The network for 'neuron development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

neuron development

The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.

Caenorhabditis elegans
Name Description Probability Func Analog Organism
egl-18 Protein EGL-18 0.983
unc-73 Protein UNC-73 0.936
elt-6 Protein ELT-6 0.909
syg-1 Protein SYG-1 0.888
egl-46 Protein EGL-46 0.829
pha-4 Protein PHA-4 0.821
bar-1 Protein BAR-1 0.783
pry-1 Protein PRY-1 0.777
ceh-20 Protein CEH-20 0.752
sem-5 Protein SEM-5 0.724
ain-1 Protein AIN-1 0.719
nhr-67 Protein NHR-67 0.704
unc-62 Protein UNC-62 0.700
ldb-1 Protein LDB-1 0.691
ten-1 Protein TEN-1 0.670
vab-3 Protein VAB-3 0.670
sma-6 Protein SMA-6 0.650
sli-1 Protein SLI-1 0.642
egl-15 Protein EGL-15 0.636
sdz-28 Protein SDZ-28 0.612
glp-1 Protein GLP-1 0.611
egl-13 Protein EGL-13 0.594
T28F4.1 Protein T28F4.1 0.589
unc-42 Protein UNC-42 0.586
let-60 Protein LET-60 0.579
cam-1 Protein CAM-1 0.576
unc-52 Protein UNC-52 0.576
goa-1 Protein GOA-1 0.565
K10D6.4 Protein K10D6.4 0.564
unc-104 Protein UNC-104 0.544
daf-11 Protein DAF-11 0.544
rpt-3 Protein RPT-3 0.539
hlh-1 Protein HLH-1 0.532
hbl-1 Protein HBL-1 0.527
teg-4 Protein TEG-4 0.521
unc-43 Protein UNC-43 0.513
lin-12 Protein LIN-12 0.513
sax-3 Protein SAX-3 0.512
ida-1 Protein IDA-1 0.510
rig-6 Protein RIG-6 0.499
lrp-2 Protein LRP-2 0.493
pdfr-1 Protein PDFR-1 0.482
egl-8 Protein EGL-8 0.474
R12E2.1 Protein R12E2.1 0.463
egl-27 Protein EGL-27 0.431
unc-9 Protein UNC-9 0.418
flt-1 Protein FLT-1 0.411
W01C8.5 Protein W01C8.5 0.408
spc-1 Protein SPC-1 0.405
unc-70 Protein UNC-70 0.402
trim-9 Protein TRIM-9 0.399
atn-1 Protein ATN-1 0.397
unc-40 Protein UNC-40 0.396
ceh-48 Protein CEH-48 0.391
hmp-1 Protein HMP-1 0.376
T27A3.1 Protein T27A3.1 0.376
shn-1 Protein SHN-1 0.370
mab-5 Protein MAB-5 0.369
nhr-34 Protein NHR-34 0.366
chd-7 Protein CHD-7 0.362
asd-1 Protein ASD-1 0.361
M01A10.1 Protein M01A10.1 0.356
clk-2 Protein CLK-2 0.355
clh-5 Protein CLH-5 0.347
cye-1 Protein CYE-1 0.346
smp-1 Protein SMP-1 0.346
rpn-1 Protein RPN-1 0.342
zip-7 Protein ZIP-7 0.334
hlh-2 Protein HLH-2 0.328
egl-30 Protein EGL-30 0.327
egl-5 Protein EGL-5 0.321
cdc-37 Protein CDC-37 0.317
mig-15 Protein MIG-15 0.313
mig-10 Protein MIG-10 0.312
mig-2 Protein MIG-2 0.311
myo-1 Protein MYO-1 0.309
mel-28 Protein MEL-28 0.308
pop-1 Protein POP-1 0.308
tag-241 Protein TAG-241 0.308
gsp-1 Protein GSP-1 0.307
syg-2 Protein SYG-2 0.306
unc-6 Protein UNC-6 0.306
enu-3 Protein ENU-3 0.305
egg-6 Protein EGG-6 0.300
F09A5.4 Protein F09A5.4 0.298
rsd-2 Protein RSD-2 0.297
R90.1 Protein R90.1 0.294
C28H8.3 Protein C28H8.3 0.285
mig-38 Protein MIG-38 0.283
ect-2 Protein ECT-2 0.283
imb-2 Protein IMB-2 0.282
CELE_C38D4.1 Protein C38D4.1 0.282
dpy-28 Protein DPY-28 0.281
ajm-1 Protein AJM-1 0.281
daf-12 Protein DAF-12 0.279
lin-17 Protein LIN-17 0.276
kal-1 Protein KAL-1 0.275
peb-1 Protein PEB-1 0.274
T24B8.3 Protein T24B8.3 0.273
hcp-3 Protein HCP-3 0.272
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
dla deltaA 1.000
prdm1a PR domain containing 1a, with ZNF domain 0.999
gdf6a growth differentiation factor 6a 0.997
spry4 sprouty (Drosophila) homolog 4 0.994
lhx2b LIM homeobox 2b 0.993
pax2a paired box gene 2a 0.993
eya1 eyes absent homolog 1 0.989
alcama activated leukocyte cell adhesion molecule a 0.983
crabp2a cellular retinoic acid binding protein 2, a 0.981
plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 0.981
foxi1 forkhead box I1 0.981
cxcr4b chemokine (C-X-C motif), receptor 4b 0.978
slc17a6b solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6b 0.976
robo2 roundabout homolog 2 0.973
cntn2 contactin 2 0.972
olig2 oligodendrocyte lineage transcription factor 2 0.969
eng2a engrailed 2a 0.967
nes nestin 0.966
fgf3 fibroblast growth factor 3 0.966
neurod neurogenic differentiation 0.965
elavl3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C) 0.965
dpysl3 dihydropyrimidinase-like 3 0.964
shha sonic hedgehog a 0.963
jag2 jagged 2 0.963
dlc deltaC 0.957
ift88 intraflagellar transport 88 homolog 0.951
atoh7 atonal homolog 7 0.951
atoh1a atonal homolog 1a 0.950
cdh23 cadherin-like 23 0.949
fn1 fibronectin 1 0.948
ndr2 nodal-related 2 0.946
wnt10a wingless-type MMTV integration site family, member 10a 0.943
flh floating head 0.943
myhz2 myosin, heavy polypeptide 2, fast muscle specific 0.942
frem3 Fras1 related extracellular matrix 3 0.940
rest RE1-silencing transcription factor 0.936
pcdh18b protocadherin 18b 0.931
gli1 GLI-Kruppel family member 1 0.929
notch1a notch homolog 1a 0.928
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.924
dlb deltaB 0.924
tp53 tumor protein p53 0.923
otx5 orthodenticle homolog 5 0.921
ptch2 patched 2 0.919
sox9a SRY-box containing gene 9a 0.911
foxp2 forkhead box P2 0.911
hoxa1a homeo box A1a 0.909
kdrl kinase insert domain receptor like 0.905
tfap2a transcription factor AP-2 alpha 0.905
fsta follistatin a 0.904
stmn2b stathmin-like 2b 0.897
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.890
fezf2 FEZ family zinc finger 2 0.876
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.868
sema3aa semaphorin 3aa 0.864
foxh1 forkhead box H1 0.862
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.857
her15.1 hairy and enhancer of split-related 15.1 0.850
lhx1a LIM homeobox 1a 0.850
pitx3 paired-like homeodomain transcription factor 3 0.848
ascl1a achaete-scute complex-like 1a (Drosophila) 0.843
runx1 runt-related transcription factor 1 0.842
otx2 orthodenticle homolog 2 0.837
camkvb CaM kinase-like vesicle-associated b 0.835
tbx1 T-box 1 0.835
jag1b jagged 1b 0.832
dlx6a distal-less homeobox gene 6a 0.831
ndrg4 N-myc downstream regulated gene 4 0.830
hand2 heart and neural crest derivatives expressed transcript 2 0.826
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.824
atoh1b atonal homolog 1b 0.822
sox4a SRY-box containing gene 4a 0.819
rx3 retinal homeobox gene 3 0.819
dag1 dystroglycan 1 0.818
pax6a paired box gene 6a 0.818
csnk1a1 casein kinase 1, alpha 1 0.816
nrp1a neuropilin 1a 0.816
sox32 SRY-box containing gene 32 0.813
her4.2 hairy-related 4.2 0.812
tnni1al troponin I, skeletal, slow like 0.806
tbx18 T-box 18 0.805
foxd3 forkhead box D3 0.804
rarab retinoic acid receptor, alpha b 0.802
lamb2 laminin, beta 2 (laminin S) 0.802
otpb orthopedia homolog b 0.801
myhz1.1 myosin, heavy polypeptide 1.1, skeletal muscle 0.797
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.796
scrt2 scratch homolog 2, zinc finger protein (Drosophila) 0.795
irx4b iroquois homeobox protein 4b 0.793
lingo1a leucine rich repeat and Ig domain containing 1a 0.792
ret1 receptor tyrosine kinase 0.792
neo1 neogenin 1 0.788
notch3 notch homolog 3 0.788
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.785
cmyb transcription factor cmyb 0.784
ptprf protein tyrosine phosphatase, receptor type, F 0.783
vsx1 visual system homeobox 1 homolog, chx10-like 0.782
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.780
lamc1 laminin, gamma 1 0.775
gpr98 G protein-coupled receptor 98 0.773
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 0.997
FN1 fibronectin 1 0.991
BCAR1 breast cancer anti-estrogen resistance 1 0.971
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.952
ATXN1 ataxin 1 0.950
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.947
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.938
RB1 retinoblastoma 1 0.924
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.919
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.915
QKI quaking homolog, KH domain RNA binding (mouse) 0.907
FYN FYN oncogene related to SRC, FGR, YES 0.882
BMI1 BMI1 polycomb ring finger oncogene 0.872
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.869
CREBBP CREB binding protein 0.863
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.850
APP amyloid beta (A4) precursor protein 0.840
DLG4 discs, large homolog 4 (Drosophila) 0.823
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.815
MAPT microtubule-associated protein tau 0.783
TP53 tumor protein p53 0.772
SMAD3 SMAD family member 3 0.739
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.733
SMAD2 SMAD family member 2 0.719
JUN jun proto-oncogene 0.713
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.713
NCOR1 nuclear receptor corepressor 1 0.710
HDAC1 histone deacetylase 1 0.699
PCGF2 polycomb group ring finger 2 0.685
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.660
EP300 E1A binding protein p300 0.659
FLNA filamin A, alpha 0.614
ATN1 atrophin 1 0.606
MOBKL3 MOB1, Mps One Binder kinase activator-like 3 (yeast) 0.579
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.564
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.552
HDAC2 histone deacetylase 2 0.541
RERE arginine-glutamic acid dipeptide (RE) repeats 0.540
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.535
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.527
CEP170 centrosomal protein 170kDa 0.522
ESR1 estrogen receptor 1 0.521
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.517
VAV1 vav 1 guanine nucleotide exchange factor 0.503
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.489
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.485
PRMT1 protein arginine methyltransferase 1 0.480
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.475
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.469
IGF1R insulin-like growth factor 1 receptor 0.465
E2F1 E2F transcription factor 1 0.459
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.443
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.440
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.438
SUMO1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.428
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.423
EPS8 epidermal growth factor receptor pathway substrate 8 0.421
SYK spleen tyrosine kinase 0.411
ITSN1 intersectin 1 (SH3 domain protein) 0.400
NCAM1 neural cell adhesion molecule 1 0.400
GRB2 growth factor receptor-bound protein 2 0.395
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.394
FASLG Fas ligand (TNF superfamily, member 6) 0.387
CREB1 cAMP responsive element binding protein 1 0.387
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.366
FGFR1 fibroblast growth factor receptor 1 0.365
MAPK8 mitogen-activated protein kinase 8 0.365
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.361
MET met proto-oncogene (hepatocyte growth factor receptor) 0.358
TAL1 T-cell acute lymphocytic leukemia 1 0.345
STK3 serine/threonine kinase 3 0.345
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.335
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.329
JAG1 jagged 1 0.323
RING1 ring finger protein 1 0.321
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.312
AR androgen receptor 0.312
SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) 0.307
GSK3B glycogen synthase kinase 3 beta 0.302
FOS FBJ murine osteosarcoma viral oncogene homolog 0.293
NRXN1 neurexin 1 0.292
TRRAP transformation/transcription domain-associated protein 0.290
VHL von Hippel-Lindau tumor suppressor 0.288
ACTB actin, beta 0.287
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.282
ARID1A AT rich interactive domain 1A (SWI-like) 0.280
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.279
FHL2 four and a half LIM domains 2 0.279
FNBP1L formin binding protein 1-like 0.277
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.277
HSPG2 heparan sulfate proteoglycan 2 0.269
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.269
DTNA dystrobrevin, alpha 0.268
FBLN1 fibulin 1 0.268
KCNA1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) 0.266
SFN stratifin 0.266
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 0.266
RANBP9 RAN binding protein 9 0.265
CFL1 cofilin 1 (non-muscle) 0.261
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.261
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 0.908
Nrxn1 neurexin 1 0.861
Calcrl calcitonin receptor-like 0.768
Lin7b lin-7 homolog b (C. elegans) 0.720
Nrcam neuronal cell adhesion molecule 0.696
Gria2 glutamate receptor, ionotropic, AMPA 2 0.668
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.658
Trib1 tribbles homolog 1 (Drosophila) 0.628
Actb actin, beta 0.625
Sncb synuclein, beta 0.621
Tgfbr2 transforming growth factor, beta receptor II 0.618
Apba1 amyloid beta (A4) precursor protein-binding, family A, member 1 0.607
Grm5 glutamate receptor, metabotropic 5 0.603
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.583
Dlgap3 discs, large (Drosophila) homolog-associated protein 3 0.568
Aqp4 aquaporin 4 0.563
Strn striatin, calmodulin binding protein 0.557
Itgam integrin, alpha M 0.542
Nefl neurofilament, light polypeptide 0.540
Atp2b3 ATPase, Ca++ transporting, plasma membrane 3 0.507
Map1b microtubule-associated protein 1B 0.507
Gria4 glutamate receptor, ionotrophic, AMPA 4 0.482
Map2 microtubule-associated protein 2 0.481
Tmod2 tropomodulin 2 0.472
Socs3 suppressor of cytokine signaling 3 0.470
Grip1 glutamate receptor interacting protein 1 0.466
Gdf11 growth differentiation factor 11 0.459
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.452
Syngap1 synaptic Ras GTPase activating protein 1 homolog (rat) 0.451
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.447
Hck hemopoietic cell kinase 0.441
Gabra4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 0.426
Camk4 calcium/calmodulin-dependent protein kinase IV 0.424
Scn3a sodium channel, voltage-gated, type III, alpha 0.424
Atf3 activating transcription factor 3 0.422
Nrxn3 neurexin 3 0.412
Olfml2b olfactomedin-like 2B 0.406
Syt4 synaptotagmin IV 0.403
Plau plasminogen activator, urokinase 0.403
Cnksr2 connector enhancer of kinase suppressor of Ras 2 0.403
Fgd4 FYVE, RhoGEF and PH domain containing 4 0.400
Gnao1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 0.396
Arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.395
Mmp12 matrix metallopeptidase 12 0.389
Nfia nuclear factor I/A 0.380
Prkcg protein kinase C, gamma 0.378
Gabrb1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.378
Myh10 myosin, heavy chain 10, non-muscle 0.375
Dlg4 discs, large homolog 4 (Drosophila) 0.373
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.371
Nr4a2 nuclear receptor subfamily 4, group A, member 2 0.367
Dlg3 discs, large homolog 3 (Drosophila) 0.367
Calm3 calmodulin 3 0.364
Ptprd protein tyrosine phosphatase, receptor type, D 0.363
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.362
Kcnh1 potassium voltage-gated channel, subfamily H (eag-related), member 1 0.360
Hoxa2 homeo box A2 0.359
St18 suppression of tumorigenicity 18 0.359
Cyth1 cytohesin 1 0.359
Cd4 Cd4 molecule 0.356
Pcsk2 proprotein convertase subtilisin/kexin type 2 0.356
Gabra5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 0.353
Dmd dystrophin 0.352
Slc24a2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 0.350
Gabra1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.348
Epha5 EphA5 0.347
Notch1 Notch homolog 1, translocation-associated (Drosophila) 0.346
Kcnt1 potassium channel, subfamily T, member 1 0.344
Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.343
Jak1 Janus kinase 1 0.336
Nrg1 neuregulin 1 0.335
Nfib nuclear factor I/B 0.334
Npy1r neuropeptide Y receptor Y1 0.334
Inpp5d inositol polyphosphate-5-phosphatase D 0.334
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.329
Slit3 slit homolog 3 (Drosophila) 0.329
Ccl2 chemokine (C-C motif) ligand 2 0.322
Pde5a phosphodiesterase 5A, cGMP-specific 0.322
Anxa2 annexin A2 0.318
Tbx2 T-box 2 0.318
Pde4b phosphodiesterase 4B, cAMP specific 0.315
Chrna4 cholinergic receptor, nicotinic, alpha 4 0.313
Clic4 chloride intracellular channel 4 0.311
Pls3 plastin 3 (T-isoform) 0.310
Hk1 hexokinase 1 0.308
Tagln3 transgelin 3 0.302
Slc4a3 solute carrier family 4 (anion exchanger), member 3 0.302
Spire1 spire homolog 1 (Drosophila) 0.300
Map1a microtubule-associated protein 1A 0.299
Nlgn1 neuroligin 1 0.297
Lzts1 leucine zipper, putative tumor suppressor 1 0.296
Cadm1 cell adhesion molecule 1 0.292
Adrb1 adrenergic, beta-1-, receptor 0.291
Tcf4 transcription factor 4 0.290
Ina internexin neuronal intermediate filament protein, alpha 0.289
Dchs1 dachsous 1 (Drosophila) 0.289
Cplx2 complexin 2 0.288
Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 0.287
Ednrb endothelin receptor type B 0.283
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.282
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism