The network for 'negative regulation of biological process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of biological process

Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

Name Description Probability Func Analog Organism
egl-18 Protein EGL-18 0.984
vab-3 Protein VAB-3 0.958
mig-5 Protein MIG-5 0.946
gpr-1 Protein GPR-1 0.923
aap-1 Protein AAP-1 0.849
cam-1 Protein CAM-1 0.817
egl-8 Protein EGL-8 0.814
par-5 Protein PAR-5 0.805
mat-3 Protein MAT-3 0.761
snr-2 Protein SNR-2 0.755
cacn-1 Protein CACN-1 0.745
kle-2 Protein KLE-2 0.744
unc-37 Protein UNC-37 0.731
sas-5 Protein SAS-5 0.728
egl-27 Protein EGL-27 0.726
dlk-1 Protein DLK-1 0.706
unc-62 Protein UNC-62 0.704
F39B2.1 Protein F39B2.1 0.699
hcf-1 Protein HCF-1 0.699
hlh-2 Protein HLH-2 0.683
pry-1 Protein PRY-1 0.680
CELE_C24H12.5 Protein C24H12.5 0.677
nhr-67 Protein NHR-67 0.666
hcp-3 Protein HCP-3 0.661
lin-25 Protein LIN-25 0.658
pha-4 Protein PHA-4 0.657
sur-2 Protein SUR-2 0.651
B0336.3 Protein B0336.3 0.642
unc-9 Protein UNC-9 0.636
pkg-1 Protein PKG-1 0.629
hbl-1 Protein HBL-1 0.627
ubc-12 Protein UBC-12 0.627
chc-1 Protein CHC-1 0.623
mex-5 Protein MEX-5 0.621
mab-5 Protein MAB-5 0.612
gld-1 Protein GLD-1 0.610
ima-3 Protein IMA-3 0.608
pdfr-1 Protein PDFR-1 0.605
gei-18 Protein GEI-18 0.604
eor-1 Protein EOR-1 0.602
ekl-6 Protein EKL-6 0.589
goa-1 Protein GOA-1 0.587
mei-1 Protein MEI-1 0.585
rnr-1 Protein RNR-1 0.583
sma-6 Protein SMA-6 0.577
inx-5 Protein INX-5 0.576
his-1 Protein HIS-1 0.575
fkh-2 Protein FKH-2 0.572
asb-2 Protein ASB-2 0.571
npp-7 Protein NPP-7 0.571
rde-1 Protein RDE-1 0.571
tag-163 Protein TAG-163 0.570
fkb-6 Protein FKB-6 0.568
bet-1 Protein BET-1 0.568
F33D11.10 Protein F33D11.10 0.568
lag-1 Protein LAG-1 0.566
ahcy-1 Protein AHCY-1 0.551
sas-6 Protein SAS-6 0.544
ced-9 Protein CED-9 0.544
pri-2 Protein PRI-2 0.540
daf-12 Protein DAF-12 0.539
lsy-2 Protein LSY-2 0.539
xpo-1 Protein XPO-1 0.535
let-60 Protein LET-60 0.532
zip-7 Protein ZIP-7 0.531
hum-5 Protein HUM-5 0.530
patr-1 Protein PATR-1 0.529
cpb-1 Protein CPB-1 0.527
egl-13 Protein EGL-13 0.525
F33E11.3 Protein F33E11.3 0.519
bub-1 Protein BUB-1 0.513
aak-2 Protein AAK-2 0.512
npp-12 Protein NPP-12 0.502
D1081.8 Protein D1081.8 0.500
sas-4 Protein SAS-4 0.498
epn-1 Protein EPN-1 0.498
apr-1 Protein APR-1 0.497
dph-1 Protein DPH-1 0.494
lin-53 Protein LIN-53 0.493
cki-1 Protein CKI-1 0.493
ceh-100 Protein CEH-100 0.491
pmk-1 Protein PMK-1 0.490
npp-4 Protein NPP-4 0.487
alg-2 Protein ALG-2 0.486
smc-3 Protein SMC-3 0.484
nhr-25 Protein NHR-25 0.483
mut-14 Protein MUT-14 0.481
unc-43 Protein UNC-43 0.480
CELE_F53C11.5 Protein F53C11.5 0.479
let-23 Protein LET-23 0.479
npp-19 Protein NPP-19 0.479
sea-2 Protein SEA-2 0.479
lmn-1 Protein LMN-1 0.478
Y77E11A.6 Protein Y77E11A.6 0.474
glp-1 Protein GLP-1 0.471
rig-1 Protein RIG-1 0.469
lir-1 Protein LIR-1 0.468
aph-1 Protein APH-1 0.464
dnj-13 Protein DNJ-13 0.462
dlc-1 Protein DLC-1 0.462
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Danio rerio
Name Description Probability Func Analog Organism
pax8 paired box gene 8 0.995
fgf3 fibroblast growth factor 3 0.992
dlc deltaC 0.992
tbx6 T-box gene 6 0.990
spry4 sprouty (Drosophila) homolog 4 0.987
tal1 T-cell acute lymphocytic leukemia 1 0.987
fgfr2 fibroblast growth factor receptor 2 0.980
cxcr4b chemokine (C-X-C motif), receptor 4b 0.970
pkd2 polycystic kidney disease 2 0.969
myod1 myogenic differentiation 1 0.969
notch1a notch homolog 1a 0.968
fgf8a fibroblast growth factor 8 a 0.967
sox2 SRY-box containing gene 2 0.966
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.966
ezh2 enhancer of zeste homolog 2 (Drosophila) 0.958
ndr2 nodal-related 2 0.957
tfap2a transcription factor AP-2 alpha 0.955
klf4a Kruppel-like transcription factor 4a 0.952
prox1 prospero-related homeobox gene 1 0.952
dlb deltaB 0.948
myf5 myogenic factor 5 0.947
dld deltaD 0.938
lhx1a LIM homeobox 1a 0.935
khdrbs1a KH domain containing, RNA binding, signal transduction associated 1a 0.935
gdf6a growth differentiation factor 6a 0.929
fgfr3 fibroblast growth factor receptor 3 0.925
csrp1a cysteine and glycine-rich protein 1a 0.923
gata6 GATA-binding protein 6 0.923
pax2a paired box gene 2a 0.919
cxcr4a chemokine (C-X-C motif) receptor 4a 0.907
bdnf brain-derived neurotrophic factor 0.904
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.904
bmp2b bone morphogenetic protein 2b 0.898
sox19a SRY-box containing gene 19a 0.896
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.895
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.892
fn1 fibronectin 1 0.889
kdrl kinase insert domain receptor like 0.886
prdm1a PR domain containing 1a, with ZNF domain 0.878
wnt11r wingless-type MMTV integration site family, member 11, related 0.874
tbx2b T-box 2b 0.872
dab1a disabled homolog 1a (Drosophila) 0.872
her6 hairy-related 6 0.872
acvr1l activin A receptor, type I like 0.869
dla deltaA 0.863
alcamb activated leukocyte cell adhesion molecule b 0.860
pea3 ETS-domain transcription factor pea3 0.859
hmx1 H6 homeo box 1 0.859
grem2 gremlin 2, cysteine knot superfamily 0.854
her1 hairy-related 1 0.852
ins preproinsulin 0.841
irx4b iroquois homeobox protein 4b 0.840
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.839
mpx myeloid-specific peroxidase 0.831
dlx5a distal-less homeobox gene 5a 0.828
cyp26a1 cytochrome P450, subfamily XXVIA, polypeptide 1 0.826
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.824
hhip hedgehog interacting protein 0.824
evx1 even-skipped homeobox 1 0.818
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.813
gata5 GATA-binding protein 5 0.812
tgfb3 transforming growth factor, beta 3 0.808
ascl1a achaete-scute complex-like 1a (Drosophila) 0.806
kal1a Kallmann syndrome 1a sequence 0.803
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.803
brd4 bromodomain containing 4 0.801
bmp4 bone morphogenetic protein 4 0.800
jag2 jagged 2 0.797
notch3 notch homolog 3 0.793
mecom MDS1 and EVI1 complex locus 0.792
tbx16 T-box gene 16 0.790
chd chordin 0.787
cd63 Cd63 antigen 0.787
snai1a snail homolog 1a (Drosophila) 0.786
dmbx1a diencephalon/mesencephalon homeobox 1a 0.785
ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.784
gro1 groucho 1 0.781
runx2b runt-related transcription factor 2b 0.777
pitx3 paired-like homeodomain transcription factor 3 0.777
tll1 tolloid-like 1 0.774
fzd7a frizzled homolog 7a 0.768
tp53 tumor protein p53 0.766
nkx2.2a NK2 transcription factor related 2a 0.766
igf1ra insulin-like growth factor 1a receptor 0.765
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.754
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.753
foxi1 forkhead box I1 0.746
fzd7b frizzled homolog 7b 0.746
fos v-fos FBJ murine osteosarcoma viral oncogene homolog 0.744
efnb2a ephrin B2a 0.743
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.739
prnprs3 prion protein, related sequence 3 0.739
gsc goosecoid 0.736
tgfbi transforming growth factor, beta-induced 0.736
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.733
admp anti-dorsalizing morphogenic protein 0.733
gata3 GATA-binding protein 3 0.733
sst1.1 somatostatin 1, tandem duplicate 1 0.727
otx5 orthodenticle homolog 5 0.723
irx1a iroquois homeobox protein 1, a 0.719
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism