The network for 'negative regulation of endothelial cell migration' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of endothelial cell migration

Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.

Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
dla deltaA 0.980
gli2a GLI-Kruppel family member GLI2a 0.834
notch3 notch homolog 3 0.784
dld deltaD 0.741
ascl1a achaete-scute complex-like 1a (Drosophila) 0.687
notch1a notch homolog 1a 0.607
kdrl kinase insert domain receptor like 0.571
dlb deltaB 0.550
eya1 eyes absent homolog 1 0.536
alcama activated leukocyte cell adhesion molecule a 0.503
dlc deltaC 0.473
prox1 prospero-related homeobox gene 1 0.411
sox9a SRY-box containing gene 9a 0.264
neurog1 neurogenin 1 0.259
cxcr4b chemokine (C-X-C motif), receptor 4b 0.195
mib mind bomb 0.189
shha sonic hedgehog a 0.159
tbx2b T-box 2b 0.133
her6 hairy-related 6 0.125
sox3 SRY-box containing gene 3 0.118
myod1 myogenic differentiation 1 0.115
foxn4 forkhead box N4 0.113
pitx3 paired-like homeodomain transcription factor 3 0.107
cdh2 cadherin 2, neuronal 0.104
dlx5a distal-less homeobox gene 5a 0.103
jag2 jagged 2 0.103
sox10 SRY-box containing gene 10 0.099
pcna proliferating cell nuclear antigen 0.091
isl1 islet1 0.089
sall1a sal-like 1a (Drosophila) 0.083
spry4 sprouty (Drosophila) homolog 4 0.081
vegfc vascular endothelial growth factor c 0.081
ptf1a pancreas specific transcription factor, 1a 0.081
ccm2 cerebral cavernous malformation 2 0.078
pax2a paired box gene 2a 0.073
fgfr2 fibroblast growth factor receptor 2 0.071
neurod neurogenic differentiation 0.071
cyp1a cytochrome P450, family 1, subfamily A 0.070
pax6a paired box gene 6a 0.069
nrarpa notch-regulated ankyrin repeat protein a 0.068
her4.2 hairy-related 4.2 0.068
edn1 endothelin 1 0.065
tal1 T-cell acute lymphocytic leukemia 1 0.064
gata3 GATA-binding protein 3 0.062
vim vimentin 0.059
insm1b insulinoma-associated 1b 0.058
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.057
copeb core promoter element binding protein 0.054
bmp4 bone morphogenetic protein 4 0.052
neurod4 neurogenic differentiation 4 0.052
cdh23 cadherin-like 23 0.051
zgc:85866 zgc:85866 0.049
insm1a insulinoma-associated 1a 0.049
meis1 myeloid ecotropic viral integration 1 0.048
birc2 baculoviral IAP repeat-containing 2 0.047
jag1b jagged 1b 0.046
met met proto-oncogene (hepatocyte growth factor receptor) 0.045
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.045
robo3 roundabout homolog 3 0.045
tp63 tumor protein p63 0.044
gata2a GATA-binding protein 2a 0.040
slc12a2 solute carrier family 12 (potassium/chloride transporters), member 2 0.040
jag1a jagged 1a 0.040
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.039
ca2 carbonic anhydrase II 0.037
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.036
elavl3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C) 0.036
mdka midkine-related growth factor 0.036
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.034
atp1a1a.2 ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide 0.034
irx3a iroquois homeobox protein 3a 0.032
neo1 neogenin 1 0.031
ahr2 aryl hydrocarbon receptor 2 0.031
nkx2.2a NK2 transcription factor related 2a 0.030
mmp2 matrix metalloproteinase 2 0.030
otpb orthopedia homolog b 0.030
tnnt2a troponin T2a, cardiac 0.029
jun jun proto-oncogene 0.029
traf4a tnf receptor-associated factor 4a 0.029
rbp4 retinol binding protein 4, plasma 0.028
cxcr4a chemokine (C-X-C motif) receptor 4a 0.028
tcf12 transcription factor 12 0.028
nrp2b neuropilin 2b 0.028
sox11a SRY-box containing gene 11a 0.028
hnf1bb HNF1 homeobox Bb 0.027
ift88 intraflagellar transport 88 homolog 0.027
notch2 notch homolog 2 0.027
midn midnolin 0.027
vsx2 visual system homeobox 2 0.026
ptgs2a prostaglandin-endoperoxide synthase 2a 0.025
ascl1b achaete-scute complex-like 1b (Drosophila) 0.024
sars seryl-tRNA synthetase 0.024
foxa1 forkhead box A1 0.024
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.024
fgf10a fibroblast growth factor 10a 0.023
sulf2 sulfatase 2 0.023
ntn1a netrin 1a 0.023
supt6h suppressor of Ty 6 homolog 0.023
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.022
ptmaa prothymosin, alpha a 0.022
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 0.988
RARA retinoic acid receptor, alpha 0.967
TGFB1 transforming growth factor, beta 1 0.930
TEK TEK tyrosine kinase, endothelial 0.899
JAG1 jagged 1 0.845
BMP2 bone morphogenetic protein 2 0.805
NOTCH1 notch 1 0.805
ENG endoglin 0.757
NOTCH3 notch 3 0.624
MED25 mediator complex subunit 25 0.596
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.496
A2M alpha-2-macroglobulin 0.488
FGA fibrinogen alpha chain 0.488
FGF1 fibroblast growth factor 1 (acidic) 0.475
TGFB3 transforming growth factor, beta 3 0.457
RXRA retinoid X receptor, alpha 0.457
FKBP1A FK506 binding protein 1A, 12kDa 0.360
NCOA1 nuclear receptor coactivator 1 0.347
FGFR1 fibroblast growth factor receptor 1 0.342
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.277
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.250
MEF2C myocyte enhancer factor 2C 0.216
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.193
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.182
NRP1 neuropilin 1 0.180
NOTCH2 notch 2 0.179
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.179
FGF10 fibroblast growth factor 10 0.177
PRKD2 protein kinase D2 0.170
FBLN1 fibulin 1 0.167
MEF2A myocyte enhancer factor 2A 0.164
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.164
BMPR1B bone morphogenetic protein receptor, type IB 0.153
NCOR2 nuclear receptor corepressor 2 0.140
HP haptoglobin 0.110
GDF5 growth differentiation factor 5 0.107
SMAD7 SMAD family member 7 0.107
FSTL1 follistatin-like 1 0.097
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.096
DLL1 delta-like 1 (Drosophila) 0.093
APOC1 apolipoprotein C-I 0.088
ACVR1 activin A receptor, type I 0.088
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.075
KLF6 Kruppel-like factor 6 0.075
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 0.073
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.073
PRKG1 protein kinase, cGMP-dependent, type I 0.072
FAM46A family with sequence similarity 46, member A 0.071
TGFBR1 transforming growth factor, beta receptor 1 0.067
BMP4 bone morphogenetic protein 4 0.067
PPARG peroxisome proliferator-activated receptor gamma 0.062
KLF4 Kruppel-like factor 4 (gut) 0.062
JAG2 jagged 2 0.060
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.060
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.058
S100B S100 calcium binding protein B 0.058
SKIL SKI-like oncogene 0.057
NR0B2 nuclear receptor subfamily 0, group B, member 2 0.055
MAPK7 mitogen-activated protein kinase 7 0.054
FOXP3 forkhead box P3 0.052
PROX1 prospero homeobox 1 0.051
HDAC4 histone deacetylase 4 0.051
PTGIS prostaglandin I2 (prostacyclin) synthase 0.050
CARHSP1 calcium regulated heat stable protein 1, 24kDa 0.049
VEGFC vascular endothelial growth factor C 0.045
VEGFA vascular endothelial growth factor A 0.045
BCL6 B-cell CLL/lymphoma 6 0.044
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 0.044
FGF2 fibroblast growth factor 2 (basic) 0.043
SAMD4A sterile alpha motif domain containing 4A 0.041
CAV1 caveolin 1, caveolae protein, 22kDa 0.040
LAMB1 laminin, beta 1 0.039
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.038
ZMYND11 zinc finger, MYND-type containing 11 0.038
FGF7 fibroblast growth factor 7 0.037
FGFR3 fibroblast growth factor receptor 3 0.037
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.036
ETS1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.035
JUN jun proto-oncogene 0.035
APP amyloid beta (A4) precursor protein 0.034
THBS1 thrombospondin 1 0.034
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) 0.033
GFI1B growth factor independent 1B transcription repressor 0.031
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.031
SREBF2 sterol regulatory element binding transcription factor 2 0.030
CDH5 cadherin 5, type 2 (vascular endothelium) 0.030
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.030
FNDC3B fibronectin type III domain containing 3B 0.029
HDAC7 histone deacetylase 7 0.027
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.027
PLXDC1 plexin domain containing 1 0.027
PPARA peroxisome proliferator-activated receptor alpha 0.026
ZBTB16 zinc finger and BTB domain containing 16 0.026
DCN decorin 0.026
SLIT2 slit homolog 2 (Drosophila) 0.026
DUSP1 dual specificity phosphatase 1 0.026
IGF2 insulin-like growth factor 2 (somatomedin A) 0.025
SNCG synuclein, gamma (breast cancer-specific protein 1) 0.025
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.025
ASRGL1 asparaginase like 1 0.024
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Mus musculus
Name Description Probability Func Analog Organism
Dll1 delta-like 1 (Drosophila) 0.999
Notch1 Notch gene homolog 1 (Drosophila) 0.999
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.995
Notch2 Notch gene homolog 2 (Drosophila) 0.995
Eng endoglin 0.983
Prl7d1 prolactin family 7, subfamily d, member 1 0.977
Psen1 presenilin 1 0.940
Fgfr1 fibroblast growth factor receptor 1 0.920
Prl7a1 prolactin family 7, subfamily a, member 1 0.896
Slit3 slit homolog 3 (Drosophila) 0.896
Prl8a2 prolactin family 8, subfamily a, member 2 0.877
Robo1 roundabout homolog 1 (Drosophila) 0.865
Cdh5 cadherin 5 0.858
Tgfbr2 transforming growth factor, beta receptor II 0.796
Prl3b1 prolactin family 3, subfamily b, member 1 0.787
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.779
Cldn5 claudin 5 0.777
Rb1 retinoblastoma 1 0.761
Nos3 nitric oxide synthase 3, endothelial cell 0.756
Tcte3 t-complex-associated testis expressed 3 0.724
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.650
Thbs2 thrombospondin 2 0.623
Prl2b1 prolactin family 2, subfamily b, member 1 0.622
Prl8a6 prolactin family 8, subfamily a, member 6 0.614
Prl6a1 prolactin family 6, subfamily a, member 1 0.612
Mmp1a matrix metallopeptidase 1a (interstitial collagenase) 0.561
Jag2 jagged 2 0.549
Tpbpa trophoblast specific protein alpha 0.545
Ptprb protein tyrosine phosphatase, receptor type, B 0.538
Prl8a9 prolactin family8, subfamily a, member 9 0.511
Col13a1 collagen, type XIII, alpha 1 0.501
Nr2f1 nuclear receptor subfamily 2, group F, member 1 0.500
Ctsr cathepsin R 0.496
Ghr growth hormone receptor 0.487
Olfr64 olfactory receptor 64 0.482
Chd7 chromodomain helicase DNA binding protein 7 0.477
Efnb2 ephrin B2 0.466
Erv3 endogenous retroviral sequence 3 0.459
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.459
Dll4 delta-like 4 (Drosophila) 0.444
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.442
Ceacam11 carcinoembryonic antigen-related cell adhesion molecule 11 0.412
Efnb1 ephrin B1 0.409
Robo2 roundabout homolog 2 (Drosophila) 0.399
Serpinb9c serine (or cysteine) peptidase inhibitor, clade B, member 9c 0.379
Hes1 hairy and enhancer of split 1 (Drosophila) 0.377
Jag1 jagged 1 0.372
Prl3a1 prolactin family 3, subfamily a, member 1 0.368
Lox lysyl oxidase 0.354
Serpinb9g serine (or cysteine) peptidase inhibitor, clade B, member 9g 0.340
Prl3d1 prolactin family 3, subfamily d, member 1 0.330
Mef2d myocyte enhancer factor 2D 0.321
Prl7a2 prolactin family 7, subfamily a, member 2 0.321
Prl5a1 prolactin family 5, subfamily a, member 1 0.310
Slit1 slit homolog 1 (Drosophila) 0.307
Sva seminal vesicle antigen 0.303
Foxg1 forkhead box G1 0.299
Klf2 Kruppel-like factor 2 (lung) 0.298
Vangl2 vang-like 2 (van gogh, Drosophila) 0.292
Dctn1 dynactin 1 0.274
Rhox9 reproductive homeobox 9 0.251
Prl2a1 prolactin family 2, subfamily a, member 1 0.245
Hand2 heart and neural crest derivatives expressed transcript 2 0.243
Psg19 pregnancy specific glycoprotein 19 0.242
Esam endothelial cell-specific adhesion molecule 0.241
Snai1 snail homolog 1 (Drosophila) 0.240
Osmr oncostatin M receptor 0.239
Prl7c1 prolactin family 7, subfamily c, member 1 0.235
Ceacam12 carcinoembryonic antigen-related cell adhesion molecule 12 0.233
Ctsj cathepsin J 0.222
Lyz2 lysozyme 2 0.220
Cyr61 cysteine rich protein 61 0.220
Masp1 mannan-binding lectin serine peptidase 1 0.219
Kng1 kininogen 1 0.217
Prl4a1 prolactin family 4, subfamily a, member 1 0.215
Map3k3 mitogen-activated protein kinase kinase kinase 3 0.213
Notch3 Notch gene homolog 3 (Drosophila) 0.212
Mdm2 transformed mouse 3T3 cell double minute 2 0.212
Sema3f sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.210
Prss58 protease, serine 58 0.208
Dusp1 dual specificity phosphatase 1 0.207
Prl8a8 prolactin family 8, subfamily a, member 81 0.206
Prl3c1 prolactin family 3, subfamily c, member 1 0.206
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.198
Adcy4 adenylate cyclase 4 0.196
Plg plasminogen 0.195
Slco6c1 solute carrier organic anion transporter family, member 6c1 0.189
Vmn1r42 vomeronasal 1 receptor 42 0.173
Plac1 placental specific protein 1 0.172
Sox17 SRY-box containing gene 17 0.168
Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 0.166
Prl3d2 prolactin family 3, subfamily d, member 1 0.164
Csn1s2a casein alpha s2-like A 0.164
She src homology 2 domain-containing transforming protein E 0.159
Irs3 insulin receptor substrate 3 0.159
Fat4 FAT tumor suppressor homolog 4 (Drosophila) 0.158
Apoa1 apolipoprotein A-I 0.156
Slco1b2 solute carrier organic anion transporter family, member 1b2 0.152
Timp3 tissue inhibitor of metalloproteinase 3 0.152
Psen2 presenilin 2 0.149
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Rattus norvegicus
Name Description Probability Func Analog Organism
C1s complement component 1, s subcomponent 0.037
Cp ceruloplasmin 0.026
Ifitm3 interferon induced transmembrane protein 3 0.021
C1r complement component 1, r subcomponent 0.019
Tcf4 transcription factor 4 0.018
Aebp1 AE binding protein 1 0.014
Dock6 dedicator of cytokinesis 6 0.012
Adcy4 adenylate cyclase 4 0.011
Bbx bobby sox homolog (Drosophila) 0.011
Dusp1 dual specificity phosphatase 1 0.011
Gja4 gap junction protein, alpha 4 0.011
C4b complement component 4B (Chido blood group) 0.011
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 0.011
Nfia nuclear factor I/A 0.010
Klf2 Kruppel-like factor 2 (lung) 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism