The network for 'negative regulation of nucleocytoplasmic transport' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of nucleocytoplasmic transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus.

Rattus norvegicus
Name Description Probability Func Analog Organism
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
plk1 polo-like kinase 1 (Drosophila) 0.327
nf1a neurofibromin 1a 0.305
LOC100535549 cytoplasmic polyadenylation element-binding protein 4-like 0.304
capns1a calpain, small subunit 1 a 0.157
cdh1 cadherin 1, epithelial 0.145
akt2 v-akt murine thymoma viral oncogene homolog 2 0.128
nf1b neurofibromin 1b 0.116
zgc:101761 zgc:101761 0.113
zgc:73328 zgc:73328 0.102
cdc20 cell division cycle 20 homolog 0.100
ppp2r5d protein phosphatase 2, regulatory subunit B', delta 0.092
atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 0.092
fmr1 fragile X mental retardation 1 0.092
gon4l gon-4-like (C.elegans) 0.089
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.087
thraa thyroid hormone receptor alpha a 0.082
trpv4 transient receptor potential cation channel, subfamily V, member 4 0.081
ptpra protein tyrosine phosphatase, receptor type, A 0.076
vgll4l vestigial like 4 like 0.076
clasp2 cytoplasmic linker associated protein 2 0.076
mad2l1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.073
gro2 groucho 2 0.071
ncaph non-SMC condensin I complex, subunit H 0.070
kdm5c lysine (K)-specific demethylase 5C 0.070
nuf2 NUF2, NDC80 kinetochore complex component, homolog 0.069
polr2a polymerase (RNA) II (DNA directed) polypeptide A 0.068
psmd11b proteasome (prosome, macropain) 216S subunit, non-ATPase, 11b 0.066
lef1 lymphocyte enhancer binding factor 1 0.063
sec24c SEC24 family, member C (S. cerevisiae) 0.061
prps1b phosphoribosyl pyrophosphate synthetase 1B 0.060
birc5a baculoviral IAP repeat-containing 5a 0.060
ahcyl2 S-adenosylhomocysteine hydrolase-like 2 0.060
lsm8 LSM8 homolog, U6 small nuclear RNA associated 0.058
kif23 kinesin family member 23 0.058
tubg1 tubulin, gamma 1 0.057
LOC567452 G protein-coupled receptor kinase 5-like 0.057
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.055
kpna2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.055
axin1 axin 1 0.055
scn1lab sodium channel, voltage-gated, type I like, alpha b 0.054
mfn2 mitofusin 2 0.053
ptpn11a protein tyrosine phosphatase, non-receptor type 11, a 0.052
acvr1b activin A receptor, type IB 0.052
ccr12.2 chemokine (C-C motif) receptor 12.2 0.050
zgc:86764 zgc:86764 0.049
ppp2r5ea protein phosphatase 2, regulatory subunit B', epsilon isoform a 0.049
mapk12 mitogen-activated protein kinase 12 0.048
krml2.2 Kreisler (mouse) maf-related leucine zipper homolog 2.2 0.047
atp6v1c1b ATPase, H+ transporting, lysosomal, V1 subunit C, isoform 1b 0.047
hddc3 HD domain containing 3 0.046
klhl11 kelch-like 11 (Drosophila) 0.046
ndc80 NDC80 homolog, kinetochore complex component (S. cerevisiae) 0.046
uspl1 ubiquitin specific peptidase like 1 0.045
ppdpfb pancreatic progenitor cell differentiation and proliferation factor b 0.045
ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.045
zgc:55307 zgc:55307 0.045
arfgef1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) 0.044
sox11b SRY-box containing gene 11b 0.043
birc2 baculoviral IAP repeat-containing 2 0.043
htt huntingtin 0.042
pdlim1 PDZ and LIM domain 1 (elfin) 0.042
cyp1a cytochrome P450, family 1, subfamily A 0.042
tmem161b transmembrane protein 161B 0.042
prdx5 peroxiredoxin 5 0.042
snx27 sorting nexin family member 27 0.041
anxa13 annexin A13 0.041
wars tryptophanyl-tRNA synthetase 0.041
jag2 jagged 2 0.040
zgc:92027 zgc:92027 0.040
tbeta-a beta thymosin-like protein 2 0.040
robo3 roundabout homolog 3 0.040
ep300b E1A binding protein p300 b 0.040
elovl1b elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1b 0.039
si:dkeyp-7c9.1 si:dkeyp-7c9.1 0.039
fbn2b fibrillin 2b 0.039
LOC564872 monocarboxylate transporter 7-like 0.038
snrpb2 small nuclear ribonucleoprotein polypeptide B2 0.038
apaf1 apoptotic protease activating factor 1 0.038
rarab retinoic acid receptor, alpha b 0.038
crsp7 cofactor required for Sp1 transcriptional activation, subunit 7 0.038
ap2a1 adaptor-related protein complex 2, alpha 1 subunit 0.038
mapk6 mitogen-activated protein kinase 6 0.038
lpp LIM domain containing preferred translocation partner in lipoma 0.038
dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) 0.037
smad9 MAD homolog 9 (Drosophila) 0.037
sb:cb252 sb:cb252 0.037
itm2bb integral membrane protein 2Bb 0.037
rsrc2 arginine/serine-rich coiled-coil 2 0.037
ncoa2 nuclear receptor coactivator 2 0.036
ap1m2 adaptor-related protein complex 1, mu 2 subunit 0.036
ddx3 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3 0.036
prpf40a PRP40 pre-mRNA processing factor 40 homolog A (yeast) 0.036
zgc:73349 zgc:73349 0.036
atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.036
clk4a CDC-like kinase 4a 0.036
mkln1 muskelin 1, intracellular mediator containing kelch motifs 0.036
serinc2 serine incorporator 2 0.035
nola1 nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs) 0.035
litaf lipopolysaccharide-induced TNF factor 0.035
pdcd6ip programmed cell death 6 interacting protein 0.035
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.655
GSK3B glycogen synthase kinase 3 beta 0.417
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.342
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.312
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.303
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.298
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.240
AXIN1 axin 1 0.186
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.173
PAX3 paired box 3 0.162
DTX3L deltex 3-like (Drosophila) 0.158
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.140
PML promyelocytic leukemia 0.130
CUL1 cullin 1 0.128
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.125
PRDX1 peroxiredoxin 1 0.123
MMS22L MMS22-like, DNA repair protein 0.112
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.111
PARP14 poly (ADP-ribose) polymerase family, member 14 0.098
CHUK conserved helix-loop-helix ubiquitous kinase 0.090
SP100 SP100 nuclear antigen 0.089
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.088
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.088
SMAD7 SMAD family member 7 0.087
PARP9 poly (ADP-ribose) polymerase family, member 9 0.077
HIPK2 homeodomain interacting protein kinase 2 0.069
CREBBP CREB binding protein 0.068
DCAF7 DDB1 and CUL4 associated factor 7 0.067
ZNF420 zinc finger protein 420 0.067
CKAP5 cytoskeleton associated protein 5 0.065
APC adenomatous polyposis coli 0.062
MAPK1 mitogen-activated protein kinase 1 0.062
HIPK3 homeodomain interacting protein kinase 3 0.061
C3orf15 chromosome 3 open reading frame 15 0.061
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.059
IRS1 insulin receptor substrate 1 0.055
YAP1 Yes-associated protein 1 0.055
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.054
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.050
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.050
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.049
BCL3 B-cell CLL/lymphoma 3 0.048
RANBP3 RAN binding protein 3 0.047
POU5F1 POU class 5 homeobox 1 0.046
PROX1 prospero homeobox 1 0.046
NXF1 nuclear RNA export factor 1 0.046
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.045
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.044
ERBB2IP erbb2 interacting protein 0.040
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.040
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.040
FAS Fas (TNF receptor superfamily, member 6) 0.039
RARA retinoic acid receptor, alpha 0.039
MAP2K5 mitogen-activated protein kinase kinase 5 0.039
ZNF84 zinc finger protein 84 0.037
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.037
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.036
SOD1 superoxide dismutase 1, soluble 0.034
SKP1 S-phase kinase-associated protein 1 0.033
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.032
AXL AXL receptor tyrosine kinase 0.032
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.032
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 0.032
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.031
TEK TEK tyrosine kinase, endothelial 0.031
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B 0.030
ZNF585A zinc finger protein 585A 0.029
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.029
SAMD9L sterile alpha motif domain containing 9-like 0.028
GLI1 GLI family zinc finger 1 0.028
IFIH1 interferon induced with helicase C domain 1 0.027
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 0.027
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.026
NUP98 nucleoporin 98kDa 0.026
E2F3 E2F transcription factor 3 0.026
SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.026
LMO4 LIM domain only 4 0.026
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.026
POU3F2 POU class 3 homeobox 2 0.025
MAPK14 mitogen-activated protein kinase 14 0.025
KPNB1 karyopherin (importin) beta 1 0.025
BTRC beta-transducin repeat containing 0.024
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.024
LZTS2 leucine zipper, putative tumor suppressor 2 0.024
ZNF432 zinc finger protein 432 0.024
SNAI1 snail homolog 1 (Drosophila) 0.023
BIRC3 baculoviral IAP repeat containing 3 0.023
SLC9A3R2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.023
FBXW11 F-box and WD repeat domain containing 11 0.023
IRS2 insulin receptor substrate 2 0.022
MAP3K1 mitogen-activated protein kinase kinase kinase 1 0.022
BBS10 Bardet-Biedl syndrome 10 0.022
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.022
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.022
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.022
DDAH2 dimethylarginine dimethylaminohydrolase 2 0.021
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.021
FBXW7 F-box and WD repeat domain containing 7 0.021
NUP50 nucleoporin 50kDa 0.020
DEAF1 deformed epidermal autoregulatory factor 1 (Drosophila) 0.020
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Mus musculus
Name Description Probability Func Analog Organism
Grb10 growth factor receptor bound protein 10 0.430
Rara retinoic acid receptor, alpha 0.406
Yap1 yes-associated protein 1 0.382
Ctnnb1 catenin (cadherin associated protein), beta 1 0.330
Trp63 transformation related protein 63 0.242
Gbp2 guanylate binding protein 2 0.230
Iigp1 interferon inducible GTPase 1 0.222
Rarg retinoic acid receptor, gamma 0.187
Gbp7 guanylate binding protein 7 0.166
Gli2 GLI-Kruppel family member GLI2 0.143
Apc adenomatosis polyposis coli 0.106
Fgfr2 fibroblast growth factor receptor 2 0.103
Gbp3 guanylate binding protein 3 0.088
Htt huntingtin 0.086
Trp53 transformation related protein 53 0.077
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.070
Rxra retinoid X receptor alpha 0.065
Gopc golgi associated PDZ and coiled-coil motif containing 0.056
Bcl2 B-cell leukemia/lymphoma 2 0.056
Irgm2 immunity-related GTPase family M member 2 0.055
Gbp10 guanylate-binding protein 10 0.053
Tgtp2 T-cell specific GTPase 2 0.052
Gli3 GLI-Kruppel family member GLI3 0.050
Kitl kit ligand 0.050
Meox2 mesenchyme homeobox 2 0.049
Igtp interferon gamma induced GTPase 0.049
Fzd8 frizzled homolog 8 (Drosophila) 0.046
Gbp6 guanylate binding protein 6 0.045
Pax8 paired box gene 8 0.043
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.042
Bcl3 B-cell leukemia/lymphoma 3 0.042
Ikbkb inhibitor of kappaB kinase beta 0.041
Rictor RPTOR independent companion of MTOR, complex 2 0.041
Ar androgen receptor 0.040
Ghr growth hormone receptor 0.038
Pkd1 polycystic kidney disease 1 homolog 0.037
Ifi47 interferon gamma inducible protein 47 0.035
Axin1 axin 1 0.033
Dlg2 discs, large homolog 2 (Drosophila) 0.029
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.029
Ifi203 interferon activated gene 203 0.029
H2-Q7 histocompatibility 2, Q region locus 7 0.028
Ret ret proto-oncogene 0.028
Wnt5a wingless-related MMTV integration site 5A 0.028
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.027
Vegfa vascular endothelial growth factor A 0.027
Mapk3 mitogen-activated protein kinase 3 0.026
Serpinb9 serine (or cysteine) peptidase inhibitor, clade B, member 9 0.026
Hoxa3 homeobox A3 0.026
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.025
Slc12a6 solute carrier family 12, member 6 0.025
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.025
Duox2 dual oxidase 2 0.025
Esr1 estrogen receptor 1 (alpha) 0.024
Fgfr1 fibroblast growth factor receptor 1 0.024
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.024
Notch2 Notch gene homolog 2 (Drosophila) 0.024
Ifih1 interferon induced with helicase C domain 1 0.024
Pten phosphatase and tensin homolog 0.023
Il6st interleukin 6 signal transducer 0.023
Smad3 MAD homolog 3 (Drosophila) 0.023
Coro1b coronin, actin binding protein 1B 0.023
Rnf115 ring finger protein 115 0.023
Mapkap1 mitogen-activated protein kinase associated protein 1 0.023
Cuedc1 CUE domain containing 1 0.022
Efnb1 ephrin B1 0.022
Cav1 caveolin 1, caveolae protein 0.021
Rptor regulatory associated protein of MTOR, complex 1 0.021
Lrp5 low density lipoprotein receptor-related protein 5 0.021
Dlg4 discs, large homolog 4 (Drosophila) 0.021
Flot2 flotillin 2 0.021
Neo1 neogenin 0.020
Tbx3 T-box 3 0.020
Oasl2 2'-5' oligoadenylate synthetase-like 2 0.020
F2r coagulation factor II (thrombin) receptor 0.020
Ifit3 interferon-induced protein with tetratricopeptide repeats 3 0.019
Bcl6 B-cell leukemia/lymphoma 6 0.019
Casp12 caspase 12 0.019
Irgm1 immunity-related GTPase family M member 1 0.019
Gimap4 GTPase, IMAP family member 4 0.019
Ncoa3 nuclear receptor coactivator 3 0.019
Trim30a tripartite motif-containing 30A 0.019
Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 0.019
Parp14 poly (ADP-ribose) polymerase family, member 14 0.018
Fzd1 frizzled homolog 1 (Drosophila) 0.018
Igbp1 immunoglobulin (CD79A) binding protein 1 0.018
Kif1b kinesin family member 1B 0.018
Aim2 absent in melanoma 2 0.017
Rras Harvey rat sarcoma oncogene, subgroup R 0.017
Ikbkg inhibitor of kappaB kinase gamma 0.017
Smo smoothened homolog (Drosophila) 0.017
Bicc1 bicaudal C homolog 1 (Drosophila) 0.017
B2m beta-2 microglobulin 0.017
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.017
Pdgfb platelet derived growth factor, B polypeptide 0.017
Cys1 cystin 1 0.017
Ap2m1 adaptor protein complex AP-2, mu1 0.017
Ddr1 discoidin domain receptor family, member 1 0.017
Irf1 interferon regulatory factor 1 0.017
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.017
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism