The network for 'cardiac muscle hypertrophy' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cardiac muscle hypertrophy

The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division.

Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.755
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.592
MYOZ1 myozenin 1 0.563
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.472
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.424
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.415
BMPR1B bone morphogenetic protein receptor, type IB 0.301
ITGB1BP3 integrin beta 1 binding protein 3 0.258
CAMK2B calcium/calmodulin-dependent protein kinase II beta 0.240
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.218
TRIM63 tripartite motif containing 63 0.150
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.142
BBS10 Bardet-Biedl syndrome 10 0.107
HDAC4 histone deacetylase 4 0.094
IGF2R insulin-like growth factor 2 receptor 0.088
CYLD cylindromatosis (turban tumor syndrome) 0.083
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.082
NEB nebulin 0.075
MYOZ2 myozenin 2 0.073
CALCA calcitonin-related polypeptide alpha 0.066
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) 0.064
MAPK6 mitogen-activated protein kinase 6 0.054
CAPN3 calpain 3, (p94) 0.051
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.048
HDAC9 histone deacetylase 9 0.048
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.048
OSGEP O-sialoglycoprotein endopeptidase 0.048
MEF2A myocyte enhancer factor 2A 0.047
NCOA3 nuclear receptor coactivator 3 0.044
KLF13 Kruppel-like factor 13 0.044
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.044
NCOA1 nuclear receptor coactivator 1 0.044
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) 0.040
MYOD1 myogenic differentiation 1 0.039
AKAP6 A kinase (PRKA) anchor protein 6 0.037
DLG2 discs, large homolog 2 (Drosophila) 0.036
TRPC3 transient receptor potential cation channel, subfamily C, member 3 0.032
MAPK1 mitogen-activated protein kinase 1 0.032
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 0.029
MAP3K1 mitogen-activated protein kinase kinase kinase 1 0.028
MYLK2 myosin light chain kinase 2 0.026
MBNL1 muscleblind-like (Drosophila) 0.025
KAT2B K(lysine) acetyltransferase 2B 0.025
CSNK1E casein kinase 1, epsilon 0.024
HIST1H3B histone cluster 1, H3b 0.022
GRIA4 glutamate receptor, ionotrophic, AMPA 4 0.022
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.021
FAF1 Fas (TNFRSF6) associated factor 1 0.021
CIAPIN1 cytokine induced apoptosis inhibitor 1 0.021
PARK2 parkinson protein 2, E3 ubiquitin protein ligase (parkin) 0.020
DCN decorin 0.020
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.020
PDPK1 3-phosphoinositide dependent protein kinase-1 0.018
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.018
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 0.017
JPH2 junctophilin 2 0.017
OBSL1 obscurin-like 1 0.017
NCOR1 nuclear receptor corepressor 1 0.017
SPTBN1 spectrin, beta, non-erythrocytic 1 0.016
CRIP1 cysteine-rich protein 1 (intestinal) 0.016
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.016
HEXDC hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing 0.016
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.016
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.015
FRZB frizzled-related protein 0.015
AXIN1 axin 1 0.015
NRIP1 nuclear receptor interacting protein 1 0.015
DEAF1 deformed epidermal autoregulatory factor 1 (Drosophila) 0.014
C16orf74 chromosome 16 open reading frame 74 0.014
PRKCQ protein kinase C, theta 0.014
TRPC6 transient receptor potential cation channel, subfamily C, member 6 0.014
HIST1H4F histone cluster 1, H4f 0.013
ACTN1 actinin, alpha 1 0.013
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.012
CELF2 CUGBP, Elav-like family member 2 0.012
TRPC5 transient receptor potential cation channel, subfamily C, member 5 0.012
CLIP1 CAP-GLY domain containing linker protein 1 0.012
NOV nephroblastoma overexpressed gene 0.012
C16orf70 chromosome 16 open reading frame 70 0.012
ARRB2 arrestin, beta 2 0.011
SOX1 SRY (sex determining region Y)-box 1 0.011
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.011
ACTA1 actin, alpha 1, skeletal muscle 0.011
SVIL supervillin 0.011
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.011
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 0.011
ZEB2 zinc finger E-box binding homeobox 2 0.011
TF transferrin 0.011
TNNI1 troponin I type 1 (skeletal, slow) 0.011
PTPRR protein tyrosine phosphatase, receptor type, R 0.011
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.010
MYPN myopalladin 0.010
MYOG myogenin (myogenic factor 4) 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Nos3 nitric oxide synthase 3, endothelial cell 0.981
Jag1 jagged 1 0.715
Rxra retinoid X receptor alpha 0.635
Gata4 GATA binding protein 4 0.625
Adrb1 adrenergic receptor, beta 1 0.613
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.559
Tgfb2 transforming growth factor, beta 2 0.440
Pnpla2 patatin-like phospholipase domain containing 2 0.426
Pparg peroxisome proliferator activated receptor gamma 0.415
Gata5 GATA binding protein 5 0.410
Hand2 heart and neural crest derivatives expressed transcript 2 0.316
Zfpm2 zinc finger protein, multitype 2 0.292
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.277
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.241
Ar androgen receptor 0.230
Bmp4 bone morphogenetic protein 4 0.192
Hivep2 human immunodeficiency virus type I enhancer binding protein 2 0.190
Mef2d myocyte enhancer factor 2D 0.187
Hand1 heart and neural crest derivatives expressed transcript 1 0.182
Abcc9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 0.161
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.160
Rhob ras homolog gene family, member B 0.146
Fgf8 fibroblast growth factor 8 0.143
Dusp1 dual specificity phosphatase 1 0.133
Ptprb protein tyrosine phosphatase, receptor type, B 0.132
Hdac4 histone deacetylase 4 0.122
Ednra endothelin receptor type A 0.120
Lox lysyl oxidase 0.120
Gdf6 growth differentiation factor 6 0.115
Efnb2 ephrin B2 0.113
Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 0.109
Cav1 caveolin 1, caveolae protein 0.108
Epor erythropoietin receptor 0.107
Kcnk3 potassium channel, subfamily K, member 3 0.105
Epas1 endothelial PAS domain protein 1 0.101
Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 0.099
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.097
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) 0.097
Pax2 paired box gene 2 0.095
Drd2 dopamine receptor D2 0.094
Ush1g Usher syndrome 1G homolog (human) 0.094
Smad6 MAD homolog 6 (Drosophila) 0.094
Klf3 Kruppel-like factor 3 (basic) 0.094
Btg2 B-cell translocation gene 2, anti-proliferative 0.092
Mef2a myocyte enhancer factor 2A 0.089
Nppa natriuretic peptide type A 0.089
Msx1 homeobox, msh-like 1 0.088
Zeb2 zinc finger E-box binding homeobox 2 0.088
Apoe apolipoprotein E 0.084
Arid1b AT rich interactive domain 1B (SWI-like) 0.081
Pthlh parathyroid hormone-like peptide 0.080
Scn5a sodium channel, voltage-gated, type V, alpha 0.080
Gata6 GATA binding protein 6 0.078
Ahr aryl-hydrocarbon receptor 0.073
March7 membrane-associated ring finger (C3HC4) 7 0.073
Kcna4 potassium voltage-gated channel, shaker-related subfamily, member 4 0.072
Epha3 Eph receptor A3 0.070
Kif5b kinesin family member 5B 0.069
Siah2 seven in absentia 2 0.069
Klf7 Kruppel-like factor 7 (ubiquitous) 0.067
Notch1 Notch gene homolog 1 (Drosophila) 0.067
Tnxb tenascin XB 0.063
Foxc2 forkhead box C2 0.063
Gdf5 growth differentiation factor 5 0.059
Grm2 glutamate receptor, metabotropic 2 0.057
Zswim6 zinc finger, SWIM domain containing 6 0.055
Slc12a1 solute carrier family 12, member 1 0.054
Hbegf heparin-binding EGF-like growth factor 0.053
Tac2 tachykinin 2 0.052
Foxc1 forkhead box C1 0.051
Tbx15 T-box 15 0.051
Rock2 Rho-associated coiled-coil containing protein kinase 2 0.051
Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 0.050
Ptprm protein tyrosine phosphatase, receptor type, M 0.049
Cxcl12 chemokine (C-X-C motif) ligand 12 0.048
Edn3 endothelin 3 0.047
Hrh1 histamine receptor H1 0.046
Zfr2 zinc finger RNA binding protein 2 0.046
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.045
Hoxb3 homeobox B3 0.045
Axl AXL receptor tyrosine kinase 0.044
Shh sonic hedgehog 0.044
Gdf9 growth differentiation factor 9 0.044
Prrx1 paired related homeobox 1 0.043
Slc4a1 solute carrier family 4 (anion exchanger), member 1 0.043
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.043
Nppb natriuretic peptide type B 0.042
Adora2a adenosine A2a receptor 0.041
Bmp5 bone morphogenetic protein 5 0.040
Ank1 ankyrin 1, erythroid 0.040
Cacna2d1 calcium channel, voltage-dependent, alpha2/delta subunit 1 0.039
Mll5 myeloid/lymphoid or mixed-lineage leukemia 5 0.039
Gfi1b growth factor independent 1B 0.039
Fos FBJ osteosarcoma oncogene 0.038
Fosb FBJ osteosarcoma oncogene B 0.038
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.038
Has1 hyaluronan synthase1 0.038
Sox17 SRY-box containing gene 17 0.038
Kcns2 K+ voltage-gated channel, subfamily S, 2 0.037
Axin1 axin 1 0.037
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Rattus norvegicus
Name Description Probability Func Analog Organism
LOC100362824 caveolin 2-like 0.041
Ahsg alpha-2-HS-glycoprotein 0.018
Cav1 caveolin 1, caveolae protein 0.018
Vom2r27 vomeronasal 2 receptor, 27 0.016
Cav2 caveolin 2 0.015
Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.013
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.013
Proc protein C 0.013
Alb albumin 0.013
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.013
Nos3 nitric oxide synthase 3, endothelial cell 0.013
Chp calcium binding protein p22 0.013
Akr1c18 aldo-keto reductase family 1, member C18 0.013
Prdm2 PR domain containing 2, with ZNF domain 0.012
Cit citron 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism