The network for 'regulation of macromolecule metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of macromolecule metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

Name Description Probability Func Analog Organism
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
vab-3 Protein VAB-3 0.984
pha-4 Protein PHA-4 0.983
egl-18 Protein EGL-18 0.972
atn-1 Protein ATN-1 0.935
nhr-67 Protein NHR-67 0.926
hlh-2 Protein HLH-2 0.925
unc-37 Protein UNC-37 0.913
elt-6 Protein ELT-6 0.871
CELE_C25A1.4 Protein C25A1.4 0.849
his-64 Protein HIS-64 0.847
egl-15 Protein EGL-15 0.839
mdf-2 Protein MDF-2 0.832
dbr-1 Protein DBR-1 0.827
csn-1 Protein CSN-1 0.816
zyg-1 Protein ZYG-1 0.807
lin-35 Protein LIN-35 0.801
unc-62 Protein UNC-62 0.797
mig-5 Protein MIG-5 0.789
aly-3 Protein ALY-3 0.783
ceh-20 Protein CEH-20 0.779
egl-13 Protein EGL-13 0.779
T26A5.5 Protein T26A5.5 0.776
csn-4 Protein CSN-4 0.773
hda-1 Protein HDA-1 0.760
daf-1 Protein DAF-1 0.758
zyg-9 Protein ZYG-9 0.757
eftu-2 Protein EFTU-2 0.748
gon-4 Protein GON-4 0.746
aap-1 Protein AAP-1 0.746
hcp-3 Protein HCP-3 0.743
rnr-1 Protein RNR-1 0.742
F33H1.4 Protein F33H1.4 0.738
hbl-1 Protein HBL-1 0.733
sli-1 Protein SLI-1 0.732
cdk-9 Protein CDK-9 0.732
nud-2 Protein NUD-2 0.710
CELE_C17E4.6 Protein C17E4.6 0.706
cacn-1 Protein CACN-1 0.697
egl-46 Protein EGL-46 0.689
emb-5 Protein EMB-5 0.688
sas-5 Protein SAS-5 0.683
pis-1 Protein PIS-1 0.674
hlh-1 Protein HLH-1 0.664
kle-2 Protein KLE-2 0.661
cnd-1 Protein CND-1 0.659
nhr-2 Protein NHR-2 0.654
lin-36 Protein LIN-36 0.648
R186.7 Protein R186.7 0.641
skp-1 Protein SKP-1 0.641
egl-27 Protein EGL-27 0.639
npp-4 Protein NPP-4 0.635
eya-1 Protein EYA-1 0.633
rnp-6 Protein RNP-6 0.630
pry-1 Protein PRY-1 0.623
mei-2 Protein MEI-2 0.623
F39B2.1 Protein F39B2.1 0.621
fli-1 Protein FLI-1 0.609
alp-1 Protein ALP-1 0.605
unc-73 Protein UNC-73 0.602
spr-5 Protein SPR-5 0.602
ubq-1 Protein UBQ-1 0.600
attf-2 Protein ATTF-2 0.597
nhr-49 Protein NHR-49 0.596
unc-40 Protein UNC-40 0.595
hum-5 Protein HUM-5 0.594
lag-1 Protein LAG-1 0.591
F25H5.5 Protein F25H5.5 0.590
W04D2.6 Protein W04D2.6 0.585
B0261.1 Protein B0261.1 0.584
dlk-1 Protein DLK-1 0.580
F33E11.3 Protein F33E11.3 0.574
his-31 Protein HIS-31 0.570
CELE_C16C10.4 Protein C16C10.4 0.559
F13E6.1 Protein F13E6.1 0.558
his-5 Protein HIS-5 0.556
klp-15 Protein KLP-15 0.554
eor-1 Protein EOR-1 0.554
sec-16 Protein SEC-16 0.553
cpg-2 Protein CPG-2 0.544
mex-5 Protein MEX-5 0.540
Y87G2A.1 Protein Y87G2A.1 0.536
F33D11.10 Protein F33D11.10 0.535
his-1 Protein HIS-1 0.533
skr-1 Protein SKR-1 0.531
ulp-2 Protein ULP-2 0.531
fkh-2 Protein FKH-2 0.529
wrm-1 Protein WRM-1 0.528
scc-1 Protein SCC-1 0.525
ced-9 Protein CED-9 0.524
H06I04.1 Protein H06I04.1 0.523
pqn-59 Protein PQN-59 0.522
T28D9.4 Protein T28D9.4 0.520
R11A8.7 Protein R11A8.7 0.518
ppfr-2 Protein PPFR-2 0.512
pmk-1 Protein PMK-1 0.509
bet-1 Protein BET-1 0.508
par-5 Protein PAR-5 0.505
aph-2 Protein APH-2 0.505
CELE_Y41E3.11 Protein Y41E3.11 0.501
mes-2 Protein MES-2 0.497
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Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.992
tfap2a transcription factor AP-2 alpha 0.992
gli1 GLI-Kruppel family member 1 0.990
ntla no tail a 0.990
shha sonic hedgehog a 0.989
bmp4 bone morphogenetic protein 4 0.984
fgf3 fibroblast growth factor 3 0.982
snai1a snail homolog 1a (Drosophila) 0.981
notch1a notch homolog 1a 0.977
eya1 eyes absent homolog 1 0.976
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.974
evx1 even-skipped homeobox 1 0.972
twist1a twist1a 0.971
foxi1 forkhead box I1 0.970
khdrbs1a KH domain containing, RNA binding, signal transduction associated 1a 0.967
gata5 GATA-binding protein 5 0.965
dlx2a distal-less homeobox gene 2a 0.960
foxh1 forkhead box H1 0.955
robo3 roundabout homolog 3 0.953
tll1 tolloid-like 1 0.949
sox9a SRY-box containing gene 9a 0.948
six4b sine oculis homeobox homolog 4b 0.946
dusp6 dual specificity phosphatase 6 0.946
bmp2a bone morphogenetic protein 2a 0.944
fgfr1a fibroblast growth factor receptor 1a 0.943
chd chordin 0.941
ndr2 nodal-related 2 0.939
prkci protein kinase C, iota 0.939
gata3 GATA-binding protein 3 0.938
lef1 lymphocyte enhancer binding factor 1 0.935
otx2 orthodenticle homolog 2 0.934
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.933
lhx1a LIM homeobox 1a 0.926
cx43 connexin 43 0.925
tp53 tumor protein p53 0.924
hoxa9a homeo box A9a 0.924
cdh1 cadherin 1, epithelial 0.922
wnt11 wingless-type MMTV integration site family, member 11 0.920
spry4 sprouty (Drosophila) homolog 4 0.917
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.915
hnf1ba HNF1 homeobox Ba 0.915
meis3 myeloid ecotropic viral integration site 3 0.912
efnb2a ephrin B2a 0.912
flh floating head 0.907
kdrl kinase insert domain receptor like 0.901
mapk1 mitogen-activated protein kinase 1 0.900
hnrnpab heterogeneous nuclear ribonucleoprotein A/B 0.898
fgfr4 fibroblast growth factor receptor 4 0.898
osr1 odd-skipped related 1 (Drosophila) 0.894
barx1 BarH-like homeobox 1 0.894
mespa mesoderm posterior a 0.892
fzd8a frizzled homolog 8a 0.885
dlx6a distal-less homeobox gene 6a 0.882
pou3f1 POU class 3 homeobox 1 0.882
pax8 paired box gene 8 0.876
nanos3 nanos homolog 3 0.875
mbnl2 muscleblind-like 2 (Drosophila) 0.874
crabp2a cellular retinoic acid binding protein 2, a 0.872
eng2a engrailed 2a 0.866
pax6b paired box gene 6b 0.855
hhip hedgehog interacting protein 0.855
dlb deltaB 0.854
pax2a paired box gene 2a 0.851
nkx2.2a NK2 transcription factor related 2a 0.850
prnprs3 prion protein, related sequence 3 0.845
sall1a sal-like 1a (Drosophila) 0.845
prdm1a PR domain containing 1a, with ZNF domain 0.843
irx1b iroquois homeobox protein 1, b 0.843
ptf1a pancreas specific transcription factor, 1a 0.842
irx4b iroquois homeobox protein 4b 0.839
runx2b runt-related transcription factor 2b 0.838
gata6 GATA-binding protein 6 0.838
pitx3 paired-like homeodomain transcription factor 3 0.836
rarab retinoic acid receptor, alpha b 0.835
six3b sine oculis homeobox homolog 3b 0.834
boc brother of CDO 0.833
rad21 RAD21 homolog (S. pombe) 0.833
dla deltaA 0.829
hoxb1b homeo box B1b 0.827
wu:fv91b12 wu:fv91b12 0.827
mecom MDS1 and EVI1 complex locus 0.827
klf4a Kruppel-like transcription factor 4a 0.825
twist3 twist3 0.824
foxp2 forkhead box P2 0.822
foxa3 forkhead box A3 0.820
sema3aa semaphorin 3aa 0.820
cdx4 caudal type homeo box transcription factor 4 0.818
gyltl1b glycosyltransferase-like 1b 0.817
ncor1 nuclear receptor co-repressor 1 0.815
wnt10a wingless-type MMTV integration site family, member 10a 0.814
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.812
olfm2 olfactomedin 2 0.809
lhx1b LIM homeobox 1b 0.809
wnt3 wingless-type MMTV integration site family, member 3 0.807
tgfb1a transforming growth factor, beta 1a 0.804
oprm1 opioid receptor, mu 1 0.804
egr1 early growth response 1 0.799
si:ch211-212m21.5 si:ch211-212m21.5 0.796
six3a sine oculis homeobox homolog 3a 0.796
otpb orthopedia homolog b 0.791
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism