type, F 0.116
cx39.9 connexin 39.9 0.116
tnnt3b troponin T3b, skeletal, fast 0.109
pdlim3b PDZ and LIM domain 3b 0.109
cacnb4a calcium channel, voltage-dependent, beta 4a subunit 0.107
spon2a spondin 2a, extracellular matrix protein 0.107
hsp90a.1 heat shock protein 90-alpha 1 0.106
tll1 tolloid-like 1 0.105
ncoa2 nuclear receptor coactivator 2 0.105
xirp2a xin actin-binding repeat containing 2a 0.103
dip2c DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.102
dlb deltaB 0.099
myog myogenin 0.099
fmr1 fragile X mental retardation 1 0.098
ap2m1a adaptor-related protein complex 2, mu 1 subunit, a 0.098
hspb8 heat shock protein, alpha-crystallin-related, b8 0.098
slc25a37 solute carrier family 25, member 37 0.097
actn3b actinin alpha 3b 0.096
chd chordin 0.095
rbpja recombination signal binding protein for immunoglobulin kappa J region a 0.095
zdhhc8b zinc finger, DHHC-type containing 8b 0.092
zeb2a zinc finger E-box binding homeobox 2a 0.091
spry2 sprouty homolog 2 0.090
her7 hairy and enhancer of split related-7 0.088
ryr1a ryanodine receptor 1a (skeletal) 0.088
ret1 receptor tyrosine kinase 0.088
traf4a tnf receptor-associated factor 4a 0.088
LOC566969 similar to MOX-2 protein 0.085
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Mhc Myosin heavy chain 0.987
sls sallimus 0.969
Pglym78 Phosphoglyceromutase 0.941
Mef2 Myocyte enhancer factor 2 0.925
PyK Pyruvate kinase 0.902
hbs hibris 0.833
S6k RPS6-p70-protein kinase 0.811
Zasp52 Z band alternatively spliced PDZ-motif protein 52 0.797
CanB2 Calcineurin B2 0.787
vg vestigial 0.748
bnl branchless 0.693
Sema-2a CG4700 gene product from transcript CG4700-RC 0.675
Dcr-2 Dicer-2 0.663
wupA wings up A 0.656
Vrp1 Verprolin 1 0.615
Act88F Actin 88F 0.609
ap apterous 0.536
rst roughest 0.531
sr stripe 0.530
Cf2 Chorion factor 2 0.522
CG3371 CG3371 gene product from transcript CG3371-RA 0.514
twi twist 0.508
fln flightin 0.491
dm diminutive 0.459
ci cubitus interruptus 0.442
LanB2 Laminin B2 0.435
Grip Glutamate receptor binding protein 0.411
ewg erect wing 0.381
Lrt Leucine-rich tendon-specific protein 0.360
tup tailup 0.357
Gapdh1 Glyceraldehyde 3 phosphate dehydrogenase 1 0.337
sns sticks and stones 0.333
flw flapwing 0.330
Mical Molecule interacting with CasL 0.322
Lim3 CG10699 gene product from transcript CG10699-RB 0.320
slou slouch 0.320
kon kon-tiki 0.300
rho rhomboid 0.293
Scgdelta Sarcoglycan delta 0.286
pan pangolin 0.282
Gpdh Glycerol 3 phosphate dehydrogenase 0.280
stumps CG31317 gene product from transcript CG31317-RC 0.275
trn tartan 0.257
abd-A abdominal A 0.254
htl heartless 0.252
sens senseless 0.241
blow blown fuse 0.239
pb proboscipedia 0.235
aop anterior open 0.228
en engrailed 0.220
lbe ladybird early 0.220
Actn alpha actinin 0.217
wb wing blister 0.205
Dfd Deformed 0.203
Alk CG8250 gene product from transcript CG8250-RA 0.200
Rac2 CG8556 gene product from transcript CG8556-RA 0.200
bin biniou 0.197
pfk piefke 0.187
al aristaless 0.180
GlyP Glycogen phosphorylase 0.178
park parkin 0.177
up upheld 0.172
CG8578 CG8578 gene product from transcript CG8578-RA 0.171
cno canoe 0.169
Pink1 PTEN-induced putative kinase 1 0.166
beat-Ia beaten path Ia 0.163
drk downstream of receptor kinase 0.160
Zasp66 Z band alternatively spliced PDZ-motif protein 66 0.160
Tpi Triose phosphate isomerase 0.159
csw corkscrew 0.147
tsh teashirt 0.147
hh hedgehog 0.147
bib big brain 0.147
Hcf Host cell factor 0.146
foxo forkhead box, sub-group O 0.144
rg rugose 0.143
Poxm Pox meso 0.140
Mlp84B Muscle LIM protein at 84B 0.139
mib2 mind bomb 2 0.138
Wnt2 Wnt oncogene analog 2 0.135
Msp-300 Muscle-specific protein 300 0.134
fj four-jointed 0.134
ro rough 0.134
sing singles bar 0.132
Mlc2 Myosin light chain 2 0.131
nau nautilus 0.130
CG3880 CG3880 gene product from transcript CG3880-RA 0.129
rols rolling pebbles 0.128
Gyc76C Guanylyl cyclase at 76C 0.126
Mer Merlin 0.125
mbl muscleblind 0.124
Atpalpha Na pump alpha subunit 0.123
ash2 absent, small, or homeotic discs 2 0.120
kel kelch 0.119
tmod tropomodulin 0.116
kug kugelei 0.114
wech CG42396 gene product from transcript CG42396-RC 0.114
Git CG16728 gene product from transcript CG16728-RA 0.113
Itp-r83A Inositol 1,4,5,-tris-phosphate receptor 0.111
Pabp2 CG2163 gene product from transcript CG2163-RA 0.111
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Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 0.958
FGF1 fibroblast growth factor 1 (acidic) 0.952
ALDOA aldolase A, fructose-bisphosphate 0.932
INSR insulin receptor 0.912
PGK1 phosphoglycerate kinase 1 0.900
IRS2 insulin receptor substrate 2 0.890
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.890
YAP1 Yes-associated protein 1 0.887
ENO1 enolase 1, (alpha) 0.878
MEIS1 Meis homeobox 1 0.834
PGAM1 phosphoglycerate mutase 1 (brain) 0.801
EGR1 early growth response 1 0.800
CREBBP CREB binding protein 0.738
PXN paxillin 0.735
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.696
GLIS2 GLIS family zinc finger 2 0.662
LDHA lactate dehydrogenase A 0.656
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.655
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.652
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.648
PDPK1 3-phosphoinositide dependent protein kinase-1 0.625
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.594
MEIS2 Meis homeobox 2 0.587
RFX1 regulatory factor X, 1 (influences HLA class II expression) 0.587
FGFR2 fibroblast growth factor receptor 2 0.506
RICTOR RPTOR independent companion of MTOR, complex 2 0.488
GPI glucose-6-phosphate isomerase 0.484
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 0.456
RBPMS RNA binding protein with multiple splicing 0.398
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 0.389
COASY CoA synthase 0.377
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.373
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.372
MEOX1 mesenchyme homeobox 1 0.372
HTT huntingtin 0.361
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like 0.346
IL4R interleukin 4 receptor 0.319
KAT2B K(lysine) acetyltransferase 2B 0.316
CAV1 caveolin 1, caveolae protein, 22kDa 0.274
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.256
NCOA2 nuclear receptor coactivator 2 0.239
TPM4 tropomyosin 4 0.231
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.230
NCOA1 nuclear receptor coactivator 1 0.216
TSC2 tuberous sclerosis 2 0.206
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.200
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.199
ECT2 epithelial cell transforming sequence 2 oncogene 0.199
FOXO1 forkhead box O1 0.195
ADRBK1 adrenergic, beta, receptor kinase 1 0.193
IRS1 insulin receptor substrate 1 0.189
FGF10 fibroblast growth factor 10 0.182
KIF23 kinesin family member 23 0.181
PKM2 pyruvate kinase, muscle 0.179
SNAI1 snail homolog 1 (Drosophila) 0.179
EGR3 early growth response 3 0.175
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.171
JAK2 Janus kinase 2 0.161
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.158
AR androgen receptor 0.155
MAPT microtubule-associated protein tau 0.145
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.136
IGF1R insulin-like growth factor 1 receptor 0.134
STAT5B signal transducer and activator of transcription 5B 0.134
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.132
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.131
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.128
IL2RB interleukin 2 receptor, beta 0.128
SUFU suppressor of fused homolog (Drosophila) 0.126
STAT5A signal transducer and activator of transcription 5A 0.125
GPSM2 G-protein signaling modulator 2 0.125
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.122
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.116
EGR2 early growth response 2 0.114
PCBP1 poly(rC) binding protein 1 0.110
TUBA1C tubulin, alpha 1c 0.108
STAP2 signal transducing adaptor family member 2 0.107
CFL1 cofilin 1 (non-muscle) 0.106
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 0.105
LAT linker for activation of T cells 0.104
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.104
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.103
IRF3 interferon regulatory factor 3 0.101
DCTN1 dynactin 1 0.101
ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.100
HOXA9 homeobox A9 0.098
TNIP1 TNFAIP3 interacting protein 1 0.096
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.092
KIF5B kinesin family member 5B 0.088
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.085
GRB10 growth factor receptor-bound protein 10 0.084
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.081
SH3RF1 SH3 domain containing ring finger 1 0.080
CDC25B cell division cycle 25 homolog B (S. pombe) 0.079
MPRIP myosin phosphatase Rho interacting protein 0.079
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 0.078
PI4KB phosphatidylinositol 4-kinase, catalytic, beta 0.078
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.077
TKT transketolase 0.077
KIF1B kinesin family member 1B 0.076
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism