The network for 'cuticle development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cuticle development

The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss.

Rattus norvegicus
Name Description Probability Func Analog Organism
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
rol-8 Protein ROL-8 0.607
dpy-4 Protein DPY-4 0.538
col-73 Protein COL-73 0.473
col-144 Protein COL-144 0.472
col-157 Protein COL-157 0.466
wrt-6 Protein WRT-6 0.444
rol-6 Protein ROL-6 0.410
sqt-1 Protein SQT-1 0.393
col-146 Protein COL-146 0.386
egl-18 Protein EGL-18 0.340
aagr-4 Protein AAGR-4 0.315
sqt-2 Protein SQT-2 0.313
col-145 Protein COL-145 0.305
col-17 Protein COL-17 0.295
col-8 Protein COL-8 0.276
dpy-13 Protein DPY-13 0.260
col-119 Protein COL-119 0.246
col-92 Protein COL-92 0.244
col-181 Protein COL-181 0.227
col-142 Protein COL-142 0.225
col-114 Protein COL-114 0.217
col-133 Protein COL-133 0.214
col-93 Protein COL-93 0.214
CELE_E01G4.6 Protein E01G4.6 0.212
col-138 Protein COL-138 0.207
col-154 Protein COL-154 0.204
col-49 Protein COL-49 0.199
alh-3 Protein ALH-3 0.199
col-111 Protein COL-111 0.194
col-140 Protein COL-140 0.192
col-160 Protein COL-160 0.192
col-38 Protein COL-38 0.189
col-71 Protein COL-71 0.189
col-107 Protein COL-107 0.189
ifb-2 Protein IFB-2 0.188
col-141 Protein COL-141 0.184
col-180 Protein COL-180 0.183
col-2 Protein COL-2 0.178
col-173 Protein COL-173 0.170
col-43 Protein COL-43 0.164
col-178 Protein COL-178 0.163
col-79 Protein COL-79 0.161
bli-2 Protein BLI-2 0.155
col-166 Protein COL-166 0.154
col-149 Protein COL-149 0.151
atn-1 Protein ATN-1 0.150
col-109 Protein COL-109 0.149
col-156 Protein COL-156 0.148
col-143 Protein COL-143 0.146
gck-2 Protein GCK-2 0.144
col-184 Protein COL-184 0.140
dpy-9 Protein DPY-9 0.140
elt-6 Protein ELT-6 0.137
dig-1 Protein DIG-1 0.134
fat-2 Protein FAT-2 0.132
T03D8.6 Protein T03D8.6 0.132
col-66 Protein COL-66 0.131
col-122 Protein COL-122 0.131
C14F11.4 Protein C14F11.4 0.130
col-98 Protein COL-98 0.127
col-63 Protein COL-63 0.123
F27C1.2 Protein F27C1.2 0.123
col-58 Protein COL-58 0.122
col-117 Protein COL-117 0.121
dpy-5 Protein DPY-5 0.119
col-120 Protein COL-120 0.119
T19A5.3 Protein T19A5.3 0.115
unc-23 Protein UNC-23 0.111
col-84 Protein COL-84 0.111
C34E7.4 Protein C34E7.4 0.110
col-129 Protein COL-129 0.110
col-125 Protein COL-125 0.109
col-130 Protein COL-130 0.109
lin-13 Protein LIN-13 0.108
col-14 Protein COL-14 0.107
col-103 Protein COL-103 0.106
nas-37 Protein NAS-37 0.105
col-90 Protein COL-90 0.104
C05C8.7 Protein C05C8.7 0.103
nab-1 Protein NAB-1 0.102
kin-2 Protein KIN-2 0.102
col-159 Protein COL-159 0.098
pmt-1 Protein PMT-1 0.098
bli-1 Protein BLI-1 0.097
col-94 Protein COL-94 0.096
cat-1 Protein CAT-1 0.096
hlh-2 Protein HLH-2 0.094
clec-63 Protein CLEC-63 0.094
ribo-1 Protein RIBO-1 0.094
col-77 Protein COL-77 0.094
col-118 Protein COL-118 0.093
col-54 Protein COL-54 0.092
C06G1.1 Protein C06G1.1 0.091
col-91 Protein COL-91 0.090
mup-4 Protein MUP-4 0.089
abu-13 Protein ABU-13 0.089
T27A10.6 Protein T27A10.6 0.088
dpy-7 Protein DPY-7 0.086
lir-1 Protein LIR-1 0.086
col-127 Protein COL-127 0.085
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Egfr Epidermal growth factor receptor 0.991
EcR Ecdysone receptor 0.980
knk knickkopf 0.978
grh grainy head 0.919
dsh dishevelled 0.867
wol wollknaeuel 0.847
Gug Grunge 0.714
verm vermiform 0.691
opa odd paired 0.688
N Notch 0.670
Mad Mothers against dpp 0.646
kkv krotzkopf verkehrt 0.620
pio piopio 0.601
Cyp12d1-p CG30489 gene product from transcript CG30489-RA 0.594
14-3-3zeta CG17870 gene product from transcript CG17870-RB 0.543
dib disembodied 0.540
sro shroud 0.539
sec23 CG1250 gene product from transcript CG1250-RA 0.538
mtg mind the gap 0.524
rtv retroactive 0.521
fw furrowed 0.521
mys myospheroid 0.500
sns sticks and stones 0.500
tsr twinstar 0.478
spo spook 0.471
Megalin CG42611 gene product from transcript CG42611-RA 0.468
TwdlL TweedleL 0.467
gho ghost 0.438
Usf CG17592 gene product from transcript CG17592-RB 0.432
Pink1 PTEN-induced putative kinase 1 0.425
hep hemipterous 0.421
por porcupine 0.396
Cyp12d1-d CG33503 gene product from transcript CG33503-RA 0.395
TwdlE TweedleE 0.389
Mes2 CG11100 gene product from transcript CG11100-RB 0.384
Ubx Ultrabithorax 0.375
ple pale 0.367
rok Rho-kinase 0.346
Cpr64Ad Cuticular protein 64Ad 0.338
Ddc Dopa decarboxylase 0.321
btl breathless 0.319
Catsup Catecholamines up 0.317
Ser Serrate 0.310
y yellow 0.307
fu fused 0.305
mmy mummy 0.302
sha shavenoid 0.295
mwh multiple wing hairs 0.293
Sec61beta CG10130 gene product from transcript CG10130-RA 0.292
BicD Bicaudal D 0.291
Src42A Src oncogene at 42A 0.286
serp serpentine 0.276
TwdlC TweedleC 0.276
vari varicose 0.269
slpr slipper 0.268
ds dachsous 0.261
Npc1b Niemann-Pick type C-1b 0.250
Tal CG2827 gene product from transcript CG2827-RA 0.248
slou slouch 0.247
pyd polychaetoid 0.245
SNF1A SNF1A/AMP-activated protein kinase 0.240
Wnt2 Wnt oncogene analog 2 0.232
m miniature 0.232
bs blistered 0.231
jeb jelly belly 0.230
Sas Sialic acid phosphate synthase 0.226
Rala Ras-related protein 0.225
fred friend of echinoid 0.222
ea easter 0.221
dp dumpy 0.212
sna snail 0.207
l(2)gl lethal (2) giant larvae 0.204
nej nejire 0.204
disp dispatched 0.199
CrebA Cyclic-AMP response element binding protein A 0.198
CG5933 CG5933 gene product from transcript CG5933-RA 0.193
sad shadow 0.192
shd shade 0.187
Hr38 Hormone receptor-like in 38 0.186
Apc2 Adenomatous polyposis coli tumor suppressor homolog 2 0.184
dome domeless 0.180
CG18766 CG18766 gene product from transcript CG18766-RB 0.171
Rac1 CG2248 gene product from transcript CG2248-RA 0.162
inx2 innexin 2 0.161
puc puckered 0.159
stnB stoned B 0.157
Myo31DF Myosin 31DF 0.156
kug kugelei 0.149
nyo nyobe 0.149
sim single-minded 0.149
Stat92E Signal-transducer and activator of transcription protein at 92E 0.148
rt rotated abdomen 0.148
Gcn2 CG1609 gene product from transcript CG1609-RA 0.146
loqs loquacious 0.143
odd odd skipped 0.141
ci cubitus interruptus 0.139
TwdlB TweedleB 0.138
CG14667 CG14667 gene product from transcript CG14667-RA 0.136
kirre kin of irre 0.132
rk rickets 0.131
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Homo sapiens
Name Description Probability Func Analog Organism
NOTCH3 notch 3 0.811
WIPF1 WAS/WASL interacting protein family, member 1 0.808
NOTCH1 notch 1 0.701
SUFU suppressor of fused homolog (Drosophila) 0.557
ZNF496 zinc finger protein 496 0.484
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.341
GFI1B growth factor independent 1B transcription repressor 0.231
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.227
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.208
VHL von Hippel-Lindau tumor suppressor 0.206
STK36 serine/threonine kinase 36 0.180
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.122
WASL Wiskott-Aldrich syndrome-like 0.102
CTNNBIP1 catenin, beta interacting protein 1 0.092
APC adenomatous polyposis coli 0.087
TCEAL5 transcription elongation factor A (SII)-like 5 0.079
HES1 hairy and enhancer of split 1, (Drosophila) 0.075
ZNF331 zinc finger protein 331 0.070
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.067
TCF4 transcription factor 4 0.053
ACTA2 actin, alpha 2, smooth muscle, aorta 0.052
TRPM6 transient receptor potential cation channel, subfamily M, member 6 0.050
JUP junction plakoglobin 0.049
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.049
SUZ12 suppressor of zeste 12 homolog (Drosophila) 0.049
RPL27A ribosomal protein L27a 0.048
FXYD3 FXYD domain containing ion transport regulator 3 0.044
CTTN cortactin 0.043
IQGAP1 IQ motif containing GTPase activating protein 1 0.041
RPL13 ribosomal protein L13 0.040
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.038
PDE4D phosphodiesterase 4D, cAMP-specific 0.038
PBX1 pre-B-cell leukemia homeobox 1 0.037
NOTCH2 notch 2 0.035
DSP desmoplakin 0.035
EGR2 early growth response 2 0.035
MYL9 myosin, light chain 9, regulatory 0.033
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.033
RCN3 reticulocalbin 3, EF-hand calcium binding domain 0.032
SIK1 salt-inducible kinase 1 0.031
PEX26 peroxisomal biogenesis factor 26 0.031
SKI v-ski sarcoma viral oncogene homolog (avian) 0.031
ACTN1 actinin, alpha 1 0.031
LTBP4 latent transforming growth factor beta binding protein 4 0.030
EGR3 early growth response 3 0.030
SNX9 sorting nexin 9 0.029
FBXW11 F-box and WD repeat domain containing 11 0.028
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.028
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.026
NCOA2 nuclear receptor coactivator 2 0.026
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.026
BAIAP2 BAI1-associated protein 2 0.026
GAS7 growth arrest-specific 7 0.025
GLI1 GLI family zinc finger 1 0.025
ASCC2 activating signal cointegrator 1 complex subunit 2 0.024
GNMT glycine N-methyltransferase 0.024
FBLN1 fibulin 1 0.023
CORO1C coronin, actin binding protein, 1C 0.023
MID1IP1 MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish)) 0.022
CNN1 calponin 1, basic, smooth muscle 0.022
RGS2 regulator of G-protein signaling 2, 24kDa 0.022
AP1M2 adaptor-related protein complex 1, mu 2 subunit 0.021
CD2 CD2 molecule 0.021
CNN2 calponin 2 0.021
HSPG2 heparan sulfate proteoglycan 2 0.021
BCL2 B-cell CLL/lymphoma 2 0.021
WDYHV1 WDYHV motif containing 1 0.020
GLIS3 GLIS family zinc finger 3 0.020
AGRN agrin 0.019
EIF3L eukaryotic translation initiation factor 3, subunit L 0.019
QPRT quinolinate phosphoribosyltransferase 0.019
BTK Bruton agammaglobulinemia tyrosine kinase 0.018
GLI3 GLI family zinc finger 3 0.018
FASLG Fas ligand (TNF superfamily, member 6) 0.018
GLIS2 GLIS family zinc finger 2 0.018
PKP3 plakophilin 3 0.017
ACTC1 actin, alpha, cardiac muscle 1 0.017
CBX7 chromobox homolog 7 0.017
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.017
EZR ezrin 0.017
ZNF512B zinc finger protein 512B 0.017
EEF2 eukaryotic translation elongation factor 2 0.017
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.017
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.017
CD83 CD83 molecule 0.017
PRSS8 protease, serine, 8 0.016
SPRR3 small proline-rich protein 3 0.016
TPM4 tropomyosin 4 0.016
BTRC beta-transducin repeat containing 0.016
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.016
FERMT2 fermitin family member 2 0.016
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.016
PABPC1 poly(A) binding protein, cytoplasmic 1 0.016
SPTBN1 spectrin, beta, non-erythrocytic 1 0.015
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.015
ARRB1 arrestin, beta 1 0.015
PRPF6 PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) 0.015
KLK7 kallikrein-related peptidase 7 0.015
PARD6G par-6 partitioning defective 6 homolog gamma (C. elegans) 0.015
JAG2 jagged 2 0.015
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Mus musculus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism