The network for 'alpha beta t cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

alpha beta t cell activation

The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.675
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.403
LCK lymphocyte-specific protein tyrosine kinase 0.241
BIRC3 baculoviral IAP repeat containing 3 0.238
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.180
TRAF1 TNF receptor-associated factor 1 0.177
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.175
CCL4 chemokine (C-C motif) ligand 4 0.150
IL4R interleukin 4 receptor 0.150
CCR7 chemokine (C-C motif) receptor 7 0.147
NCOR2 nuclear receptor corepressor 2 0.136
IL2RG interleukin 2 receptor, gamma 0.121
CD2 CD2 molecule 0.097
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.087
GRAP2 GRB2-related adaptor protein 2 0.080
CCR5 chemokine (C-C motif) receptor 5 0.076
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.076
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.072
CXCL10 chemokine (C-X-C motif) ligand 10 0.071
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.067
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.065
CD247 CD247 molecule 0.062
CXCL9 chemokine (C-X-C motif) ligand 9 0.058
ICAM1 intercellular adhesion molecule 1 0.056
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.055
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.049
CCL5 chemokine (C-C motif) ligand 5 0.047
IL1B interleukin 1, beta 0.046
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.045
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.044
IL15RA interleukin 15 receptor, alpha 0.041
CXCL11 chemokine (C-X-C motif) ligand 11 0.036
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.036
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.035
CD40 CD40 molecule, TNF receptor superfamily member 5 0.033
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.033
IL2RB interleukin 2 receptor, beta 0.032
IFNG interferon, gamma 0.031
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.030
LAT linker for activation of T cells 0.030
SH2D1A SH2 domain containing 1A 0.029
CCL2 chemokine (C-C motif) ligand 2 0.028
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.027
IL8 interleukin 8 0.026
IL4 interleukin 4 0.026
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.025
SIGLEC7 sialic acid binding Ig-like lectin 7 0.025
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.025
TRAF3 TNF receptor-associated factor 3 0.024
IL7R interleukin 7 receptor 0.024
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.023
CCL8 chemokine (C-C motif) ligand 8 0.023
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.022
CCL22 chemokine (C-C motif) ligand 22 0.021
CREBBP CREB binding protein 0.021
RUNX1 runt-related transcription factor 1 0.021
LIN9 lin-9 homolog (C. elegans) 0.020
CD86 CD86 molecule 0.020
ZMYND11 zinc finger, MYND-type containing 11 0.020
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.019
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.018
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.018
IL23A interleukin 23, alpha subunit p19 0.018
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.018
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.018
RXRA retinoid X receptor, alpha 0.018
ITGB1BP3 integrin beta 1 binding protein 3 0.018
PDZD11 PDZ domain containing 11 0.017
CCR1 chemokine (C-C motif) receptor 1 0.017
CD3G CD3g molecule, gamma (CD3-TCR complex) 0.017
IL10 interleukin 10 0.017
CD80 CD80 molecule 0.017
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.016
MED25 mediator complex subunit 25 0.015
SOD2 superoxide dismutase 2, mitochondrial 0.015
SYK spleen tyrosine kinase 0.014
IRF4 interferon regulatory factor 4 0.014
TGFB3 transforming growth factor, beta 3 0.013
CSNK1G1 casein kinase 1, gamma 1 0.013
CXCL13 chemokine (C-X-C motif) ligand 13 0.013
CTBP1 C-terminal binding protein 1 0.012
VCAM1 vascular cell adhesion molecule 1 0.012
BCL2A1 BCL2-related protein A1 0.011
CXCR6 chemokine (C-X-C motif) receptor 6 0.011
TRAF3IP3 TRAF3 interacting protein 3 0.011
TBX21 T-box 21 0.011
RUNX3 runt-related transcription factor 3 0.011
IL6 interleukin 6 (interferon, beta 2) 0.011
IRF8 interferon regulatory factor 8 0.011
IL6R interleukin 6 receptor 0.011
DPP4 dipeptidyl-peptidase 4 0.011
TRAF5 TNF receptor-associated factor 5 0.011
PILRA paired immunoglobin-like type 2 receptor alpha 0.010
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.010
PIK3CA phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.010
CCL20 chemokine (C-C motif) ligand 20 0.010
CCL13 chemokine (C-C motif) ligand 13 0.010
STAT4 signal transducer and activator of transcription 4 0.010
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Sox9 SRY-box containing gene 9 0.992
Ikzf1 IKAROS family zinc finger 1 0.991
Foxp3 forkhead box P3 0.982
Stat3 signal transducer and activator of transcription 3 0.961
Jak2 Janus kinase 2 0.959
Socs1 suppressor of cytokine signaling 1 0.954
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.943
Il2rb interleukin 2 receptor, beta chain 0.924
Bcl2 B-cell leukemia/lymphoma 2 0.906
Cd28 CD28 antigen 0.901
Gli2 GLI-Kruppel family member GLI2 0.875
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.865
Fyn Fyn proto-oncogene 0.838
Zeb1 zinc finger E-box binding homeobox 1 0.836
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.831
Cd40 CD40 antigen 0.828
Il27ra interleukin 27 receptor, alpha 0.825
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.812
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.812
Il4ra interleukin 4 receptor, alpha 0.811
Cd7 CD7 antigen 0.808
Pitx1 paired-like homeodomain transcription factor 1 0.799
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.775
Myd88 myeloid differentiation primary response gene 88 0.746
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.742
Ccr7 chemokine (C-C motif) receptor 7 0.741
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.732
Ptprc protein tyrosine phosphatase, receptor type, C 0.725
Irf4 interferon regulatory factor 4 0.691
Lef1 lymphoid enhancer binding factor 1 0.683
Batf basic leucine zipper transcription factor, ATF-like 0.678
Il2rg interleukin 2 receptor, gamma chain 0.674
Sh2d2a SH2 domain protein 2A 0.674
Il18rap interleukin 18 receptor accessory protein 0.671
Fgf10 fibroblast growth factor 10 0.664
H2-K1 histocompatibility 2, K1, K region 0.662
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.660
Icos inducible T-cell co-stimulator 0.658
Cd86 CD86 antigen 0.656
Bcl3 B-cell leukemia/lymphoma 3 0.653
Itgax integrin alpha X 0.649
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.635
Irf5 interferon regulatory factor 5 0.624
Tbx3 T-box 3 0.618
Ctsw cathepsin W 0.612
Atxn1 ataxin 1 0.604
Stat5a signal transducer and activator of transcription 5A 0.603
Cd5 CD5 antigen 0.575
Stat5b signal transducer and activator of transcription 5B 0.572
Tnf tumor necrosis factor 0.566
Lta lymphotoxin A 0.565
Foxf1a forkhead box F1a 0.555
H2-Aa histocompatibility 2, class II antigen A, alpha 0.553
Tgfbr1 transforming growth factor, beta receptor I 0.545
Traf6 TNF receptor-associated factor 6 0.537
Ccr2 chemokine (C-C motif) receptor 2 0.523
Clec4d C-type lectin domain family 4, member d 0.522
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.522
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.521
Lck lymphocyte protein tyrosine kinase 0.512
Cd19 CD19 antigen 0.503
Runx1 runt related transcription factor 1 0.498
Ifng interferon gamma 0.489
Fgfr2 fibroblast growth factor receptor 2 0.489
Gpr132 G protein-coupled receptor 132 0.480
Prdm1 PR domain containing 1, with ZNF domain 0.473
Ccl2 chemokine (C-C motif) ligand 2 0.467
Ccl5 chemokine (C-C motif) ligand 5 0.466
Lat linker for activation of T cells 0.465
Pdcd1 programmed cell death 1 0.464
Rarg retinoic acid receptor, gamma 0.463
Prkce protein kinase C, epsilon 0.460
Fas Fas (TNF receptor superfamily member 6) 0.459
Itk IL2-inducible T-cell kinase 0.452
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.451
Irf8 interferon regulatory factor 8 0.440
Il7r interleukin 7 receptor 0.440
Ncr1 natural cytotoxicity triggering receptor 1 0.434
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.431
Il10ra interleukin 10 receptor, alpha 0.430
Sfpi1 SFFV proviral integration 1 0.423
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.419
Il4 interleukin 4 0.418
Itgal integrin alpha L 0.416
Fasl Fas ligand (TNF superfamily, member 6) 0.412
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.411
Cyld cylindromatosis (turban tumor syndrome) 0.405
Il18r1 interleukin 18 receptor 1 0.402
Pitx3 paired-like homeodomain transcription factor 3 0.399
Cd8a CD8 antigen, alpha chain 0.395
Shh sonic hedgehog 0.384
Traf1 TNF receptor-associated factor 1 0.383
Gzmk granzyme K 0.377
Cd4 CD4 antigen 0.376
Gzma granzyme A 0.367
Cd3e CD3 antigen, epsilon polypeptide 0.366
Il6 interleukin 6 0.365
Lyz2 lysozyme 2 0.361
Myo1f myosin IF 0.356
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.353
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cd37 CD37 molecule 0.085
Lst1 leukocyte specific transcript 1 0.057
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.050
Pecam1 platelet/endothelial cell adhesion molecule 1 0.041
Ptafr platelet-activating factor receptor 0.041
Hmha1 histocompatibility (minor) HA-1 0.036
Cd5 Cd5 molecule 0.036
Fut4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.035
Cd2 Cd2 molecule 0.034
Ccr5 chemokine (C-C motif) receptor 5 0.033
Hcst hematopoietic cell signal transducer 0.033
Smad7 SMAD family member 7 0.031
Myo1f myosin IF 0.030
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.030
Hoxc4 homeo box C4 0.029
Cxcr4 chemokine (C-X-C motif) receptor 4 0.028
Nkg7 natural killer cell group 7 sequence 0.027
Arhgap25 Rho GTPase activating protein 25 0.026
Gimap4 GTPase, IMAP family member 4 0.026
Cfp complement factor properdin 0.025
Lepr leptin receptor 0.025
Igfbp5 insulin-like growth factor binding protein 5 0.025
Nfic nuclear factor I/C 0.025
Tcrb T-cell receptor beta chain 0.025
Itgb7 integrin, beta 7 0.024
Bin2 bridging integrator 2 0.024
Galr3 galanin receptor 3 0.022
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.022
Rxra retinoid X receptor alpha 0.022
Cd3g CD3 molecule, gamma 0.022
Itgal integrin, alpha L 0.021
Lrrc33 leucine rich repeat containing 33 0.021
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.021
Prkch protein kinase C, eta 0.021
LOC100364854 similar to RIKEN cDNA A430107P09 gene-like 0.021
Itgam integrin, alpha M 0.021
Stat6 signal transducer and activator of transcription 6 0.020
Ict1 immature colon carcinoma transcript 1 0.020
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.020
Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 0.019
Rara retinoic acid receptor, alpha 0.019
Il2rg interleukin 2 receptor, gamma 0.019
Abi3 ABI family, member 3 0.019
Ccl5 chemokine (C-C motif) ligand 5 0.019
Lck lymphocyte-specific protein tyrosine kinase 0.019
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.018
Sh2d1a SH2 domain protein 1A 0.018
Cd4 Cd4 molecule 0.018
Mov10 Moloney leukemia virus 10 0.018
Rcsd1 RCSD domain containing 1 0.018
Sell selectin L 0.018
Spn sialophorin 0.018
Tfec transcription factor EC 0.018
Apol3 apolipoprotein L, 3 0.018
Gzmm granzyme M (lymphocyte met-ase 1) 0.018
Cd8b CD8b molecule 0.017
Sorbs1 sorbin and SH3 domain containing 1 0.017
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.017
Epn1 Epsin 1 0.017
Il1rn interleukin 1 receptor antagonist 0.017
Gja4 gap junction protein, alpha 4 0.017
Ly86 lymphocyte antigen 86 0.017
RT1-T24-3 RT1 class I, locus T24, gene 3 0.016
Hdac7 histone deacetylase 7 0.016
Timm13 translocase of inner mitochondrial membrane 13 homolog (yeast) 0.016
Rhoh ras homolog gene family, member H 0.016
RT1-Db1 RT1 class II, locus Db1 0.016
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.016
Nos3 nitric oxide synthase 3, endothelial cell 0.016
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.016
Csk c-src tyrosine kinase 0.016
Cd80 Cd80 molecule 0.016
Gpsm3 G-protein signaling modulator 3 (AGS3-like, C. elegans) 0.016
Adrb2 adrenergic, beta-2-, receptor, surface 0.016
Vav1 vav 1 guanine nucleotide exchange factor 0.016
Tceb3 transcription elongation factor B (SIII), polypeptide 3 0.016
Batf3 basic leucine zipper transcription factor, ATF-like 3 0.015
Map3k3 mitogen activated protein kinase kinase kinase 3 0.015
Apcs amyloid P component, serum 0.015
Psd4 pleckstrin and Sec7 domain containing 4 0.015
Il6 interleukin 6 0.015
Sdc3 syndecan 3 0.015
Btk Bruton agammaglobulinemia tyrosine kinase 0.015
Gzmk granzyme K 0.015
Prf1 perforin 1 (pore forming protein) 0.015
Cela1 chymotrypsin-like elastase family, member 1 0.014
Socs3 suppressor of cytokine signaling 3 0.014
LOC60591 calcium-activated potassium channel beta subunit 0.014
Hck hemopoietic cell kinase 0.014
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.014
Ccdc69 coiled-coil domain containing 69 0.014
Arnt aryl hydrocarbon receptor nuclear translocator 0.014
Il2rb interleukin 2 receptor, beta 0.014
Cd180 CD180 molecule 0.013
LOC363326 hypothetical LOC363326 0.013
Cops5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 0.013
Arhgap4 Rho GTPase activating protein 4 0.013
Fam26f family with sequence similarity 26, member F 0.013
Lyl1 lymphoblastic leukemia derived sequence 1 0.013
Gata3 GATA binding protein 3 0.013
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism