The network for 'smoothened signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

smoothened signaling pathway

A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.

Rattus norvegicus
Name Description Probability Func Analog Organism
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
shha sonic hedgehog a 0.993
gli1 GLI-Kruppel family member 1 0.960
gli2a GLI-Kruppel family member GLI2a 0.919
ift57 intraflagellar transport protein 57 0.868
ptch2 patched 2 0.826
rspo3 R-spondin 3 homolog (Xenopus laevis) 0.803
ift88 intraflagellar transport 88 homolog 0.801
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.793
notch1a notch homolog 1a 0.725
dla deltaA 0.610
lhx2b LIM homeobox 2b 0.597
atoh1b atonal homolog 1b 0.591
gli3 GLI-Kruppel family member GLI3 0.544
mib mind bomb 0.536
smo smoothened homolog (Drosophila) 0.509
dmd dystrophin 0.489
cc2d2a coiled-coil and C2 domain containing 2A 0.459
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.414
col2a1a collagen type II, alpha-1a 0.344
ihha Indian hedgehog homolog a 0.319
tbx1 T-box 1 0.305
gnat2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 0.290
bmp2b bone morphogenetic protein 2b 0.272
dzip1 DAZ interacting protein 1 0.265
lrrc6 leucine rich repeat containing 6 0.264
rerea arginine-glutamic acid dipeptide (RE) repeats a 0.246
sox9a SRY-box containing gene 9a 0.228
fbln4 fibulin 4 0.228
ccdc40 coiled-coil domain containing 40 0.218
gpc4 glypican 4 0.217
guca1c guanylate cyclase activator 1C 0.217
ift52 intraflagellar transport protein 52 0.211
fn1 fibronectin 1 0.205
boc brother of CDO 0.203
neo1 neogenin 1 0.187
sulf2l sulfatase 2, like 0.184
wnt5b wingless-type MMTV integration site family, member 5b 0.171
fgf8a fibroblast growth factor 8 a 0.165
bmp1a bone morphogenetic protein 1a 0.159
extl3 exostoses (multiple)-like 3 0.157
pdzrn3 PDZ domain containing RING finger 3 and PDZ domain containing ring finger 3 0.155
ift172 intraflagellar transport 172 0.154
crb2a crumbs homolog 2a 0.148
dlx2a distal-less homeobox gene 2a 0.147
sox11b SRY-box containing gene 11b 0.147
cftr cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) 0.144
scube2 signal peptide, CUB domain, EGF-like 2 0.144
cluap1 clusterin associated protein 1 0.141
smad5 MAD homolog 5 (Drosophila) 0.140
axin2 axin 2 (conductin, axil) 0.137
ift46 intraflagellar transport protein 46 0.135
disp1 dispatched homolog 1 (Drosophila) 0.133
sox2 SRY-box containing gene 2 0.132
cdon cell adhesion molecule-related/down-regulated by oncogenes 0.127
pde6c phosphodiesterase 6C, cGMP-specific, cone, alpha prime 0.118
frzb frizzled-related protein 0.110
ephb4b eph receptor B4b 0.110
osr2 odd-skipped related 2 (Drosophila) 0.109
znf503 zinc finger protein 503 0.108
tube1 tubulin, epsilon 1 0.106
nr2f1a nuclear receptor subfamily 2, group F, member 1a 0.104
mapta microtubule-associated protein tau a 0.102
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.099
fezf2 FEZ family zinc finger 2 0.099
crb2b crumbs homolog 2b 0.096
kif17 kinesin family member 17 0.093
wnt3 wingless-type MMTV integration site family, member 3 0.093
otpb orthopedia homolog b 0.091
twist2 twist2 0.090
wnt4a wingless-type MMTV integration site family, member 4a 0.089
pou3f3b POU class 3 homeobox 3b 0.089
nkx2.9 NK2 transcription factor related, locus 9 (Drosophila) 0.088
pou3f2 POU class 3 homeobox 2 0.085
nog1 noggin 1 0.085
sox11a SRY-box containing gene 11a 0.084
ext1b exostoses (multiple) 1b 0.084
grk1b G protein-coupled receptor kinase 1 b 0.082
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.080
arl13b ADP-ribosylation factor-like 13b 0.079
sox19a SRY-box containing gene 19a 0.079
ntla no tail a 0.076
shhb sonic hedgehog b 0.074
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.071
wnt9b wingless-type MMTV integration site family, member 9B 0.071
fstl5 follistatin-like 5 and follistatin-like 5 0.069
lamb1a laminin, beta 1a 0.069
slc12a2 solute carrier family 12 (potassium/chloride transporters), member 2 0.068
pax2a paired box gene 2a 0.067
flh floating head 0.067
ift80 intraflagellar transport 80 homolog (Chlamydomonas) 0.067
prickle1a prickle-like 1 (Drosophila) a 0.064
wnt8b wingless-type MMTV integration site family, member 8b 0.062
szl sizzled 0.062
rest RE1-silencing transcription factor 0.061
cby1 chibby homolog 1 (Drosophila) 0.060
scrib scribbled homolog (Drosophila) 0.059
crx cone-rod homeobox 0.058
fgf10a fibroblast growth factor 10a 0.058
ndr2 nodal-related 2 0.058
khdrbs1b KH domain containing, RNA binding, signal transduction associated 1b 0.057
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Drosophila melanogaster
Name Description Probability Func Analog Organism
ci cubitus interruptus 0.953
wg wingless 0.863
ato atonal 0.682
Gp150 CG5820 gene product from transcript CG5820-RA 0.607
ac achaete 0.588
fu fused 0.586
CtBP C-terminal Binding Protein 0.500
HLHm7 E(spl) region transcript m7 0.498
hh hedgehog 0.480
HLHmdelta E(spl) region transcript mdelta 0.428
emc extra macrochaetae 0.403
HLHm5 E(spl) region transcript m5 0.401
cos costa 0.392
ttv tout-velu 0.392
Pka-C1 cAMP-dependent protein kinase 1 0.380
Ext2 CG8433 gene product from transcript CG8433-RA 0.361
E(spl) Enhancer of split 0.351
brk brinker 0.332
pan pangolin 0.313
Dll Distal-less 0.244
HLHmbeta E(spl) region transcript mbeta 0.239
HLHmgamma E(spl) region transcript mgamma 0.196
twi twist 0.191
yki yorkie 0.169
sd scalloped 0.162
hbs hibris 0.159
malpha E(spl) region transcript malpha 0.157
amos absent MD neurons and olfactory sensilla 0.155
bin biniou 0.152
noc no ocelli 0.148
Ubx Ultrabithorax 0.137
m2 E(spl) region transcript m2 0.129
dally division abnormally delayed 0.126
fz frizzled 0.111
fz2 frizzled 2 0.107
nkd naked cuticle 0.103
eyg eyegone 0.103
sna snail 0.103
hth homothorax 0.102
tow target of wingless 0.100
Notum CG13076 gene product from transcript CG13076-RB 0.098
boi brother of iHog 0.097
fkh fork head 0.094
snf sans fille 0.091
Sulf1 Sulfated 0.089
ed echinoid 0.089
mib1 mind bomb 1 0.088
nompA no mechanoreceptor potential A 0.087
lsn larsen 0.087
sns sticks and stones 0.084
tkv thickveins 0.084
HLHm3 E(spl) region transcript m3 0.083
N Notch 0.082
mirr mirror 0.080
gcm glial cells missing 0.078
kirre kin of irre 0.078
Cul-3 Cullin-3 0.077
Egfr Epidermal growth factor receptor 0.075
vvl ventral veins lacking 0.074
MED19 Mediator complex subunit 19 0.072
G-oalpha47A G protein oalpha 47A 0.071
f forked 0.070
ft fat 0.070
dsh dishevelled 0.070
dlg1 discs large 1 0.070
egh egghead 0.069
rempA reduced mechanoreceptor potential A 0.068
bnl branchless 0.065
gbb glass bottom boat 0.064
sc scute 0.064
stumps CG31317 gene product from transcript CG31317-RC 0.064
ara araucan 0.064
Elongin-C Elongin C 0.064
bi bifid 0.061
inv invected 0.059
eag ether a go-go 0.058
Dsk Drosulfakinin 0.057
sfl sulfateless 0.056
m4 E(spl) region transcript m4 0.056
RYBP Ring and YY1 Binding Protein 0.054
kni knirps 0.054
ctp cut up 0.053
rhea CG6831 gene product from transcript CG6831-RA 0.053
tio tiptop 0.053
na narrow abdomen 0.052
sog short gastrulation 0.051
opa odd paired 0.051
Abl Abl tyrosine kinase 0.050
jeb jelly belly 0.049
Wnt2 Wnt oncogene analog 2 0.049
argos CG4531 gene product from transcript CG4531-RA 0.048
slmb supernumerary limbs 0.048
inx3 innexin 3 0.048
arr arrow 0.047
ex expanded 0.047
Tom Twin of m4 0.046
ase asense 0.046
smt3 CG4494 gene product from transcript CG4494-RA 0.045
pygo pygopus 0.045
Atx2 Ataxin-2 0.045
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Homo sapiens
Name Description Probability Func Analog Organism
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.971
SUFU suppressor of fused homolog (Drosophila) 0.809
BTRC beta-transducin repeat containing 0.764
BBS10 Bardet-Biedl syndrome 10 0.699
DCAF7 DDB1 and CUL4 associated factor 7 0.695
TP53 tumor protein p53 0.503
GLI1 GLI family zinc finger 1 0.502
CUL1 cullin 1 0.485
FGF1 fibroblast growth factor 1 (acidic) 0.446
APC adenomatous polyposis coli 0.393
FSTL1 follistatin-like 1 0.390
FBXW11 F-box and WD repeat domain containing 11 0.377
BMPR1A bone morphogenetic protein receptor, type IA 0.372
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.310
GLI3 GLI family zinc finger 3 0.289
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.285
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.270
SKP1 S-phase kinase-associated protein 1 0.264
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.262
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.258
TGFB1 transforming growth factor, beta 1 0.256
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.255
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.220
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.218
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.209
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.188
NFYA nuclear transcription factor Y, alpha 0.172
AR androgen receptor 0.161
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 0.149
PTCH1 patched 1 0.139
SASS6 spindle assembly 6 homolog (C. elegans) 0.133
CREBBP CREB binding protein 0.122
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.114
SMO smoothened homolog (Drosophila) 0.106
RCN3 reticulocalbin 3, EF-hand calcium binding domain 0.104
CD247 CD247 molecule 0.102
CDC34 cell division cycle 34 homolog (S. cerevisiae) 0.098
CENPJ centromere protein J 0.096
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.095
BBS4 Bardet-Biedl syndrome 4 0.089
STK36 serine/threonine kinase 36 0.088
CSNK1E casein kinase 1, epsilon 0.085
BMP1 bone morphogenetic protein 1 0.080
LCK lymphocyte-specific protein tyrosine kinase 0.080
YAP1 Yes-associated protein 1 0.078
ERBB2IP erbb2 interacting protein 0.077
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.075
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.070
TGFB3 transforming growth factor, beta 3 0.070
AKAP11 A kinase (PRKA) anchor protein 11 0.069
CSNK2B casein kinase 2, beta polypeptide 0.065
GSK3B glycogen synthase kinase 3 beta 0.065
BBS2 Bardet-Biedl syndrome 2 0.062
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B 0.059
RUNX1 runt-related transcription factor 1 0.049
BECN1 beclin 1, autophagy related 0.046
FGFR1 fibroblast growth factor receptor 1 0.042
AXIN1 axin 1 0.042
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 0.040
LZTS2 leucine zipper, putative tumor suppressor 2 0.039
STRN3 striatin, calmodulin binding protein 3 0.039
FGF10 fibroblast growth factor 10 0.039
ARL6 ADP-ribosylation factor-like 6 0.039
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.037
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.037
BBS9 Bardet-Biedl syndrome 9 0.032
FGFR2 fibroblast growth factor receptor 2 0.032
UBE2M ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) 0.032
SIRT1 sirtuin 1 0.032
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 0.031
BCL2L1 BCL2-like 1 0.029
FBXO33 F-box protein 33 0.029
MAPK14 mitogen-activated protein kinase 14 0.028
FBXW2 F-box and WD repeat domain containing 2 0.028
ARF6 ADP-ribosylation factor 6 0.027
SMAD3 SMAD family member 3 0.027
ARL4D ADP-ribosylation factor-like 4D 0.026
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 0.026
UNC119 unc-119 homolog (C. elegans) 0.024
NEK1 NIMA (never in mitosis gene a)-related kinase 1 0.024
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.024
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.024
FERMT2 fermitin family member 2 0.024
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.023
CSNK1G3 casein kinase 1, gamma 3 0.023
RAD54B RAD54 homolog B (S. cerevisiae) 0.023
RBL1 retinoblastoma-like 1 (p107) 0.023
GLI2 GLI family zinc finger 2 0.022
WEE1 WEE1 homolog (S. pombe) 0.022
ATF2 activating transcription factor 2 0.022
AKIP1 A kinase (PRKA) interacting protein 1 0.022
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.021
LAT linker for activation of T cells 0.021
TP53BP2 tumor protein p53 binding protein, 2 0.021
TCF4 transcription factor 4 0.021
AXIN2 axin 2 0.021
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.020
FOXF2 forkhead box F2 0.020
KIF5B kinesin family member 5B 0.019
PEX26 peroxisomal biogenesis factor 26 0.019
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Mks1 Meckel syndrome, type 1 1.000
Ctnnb1 catenin (cadherin associated protein), beta 1 1.000
Bmp4 bone morphogenetic protein 4 1.000
Gli2 GLI-Kruppel family member GLI2 1.000
Sox9 SRY-box containing gene 9 0.999
Ift88 intraflagellar transport 88 homolog (Chlamydomonas) 0.999
Foxc1 forkhead box C1 0.998
Fgfr2 fibroblast growth factor receptor 2 0.998
Kif3a kinesin family member 3A 0.997
Nog noggin 0.995
Pax3 paired box gene 3 0.993
Pax6 paired box gene 6 0.991
Nodal nodal 0.991
Chrd chordin 0.987
Fgfr3 fibroblast growth factor receptor 3 0.986
B9d1 B9 protein domain 1 0.975
Pten phosphatase and tensin homolog 0.973
Fgf10 fibroblast growth factor 10 0.971
Fuz fuzzy homolog (Drosophila) 0.970
Insm1 insulinoma-associated 1 0.967
Ret ret proto-oncogene 0.967
Tgfbr2 transforming growth factor, beta receptor II 0.967
Rarb retinoic acid receptor, beta 0.967
Smo smoothened homolog (Drosophila) 0.945
Pitx2 paired-like homeodomain transcription factor 2 0.942
Isl1 ISL1 transcription factor, LIM/homeodomain 0.942
Ptch1 patched homolog 1 0.940
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.935
Dlx5 distal-less homeobox 5 0.928
Cdon cell adhesion molecule-related/down-regulated by oncogenes 0.921
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.897
Lmx1a LIM homeobox transcription factor 1 alpha 0.893
Tgfb2 transforming growth factor, beta 2 0.890
Sall4 sal-like 4 (Drosophila) 0.887
Fgf8 fibroblast growth factor 8 0.887
Nkx2-2 NK2 transcription factor related, locus 2 (Drosophila) 0.885
Twist2 twist homolog 2 (Drosophila) 0.880
Sox2 SRY-box containing gene 2 0.878
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.875
Evc Ellis van Creveld gene homolog (human) 0.871
Rara retinoic acid receptor, alpha 0.863
Pou3f3 POU domain, class 3, transcription factor 3 0.848
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.840
Rarg retinoic acid receptor, gamma 0.837
Fgf9 fibroblast growth factor 9 0.828
Acvr1 activin A receptor, type 1 0.823
Megf8 multiple EGF-like-domains 8 0.802
Ntf3 neurotrophin 3 0.800
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.800
Tcfap2a transcription factor AP-2, alpha 0.795
Gdnf glial cell line derived neurotrophic factor 0.787
Bmi1 Bmi1 polycomb ring finger oncogene 0.779
Zic4 zinc finger protein of the cerebellum 4 0.778
Lhx1 LIM homeobox protein 1 0.774
Lrp2 low density lipoprotein receptor-related protein 2 0.767
Evc2 Ellis van Creveld syndrome 2 homolog (human) 0.762
Htt huntingtin 0.757
Prrx2 paired related homeobox 2 0.749
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.737
Bmpr1a bone morphogenetic protein receptor, type 1A 0.727
Rnf2 ring finger protein 2 0.712
Ptf1a pancreas specific transcription factor, 1a 0.709
Meox2 mesenchyme homeobox 2 0.700
Gsc goosecoid homeobox 0.685
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.680
Nr0b1 nuclear receptor subfamily 0, group B, member 1 0.666
Adra1a adrenergic receptor, alpha 1a 0.665
Ece1 endothelin converting enzyme 1 0.650
Sox10 SRY-box containing gene 10 0.643
Hoxa3 homeobox A3 0.636
Neurod1 neurogenic differentiation 1 0.626
Apaf1 apoptotic peptidase activating factor 1 0.622
Ahi1 Abelson helper integration site 1 0.618
Otx2 orthodenticle homolog 2 (Drosophila) 0.617
Pdx1 pancreatic and duodenal homeobox 1 0.604
Pkdcc protein kinase domain containing, cytoplasmic 0.594
Ift140 intraflagellar transport 140 homolog (Chlamydomonas) 0.592
Lhx3 LIM homeobox protein 3 0.590
Pax8 paired box gene 8 0.573
Pax2 paired box gene 2 0.573
Psen1 presenilin 1 0.567
Tlx3 T-cell leukemia, homeobox 3 0.566
Gli1 GLI-Kruppel family member GLI1 0.565
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.564
Tbx15 T-box 15 0.559
Apc adenomatosis polyposis coli 0.555
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.555
Bbs1 Bardet-Biedl syndrome 1 (human) 0.532
Bmp7 bone morphogenetic protein 7 0.529
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.526
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.522
Mesp1 mesoderm posterior 1 0.519
Ccdc39 coiled-coil domain containing 39 0.517
Msx1 homeobox, msh-like 1 0.511
Msx2 homeobox, msh-like 2 0.504
Prrx1 paired related homeobox 1 0.494
Wnt10b wingless related MMTV integration site 10b 0.486
Hoxd11 homeobox D11 0.486
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism