The network for 'regulation of cell death' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of cell death

Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.

Caenorhabditis elegans
Name Description Probability Func Analog Organism
egl-18 Protein EGL-18 0.679
par-5 Protein PAR-5 0.437
eya-1 Protein EYA-1 0.313
ceh-20 Protein CEH-20 0.289
F36D4.5 Protein F36D4.5 0.247
egl-46 Protein EGL-46 0.212
cam-1 Protein CAM-1 0.192
lmn-1 Protein LMN-1 0.185
sem-5 Protein SEM-5 0.181
hcp-3 Protein HCP-3 0.149
mab-31 Protein MAB-31 0.145
hsp-1 Protein HSP-1 0.142
nhr-67 Protein NHR-67 0.126
bar-1 Protein BAR-1 0.125
drp-1 Protein DRP-1 0.123
hum-6 Protein HUM-6 0.119
unc-70 Protein UNC-70 0.119
inx-13 Protein INX-13 0.110
unc-9 Protein UNC-9 0.107
pha-4 Protein PHA-4 0.105
ftt-2 Protein FTT-2 0.105
F36A2.13 Protein F36A2.13 0.100
hum-5 Protein HUM-5 0.099
rlbp-1 Protein RLBP-1 0.099
mel-11 Protein MEL-11 0.095
K10D6.4 Protein K10D6.4 0.095
C28H8.3 Protein C28H8.3 0.093
sax-7 Protein SAX-7 0.093
fkh-2 Protein FKH-2 0.092
rnr-2 Protein RNR-2 0.092
mat-3 Protein MAT-3 0.090
soc-2 Protein SOC-2 0.085
vab-3 Protein VAB-3 0.085
trim-9 Protein TRIM-9 0.084
CELE_Y41E3.7 Protein Y41E3.7 0.078
erm-1 Protein ERM-1 0.077
pdfr-1 Protein PDFR-1 0.076
inx-3 Protein INX-3 0.075
F39B2.1 Protein F39B2.1 0.075
xbp-1 Protein XBP-1 0.074
eef-1A.1 Protein EEF-1A.1 0.073
unc-52 Protein UNC-52 0.073
ceh-44 Protein CEH-44 0.070
vhp-1 Protein VHP-1 0.069
lst-4 Protein LST-4 0.069
sma-6 Protein SMA-6 0.069
lin-17 Protein LIN-17 0.069
exc-5 Protein EXC-5 0.068
egl-30 Protein EGL-30 0.067
F59E12.9 Protein F59E12.9 0.065
unc-86 Protein UNC-86 0.064
sym-4 Protein SYM-4 0.064
unc-73 Protein UNC-73 0.064
let-756 Protein LET-756 0.064
syg-1 Protein SYG-1 0.063
scd-1 Protein SCD-1 0.063
zyg-9 Protein ZYG-9 0.063
CELE_F14E5.2 Protein F14E5.2 0.062
ttx-1 Protein TTX-1 0.061
rme-4 Protein RME-4 0.060
age-1 Protein AGE-1 0.060
sos-1 Protein SOS-1 0.060
lig-4 Protein LIG-4 0.059
unc-43 Protein UNC-43 0.058
gex-3 Protein GEX-3 0.058
nhr-34 Protein NHR-34 0.058
ets-4 Protein ETS-4 0.058
F44E7.4 Protein F44E7.4 0.057
tag-260 Protein TAG-260 0.056
cey-1 Protein CEY-1 0.055
CELE_Y52B11A.10 Protein Y52B11A.10 0.054
atp-2 Protein ATP-2 0.054
skp-1 Protein SKP-1 0.054
zip-7 Protein ZIP-7 0.054
clic-1 Protein CLIC-1 0.053
T28C6.7 Protein T28C6.7 0.053
gpb-2 Protein GPB-2 0.053
pal-1 Protein PAL-1 0.053
mef-2 Protein MEF-2 0.053
tra-3 Protein TRA-3 0.052
nhr-45 Protein NHR-45 0.052
egl-27 Protein EGL-27 0.051
T05E8.3 Protein T05E8.3 0.051
T23F4.2 Protein T23F4.2 0.050
dcr-1 Protein DCR-1 0.050
amph-1 Protein AMPH-1 0.050
egl-5 Protein EGL-5 0.050
rgs-7 Protein RGS-7 0.050
F31C3.3 Protein F31C3.3 0.050
hpo-34 Protein HPO-34 0.049
eat-6 Protein EAT-6 0.049
ifg-1 Protein IFG-1 0.048
tbx-8 Protein TBX-8 0.048
act-5 Protein ACT-5 0.048
mig-5 Protein MIG-5 0.048
egl-13 Protein EGL-13 0.048
aap-1 Protein AAP-1 0.047
R90.1 Protein R90.1 0.047
vav-1 Protein VAV-1 0.047
lag-1 Protein LAG-1 0.047
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Danio rerio
Name Description Probability Func Analog Organism
fgfr1a fibroblast growth factor receptor 1a 0.943
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.902
gata3 GATA-binding protein 3 0.891
gcm2 glial cells missing homolog 2 (Drosophila) 0.842
fgf3 fibroblast growth factor 3 0.836
pitx3 paired-like homeodomain transcription factor 3 0.744
cmyb transcription factor cmyb 0.677
shha sonic hedgehog a 0.676
baxa bcl2-associated X protein, a 0.631
tp53 tumor protein p53 0.617
bdnf brain-derived neurotrophic factor 0.611
fgf8a fibroblast growth factor 8 a 0.610
tbx1 T-box 1 0.594
hif1ab hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b 0.557
efnb2a ephrin B2a 0.542
rarga retinoic acid receptor gamma a 0.541
evx1 even-skipped homeobox 1 0.534
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.533
chd chordin 0.511
tbx20 T-box 20 0.506
runx2b runt-related transcription factor 2b 0.506
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.496
xbp1 X-box binding protein 1 0.494
sfrp5 secreted frizzled-related protein 5 0.489
flt4 fms-related tyrosine kinase 4 0.488
ef1a elongation factor 1-alpha 0.476
ndr2 nodal-related 2 0.460
arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.447
kita kit receptor a 0.439
plcg1 phospholipase C, gamma 1 0.436
pax2a paired box gene 2a 0.420
atp6v1ba ATPase, H+ transporting, lysosomal, V1 subunit B, member a 0.410
bbc3 BCL2 binding component 3 0.397
tnfrsfa tumor necrosis factor receptor superfamily, member a 0.393
smc3 structural maintenance of chromosomes 3 0.393
bmp2b bone morphogenetic protein 2b 0.390
pcdh17 protocadherin 17 0.386
bactin1 bactin1 0.384
ptf1a pancreas specific transcription factor, 1a 0.382
ascl1a achaete-scute complex-like 1a (Drosophila) 0.379
dusp6 dual specificity phosphatase 6 0.374
hoxb1b homeo box B1b 0.373
dkk1b dickkopf 1b 0.367
nadl1.2 neural adhesion molecule L1.2 0.360
fn1 fibronectin 1 0.359
col14a1 collagen, type XIV, alpha 1 0.353
bcl2l1 bcl2-like 1 0.342
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.336
tyr tyrosinase 0.334
boc brother of CDO 0.321
cav1 caveolin 1 0.315
met met proto-oncogene (hepatocyte growth factor receptor) 0.313
mcl1a myeloid cell leukemia sequence 1a 0.308
gli1 GLI-Kruppel family member 1 0.300
jag1a jagged 1a 0.298
ptpra protein tyrosine phosphatase, receptor type, A 0.296
piwil2 piwi-like 2 (Drosophila) 0.295
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.294
nrg2a neuregulin 2a 0.291
atp6v0ca ATPase, H+ transporting, lysosomal, V0 subunit c, a 0.288
rag1 recombination activating gene 1 0.288
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.287
th tyrosine hydroxylase 0.285
fgfr4 fibroblast growth factor receptor 4 0.285
cdh1 cadherin 1, epithelial 0.280
spry4 sprouty (Drosophila) homolog 4 0.277
tp63 tumor protein p63 0.274
bnc2 basonuclin 2 0.273
gata4 GATA-binding protein 4 0.272
csnk1da casein kinase 1, delta a 0.272
rorca RAR-related orphan receptor C a 0.270
nadl1.1 neural adhesion molecule L1.1 0.269
rbb4l retinoblastoma binding protein 4, like 0.269
cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 0.267
rasl11b RAS-like, family 11, member B 0.267
alcama activated leukocyte cell adhesion molecule a 0.266
ptgs2a prostaglandin-endoperoxide synthase 2a 0.264
notch1a notch homolog 1a 0.263
col12a1 collagen, type XII, alpha 1 0.259
hspa5 heat shock protein 5 0.256
six3b sine oculis homeobox homolog 3b 0.253
foxp2 forkhead box P2 0.248
myod1 myogenic differentiation 1 0.247
tbx16 T-box gene 16 0.247
wnt4a wingless-type MMTV integration site family, member 4a 0.246
klf4 Kruppel-like factor 4 0.246
esr2a estrogen receptor 2a 0.243
sulf2l sulfatase 2, like 0.242
otpa orthopedia homolog a 0.240
wnt11r wingless-type MMTV integration site family, member 11, related 0.238
barhl1.2 BarH-like 1.2 0.234
stmn1b stathmin 1b 0.229
cdh23 cadherin-like 23 0.226
cct6a chaperonin containing TCP1, subunit 6A (zeta 1) 0.226
tshb thyroid stimulating hormone, beta subunit 0.225
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.225
sema3aa semaphorin 3aa 0.222
tnc tenascin C 0.217
notch2 notch homolog 2 0.217
bad BCL2-antagonist of cell death 0.216
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Drosophila melanogaster
Name Description Probability Func Analog Organism
nej nejire 0.999
slmb supernumerary limbs 0.993
wg wingless 0.990
tkv thickveins 0.989
EcR Ecdysone receptor 0.986
Akt1 CG4006 gene product from transcript CG4006-RA 0.977
dm diminutive 0.973
Mad Mothers against dpp 0.959
Ras85D Ras oncogene at 85D 0.952
ci cubitus interruptus 0.936
Atg1 Autophagy-specific gene 1 0.935
kay kayak 0.935
rpr reaper 0.914
lea leak 0.837
hep hemipterous 0.834
shi shibire 0.833
Rbf Retinoblastoma-family protein 0.809
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.807
CG11347 CG11347 gene product from transcript CG11347-RE 0.791
Egfr Epidermal growth factor receptor 0.784
kibra kibra ortholog 0.777
chico CG5686 gene product from transcript CG5686-RB 0.774
pan pangolin 0.770
S6k RPS6-p70-protein kinase 0.758
Dcp-1 Death caspase-1 0.727
ems empty spiracles 0.717
drk downstream of receptor kinase 0.693
tws twins 0.684
hth homothorax 0.676
foxo forkhead box, sub-group O 0.672
CtBP C-terminal Binding Protein 0.641
Gyc76C Guanylyl cyclase at 76C 0.611
mrn marionette 0.603
rap retina aberrant in pattern 0.601
gig gigas 0.599
Trf2 TATA box binding protein-related factor 2 0.596
Pten CG5671 gene product from transcript CG5671-RB 0.592
p53 CG33336 gene product from transcript CG33336-RB 0.590
cutlet CG33122 gene product from transcript CG33122-RA 0.590
Tor Target of rapamycin 0.585
CadN Cadherin-N 0.581
Pak PAK-kinase 0.575
Src42A Src oncogene at 42A 0.566
da daughterless 0.564
pAbp polyA-binding protein 0.564
trp transient receptor potential 0.559
Ubx Ultrabithorax 0.559
sd scalloped 0.557
Atx2 Ataxin-2 0.556
kis kismet 0.553
Top2 Topoisomerase 2 0.549
brm brahma 0.547
Aos1 CG12276 gene product from transcript CG12276-RA 0.542
CG9772 CG9772 gene product from transcript CG9772-RB 0.538
W Wrinkled 0.534
bel belle 0.532
ago archipelago 0.531
th thread 0.524
crol crooked legs 0.523
Fmr1 CG6203 gene product from transcript CG6203-RC 0.522
milt milton 0.520
Mekk1 CG7717 gene product from transcript CG7717-RB 0.514
Gp150 CG5820 gene product from transcript CG5820-RA 0.505
flw flapwing 0.504
InR Insulin-like receptor 0.503
Hnf4 Hepatocyte nuclear factor 4 0.501
shn schnurri 0.500
Dref DNA replication-related element factor 0.499
Hel25E Helicase at 25E 0.494
ed echinoid 0.486
Dad Daughters against dpp 0.486
elav embryonic lethal abnormal vision 0.482
mp multiplexin 0.473
dsh dishevelled 0.471
DAAM Dishevelled Associated Activator of Morphogenesis 0.459
arm armadillo 0.459
eIF-4E Eukaryotic initiation factor 4E 0.451
caz cabeza 0.447
jar jaguar 0.442
nkd naked cuticle 0.441
SoxN SoxNeuro 0.440
Trxr-1 Thioredoxin reductase-1 0.440
zip zipper 0.427
Arr2 Arrestin 2 0.425
msn misshapen 0.424
trpl trp-like 0.424
trio CG18214 gene product from transcript CG18214-RA 0.422
ex expanded 0.421
TBPH CG10327 gene product from transcript CG10327-RC 0.421
drl derailed 0.419
Nop60B Nucleolar protein at 60B 0.418
Su(H) Suppressor of Hairless 0.413
Fs Follistatin 0.408
Antp Antennapedia 0.404
Dsp1 Dorsal switch protein 1 0.403
wit wishful thinking 0.402
Trx-2 thioredoxin-2 0.398
beta-Spec beta Spectrin 0.397
alpha-Adaptin CG4260 gene product from transcript CG4260-RA 0.395
wts warts 0.393
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
HYP2 Hyp2p 0.011
SLT2 Slt2p 0.011