The network for 'neuron fate commitment' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

neuron fate commitment

The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron.

Caenorhabditis elegans
Name Description Probability Func Analog Organism
pha-4 Protein PHA-4 0.745
elt-6 Protein ELT-6 0.607
egl-18 Protein EGL-18 0.475
nhr-67 Protein NHR-67 0.290
unc-42 Protein UNC-42 0.157
ceh-27 Protein CEH-27 0.120
rig-6 Protein RIG-6 0.116
hnd-1 Protein HND-1 0.111
cnd-1 Protein CND-1 0.098
lin-11 Protein LIN-11 0.071
lin-17 Protein LIN-17 0.070
fkh-2 Protein FKH-2 0.068
hlh-2 Protein HLH-2 0.067
egl-46 Protein EGL-46 0.063
unc-62 Protein UNC-62 0.055
egl-5 Protein EGL-5 0.053
cki-1 Protein CKI-1 0.051
lin-29 Protein LIN-29 0.050
sem-5 Protein SEM-5 0.040
bar-1 Protein BAR-1 0.039
vab-3 Protein VAB-3 0.038
hbl-1 Protein HBL-1 0.033
hlh-14 Protein HLH-14 0.032
hlh-1 Protein HLH-1 0.030
pop-1 Protein POP-1 0.030
sel-12 Protein SEL-12 0.027
sdz-28 Protein SDZ-28 0.027
lin-12 Protein LIN-12 0.027
lsy-2 Protein LSY-2 0.024
let-60 Protein LET-60 0.023
zip-7 Protein ZIP-7 0.023
unc-86 Protein UNC-86 0.023
ast-1 Protein AST-1 0.022
ten-1 Protein TEN-1 0.022
elc-1 Protein ELC-1 0.021
ceh-36 Protein CEH-36 0.020
lgc-55 Protein LGC-55 0.015
tbx-8 Protein TBX-8 0.015
mls-2 Protein MLS-2 0.015
sel-7 Protein SEL-7 0.015
pes-1 Protein PES-1 0.015
sfrp-1 Protein SFRP-1 0.015
insc-1 Protein INSC-1 0.015
cam-1 Protein CAM-1 0.014
dma-1 Protein DMA-1 0.013
sos-1 Protein SOS-1 0.013
irx-1 Protein IRX-1 0.013
nhr-25 Protein NHR-25 0.012
clec-180 Protein CLEC-180 0.012
ceh-48 Protein CEH-48 0.012
zig-10 Protein ZIG-10 0.011
ham-2 Protein HAM-2 0.011
dyf-7 Protein DYF-7 0.011
ceh-20 Protein CEH-20 0.011
fmi-1 Protein FMI-1 0.011
ref-2 Protein REF-2 0.011
mrck-1 Protein MRCK-1 0.011
rig-5 Protein RIG-5 0.010
tbc-12 Protein TBC-12 0.010
CELE_Y113G7B.11 Protein Y113G7B.11 0.010
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Danio rerio
Name Description Probability Func Analog Organism
pax2a paired box gene 2a 0.995
lhx1a LIM homeobox 1a 0.991
tbx1 T-box 1 0.990
dld deltaD 0.988
fezf2 FEZ family zinc finger 2 0.976
bmp4 bone morphogenetic protein 4 0.975
dla deltaA 0.965
eng2a engrailed 2a 0.965
otpb orthopedia homolog b 0.964
shha sonic hedgehog a 0.951
lhx5 LIM homeobox 5 0.943
sox3 SRY-box containing gene 3 0.937
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.935
prdm1a PR domain containing 1a, with ZNF domain 0.916
ndr2 nodal-related 2 0.895
dlx2a distal-less homeobox gene 2a 0.885
nkx2.2a NK2 transcription factor related 2a 0.865
olig2 oligodendrocyte lineage transcription factor 2 0.849
notch1a notch homolog 1a 0.846
pax6a paired box gene 6a 0.834
evx1 even-skipped homeobox 1 0.834
mib mind bomb 0.829
irx3a iroquois homeobox protein 3a 0.822
insm1b insulinoma-associated 1b 0.810
neurod neurogenic differentiation 0.797
prl prolactin 0.793
dlc deltaC 0.790
pitx3 paired-like homeodomain transcription factor 3 0.788
ascl1a achaete-scute complex-like 1a (Drosophila) 0.780
tbx2b T-box 2b 0.779
otx2 orthodenticle homolog 2 0.776
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.773
barhl2 BarH-like 2 0.759
mnx1 motor neuron and pancreas homeobox 1 0.753
dlx1a distal-less homeobox gene 1a 0.753
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.741
nkx2.2b NK2 transcription factor related 2b 0.716
tfap2a transcription factor AP-2 alpha 0.707
fgf8a fibroblast growth factor 8 a 0.703
six3b sine oculis homeobox homolog 3b 0.701
foxg1a forkhead box G1a 0.693
six3a sine oculis homeobox homolog 3a 0.682
gli1 GLI-Kruppel family member 1 0.668
isl1 islet1 0.665
dlx5a distal-less homeobox gene 5a 0.661
olig4 oligodendrocyte transcription factor 4 0.658
pitx2 paired-like homeodomain transcription factor 2 0.654
dlx2b distal-less homeobox gene 2b 0.607
nkx2.1a NK2 homeobox 1a 0.603
atoh1a atonal homolog 1a 0.602
bhlhe22 basic helix-loop-helix family, member e22 0.558
hlxb9la homeo box HB9 like a 0.556
gli2a GLI-Kruppel family member GLI2a 0.526
neurog1 neurogenin 1 0.525
hmx3 homeo box (H6 family) 3 0.506
sox1a SRY-box containing gene 1a 0.498
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.476
otx1b orthodenticle homolog 1b 0.463
tal1 T-cell acute lymphocytic leukemia 1 0.451
zic4 zic family member 4 0.445
ptf1a pancreas specific transcription factor, 1a 0.445
foxd3 forkhead box D3 0.425
lhx2b LIM homeobox 2b 0.413
wnt11 wingless-type MMTV integration site family, member 11 0.412
dlb deltaB 0.408
cdh2 cadherin 2, neuronal 0.406
lef1 lymphocyte enhancer binding factor 1 0.406
rx3 retinal homeobox gene 3 0.405
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.403
pax6b paired box gene 6b 0.402
myod1 myogenic differentiation 1 0.393
msxc muscle segment homeobox C 0.387
olig3 oligodendrocyte transcription factor 3 0.373
wnt8b wingless-type MMTV integration site family, member 8b 0.370
eng2b engrailed 2b 0.353
crestin crestin 0.352
hhip hedgehog interacting protein 0.333
phox2a paired-like homeobox 2a 0.325
dcc deleted in colorectal carcinoma 0.324
sox4b SRY-box containing gene 4b 0.322
zic5 zic family member 5 (odd-paired homolog, Drosophila) 0.317
nkx2.1b NK2 homeobox 1b 0.315
gbx2 gastrulation brain homeo box 2 0.314
eomesa eomesodermin homolog a 0.307
hnf1ba HNF1 homeobox Ba 0.307
sox19a SRY-box containing gene 19a 0.292
meis3 myeloid ecotropic viral integration site 3 0.291
otpa orthopedia homolog a 0.279
nadl1.1 neural adhesion molecule L1.1 0.274
sox2 SRY-box containing gene 2 0.273
vsx1 visual system homeobox 1 homolog, chx10-like 0.270
six4b sine oculis homeobox homolog 4b 0.259
nr2e3 nuclear receptor subfamily 2, group E, member 3 0.256
flh floating head 0.251
pcdh18b protocadherin 18b 0.250
spaw southpaw 0.247
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.241
tgfb3 transforming growth factor, beta 3 0.241
dbx1a developing brain homeobox 1a 0.239
ncs1a neuronal calcium sensor 1a 0.235
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Drosophila melanogaster
Name Description Probability Func Analog Organism
dsh dishevelled 0.964
ato atonal 0.909
nkd naked cuticle 0.906
E(spl) Enhancer of split 0.882
wg wingless 0.815
eyg eyegone 0.807
Dl Delta 0.807
HLHm7 E(spl) region transcript m7 0.791
N Notch 0.776
Egfr Epidermal growth factor receptor 0.766
ems empty spiracles 0.727
ro rough 0.712
B-H2 BarH2 0.696
oc ocelliless 0.684
ttk tramtrack 0.645
klu klumpfuss 0.643
tutl turtle 0.632
rap retina aberrant in pattern 0.604
kuz kuzbanian 0.583
HLHmdelta E(spl) region transcript mdelta 0.547
HGTX CG13475 gene product from transcript CG13475-RB 0.542
phl pole hole 0.537
spi spitz 0.526
hh hedgehog 0.514
sog short gastrulation 0.510
Ser Serrate 0.501
kay kayak 0.499
gsb gooseberry 0.495
SoxN SoxNeuro 0.493
sev sevenless 0.491
gcm glial cells missing 0.491
cnk connector enhancer of ksr 0.467
sens senseless 0.464
Wnt4 Wnt oncogene analog 4 0.463
tkv thickveins 0.460
so sine oculis 0.459
aop anterior open 0.457
lbl ladybird late 0.452
Gap1 GTPase-activating protein 1 0.440
Nedd4 CG42279 gene product from transcript CG42279-RJ 0.424
eve even skipped 0.390
HLHmbeta E(spl) region transcript mbeta 0.389
dac dachshund 0.371
argos CG4531 gene product from transcript CG4531-RA 0.371
hth homothorax 0.361
al aristaless 0.347
slp1 sloppy paired 1 0.340
csw corkscrew 0.335
sty sprouty 0.323
tll tailless 0.318
Kr Kruppel 0.317
B-H1 BarH1 0.314
pnt pointed 0.310
en engrailed 0.304
brk brinker 0.302
Antp Antennapedia 0.302
vvl ventral veins lacking 0.297
HLHm5 E(spl) region transcript m5 0.294
dpn deadpan 0.292
nub nubbin 0.288
svp seven up 0.282
HLHmgamma E(spl) region transcript mgamma 0.280
HLHm3 E(spl) region transcript m3 0.274
unc-5 CG8166 gene product from transcript CG8166-RA 0.272
disco disconnected 0.266
sim single-minded 0.260
run runt 0.250
ac achaete 0.244
insc inscuteable 0.235
trio CG18214 gene product from transcript CG18214-RA 0.230
Ras85D Ras oncogene at 85D 0.227
Taf4 TBP-associated factor 4 0.217
slp2 sloppy paired 2 0.213
InR Insulin-like receptor 0.212
amos absent MD neurons and olfactory sensilla 0.210
fz2 frizzled 2 0.208
Taf1 TBP-associated factor 1 0.202
eya eyes absent 0.193
bin biniou 0.193
emc extra macrochaetae 0.192
cdi center divider 0.192
hkb huckebein 0.190
gsb-n gooseberry-neuro 0.189
mam mastermind 0.185
PTP-ER Protein tyrosine phosphatase-ERK/Enhancer of Ras1 0.184
ptc patched 0.182
pdm2 POU domain protein 2 0.178
nab CG33545 gene product from transcript CG33545-RC 0.176
ash2 absent, small, or homeotic discs 2 0.174
Lim1 CG11354 gene product from transcript CG11354-RA 0.173
CadN Cadherin-N 0.168
lz lozenge 0.168
Tollo CG6890 gene product from transcript CG6890-RA 0.168
bowl brother of odd with entrails limited 0.166
dpp decapentaplegic 0.161
inv invected 0.159
ci cubitus interruptus 0.158
phyl phyllopod 0.145
rst roughest 0.142
ey eyeless 0.140
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Homo sapiens
Name Description Probability Func Analog Organism
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 1.000
NOTCH1 notch 1 1.000
TAL1 T-cell acute lymphocytic leukemia 1 1.000
NOTCH3 notch 3 1.000
JAG1 jagged 1 1.000
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 1.000
SMAD4 SMAD family member 4 0.999
MYOD1 myogenic differentiation 1 0.997
SUFU suppressor of fused homolog (Drosophila) 0.996
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.996
FOXD3 forkhead box D3 0.990
NKX2-1 NK2 homeobox 1 0.988
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.988
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.986
PDX1 pancreatic and duodenal homeobox 1 0.983
CDK2 cyclin-dependent kinase 2 0.981
PAX8 paired box 8 0.980
C2orf65 chromosome 2 open reading frame 65 0.979
SKI v-ski sarcoma viral oncogene homolog (avian) 0.977
SKIL SKI-like oncogene 0.977
POU3F2 POU class 3 homeobox 2 0.974
SOX10 SRY (sex determining region Y)-box 10 0.970
TCF12 transcription factor 12 0.968
GFI1B growth factor independent 1B transcription repressor 0.955
LMX1A LIM homeobox transcription factor 1, alpha 0.953
FOXA2 forkhead box A2 0.947
LBX1 ladybird homeobox 1 0.946
MEOX2 mesenchyme homeobox 2 0.946
ZFYVE9 zinc finger, FYVE domain containing 9 0.930
GLI1 GLI family zinc finger 1 0.922
SMAD2 SMAD family member 2 0.920
SMAD9 SMAD family member 9 0.916
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.914
RCN3 reticulocalbin 3, EF-hand calcium binding domain 0.911
SMAD7 SMAD family member 7 0.911
RAX retina and anterior neural fold homeobox 0.886
STK36 serine/threonine kinase 36 0.881
PTCH1 patched 1 0.879
PAX6 paired box 6 0.873
MAML1 mastermind-like 1 (Drosophila) 0.872
OLIG2 oligodendrocyte lineage transcription factor 2 0.860
RUNX1 runt-related transcription factor 1 0.843
FGF3 fibroblast growth factor 3 0.840
PAX2 paired box 2 0.826
HOXD12 homeobox D12 0.819
SIX3 SIX homeobox 3 0.807
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.805
LHX1 LIM homeobox 1 0.795
TRIM33 tripartite motif containing 33 0.792
SMAD3 SMAD family member 3 0.791
SOX11 SRY (sex determining region Y)-box 11 0.778
CDX2 caudal type homeobox 2 0.776
CCNE1 cyclin E1 0.771
NOTCH2 notch 2 0.755
SFRP5 secreted frizzled-related protein 5 0.748
NCOR1 nuclear receptor corepressor 1 0.744
BHLHE23 basic helix-loop-helix family, member e23 0.740
NKX2-2 NK2 homeobox 2 0.734
FEV FEV (ETS oncogene family) 0.732
SOX1 SRY (sex determining region Y)-box 1 0.730
CDK6 cyclin-dependent kinase 6 0.702
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.698
LHX5 LIM homeobox 5 0.697
SOX2 SRY (sex determining region Y)-box 2 0.692
MNX1 motor neuron and pancreas homeobox 1 0.685
HOXC8 homeobox C8 0.683
HOXB9 homeobox B9 0.678
TP73 tumor protein p73 0.664
HOXB13 homeobox B13 0.660
GBX2 gastrulation brain homeobox 2 0.642
AR androgen receptor 0.641
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.623
GSC goosecoid homeobox 0.620
RBPMS RNA binding protein with multiple splicing 0.619
C1QL1 complement component 1, q subcomponent-like 1 0.614
TCF4 transcription factor 4 0.608
WNT1 wingless-type MMTV integration site family, member 1 0.602
HOXD9 homeobox D9 0.599
ALX4 ALX homeobox 4 0.598
TGFB1 transforming growth factor, beta 1 0.597
SIM2 single-minded homolog 2 (Drosophila) 0.596
FOXB1 forkhead box B1 0.594
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.593
FOXE1 forkhead box E1 (thyroid transcription factor 2) 0.593
OTP orthopedia homeobox 0.585
PAX7 paired box 7 0.584
MSX1 msh homeobox 1 0.577
PYY peptide YY 0.576
HES2 hairy and enhancer of split 2 (Drosophila) 0.573
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.573
POU4F1 POU class 4 homeobox 1 0.568
WNT10A wingless-type MMTV integration site family, member 10A 0.567
POU4F2 POU class 4 homeobox 2 0.559
VAX2 ventral anterior homeobox 2 0.555
DLL3 delta-like 3 (Drosophila) 0.553
HOXD13 homeobox D13 0.541
DLL1 delta-like 1 (Drosophila) 0.529
COL2A1 collagen, type II, alpha 1 0.521
HOXD11 homeobox D11 0.518
ZIC1 Zic family member 1 (odd-paired homolog, Drosophila) 0.516
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Id3 inhibitor of DNA binding 3 0.347
Id1 inhibitor of DNA binding 1 0.132
Unc5b unc-5 homolog B (C. elegans) 0.101
Nrarp Notch-regulated ankyrin repeat protein 0.080
Cep78 centrosomal protein 78 0.065
Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 0.062
Klf2 Kruppel-like factor 2 (lung) 0.061
Gipr gastric inhibitory polypeptide receptor 0.058
Gpr20 G protein-coupled receptor 20 0.056
Znf76 zinc finger protein 76 (expressed in testis) 0.055
Sult5a1 sulfotransferase family 5A, member 1 0.052
Barhl2 BarH-like homeobox 2 0.049
Pou2f3 POU class 2 homeobox 3 0.049
Foxs1 forkhead box S1 0.048
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.048
Dchs1 dachsous 1 (Drosophila) 0.048
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.047
Oxt oxytocin, prepropeptide 0.047
Adam10 ADAM metallopeptidase domain 10 0.047
Gdf11 growth differentiation factor 11 0.046
Acan aggrecan 0.046
Smad7 SMAD family member 7 0.040
Tcp11 t-complex protein 11 0.039
Scn4a sodium channel, voltage-gated, type IV, alpha subunit 0.039
Bbx bobby sox homolog (Drosophila) 0.038
Lef1 lymphoid enhancer binding factor 1 0.038
Cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.038
Tgfbr2 transforming growth factor, beta receptor II 0.038
Abcc1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 0.037
Foxd3 forkhead box D3 0.037
Teddm1 transmembrane epididymal protein 1 0.036
Sox10 SRY (sex determining region Y)-box 10 0.036
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.036
Twist1 twist homolog 1 (Drosophila) 0.036
Brca1 breast cancer 1 0.034
Ednrb endothelin receptor type B 0.034
Kcnh6 potassium voltage-gated channel, subfamily H (eag-related), member 6 0.034
Kl Klotho 0.033
Ptgir prostaglandin I2 (prostacyclin) receptor (IP) 0.033
Ckm creatine kinase, muscle 0.033
Htr5b 5-hydroxytryptamine (serotonin) receptor 5B 0.033
Tcof1 Treacher Collins-Franceschetti syndrome 1 homolog (human) 0.033
Pak2 p21 protein (Cdc42/Rac)-activated kinase 2 0.033
Tmod2 tropomodulin 2 0.032
Gabre gamma-aminobutyric acid (GABA) A receptor, epsilon 0.032
Foxm1 forkhead box M1 0.031
Isl2 ISL LIM homeobox 2 0.031
Gstp1 glutathione S-transferase pi 1 0.030
Epha8 Eph receptor A8 0.029
Sept8 septin 8 0.029
Flt1 FMS-related tyrosine kinase 1 0.028
Phox2a paired-like homeobox 2a 0.028
Itpr3 inositol 1,4,5-triphosphate receptor, type 3 0.028
Six3 SIX homeobox 3 0.028
Notch1 Notch homolog 1, translocation-associated (Drosophila) 0.028
Grip2 glutamate receptor interacting protein 2 0.027
Alpk3 alpha-kinase 3 0.027
Calcr calcitonin receptor 0.027
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.027
Nfix nuclear factor I/X (CCAAT-binding transcription factor) 0.027
Mcam melanoma cell adhesion molecule 0.027
Mpp4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 0.027
Cd9 CD9 molecule 0.026
Nlgn2 neuroligin 2 0.026
Tulp1 tubby like protein 1 0.026
Kctd15 potassium channel tetramerisation domain containing 15 0.026
Nxph4 neurexophilin 4 0.026
Ecel1 endothelin converting enzyme-like 1 0.025
Pde4c phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila) 0.025
Robo1 roundabout homolog 1 (Drosophila) 0.025
Cdk2 cyclin dependent kinase 2 0.025
Cyth3 cytohesin 3 0.025
Hspb2 heat shock protein beta 2 0.025
Cdk7 cyclin-dependent kinase 7 0.025
Htr3a 5-hydroxytryptamine (serotonin) receptor 3a 0.025
Sema3a sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.024
Igfbp5 insulin-like growth factor binding protein 5 0.024
Tcf4 transcription factor 4 0.024
Hapln1 hyaluronan and proteoglycan link protein 1 0.024
P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 0.024
Egfl7 EGF-like-domain, multiple 7 0.024
Ddr1 discoidin domain receptor tyrosine kinase 1 0.024
Stc1 stanniocalcin 1 0.023
Tnr tenascin R 0.023
Jtb jumping translocation breakpoint 0.023
Mxd4 Max dimerization protein 4 0.023
Hoxb8 homeo box B8 0.023
Dlg4 discs, large homolog 4 (Drosophila) 0.023
Nfasc neurofascin 0.023
Nrm nurim (nuclear envelope membrane protein) 0.022
Dpf1 D4, zinc and double PHD fingers family 1 0.022
Olr825 olfactory receptor 825 0.022
Hist1h1a histone cluster 1, H1a 0.022
Add3 adducin 3 (gamma) 0.022
Brca2 breast cancer 2 0.021
Nptxr neuronal pentraxin receptor 0.021
Brunol5 bruno-like 5, RNA binding protein (Drosophila) 0.021
Elavl4 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) 0.021
Zfp706 zinc finger protein 706 0.021
Ncam1 neural cell adhesion molecule 1 0.021
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism